Skip to main content

Concerns of Hereditary Breast Cancer in Pregnancy and Lactation

  • Chapter
  • First Online:
Diseases of the Breast during Pregnancy and Lactation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1252))

Abstract

Genetic testing should be offered to all women less than 40 years of age who are diagnosed with breast cancer, and patients with PABC are generally among them. However, there is no specific study about these cases, and whether genetic testing should be carried out during or after pregnancy is not known. Generally, testing before delivery should only be performed if positive results change management plans, such as undergoing fetal testing and choosing mastectomy instead of breast conserving surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Manahan ER, Kuerer HM, Sebastian M, Hughes KS, Boughey JC, Euhus DM et al (2019) Consensus guidelines on genetictesting for hereditary breast cancer from the American Society of Breast Surgeons. Ann Surg Oncol 26(10):3025–3031

    Article  Google Scholar 

  2. Lynch JA, Venne V, Berse B (2015) Genetic tests to identify risk for breast cancer. Semin Oncol Nurs 31(2):100–107

    Article  Google Scholar 

  3. Moyer VA (2014) Force USPST. Risk assessment, genetic counseling, and genetic testing for BRCA-related cancer in women: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 160(4):271–281

    Article  Google Scholar 

  4. Bevers TB, Helvie M, Bonaccio E, Calhoun KE, Daly MB, Farrar WB et al (2018) Breast cancer screening and diagnosis, version 3.2018, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw 16(11):1362–1389

    Article  Google Scholar 

  5. Gage M, Wattendorf D, Henry LR (2012) Translational advances regarding hereditary breast cancer syndromes. J Surg Oncol 105(5):444–451

    Article  CAS  Google Scholar 

  6. Campeau PM, Foulkes WD, Tischkowitz MD (2008) Hereditary breast cancer: new genetic developments, new therapeutic avenues. Hum Genet 124(1):31–42

    Article  CAS  Google Scholar 

  7. Lalloo F, Varley J, Ellis D, Moran A, O’Dair L, Pharoah P et al (2003) Prediction of pathogenic mutations in patients with early-onset breast cancer by family history. Lancet 361(9363):1101–1102

    Article  CAS  Google Scholar 

  8. Gonzalez KD, Noltner KA, Buzin CH, Gu D, Wen-Fong CY, Nguyen VQ et al (2009) Beyond Li Fraumeni Syndrome: clinical characteristics of families with p53 germline mutations. J Clin Oncol 27(8):1250–1256

    Article  CAS  Google Scholar 

  9. Schon K, Tischkowitz M (2018) Clinical implications of germline mutations in breast cancer: TP53. Breast Cancer Res Treat 167(2):417–423

    Article  CAS  Google Scholar 

  10. Elezaby M, Lees B, Maturen KE, Barroilhet L, Wisinski KB, Schrager S, Wilke LG, Sadowski E (2019 Apr 30) BRCA mutation carriers: breast and ovarian cancer screening guidelines and imaging considerations. Radiology 291(3):554–569

    Article  Google Scholar 

  11. Warner E (2018) Screening BRCA1 and BRCA2 mutation carriers for breast cancer. Cancers 10(12):477

    Article  CAS  Google Scholar 

  12. Monticciolo DL, Newell MS, Moy L, Niell B, Monsees B, Sickles EA (2018) Breast cancer screening in women at higher-than-average risk: recommendations from the ACR. J Am Coll Radiol 15(3):408–414

    Article  Google Scholar 

  13. Carmichael H, Matsen C, Freer P, Kohlmann W, Stein M, Buys SS et al (2017) Breast cancer screening of pregnant and breastfeeding women with BRCA mutations. Breast Cancer Res Treat 162(2):225–230

    Article  Google Scholar 

  14. Clancy T (2010) A clinical perspective on ethical arguments around prenatal diagnosis and preimplantation genetic diagnosis for later onset inherited cancer predispositions. Familial Cancer 9(1):9–14

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mehran Habibi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Chen, J., Prasath, V., Axilbund, J., Habibi, M. (2020). Concerns of Hereditary Breast Cancer in Pregnancy and Lactation. In: Alipour, S., Omranipour, R. (eds) