Skip to main content

Congenital Ptosis

  • Reference work entry
  • First Online:
Albert and Jakobiec's Principles and Practice of Ophthalmology
  • 142 Accesses

Abstract

Congenital ptosis is most commonly caused by maldevelopment of the levator palpebrae superioris muscle complex. It is less frequently associated with neurologic, myopathic, and other congenital syndromes. Congenital ptosis may cause amblyopia from visual deprivation or induced astigmatism, especially if it is unilateral or asymmetric. Therefore, once congenital ptosis is identified after birth, early evaluation and management is essential to maximize potential visual development. A complete history and examination are necessary to determine the correct etiology of the ptosis, and in cases of neurogenic ptosis or in the setting of other associated syndromic findings, neuroimaging and genetic testing may be needed to provide optimal medical and surgical management.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 5,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 6,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Gregory J, Griepentrog MD, Nancy Diehl BS, Brian G, Mohney MD. Incidence and demographics of childhood ptosis. Ophthalmology. 2011;118(6):1180–3.

    Article  Google Scholar 

  2. Marenco M, Macchi I, Macchi I, Galassi E, Massaro-Giordano M, Lambiase A. Clinical presentation and management of congenital ptosis. Clin Ophthalmol. 2017;11:453–63. https://doi.org/10.2147/OPTH.S111118. eCollection 2017.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Heher KL, Katowitz JA. Pediatric ptosis. Chapter 15. In: Katowitz JA, editor. Pediatric oculoplastic surgery. New York: Springer; 2002. p. 253–88.

    Chapter  Google Scholar 

  4. Jubbal KT, Kania K, Braun TL, Katowitz WR, Marx DP. Pediatric blepharoptosis. Semin Plast Surg. 2017;31(1):58–64. https://doi.org/10.1055/s-0037-1598631.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Lim JM, Hou JH, Singa RM, Aakalu VK, Setabutr P. Relative incidence of blepharoptosis subtypes in an oculoplastics practice at a tertiary care center. Orbit. 2013;32(4):231–4. https://doi.org/10.3109/01676830.2013.788673. Epub 2013 May 10.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Surve A, Sharma MC, Pushker N, Bajaj MS, Meel R, Kashyap S. A study of changes in levator muscle in congenital ptosis. Int Ophthalmol. 2019;39(6):1231–8. https://doi.org/10.1007/s10792-018-0931-1. Epub 2018 Apr 28.

    Article  PubMed  Google Scholar 

  7. Alshehri MD, Al-Fakey YH, Alkhalidi HM, Mubark MA, Alsuhaibani AH. Microscopic and ultrastructural changes of Müller’s muscle in patients with simple congenital ptosis. Ophthalmic Plast Reconstr Surg. 2014;30(4):337–41. https://doi.org/10.1097/IOP.0000000000000104.

    Article  PubMed  Google Scholar 

  8. Iljin A, Zielinska A, Karasek M, Zielinski A, Omulecka A. Structural abnormalities in the levator palpebrae superioris muscle in patients with congenital blepharoptosis. Ophthalmic Surg Lasers Imaging. 2007;38(4):283–9.

    Article  PubMed  Google Scholar 

  9. Wabbels B, Schroeder JA, Voll B, Siegmund H, Lorenz B. Electron microscopic findings in levator muscle biopsies of patients with isolated congenital or acquired ptosis. Graefes Arch Clin Exp Ophthalmol. 2007;245(10):1533–41. Epub 2007 May 24.

    Article  PubMed  Google Scholar 

  10. Baldwin HC, Manners RM. Congenital blepharoptosis: a literature review of the histology of levator palpebrae superioris muscle. Ophthalmic Plast Reconstr Surg. 2002;18(4):301–7.

    Article  PubMed  Google Scholar 

  11. Edmunds B, Manners RM, Weller RO, Steart P, Collin JR. Levator palpebrae superioris fibre size in normals and patients with congenital ptosis. Eye (Lond). 1998;12(Pt 1):47–50.

    Article  Google Scholar 

  12. Bagheri A, Tavakoli M, Najmi H, Erfanian Salim R, Yazdani S. Comparison between eyelid indices of ptotic eye and normal fellow eye in patients with unilateral congenital ptosis. J Plast Reconstr Aesthet Surg. 2016;69(1):e5–9. https://doi.org/10.1016/j.bjps.2015.10.004. Epub 2015 Oct 22.

    Article  PubMed  Google Scholar 

  13. Nagpal RC, Raj A, Maitreya A. Congenital double elevator palsy with sensory exotropia: a unique surgical management. J Ophthalmic Vis Res. 2017;12(2):222–4. https://doi.org/10.4103/2008-322X.205380.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Ng JK, Stout AU, Aaby AA, Ng JD. Blepharophimosis syndrome with absent tear production. Ophthalmic Plast Reconstr Surg. 2015;31(3):e62. https://doi.org/10.1097/IOP.0000000000000073.

    Article  PubMed  Google Scholar 

  15. Athappilly GK, Braverman RS. Congenital alacrima in a patient with blepharophimosis syndrome. Ophthalmic Genet. 2009;30(1):37–9. https://doi.org/10.1080/13816810802452176.

    Article  PubMed  Google Scholar 

  16. Duarte AF, Akaishi PM, de Molfetta GA, Chodraui-Filho S, Cintra M, Toscano A, Silva WA Jr, Cruz AA. Lacrimal gland involvement in blepharophimosis-ptosis-epicanthus inversus syndrome. Ophthalmology. 2017;124(3):399–406. https://doi.org/10.1016/j.ophtha.2016.10.028. Epub 2016 Nov 30.

    Article  PubMed  Google Scholar 

  17. Bunyan DJ, Thomas NS. Screening of a large cohort of blepharophimosis, ptosis, and epicanthus inversus syndrome patients reveals a very strong paternal inheritance bias and a wide spectrum of novel FOXL2 mutations. Eur J Med Genet. 2019. pii: S1769-7212(19)30176-4. https://doi.org/10.1016/j.ejmg.2019.05.007. Epub ahead of print.

  18. Lin B, Zeng B, Zhao J, Xu T, Wang Y, Hu B, Li F, Zhao Q, Liu R, Liu J, Chen JM, Huang D, Wang Y. Seven novel and three known mutations in FOXL2 in 10 Chinese families with blepharophimosis syndrome. Curr Mol Med. 2018;18(3):152–9. https://doi.org/10.2174/1566524018666180907162619.

    Article  CAS  PubMed  Google Scholar 

  19. Bouman A, van Haelst M, van Spaendonk R. Blepharophimosis-ptosis-epicanthus inversus syndrome caused by a 54-kb microdeletion in a FOXL2 cis-regulatory element. Clin Dysmorphol. 2018;27(2):58–62. https://doi.org/10.1097/MCD.0000000000000216.

    Article  PubMed  Google Scholar 

  20. Elzaiat M, Todeschini AL, Caburet S, Veitia RA. The genetic make-up of ovarian development and function: the focus on the transcription factor FOXL2. Clin Genet. 2017;91(2):173–82. https://doi.org/10.1111/cge.12862. Epub 2016 Sep 29.

    Article  CAS  PubMed  Google Scholar 

  21. Nuovo S, Passeri M, Di Benedetto E, Calanchini M, Meldolesi I, Di Giacomo MC, Petruzzi D, Piemontese MR, Zelante L, Sangiuolo F, Novelli G, Fabbri A, Brancati F. Characterization of endocrine features and genotype-phenotypes correlations in blepharophimosis-ptosis-epicanthus inversus syndrome type 1. J Endocrinol Investig. 2016;39(2):227–33. https://doi.org/10.1007/s40618-015-0334-3. Epub 2015 June 23.

    Article  CAS  Google Scholar 

  22. Demer JL, Clark RA, Tischfield MA, Engle EC. Evidence of an asymmetrical endophenotype in congenital fibrosis of extraocular muscles type 3 resulting from TUBB3 mutations. Invest Ophthalmol Vis Sci. 2010;51(9):4600–11. https://doi.org/10.1167/iovs.10-5438. Epub 2010 Apr 14.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Heidary G, Engle EC, Hunter DG. Congenital fibrosis of the extraocular muscles. Semin Ophthalmol. 2008;23(1):3–8. https://doi.org/10.1080/08820530701745181.

    Article  PubMed  Google Scholar 

  24. Aubourg P, Krahn M, Bernard R, Nguyen K, Forzano O, Boccaccio I, Delague V, De Sandre-Giovannoli A, Pouget J, Depétris D, Mattei MG, Philip N, Lévy N. Assignment of a new congenital fibrosis of extraocular muscles type 3 (CFEOM3) locus, FEOM4, based on a balanced translocation t(2;13) (q37.3;q12.11) and identification of candidate genes. J Med Genet. 2005;42(3):253–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Demer JL, Clark RA, Engle EC. Magnetic resonance imaging evidence for widespread orbital dysinnervation in congenital fibrosis of extraocular muscles due to mutations in KIF21A. Invest Ophthalmol Vis Sci. 2005;46(2):530–9.

    Article  PubMed  Google Scholar 

  26. Yamada K, Chan WM, Andrews C, Bosley TM, Sener EC, Zwaan JT, Mullaney PB, Oztürk BT, Akarsu AN, Sabol LJ, Demer JL, Sullivan TJ, Gottlob I, Roggenkäemper P, Mackey DA, De Uzcategui CE, Uzcategui N, Ben-Zeev B, Traboulsi EI, Magli A, de Berardinis T, Gagliardi V, Awasthi-Patney S, Vogel MC, Rizzo JF 3rd, Engle EC. Identification of KIF21A mutations as a rare cause of congenital fibrosis of the extraocular muscles type 3 (CFEOM3). Invest Ophthalmol Vis Sci. 2004;45(7):2218–23.

    Article  PubMed  Google Scholar 

  27. Engle EC. The molecular basis of the congenital fibrosis syndromes. Strabismus. 2002;10(2):125–8.

    Article  PubMed  Google Scholar 

  28. Schoser BG, Pongratz D. Extraocular mitochondrial myopathies and their differential diagnoses. Strabismus. 2006;14(2):107–13.

    Article  PubMed  Google Scholar 

  29. Allen RC. Genetic diseases affecting the eyelids: what should a clinician know? Curr Opin Ophthalmol. 2013;24(5):463–77. https://doi.org/10.1097/ICU.0b013e3283638219.

    Article  PubMed  Google Scholar 

  30. Cahill JA, Ross J. Eye on children: acute work-up for pediatric Horner’s syndrome. Case presentation and review of the literature. J Emerg Med. 2015;48(1):58–62. https://doi.org/10.1016/j.jemermed.2014.07.041. Epub 2014 Oct 1.

    Article  PubMed  Google Scholar 

  31. Hageman G, Ippel PF, te Nijenhuis FC. Autosomal dominant congenital Horner’s syndrome in a Dutch family. J Neurol Neurosurg Psychiatry. 1992;55(1):28–30.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Zafeiriou DI, Economou M, Koliouskas D, Triantafyllou P, Kardaras P, Gombakis N. Congenital Horner’s syndrome associated with cervical neuroblastoma. Eur J Paediatr Neurol. 2006;10(2):90–2. Epub 2006 Apr 3.

    Article  PubMed  Google Scholar 

  33. Tsaloumas MD, Willshaw HE. Congenital oculomotor palsy: associated neurological and ophthalmological findings. Eye (Lond). 1997;11(Pt 4):500–3.

    Article  PubMed  Google Scholar 

  34. Ng YS, Lyons CJ. Oculomotor nerve palsy in childhood. Can J Ophthalmol. 2005;40(5):645–53.

    Article  PubMed  Google Scholar 

  35. Hamed LM. Associated neurologic and ophthalmologic findings in congenital oculomotor nerve palsy. Ophthalmology. 1991;98(5):708–14.

    Article  CAS  PubMed  Google Scholar 

  36. Balkan R, Hoyt CS. Associated neurologic abnormalities in congenital third nerve palsies. Am J Ophthalmol. 1984;97(3):315–9.

