Skip to main content
SpringerLink
Log in

Lacrimal Sac Tumors: Diagnosis and Treatment

  • Chapter
  • First Online:
Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery

  • 1309 Accesses

Abstract

Lacrimal sac tumors are uncommon, but noteworthy as they are frequently locally invasive and can result in death. Approximately 850 cases have been reported in the literature over the last century, of which over 50% were malignant. The benign tumors include squamous papilloma, transitional papilloma, fibrous histiocytoma, oncocytoma, and hemangiopericytoma. The malignant tumors include squamous cell carcinoma, lymphoma, melanoma, transitional carcinoma, mucoepidermoid carcinoma, and adenocarcinoma in order of frequency. The most serious malignancies of the lacrimal sac are melanoma and transitional cell carcinoma, where the latter is associated with a 100% mortality rate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Stefanyszyn MA, Hidayat AA, Pe’er JJ, Flanagan JC. Lacrimal sac tumors. Ophthal Plast Reconstr Surg. 1994;10:169–84.

    Article  CAS  Google Scholar 

  2. Ni C, D’Amico DJ, Fan CQ, Kuo PK. Tumors of the lacrimal sac: a clinicopathological analysis of 82 cases. Int Ophthalmol Clin. 1982;22:121–40.

    Article  CAS  Google Scholar 

  3. Radnot M, Gall J. Tumors of the lacrimal sac. Ophthalmologica. 1966;151:2–22.

    Article  CAS  Google Scholar 

  4. Harry J, Ashton N. The pathology of tumours of the lacrimal sac. Trans Ophthalmol Soc UK. 1969;88:19–35.

    CAS  PubMed  Google Scholar 

  5. Schenck NL, Ogura JH, Pratt LL. Cancer of the lacrimal sac. Presentation of five cases and review of the literature. Ann Otol Rhinol Laryngol. 1973;82:153–61.

    Article  CAS  Google Scholar 

  6. Ryan SJ, Font RL. Primary epithelial neoplasms of the lacrimal sac. Am J Ophthalmol. 1973;76:73–88.

    Article  CAS  Google Scholar 

  7. Yip CC, Bartley GB, Habermann TM, Garrity JA. Involvement of the lacrimal drainage system by leukemia or lymphoma. Ophthal Plast Reconstr Surg. 2002;18:242–6.

    Article  Google Scholar 

  8. Anderson NG, Wojno TH, Grossniklaus HE. Clinicopathologic findings from lacrimal sac biopsy specimens obtained during dacryocystorhinostomy. Ophthal Plast Reconstr Surg. 2003;19:173–6.

    Article  Google Scholar 

  9. Parmar DN, Rose GE. Management of lacrimal sac tumours. Eye (London). 2003;17:599–606.

    Article  CAS  Google Scholar 

  10. Jordan DR. Re: “Clinicopathologic findings from lacrimal sac biopsy specimens obtained during dacryocystorhinostomy”. Ophthal Plast Reconstr Surg. 2004;20:176–7.

    Article  Google Scholar 

  11. Marthin JK, Lindegaard J, Prause JU, Heegaard S. Lesions of the lacrimal drainage system: a clinicopathological study of 643 biopsy specimens of the lacrimal drainage system in Denmark 1910–1999. Acta Ophthalmol Scand. 2005;83:94–9.

    Article  Google Scholar 

  12. Sjo LD, Ralfkiaer E, Juhl BR, et al. Primary lymphoma of the lacrimal sac: an EORTC ophthalmic oncology task force study. Br J Ophthalmol. 2006;90:1004–9.

    Article  CAS  Google Scholar 

  13. Bi YW, Chen RJ, Li XP. Clinical and pathological analysis of primary lacrimal sac tumors. Zhonghua Yan Ke Za Zhi. 2007;43:499–504.

    PubMed  Google Scholar 

  14. Sjo NC, von Buchwald C, Cassonnet P, et al. Human papillomavirus: cause of epithelial lacrimal sac neoplasia? Acta Ophthalmol Scand. 2007;85:551–6.

    Article  Google Scholar 

  15. Song X, Wang J, Wang S, Wang W, Wang S, Zhu W. Clinical analysis of 90 cases of malignant lacrimal sac tumor. Graefe’s Arch Clin Exp Ophthal. 2018;256:1333–8.

