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Principles of Diagnosis and Treatment of Bone Remodeling Disorders

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Clinical Foundations of Musculoskeletal Medicine

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Abstract

Bone is constantly being remodeled to ensure development and maintenance of a healthy skeletal system. Normal bone remodeling is dependent upon several factors. Bone remodeling is under the auspices of osteoclasts which cause bone resorption, and osteoblasts which stimulate bone formation. This interplay between osteoclasts and osteoblasts is under a system of checks and balances through a complex signaling cascade that ensures healthy bone formation. Disruption of this signaling cascade can lead to abnormal bone remodeling and ultimately result in diseased bones. This can occur in a variety of manners that will be elaborated on in this chapter.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, University of North Carolina, Chapel Hill, NC, USA

    Roger Harty & Morgan S. Jones

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  1. Roger Harty
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  2. Morgan S. Jones
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Correspondence to Morgan S. Jones .

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Editors and Affiliations

  1. Department of Orthopedics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Robert J. Esther

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Harty, R., Jones, M.S. (2021). Principles of Diagnosis and Treatment of Bone Remodeling Disorders. In: Esther, R.J. (eds) Clinical Foundations of Musculoskeletal Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-42894-5_5

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  • DOI: https://doi.org/10.1007/978-3-030-42894-5_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-42893-8

  • Online ISBN: 978-3-030-42894-5

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