Abstract
Renal failure during pregnancy and the peripartum period encompasses acute kidney injury (AKI), chronic kidney disease, and end-stage renal disease (ESRD). The epidemiology of these conditions varies worldwide. Acute kidney injury may be due to conditions specific to pregnancy, disorders that coincide with pregnancy, or an exacerbation of a pre-existing renal disorder. Management consists of prompt resuscitation of hemodynamic and fluid status, treatment of the underlying disease, and renal replacement therapy (RRT) in case of complications of AKI.
This chapter summarizes the most common causes of AKI; describes therapeutic options, including RRT; and emphasizes the need for close multidisciplinary management during the acute period and beyond.
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References
Machado S, Figueiredo N, Borges A, et al. Acute kidney injury in pregnancy: a clinical challenge. J Nephrol. 2012;25:19–30.
American College of Obstetricians and Gynecologists. Task force on hypertension in pregnancy; 2013. https://www.acog.org/~/media/Task%20Force%20and%20Work%20Group%20Reports/public/HypertensioninPregnancy.pdf. Last Accessed 25 Feb 2018.
Liu Y, Ma X, Zheng J, Liu X, Yan T. Pregnancy outcomes in patients with acute kidney injury during pregnancy: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2017;17(1):235.
Mehrabadi A, Dahhou M, Joseph KS, Kramer MS. Investigation of a rise in obstetric acute renal failure in the United States, 1999–2011. Obstet Gynecol. 2016;127(5):899–906.
Gopalakrishnan N, Dhanapriya J, Muthukumar P, et al. Acute kidney injury in pregnancy–a single center experience. Ren Fail. 2015;37:1476–80.
Kamal EM, Behery MM, Sayed GA, Abdulatif HK. RIFLE classification and mortality in obstetric patients admitted to the intensive care unit with acute kidney injury: a 3-year prospective study. Reprod Sci. 2014;21:1281–7.
Gurrieri C, Garovic VD, Gullo A, et al. Kidney injury during pregnancy: associated comorbid conditions and outcomes. Arch Gynecol Obstet. 2012;286:567–73.
Prakash J, Pant P, Prakash S, et al. Changing picture of acute kidney injury in pregnancy: study of 259 cases over a period of 33 years. Indian J Nephrol. 2016;26(4):262–7.
Hildebrand AM, Liu K, Shariff SZ, et al. Characteristics and outcomes of AKI treated with dialysis during pregnancy and the postpartum period. J Am Soc Nephrol. 2015;26(12):3085–91.
Patel M, Sachan R, Gangwar R, Sachan P, Natu S. Correlation of serum neutrophil gelatinase-associated lipocalin with acute kidney injury in hypertensive disorders of pregnancy. Int J Nephrol Renovasc Dis. 2013;6:181–6.
Drakeley AJ, Le Roux PA, Anthony J, Penny J. Acute renal failure complicating severe preeclampsia requiring admission to an obstetric intensive care unit. Am J Obstet Gynecol. 2002;186(2):253–6.
Mehta RL, Burdmann EA, Cerda J, et al. Recognition and management of acute kidney injury in the International Society of Nephrology 0by25 Global Snapshot: a multinational cross-sectional study. Lancet. 2016;387(10032):2017–25.
Pourrat O, Coudroy R, Pierre F. Differentiation between severe HELLP syndrome and thrombotic microangiopathy, thrombotic thrombocytopenic purpura and other imitators. Eur J Obstet Gynecol Reprod Biol. 2015;189:68–72.
Fakhouri F, Vercel C, Fremeaux-Bacchi V. Obstetric nephrology: AKI and thrombotic microangiopathies in pregnancy. Clin J Am Soc Nephrol. 2012;7:2100–6.
Prakash J, Ganiger VC. Acute kidney injury in pregnancy—specific disorders. Indian J Nephrol. 2017;27(4):258–70.
Ostermann M, Liu K. Pathophysiology of AKI. Best Pract Res Clin Anaesthesiol. 2017;31(3):305–14.
Lombardi R, Rosa-Diez G, Ferreiro A, et al. Acute kidney injury in Latin America: a view on renal replacement therapy resources. Nephrol Dial Transplant. 2014;29(7):1369–76.
Prakash J, Ganiger VC, Prakash S, et al. Acute kidney injury in pregnancy with special reference to pregnancy-specific disorders: a hospital based study (2014–2016). J Nephrol. 2018;31(1):79–85.
Rasmussen PE, Nielsen FR. Hydronephrosis during pregnancy: a literature survey. Eur J Obstet Gynecol Reprod Biol. 1988;27(3):249–59.
