Abstract
Clinical trial is a prescribed learning process for identifying safe and effective treatments. In recent years, rapid advancements in cancer biology, immunology, genomics, and treatment development have demanded innovative methods to identify better therapies for the most appropriate population in a timely, efficient, accurate, and cost-effective way. In this chapter, we will first illustrate the concept of Bayesian update and Bayesian inference, which is a superior alternative to the traditional frequentist approach. Bayesian methods take the "learn as we go" approach, making them innately suitable for clinical trials. Then, we will give an overview of Bayesian adaptive designs in the areas of adaptive dose finding, posterior probability and predictive probability calculation, outcome adaptive randomization, multi-endpoint phase II design, multi-arm, multi-stage platform design, hierarchical modeling, etc. In particular, a new class of model-assisted designs will be introduced, which combine the transparency and simplicity of conventional algorithm-based designs with the superiority and rigorousness of model-based designs. These designs enjoy superior performance comparable to more complicated, model-based designs, though they are also capable of simplicity similar to conventional designs. Examples of the Bayesian optimal interval (BOIN), the keyboard, the time-to-event BOIN (TITE-BOIN), the BOIN combination, and the Bayesian Optimal Phase 2 (BOP2) designs will be discussed. Real applications, including BATTLE trial in lung cancer, I-SPY 2 trial in breast cancer, and GBM AGILE in glioblastoma, will be given. The chapter will also introduce software tools, including downloadable programs and online Shiny applications for the design and conduct of clinical trials. Bayesian adaptive clinical trial designs increase study efficiency, allow more flexible trial conduct, and treat a greater number of patients with more effective treatments in the trial. They also possess desirable frequentist properties. Useful software tools can be found at: https://biostatistics.mdanderson.org/SoftwareDownload/and https://trialdesign.org/.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alexander, B. M., Ba, S., Berger, M. S., Berry, D. A., Cavenee, W. K., Chang, S. M., et al. (2018). Adaptive global innovative learning environment for Glioblastoma: GBM AGILE. Clinical Cancer Research, 24(4), 737–743.
Avorn, J. (2015). The $2.6 billion pill - methodologic and policy considerations. New England Journal of Medicine, 372(20), 1877–1879.
Barker, A. D., Sigman, C. C., Kelloff, G. J., Hylton, N. M., Berry, D. A., & Esserman, L. J. (2009). I-SPY 2: An adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy. Clinical Pharmacology & Therapeutics, 86(1), 97–100.
Berger, Z. (2010). Bayesian and frequentist models: Legitimate choices for different purposes of clinical research. Journal of Evaluation in Clinical Practice, 16(6), 1045–1047.
Berry, D. A. (2006). Bayesian clinical trials. Nature Reviews Drug Discovery, 5(1), 27–36.
Berry, D. A. (2015). The Brave New World of clinical cancer research: Adaptive biomarker-driven trials integrating clinical practice with clinical research. Molecular Oncology, 9(5), 951–959.
Bhatt, A. (2010). Evolution of clinical research: A history before and beyond james lind. Perspectives in Clinical Research, 1(1), 6–10.
Biswas, S., Liu, D. D., Lee, J. J., & Berry, D. A. (2009). Bayesian clinical trials at the University of Texas M. D. Anderson Cancer Center. Clinical Trials, 6(3), 205–216.
Braun, T. M., & Wang, S. (2010). A hierarchical Bayesian design for phase I trials of novel combinations of cancer therapeutic agents. Biometrics, 66(3), 805–812.
Carey, L. A., & Winer, E. P. (2016). I-SPY 2--toward more rapid progress in breast cancer treatment. The New England Journal of Medicine, 375(1), 83–84.
Cheung, Y. K., & Chappell, R. (2000). Sequential designs for phase I clinical trials with late-onset toxicities. Biometrics, 56(4), 1177–1182.
Chevret, S. (2012). Bayesian adaptive clinical trials: A dream for statisticians only? Statistics in Medicine, 31(11–12), 1002–1013.
Chow, S. C., & Chang, M. (2008). Adaptive design methods in clinical trials - a review. Orphanet Journal of Rare Diseases, 3, 11.
DiMasi, J. A., Reichert, J. M., Feldman, L., & Malins, A. (2013). Clinical approval success rates for investigational cancer drugs. Clinical Pharmacology & Therapeutics, 94(3), 329–335.
Friedman, L. M., Furberg, C., & DeMets, D. L. (2010). Fundamentals of clinical trials (4th ed.). New York: Springer.
Goodman, S. N., Zahurak, M. L., & Piantadosi, S. (1995). Some practical improvements in the continual reassessment method for phase-I studies. Statistics in Medicine, 14(11), 1149–1161.
