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The Role of Nrf2 in the Cardiovascular System and Atherosclerosis

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Nrf2 and its Modulation in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR,volume 85))

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Abstract

The cardiovascular system is an important transport system comprised of the heart and associated blood vessels. Within this transport network, various biochemical reactions (including gas transfer, immune modulation, waste transport, and fluid transfer) take place within a three-layered vascular structure that is highly susceptible to damage from bacterial polysaccharides, elevated blood lipids, immune by-products, and reactive oxygen species (ROS). Recently, ROS have come to the forefront of translational research as reports show a key role for ROS and unchecked vascular cell proliferation in the development of atherosclerotic plaques as well as damage to the myocardium. Of prime importance in the maintenance of homeostasis against these insults is the body’s innate antioxidant system which is controlled almost entirely by the master transcription factor Nrf2. This chapter will explain the molecular mechanism behind the regulation of Nrf2, explore the impact of Nrf2 on the cardiovascular system and probable link to autophagy, and explicate the large number of exogenous chemical regulators of Nrf2 that are available for use in both in vitro and in vivo cardiovascular studies.

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Acknowledgments

The authors have no acknowledgements to declare.

Conflicts of Interest: The authors have no conflicts of interest to declare.

Memorium: B.J.M. wishes to dedicate this manuscript to the memory of Charles Edward Milliken who was a great scientist, friend, and mentor.

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  1. Faculty of Medicine, University of Tsukuba Affiliated Hospital, Ibaraki, Japan

    Bryan J. Mathis

  2. Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC, USA

    Taixing Cui

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    Huai Deng

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Mathis, B.J., Cui, T. (2020). The Role of Nrf2 in the Cardiovascular System and Atherosclerosis. In: Deng, H. (eds) Nrf2 and its Modulation in Inflammation. Progress in Inflammation Research, vol 85. Springer, Cham. https://doi.org/10.1007/978-3-030-44599-7_5

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