Rajasekar D, Hall M. Urinary tract injuries during obstetric intervention. Br J Obstet Gynaecol. 1997;104(6):731–4.
Gammill HS, Jeyabalan A. Acute renal failure in pregnancy. Crit Care Med. 2005;33(10 Suppl):S372–84.
Clark SL, Hankins GD, Dudley DA, et al. Amniotic fluid embolism: analysis of national registry. Am J Obstet Gynecol. 1995;172:1158–69.
Clark SL, Pavlova Z, Greenspoon J, Horenstein J, Phelan JP. Squamous cells in the maternal pulmonary circulation. Am J Obstet Gynecol. 1986;154(1):104–6.
Saad AF, Roman J, Wyble A, Pacheco LD. Pregnancy-associated atypical hemolytic-uremic syndrome. AJP Rep. 2016;6(1):e125–8.
Delmas Y, Helou S, Chabanier P, et al. Incidence of obstetrical thrombotic thrombocytopenic purpura in a retrospective study within thrombocytopenic pregnant women. A difficult diagnosis and a treatable disease. BMC Pregnancy Childbirth. 2015;15:137.
Kiuttu J, Hartikainen-Sorri AL, Mäkitalo R. Occurrence of antinuclear antibodies in an unselected pregnancy population. Gynecol Obstet Investig. 1992;33(1):21–5.
Darmon M, Ostermann M, Cerda J, et al. Diagnostic work-up and specific causes of acute kidney injury. Intensive Care Med. 2017;43(6):829–40.
Clowse ME, Magder LS, Petri M. The clinical utility of measuring complement and anti-dsDNA antibodies during pregnancy in patients with systemic lupus erythematosus. J Rheumatol. 2011;38(6):1012–6.
Piccoli GB, Daidola G, Attini R, et al. Kidney biopsy in pregnancy: evidence for counselling? A systematic narrative review. BJOG. 2013;120(4):412–27.
Joannidis M, Druml W, Forni LG, et al. Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017: expert opinion of the working group on prevention, AKI section, European Society of Intensive Care Medicine. Intensive Care Med. 2017;43(6):730–49.
Brown CM, Garovic VD. Drug treatment of hypertension in pregnancy. Drugs. 2014;74(3):283–98.
Semins MJ, Trock BJ, Matlaga BR. The safety of ureteroscopy during pregnancy: a systematic review and meta-analysis. J Urol. 2009;181(1):139–43.
Semins MJ, Matlaga BR. Ureteroscopy during pregnancy. Indian J Urol. 2009;25(3):291–5.
Society for Maternal-Fetal Medicine (SMFM), Pacheco LD, Saade G, Hankins GD, Clark SL. Amniotic fluid embolism: diagnosis and management. Am J Obstet Gynecol. 2016;215(2):B16–24.
Bagshaw SM, Darmon M, Ostermann M, et al. Current state of the art for renal replacement therapy in critically ill patients with acute kidney injury. Intensive Care Med. 2017;43(6):841–54.
Ostermann M, Wald R, Bagshaw SM. Timing of renal replacement therapy in acute kidney injury. Contrib Nephrol. 2016;187:106–20.
Nash DM, Prech S, Wald R, O’Reilly D. Systematic review and meta-analysis of renal replacement therapy modalities for acute kidney injury in the intensive care unit. J Crit Care. 2017;41:138–44.
Manisco G, Poti M, Maggiulli G, et al. Pregnancy in end-stage renal disease patients on dialysis: how to achieve a successful delivery. Clin Kidney J. 2015;8(3):293–9.
Piccoli GB, Minelli F, Versino E, et al. Pregnancy in dialysis patients in the new millennium: a systematic review and meta-regression analysis correlating dialysis schedules and pregnancy outcomes. Nephrol Dial Transplant. 2016;31(11):1915–34.
Morabito S, Pistolesi V, Tritapepe L, et al. Regional citrate anticoagulation for RRTs in critically ill patients with AKI. Clin J Am Soc Nephrol. 2014;9(12):2173–88.
Gul A, Aslan H, Cebeci A, et al. Maternal and fetal outcomes in HELLP syndrome complicated with acute renal failure. Ren Fail. 2004;35:557–62.
Hladunewich M, Schatell D. Intensive dialysis and pregnancy. Hemodial Int. 2016;20(3):339–48.
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Roche-Kelly, E., Ostermann, M. (2020). Renal Failure and Renal Replacement Therapy During Pregnancy and the Peripartum Period. In: Einav, S., Weiniger, C.F., Landau, R. (eds) Principles and Practice of Maternal Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-030-43477-9_31
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DOI: https://doi.org/10.1007/978-3-030-43477-9_31
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