Gu, X., Chen, N., Wei, C., Liu, S., Papadimitrakopoulou, V. A., Herbst, R. S., et al. (2016). Bayesian two-stage biomarker-based adaptive design for targeted therapy development. Statistics in Biosciences, 8(1), 99–128.
Guo, W., Wang, S.-J., Yang, S., Lynn, H., & Ji, Y. (2017). A Bayesian interval dose-finding design addressing Ockham’s razor: mTPI-2. Contemporary Clinical Trials, 58, 23–33.
Heitjan, D. F. (1997). Bayesian interim analysis of phase II cancer clinical trials. Statistics in Medicine, 16(16), 1791–1802.
Hobbs, B. P., Chen, N., & Lee, J. J. (2018). Controlled multi-arm platform design using predictive probability. Statistical Methods in Medical Research, 27(1), 65–78.
Howard, D. R., Brown, J. M., Todd, S., & Gregory, W. M. (2018). Recommendations on multiple testing adjustment in multi-arm trials with a shared control group. Statistical Methods in Medical Research, 27(5), 1513–1530.
Hu, F., & Rosenberger, W. F. (2006). The theory of response-adaptive randomization in clinical trials (Vol. 525). Hoboken: John Wiley & Sons.
Iasonos, A., Wages, N. A., Conaway, M. R., Cheung, K., Yuan, Y., & O’Quigley, J. (2016). Dimension of model parameter space and operating characteristics in adaptive dose-finding studies. Statistics in Medicine, 35(21), 3760–3775.
Ji, Y., Liu, P., Li, Y., & Bekele, B. N. (2010). A modified toxicity probability interval method for dose-finding trials. Clinical Trials, 7(6), 653–663.
Kim, E. S., Herbst, R. S., Wistuba, I. I., Lee, J. J., Blumenschein, G. R., Tsao, A., et al. (2011). The BATTLE trial: Personalizing therapy for lung cancer. Cancer Discovery, 1(1), 44–53.
Lee, J. J., & Berry, D. A. (2016). Statistical innovations in cancer research. Holland-Frei Cancer Medicine, 6, 1–18.
Lee, J. J., & Chu, C. T. (2012). Bayesian clinical trials in action. Statistics in Medicine, 31(25), 2955–2972.
Lee, J. J., & Liu, D. D. (2008). A predictive probability design for phase II cancer clinical trials. Clinical Trials, 5(2), 93–106.
Lee, K. M., Wason, J., & Stallard, N. (2019). To add or not to add a new treatment arm to a multiarm study: A decision-theoretic framework. Statistics in Medicine, 32, 3305–3321.
Lin, R. (2018). Bayesian optimal interval design with multiple toxicity constraints. Biometrics, 74(4), 1320–1330.
Lin, R., Coleman, R. L., & Yuan, Y. (2019). Top: Time-to-event bayesian optimal phase ii trial design for cancer immunotherapy. Journal of the National Cancer Institute, 112(1), 38–45.
Lin, R., & Yin, G. (2016). Bootstrap aggregating continual reassessment method for dose finding in drug-combination trials. Annals of Applied Statistics, 10(4), 2349–2376.
Lin, R., & Yin, G. (2017a). Bayesian optimal interval design for dose finding in drug-combination trials. Statistical Methods in Medical Research, 26(5), 2155–2167.
Lin, R., & Yin, G. (2017b). STEIN: A simple toxicity and efficacy interval design for seamless phase I/II clinical trials. Statistics in Medicine, 36(26), 4106–4120.
Lin, R., & Yin, G. (2018). Uniformly most powerful Bayesian interval design for phase I dose-finding trials. Pharmaceutical Statistics, 17(6), 710–724.
Lin, R., & Yuan, Y. (2019). On the relative efficiency of model-assisted designs: A conditional approach. Journal of Biopharmaceutical Statistics, 29, 648–662.
Liu, S., & Lee, J. J. (2015). An overview of the design and conduct of the BATTLE trials. Chinese Clinical Oncology, 4(3), 33.
Liu, S. Y., & Johnson, V. E. (2016). A robust Bayesian dose-finding design for phase I/II clinical trials. Biostatistics, 17(2), 249–263.
Liu, S. Y., & Yuan, Y. (2015). Bayesian optimal interval designs for phase I clinical trials. Journal of the Royal Statistical Society Series C-Applied Statistics, 64(3), 507–523.
Mahajan, R., & Gupta, K. (2010). Adaptive design clinical trials: Methodology, challenges and prospect. Indian Journal of Pharmacology, 42(4), 201–207.
Nass, S. J., Rothenberg, M. L., Pentz, R., Hricak, H., Abernethy, A., Anderson, K., et al. (2018). Accelerating anticancer drug development - opportunities and trade-offs. Nature Reviews Clinical Oncology, 15(12), 777–786.
Neuenschwander, B., Branson, M., & Gsponer, T. (2008). Critical aspects of the Bayesian approach to phase I cancer trials. Statistics in Medicine, 27(13), 2420–2439.
O’Quigley, J., Pepe, M., & Fisher, L. (1990). Continual reassessment method: A practical design for phase 1 clinical trials in cancer. Biometrics, 46(1), 33–48.
Papadimitrakopoulou, V., Lee, J. J., Wistuba, I. I., Tsao, A. S., Fossella, F. V., Kalhor, N., et al. (2016). The BATTLE-2 study: A biomarker-integrated targeted therapy study in previously treated patients with advanced non-small-cell lung cancer. Journal of Clinical Oncology, 34(30), 3638–3647.
Park, J. W., Liu, M. C., Yee, D., Yau, C., van’t Veer, L. J., Symmans, W. F., et al. (2016). Adaptive randomization of Neratinib in Early Breast Cancer. The New England Journal of Medicine, 375(1), 11–22.
Piantadosi, S. (2017). Clinical trials: A methodologic perspective (3rd ed.). Hoboken: Wiley.
Proschan, M. A., & Hunsberger, S. A. (1995). Designed extension of studies based on conditional power. Biometrics, 51(4), 1315–1324.
Riviere, M. K., Dubois, F., & Zohar, S. (2015). Competing designs for drug combination in phase I dose-finding clinical trials. Statistics in Medicine, 34(1), 1–12.
Rogatko, A., Schoeneck, D., Jonas, W., Tighiouart, M., Khuri, F. R., & Porter, A. (2007). Translation of innovative designs into phase I trials. Journal of Clinical Oncology, 25(31), 4982–4986.
Rosenberger, W. F. (1999). Randomized play-the-winner clinical trials: Review and recommendations. Controlled Clinical Trials, 20(4), 328–342.
Rosenberger, W. F., Stallard, N., Ivanova, A., Harper, C. N., & Ricks, M. L. (2001). Optimal adaptive designs for binary response trials. Biometrics, 57(3), 909–913.
Rugo, H. S., Olopade, O. I., DeMichele, A., Yau, C., van’t Veer, L. J., Buxton, M. B., et al. (2016). Adaptive randomization of veliparib-carboplatin treatment in breast cancer. The New England Journal of Medicine, 375(1), 23–34.
Saville, B. R., & Berry, S. M. (2016). Efficiencies of platform clinical trials: A vision of the future. Clinical Trials, 13(3), 358–366.
Simon, N., & Simon, R. (2017). Using Bayesian modeling in frequentist adaptive enrichment designs. Biostatistics, 19(1), 27–41.
Simon, R. (1989). Optimal two-stage designs for phase II clinical trials. Controlled Clinical Trials, 10(1), 1–10.
Skolnik, J. M., Barrett, J. S., Jayaraman, B., Patel, D., & Adamson, P. C. (2008). Shortening the timeline of pediatric phase I trials: The rolling six design. Journal of Clinical Oncology, 26(2), 190–195.
Takeda, K., Taguri, M., & Morita, S. (2018). BOIN-ET: Bayesian optimal interval design for dose finding based on both efficacy and toxicity outcomes. Pharmaceutical Statistics, 17(4), 383–395.
Thall, P. F., & Cook, J. D. (2004). Dose-finding based on efficacy-toxicity trade-offs. Biometrics, 60(3), 684–693.
Thall, P. F., Millikan, R. E., Mueller, P., & Lee, S. J. (2003). Dose-finding with two agents in Phase I oncology trials. Biometrics, 59(3), 487–496.
Thall, P. F., & Simon, R. (1994). Practical Bayesian guidelines for phase IIB clinical trials. Biometrics, 50(2), 337–349.
Thall, P. F., Simon, R. M., & Estey, E. H. (1995). Bayesian sequential monitoring designs for single-arm clinical trials with multiple outcomes. Statistics in Medicine, 14(4), 357–379.
Thall, P. F., & Wathen, J. K. (2007). Practical Bayesian adaptive randomisation in clinical trials. European Journal of Cancer, 43(5), 859–866.
Thall, P. F., Wathen, J. K., Bekele, B. N., Champlin, R. E., Baker, L. H., & Benjamin, R. S. (2003). Hierarchical Bayesian approaches to phase II trials in diseases with multiple subtypes. Statistics in Medicine, 22(5), 763–780.
Tidwell, R. S. S., Peng, A., Chen, M., Liu, D., Yuan, Y., & Lee, J. J. (2019). Bayesian clinical trials at the University of Texas MD Anderson Cancer Center: An update. Clinical Trials, 16(6), 645–656.
Ventz, S., Barry, W. T., Parmigiani, G., & Trippa, L. (2017). Bayesian response-adaptive designs for basket trials. Biometrics, 73(3), 905–915.