    Article  CAS  PubMed  Google Scholar 

  37. Demirci H, Frueh BR, Nelson CC. Marcus Gunn jaw-winking synkinesis: clinical features and management. Ophthalmology. 2010;117(7):1447–52. https://doi.org/10.1016/j.ophtha.2009.11.014. Epub 2010 Feb 25.

    Article  PubMed  Google Scholar 

  38. Sobel RK, Allen RC. Incidence of bilateral Marcus Gunn jaw-wink. Ophthalmic Plast Reconstr Surg. 2014;30(3):e54–5. https://doi.org/10.1097/IOP.0b013e31829bb405.

    Article  PubMed  Google Scholar 

  39. Mansukhani SA, Bothun ED, Diehl NN, Mohney BG. Incidence and ocular features of pediatric myasthenias. Am J Ophthalmol. 2019;200:242–9. https://doi.org/10.1016/j.ajo.2019.01.004. Epub 2019 Jan 14.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Peragallo JH. Pediatric Myasthenia gravis. Semin Pediatr Neurol. 2017;24(2):116–21. https://doi.org/10.1016/j.spen.2017.04.003. Epub 2017 Apr 7.

    Article  PubMed  Google Scholar 

  41. Pavone P, Polizzi A, Longo MR, Romano K, Vecchio M, Praticò AD, Falsaperla R. Congenital myasthenic syndromes: clinical and molecular report on 7 sicilian patients. J Pediatr Neurosci. 2013;8(1):19–21. https://doi.org/10.4103/1817-1745.111416.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Rasiah S, Hardy TG, Elder JE, Ng CY, McNab A. Etiology of pediatric acquired blepharoptosis. J AAPOS. 2017;21(6):485–7. https://doi.org/10.1016/j.jaapos.2017.08.005. Epub 2017 Nov 3.

    Article  PubMed  Google Scholar 

  43. Leone F, Benanti E, Marchesi A, Marcelli S, Gazzola R, Vaienti L. Surgical excision of infantile haemangiomas: a technical refinement to prevent bleeding complications. Pediatr Med Chir. 2014;36(3):7. https://doi.org/10.4081/pmc.2014.7.

    Article  CAS  PubMed  Google Scholar 

  44. Awadein A, Fakhry MA. Evaluation of intralesional propranolol for periocular capillary hemangioma. Clin Ophthalmol. 2011;5:1135–40. https://doi.org/10.2147/OPTH.S22909. Epub 2011 Aug 15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Arneja JS, Mulliken JB. Resection of amblyogenic periocular hemangiomas: indications and outcomes. Plast Reconstr Surg. 2010;125(1):274–81. https://doi.org/10.1097/PRS.0b013e3181c49708.

    Article  CAS  PubMed  Google Scholar 

  46. Slaughter K, Sullivan T, Boulton J, O’Reagan P, Gole G. Early surgical intervention as definitive treatment for ocular adnexal capillary haemangioma. Clin Exp Ophthalmol. 2003;31(5):418–23.

    Article  PubMed  Google Scholar 

  47. Walker RS, Custer PL, Nerad JA. Surgical excision of periorbital capillary hemangiomas. Ophthalmology. 1994;101(8):1333–40.

    Article  CAS  PubMed  Google Scholar 

  48. Paik JS, Kim SA, Park SH, Yang SW. Refractive error characteristics in patients with congenital blepharoptosis before and after ptosis repair surgery. BMC Ophthalmol. 2016;16(1):177.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Anderson RL, Baumgartner SA. Amblyopia in ptosis. Arch Ophthalmol. 1980;98(6):1068–9.

    Article  CAS  PubMed  Google Scholar 

  50. Dogan AS, Acar M, Kosker M, Arslan N, Gurdal C. Alterations in corneal epithelial thickness in patients with congenital myogenic eyelid ptosis. Int Ophthalmol. 2018;38(1):53–7. https://doi.org/10.1007/s10792-016-0419-9. Epub 2016 Dec 26.

