Abstract
Arbovirus infections currently represent an important worldwide public health problem. The clinical spectrum of this group of diseases varies from asymptomatic disease to severe forms and is characterized by bleeding events (hemorrhagic fever) or neurological manifestations. Currently, the four arbovirus-related infections of main public health importance are yellow fever (YF), dengue fever (DEN), chikungunya (CHIK), and zika (ZIKA), all capable of being transmitted by the same vectors, mainly Aedes aegypti and Aedes albopictus. This chapter aims to describe the most common arbovirus-related diseases in Brazil, their clinical and epidemiological aspects, emphasizing the features related to renal involvement in these diseases. Acute kidney injury (AKI) is a widely reported complication in the literature and can significantly affect morbidity and mortality in dengue patients. This can result in reduced renal perfusion, leading to acute tubular necrosis (ATN). There are reports in the literature of ATN cases in dengue patients, even when there is no progression to dengue hemorrhagic fever (DHF). Another reported mechanism has been coagulopathy combined with hypotension as the primary cause of AKI in dengue patients. Few studies have evaluated renal alterations in patients with chikungunya and zika virus infections. Electrolyte abnormalities and urinary alterations in these arbovirus infections are not well known. However, some patients may develop more severe renal damage, leading to acute kidney injury, especially in the context of chikungunya infection. Chikungunya infection in patients with chronic kidney disease or in kidney transplant recipients may complicate the clinical course, presenting with proteinuria and worsening renal function and requiring specific interventions.
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da Justa Pires Neto, R., Bezerra da Silva Junior, G. (2020). Renal Involvement in Patients with Arbovirus Infections. In: Bezerra da Silva Junior, G., De Francesco Daher, E., Barros, E. (eds) Tropical Nephrology. Springer, Cham. https://doi.org/10.1007/978-3-030-44500-3_7
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DOI: https://doi.org/10.1007/978-3-030-44500-3_7
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