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Long Noncoding RNAs as Players in Breast Tumorigenesis

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The Chemical Biology of Long Noncoding RNAs

Part of the book series: RNA Technologies ((RNATECHN,volume 11))

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Abstract

Comprehensive analysis of the mammalian genome uncovered the discovery of pervasive transcription of large RNA transcripts that do not code for proteins, namely, long noncoding RNAs (lncRNAs). LncRNAs play important roles in the regulation of gene expression from integration of chromatin remodeling complexes to transcriptional and posttranscriptional regulation of protein-coding genes. Application of next-generation sequencing technologies to cancer transcriptomes has revealed that aberrant expression of lncRNAs is associated with tumor progression and metastasis. Although thousands of lncRNAs have been shown to be dysregulated in different cancer types, just few of them have been fully characterized. In this book chapter, we aim to highlight recent findings of the mechanistic function of lncRNAs in breast cancer and summarize key examples of lncRNAs that are misregulated during breast tumorigenesis. We have categorized breast cancer–associated lncRNA according to their contribution to tumor suppression or tumor progression based on recent studies. Because some of them are expressed in a specific molecular breast cancer subtype, we have outlined lncRNAs that can potentially serve as diagnostic and prognostic markers, in which expression is linked to chemotherapy resistance. Finally, we have discussed current limitations and perspectives on potential lncRNA targets for use in therapies against breast cancer.

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Change history

  • 29 December 2020

    The original version of chapter 15 was inadvertently published with an error in the chapter title. The correct chapter title is mentioned below and the chapter has now been corrected.

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Acknowledgments

We sincerely apologize to authors whose work could not be included due to space limitations. This work is supported by grants from the Knut and Alice Wallenberg Foundation, Umeå University, Västerbotten County Council, Kempe Foundation, Swedish Research Council, Cancerfonden, and the Cancer Research Foundation in Northern Sweden.

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Authors and Affiliations

  1. Wallenberg Centre for Molecular Medicine (WCMM), Umeå University, Umeå, Sweden

    Cyrinne Achour & Francesca Aguilo

  2. Department of Medical Biosciences, Umeå University, Umeå, Sweden

    Cyrinne Achour & Francesca Aguilo

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  1. Cyrinne Achour
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  2. Francesca Aguilo
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Correspondence to Francesca Aguilo .

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Editors and Affiliations

  1. Nanobiomedical Center of the Adam Mickiewicz University,, Poznań, Poland

    Stefan Jurga

  2. Nanobiomedical Center of the Adam Mickiewicz University,, Poznań, Poland

    Jan Barciszewski

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Achour, C., Aguilo, F. (2020). Long Noncoding RNAs as Players in Breast Tumorigenesis. In: Jurga, S., Barciszewski, J. (eds) The Chemical Biology of Long Noncoding RNAs. RNA Technologies, vol 11. Springer, Cham. https://doi.org/10.1007/978-3-030-44743-4_15

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