    Article  PubMed  Google Scholar 

  51. Langford JD, Linberg JV, Blaylock WK, Chao GM. Axial myopia in congenital ptosis: an animal model. Ophthalmic Plast Reconstr Surg. 1998;14(4):261–5.

    Article  CAS  PubMed  Google Scholar 

  52. Boricean ID, Bărar A. Understanding ocular torticollis in children. Oftalmologia. 2011;55(1):10–26.

    PubMed  Google Scholar 

  53. Pratt SG, Beyer CK, Johnson CC. The Marcus Gunn phenomenon. A review of 71 cases. Ophthalmology. 1984;91(1):27–30.

    Article  CAS  PubMed  Google Scholar 

  54. Wong JF, Thériault JF, Bouzouaya C, Codère F. Marcus Gunn jaw-winking phenomenon: a new supplemental test in the preoperative evaluation. Ophthalmic Plast Reconstr Surg. 2001;17(6):412–8.

    Article  CAS  PubMed  Google Scholar 

  55. Luk HM, Lo IF, Lai CW, Ma LC, Tong TM, Chan DH, Lam ST. Congenital fibrosis of extraocular muscle type 1A due to KIF21A mutation: first case report from Hong Kong. Hong Kong Med J. 2013;19(2):182–5.

    CAS  PubMed  Google Scholar 

  56. Engle EC, Castro AE, Macy ME, Knoll JH, Beggs AH. A gene for isolated congenital ptosis maps to a 3-cM region within 1p32-p34.1. Am J Hum Genet. 1997;60(5):1150–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  57. McMullan TF, Collins AR, Tyers AG, Robinson DO. A novel X-linked dominant condition: X-linked congenital isolated ptosis. Am J Hum Genet. 2000;66(4):1455–60. Epub 2000 Mar 14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. McMullan TW, Crolla JA, Gregory SG, Carter NP, Cooper RA, Howell GR, Robinson DO. A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. Hum Genet. 2002;110(3):244–50. Epub 2002 Feb 01.

    Article  CAS  PubMed  Google Scholar 

  59. Be YS, Tsai PJ, Lin MC, Chu MY. Factors related to amblyopia in congenital ptosis after frontalis sling surgery. BMC Ophthalmol. 2018;18(1):302. https://doi.org/10.1186/s12886-018-0962-4.

    Article  Google Scholar 

  60. Feldman I, Brusasco L, Malhotra R. Improving outcomes of posterior approach levatorpexy for congenital ptosis with reduced levator function. Ophthalmic Plast Reconstr Surg. 2018;34(5):460–2. https://doi.org/10.1097/IOP.0000000000001056.

    Article  PubMed  Google Scholar 

  61. Gazit I, Gildener-Leapman J, Or L, Burkat CN, Pras E, Hartstein ME. Müller’s muscle-conjunctival resection combined with tarsectomy for treatment of congenital ptosis. Ophthalmic Plast Reconstr Surg. 2019. https://doi.org/10.1097/IOP.0000000000001410. [Epub ahead of print].

  62. Medel R, Molina S, Vasquez LM, Visa J, Wert A, Wolley-Dod C. Frontalis muscle flap versus maximal anterior levator resection as first option for patients with severe congenital ptosis. Ophthalmic Plast Reconstr Surg. 2018;34(6):565–9. https://doi.org/10.1097/IOP.0000000000001105.

    Article  PubMed  Google Scholar 

  63. Gazzola R, Piozzi E, Vaienti L, Wilhelm Baruffaldi Preis F. Therapeutic algorithm for congenital ptosis repair with levator resection and frontalis suspension: results and literature review. Semin Ophthalmol. 2018;33(4):454–60. https://doi.org/10.1080/08820538.2017.1297840. Epub 2017 Mar 15.

    Article  PubMed  Google Scholar 

  64. Lee JH, Aryasit O, Kim YD, Woo KI, Lee L, Johnson ON 3rd. Maximal levator resection in unilateral congenital ptosis with poor levator function. Br J Ophthalmol. 2017;101(6):740–6. https://doi.org/10.1136/bjophthalmol-2016-309163. Epub 2016 Sep 6.