    Article  Google Scholar 

  16. Spaeth EB. A surgical technique for lacrimal sac malignancy. Trans Ophthalmol Soc UK. 1970;89:351–4.

    CAS  PubMed  Google Scholar 

  17. Flanagan JC, Stokes DP. Lacrimal sac tumors. Ophthalmology. 1978;85:1282–7.

    Article  CAS  Google Scholar 

  18. Schefler AC, Shields CL, Shields JA, Demirci H, Maus M, Eagle RC Jr. Lacrimal sac lymphoma in a child. Arch Ophthalmol. 2003;121:1330–3.

    Article  Google Scholar 

  19. Pe’er J, Hidayat AA, Ilsar M, Landau L, Stefanyszyn MA. Glandular tumors of the lacrimal sac. Their histopathologic patterns and possible origins. Ophthalmology. 1996;103:1601–5.

    Article  Google Scholar 

  20. Pe’er JJ, Stefanyszyn M, Hidayat AA. Nonepithelial tumors of the lacrimal sac. Am J Ophthalmol. 1994;118:650–8.

    Article  Google Scholar 

  21. Madreperla SA, Green WR, Daniel R, Shah KV. Human papillomavirus in primary epithelial tumors of the lacrimal sac. Ophthalmology. 1993;100:569–73.

    Article  CAS  Google Scholar 

  22. Gleizal A, Nimeskern N, Kodjikian L, Beziat JL. Lacrimal sac melanoma. Rev. Stomatol Chir Maxillofac. 2005;106:103–5.

    Article  CAS  Google Scholar 

  23. Lee HM, Kang HJ, Choi G, et al. Two cases of primary malignant melanoma of the lacrimal sac. Head Neck. 2001;23:809–13.

    Article  CAS  Google Scholar 

  24. Eide N, Refsum SB, Bakke S. Primary malignant melanoma of the lacrimal sac. Acta Ophthalmol (Copenh). 1993;71:273–6.

    Article  CAS  Google Scholar 

  25. Malik TY, Sanders R, Young JD, Brennand E, Evans AT. Malignant melanoma of the lacrimal sac. Eye (Lond). 1997;11:935–7.

    Article  Google Scholar 

  26. Sitole S, Zender CA, Ahmad AZ, Hammadeh R, Petruzzelli GJ. Lacrimal sac melanoma. Ophthal Plast Reconstr Surg. 2007;23:417–9.

    Article  Google Scholar 

  27. Stokes DP, Flanagan JC. Dacryocystectomy for tumors of the lacrimal sac. Ophthalmic Surg. 1977;8:85–90.

    CAS  PubMed  Google Scholar 

  28. Hurwitz JJ. Re: “Clinicopathologic findings from lacrimal sac biopsies obtained during dacryocystorhinostomy”. Ophthal Plast Reconstr Surg. 2003;19:412; author reply 412–3

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Oculofacial Plastic Surgery, The Permanente Medical Group, Department of Ophthalmology, Union City, CA, USA

    H. Jane Kim

  2. Division of Ophthalmic Plastic, Reconstructive, and Orbital Surgery, Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ, USA

    Paul D. Langer

Authors
  1. H. Jane Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Paul D. Langer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Oculofacial Plastic Surgeons of Georgia, Suwanee, GA, USA

    J. Javier Servat

  2. Consultants in Ophthalmic and Facial Plastic Surgery, P.C., Southfield, MI, USA

    Evan H. Black

  3. Beaumont Eye Institute, William Beaumont School of Medicine of Oakland University, Rochester, MI, USA

    Frank A. Nesi

  4. Consultants in Ophthalmic and Facial Plastic Surgery, P.C., Southfield, MI, USA

    Geoffrey J. Gladstone

  5. San Antonio Military Medical Center/Wilford Hall Ambulatory Surgery Center, Department of Ophthalmology and Oculoplastic Surgery, San Antonio, TX, USA

    Christopher J. Calvano

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Kim, H.J., Langer, P.D. (2021). Lacrimal Sac Tumors: Diagnosis and Treatment. In: Servat, J.J., Black, E.H., Nesi, F.A., Gladstone, G.J., Calvano, C.J. (eds) Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-41720-8_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-41720-8_30

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-41719-2

  • Online ISBN: 978-3-030-41720-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation