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Cell Polarity in Drosophila Retina

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Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye

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Abstract

Apical-basal cell polarity is crucial for the development of multicellular organisms and for the diverse functions of epithelial cells in diverse organs. Cell polarity in epithelial cells is characterized by differential distributions of components in the apical and basolateral membrane domains, as well as the asymmetric distributions of intracellular materials. The cell polarity is mainly regulated by evolutionary conserved genes which are Crumbs complex of Crb, Stardust (Sdt), Pals-1-associated tight junction protein (Patj), and partitioning-defective (Par) complex of Par-3 (Bazooka, Baz), Par-6 and atypical protein kinase C (aPKC). These cell polarity complexes play fundamental roles in initial cell polarity establishment and its maintenance and regulation. Recently, the roles of these cell polarity genes and their regulations were identified in Drosophila retina development. Here, we review recent discoveries of the roles of Crb and Par complexes and their regulators in morphogenesis and organogenesis of Drosophila retina.

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  1. Department of Biology, Hillsdale College, Hillsdale, MI, USA

    Sang-Chul Nam

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  1. Department of Biology, University of Dayton, Dayton, OH, USA

    Amit Singh

  2. Department of Biology Office: SC303C, University of Dayton, Dayton, OH, USA

    Madhuri Kango-Singh

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Nam, SC. (2020). Cell Polarity in Drosophila Retina. In: Singh, A., Kango-Singh, M. (eds) Molecular Genetics of Axial Patterning, Growth and Disease in Drosophila Eye. Springer, Cham. https://doi.org/10.1007/978-3-030-42246-2_5

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