    Article  PubMed  Google Scholar 

  65. Daoudi C, Chahdi KO, Lezrek O, Karim A, Daoudi R. Whitnall’s ligament suspension technique in ptosis surgery. J Fr Ophtalmol. 2017;40(9):763–9.

    Article  CAS  PubMed  Google Scholar 

  66. Molinari A, Weaver DT, Goldblum TA, Silbert D, Lopez SP, Matta N. Pediatric frontalis suspension with braided polyester: a comparison of two techniques. J Pediatr Ophthalmol Strabismus. 2018;55(4):229–33. https://doi.org/10.3928/01913913-20180213-02. Epub 2018 May 1.

    Article  PubMed  Google Scholar 

  67. Mehta A, Garg P, Naik M, Kumari A. Congenital ptosis repair with a frontalis silicon sling: comparison between Fox’s single pentagon technique and a modified Crawford double triangle technique. J AAPOS. 2017;21(5):365–9. https://doi.org/10.1016/j.jaapos.2017.05.029. Epub 2017 July 14.

    Article  PubMed  Google Scholar 

  68. Zaky AG, Mandour SS, Zaky MA, Ebrahem AM. Two different techniques for frontalis suspension using Gore-Tex to treat severe congenital ptosis. Graefes Arch Clin Exp Ophthalmol. 2017;255(4):831–5. https://doi.org/10.1007/s00417-017-3611-3. Epub 2017 Feb 21.

    Article  PubMed  Google Scholar 

  69. Chung HW, Seah LL. Cosmetic and functional outcomes of frontalis suspension surgery using autologous fascia lata or silicone rods in pediatric congenital ptosis. Clin Ophthalmol. 2016;10:1779–83. eCollection 2016.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Bansal RK, Sharma S. Results and complications of silicone frontalis sling surgery for ptosis. J Pediatr Ophthalmol Strabismus. 2015;52(2):93–7.

    Article  PubMed  Google Scholar 

  71. Sokol JA, Thornton IL, Lee HB, Nunery WR. Modified frontalis suspension technique with review of large series. Ophthalmic Plast Reconstr Surg. 2011;27(3):211–5. https://doi.org/10.1097/IOP.0b013e3181ef72cd.

    Article  PubMed  Google Scholar 

  72. Morris CL, Buckley EG, Enyedi LB, Stinnett S, Freedman SE. Safety and efficacy of silicone rod frontalis suspension surgery for childhood ptosis repair. J Pediatr Ophthalmol Strabismus. 2008;45(5):280–8; quiz 289–90.

    Article  PubMed  Google Scholar 

  73. Kersten RC, Bernardini FP, Khouri L, Moin M, Roumeliotis AA, Kulwin DR. Unilateral frontalis sling for the surgical correction of unilateral poor-function ptosis. Ophthalmic Plast Reconstr Surg. 2005;21(6):412–6; discussion 416–7.

    Article  PubMed  Google Scholar 

  74. Li J, Dong C, Liu X, He W. Treatment of children with congenital severe blepharoptosis by frontalis aponeurosis flap advancement under general anesthesia in a single incision. J Craniofac Surg. 2017;28(6):1495–7. https://doi.org/10.1097/SCS.0000000000003948.

    Article  PubMed  Google Scholar 

  75. Liu H, Shao Y, Zhao Z, Zhang D. One-stage correction of blepharophimosis-ptosis-epicanthus inversus syndrome using a frontalis muscle transfer technique. J Plast Surg Hand Surg. 2014;48(1):74–9. https://doi.org/10.3109/2000656X.2013.819004. Epub 2013 Aug 23.

    Article  PubMed  Google Scholar 

  76. Tsai CC, Lin TM, Lai CS, Lin SD. Use of the orbicularis oculi muscle flap for severe Marcus Gunn ptosis. Ann Plast Surg. 2002;48(4):431–4.

    Article  PubMed  Google Scholar 

  77. Bowyer JD, Sullivan TJ. Management of Marcus Gunn jaw winking synkinesis. Ophthalmic Plast Reconstr Surg. 2004;20(2):92–8.

