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Cardiac Regeneration and Repair: From Mechanisms to Therapeutic Strategies

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Concepts and Applications of Stem Cell Biology

Part of the book series: Learning Materials in Biosciences ((LMB))

Abstract

Cardiovascular diseases lead the ranking of lethal causalities worldwide, which has been largely attributed to the limited regenerative capacity of the human heart. This restricted myocardial renewing capacity and exacerbated fibrosis often result in heart failure. Currently, the only long-term efficient therapy for this condition is whole-organ transplantation, which is limited by the shortage of donors and physiological constraints. Hence, several cutting-edge strategies to improve cardiac function, namely, gene and cellular therapies, biomaterial design and delivery, either solely or combined, are under investigation. In parallel, studies on heart development and on regenerative mechanisms evolutionarily conserved amongst species have highlighted molecules that hold potential for future therapeutic purposes. This perspective gained further relevance with recent advances showing that murine hearts display regenerative potential yet restrict to a limited period after birth. This chapter will revisit the regenerative capacity of the heart across species and throughout the lifespan, while discussing current advances in therapeutic alternatives for heart failure.

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Acknowledgments

This work was funded by the European Regional Development Fund (ERDF) through COMPETE 2020, Portugal 2020 and by FCT (Fundação para a Ciência e Tecnologia, [POCI-01-0145-FEDER-030985] and [POCI-01-0145-FEDER-031120]; and by FCT/Ministério da Ciência, Tecnologia e Inovação in the framework of individual funding: [SFRH/BD/111799/2015] to V.S.-P. and [CEECINST/00091/2018] to DSN.

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Authors and Affiliations

  1. i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

    Vasco Sampaio-Pinto, Ana C. Silva, Perpétua Pinto-do-Ó & Diana S. Nascimento

  2. INEB – Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Porto, Portugal

    Vasco Sampaio-Pinto, Ana C. Silva, Perpétua Pinto-do-Ó & Diana S. Nascimento

  3. ICBAS – Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal

    Vasco Sampaio-Pinto, Ana C. Silva, Perpétua Pinto-do-Ó & Diana S. Nascimento

  4. Department of Cardiology, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands

    Vasco Sampaio-Pinto

  5. Department of Molecular Genetics, Faculty of Sciences and Engineering, Maastricht University, Maastricht, The Netherlands

    Vasco Sampaio-Pinto

  6. Gladstone Institutes, University of California San Francisco, San Francisco, CA, USA

    Ana C. Silva

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  1. Vasco Sampaio-Pinto
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  3. Perpétua Pinto-do-Ó
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  4. Diana S. Nascimento
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Correspondence to Diana S. Nascimento .

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  1. Centro de Ecologia, Evolução e Alterações Ambientais, Departamento de Biologia Animal, Faculdade de Ciências da, Universidade de Lisboa, Lisbon, Portugal

    Gabriela Rodrigues

  2. Embryology, Anatomy and Physiology, Department Clinical Sciences, Faculty of Veterinary Medicine, Utrecht Universtity, Utrecht, The Netherlands

    Bernard A. J. Roelen

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Sampaio-Pinto, V., Silva, A.C., Pinto-do-Ó, P., Nascimento, D.S. (2020). Cardiac Regeneration and Repair: From Mechanisms to Therapeutic Strategies. In: Rodrigues, G., Roelen, B.A.J. (eds) Concepts and Applications of Stem Cell Biology. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-43939-2_10

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