Wason, J., Magirr, D., Law, M., & Jaki, T. (2016). Some recommendations for multi-arm multi-stage trials. Statistical Methods in Medical Research, 25(2), 716–727.
Wason, J. M., & Jaki, T. (2012). Optimal design of multi-arm multi-stage trials. Statistics in Medicine, 31(30), 4269–4279.
Wathen, J. K., & Thall, P. F. (2017). A simulation study of outcome adaptive randomization in multi-arm clinical trials. Clinical Trials, 14(5), 432–440.
Yan, F., Mandrekar, S. J., & Yuan, Y. (2017). Keyboard: a novel Bayesian toxicity probability interval design for phase i clinical trials. Clinical Cancer Research, 23(15), 3994–4003.
Yin, G., Chen, N., & Lee, J. J. (2012). Phase II trial design with Bayesian adaptive randomization and predictive probability. Journal of the Royal Statistical Society. Series C, Applied Statistics, 61(2), 219–235.
Yin, G., Chen, N., & Lee, J. J. (2018). Bayesian adaptive randomization and trial monitoring with predictive probability for time-to-event endpoint. Statistics in Biosciences, 10(2), 420–438.
Yin, G., & Lin, R. (2015). Comments on ‘competing designs for drug combination in phase I dose-finding clinical trials’ by M-K. Riviere, F. Dubois, and S. Zohar. Statistics in Medicine, 34(1), 13–17.
Yin, G. S., & Yuan, Y. (2009a). Bayesian dose finding in oncology for drug combinations by copula regression. Journal of the Royal Statistical Society Series C-Applied Statistics, 58, 211–224.
Yin, G. S., & Yuan, Y. (2009b). Bayesian model averaging continual reassessment method in Phase I clinical trials. Journal of the American Statistical Association, 104(487), 954–968.
Yuan, Y., Lee, J. J., & Hilsenbeck, S. G. (2019). Model-assisted designs for early phase clinical trials: Simplicity meets superiority. JCO Precision Oncology, 3, 1–12.
Yuan, Y., Lin, R., Li, D., Nie, L., & Warren, K. E. (2018). Time-to-event Bayesian optimal interval design to accelerate Phase I trials. Clinical Cancer Research, 24(20), 4921–4930.
Yuan, Y., Nguyen, H. Q., & Thall, P. F. (2017). Bayesian designs for phase I-II clinical trials. Boca Raton: Chapman and Hall/CRC.
Zang, Y., & Lee, J. J. (2014). Adaptive clinical trial designs in oncology. Chinese Clinical Oncology, 3(4), 49.
Zang, Y., & Lee, J. J. (2017). A robust two-stage design identifying the optimal biological dose for phase I/II clinical trials. Statistics in Medicine, 36(1), 27–42.
Zang, Y., Lee, J. J., & Yuan, Y. (2014). Adaptive designs for identifying optimal biological dose for molecularly targeted agents. Clinical Trials, 11(3), 319–327.
Zhang, L. C., & Yuan, Y. (2016). A practical Bayesian design to identify the maximum tolerated dose contour for drug combination trials. Statistics in Medicine, 35(27), 4924–4936.
Zhang, Y., Trippa, L., & Parmigiani, G. (2019). Frequentist operating characteristics of Bayesian optimal designs via simulation. Statistics in Medicine, 38(21), 4026–4039.
Zhou, H., Lee, J. J., & Yuan, Y. (2017). BOP2: Bayesian optimal design for phase II clinical trials with simple and complex endpoints. Statistics in Medicine, 36(21), 3302–3314.
Zhou, H., Murray, T. A., Pan, H., & Yuan, Y. (2018a). Comparative review of novel model-assisted designs for phase I clinical trials. Statistics in Medicine, 37(14), 2208–2222.
Zhou, H., Yuan, Y., & Nie, L. (2018b). Accuracy, safety, and reliability of novel Phase I trial designs. Clinical Cancer Research, 24(18), 4357–4364.
Zhou, X., Liu, S., Kim, E. S., Herbst, R. S., & Lee, J. J. (2008). Bayesian adaptive design for targeted therapy development in lung cancer - a step toward personalized medicine. Clinical Trials, 5(3), 181–193.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Lin, R., Lee, J.J. (2020). Novel Bayesian Adaptive Designs and Their Applications in Cancer Clinical Trials. In: Bekker, A., Chen, (.DG., Ferreira, J.T. (eds) Computational and Methodological Statistics and Biostatistics. Emerging Topics in Statistics and Biostatistics . Springer, Cham. https://doi.org/10.1007/978-3-030-42196-0_17
Download citation
DOI: https://doi.org/10.1007/978-3-030-42196-0_17
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-42195-3
Online ISBN: 978-3-030-42196-0
eBook Packages: Mathematics and StatisticsMathematics and Statistics (R0)