    Article  PubMed  Google Scholar 

  78. Khwarg SI, Tarbet KJ, Dortzbach RK, Lucarelli MJ. Management of moderate-to-severe Marcus-Gunn jaw-winking ptosis. Ophthalmology. 1999;106(6):1191–6.

    Article  CAS  PubMed  Google Scholar 

  79. Bartkowski SB, Zapala J, Wyszyńska-Pawelec G, Krzystkowa KM. Marcus Gunn Jaw-Winking Phenomenon: management and results of treatment in 19 patients. J Craniomaxillofac Surg. 1999;27(1):25–9.

    Article  CAS  PubMed  Google Scholar 

  80. Savino G, Mandarà E, Calandriello L, Dickmann A, Petroni S. A modified one-stage early correction of blepharophimosis syndrome using tutopatch slings. Orbit. 2015;34(4):186–91. https://doi.org/10.3109/01676830.2015.1015146. Epub 2015 June 4.

    Article  PubMed  Google Scholar 

  81. Parvizi S, Ong J, Abou Rayyah Y, Dunaway D. A novel medial canthal reconstruction technique in children with blepharophimosis syndrome. Ophthalmic Plast Reconstr Surg. 2019. https://doi.org/10.1097/IOP.0000000000001390. [Epub ahead of print].

  82. Yamaguchi K, Imai K, Fujimoto T, Takahashi M, Maruyama Y. Cosmetic comparison between the modified Uchida method and the Mustarde method for blepharophimosis-ptosis-epicanthus inversus syndrome. Ann Plast Surg. 2015;75(5):518–21. https://doi.org/10.1097/SAP.0000000000000198.

    Article  CAS  PubMed  Google Scholar 

  83. Song X, Jia R, Zhu H, Zhou Y, Sun Y, Lin M, Fu Y, Li J, Li Z, Lu L, Shen Y, Ge S, Fan X. A modified staged surgical intervention for blepharophimosis-ptosis-epicanthus inversus syndrome: 125 cases with encouraging results. Ann Plast Surg. 2015;74(4):410–7. https://doi.org/10.1097/01.sap.0000437072.17014.41.

    Article  CAS  PubMed  Google Scholar 

  84. Mandal SK, Mandal A, Fleming JC, Goecks T, Meador A, Fowler BT. Surgical outcome of epicanthus and telecanthus correction by Double Z-Plasty and Trans-Nasal fixation with prolene suture in blepharophimosis syndrome. J Clin Diagn Res. 2017;11(3):NC05–8. https://doi.org/10.7860/JCDR/2017/25651.9496. Epub 2017 Mar.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Chen L, Pi L, Ke N, Chen X, Liu Q. The protective efficacy and safety of bandage contact lenses in children aged 5–11 after frontalis muscle flap suspension for congenital blepharoptosis: a single-center randomized controlled trial. Medicine (Baltimore). 2017;96(36):e8003. https://doi.org/10.1097/MD.0000000000008003.

    Article  Google Scholar 

  86. Goel R, Kishore D, Nagpal S, Jain S, Agarwal T. The relationship of amount of resection and time for recovery of Bell’s phenomenon after levator resection in congenital ptosis. Open Ophthalmol J. 2017;11:24–30. https://doi.org/10.2174/1874364101711010024. eCollection 2017.

    Article  PubMed  PubMed Central  Google Scholar 

  87. Kim CY, Son BJ, Son J, Hong J, Lee SY. Analysis of the causes of recurrence after frontalis suspension using silicone rods for congenital ptosis. PLoS One. 2017;12(2):e0171769. https://doi.org/10.1371/journal.pone.0171769. eCollection 2017.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to John D. Ng .

Editor information

Editors and Affiliations

Section Editor information

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Ng, J.D. (2022). Congenital Ptosis. In: Albert, D.M., Miller, J.W., Azar, D.T., Young, L.H. (eds) Albert and Jakobiec's Principles and Practice of Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-030-42634-7_83

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-42634-7_83

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-42633-0

  • Online ISBN: 978-3-030-42634-7

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics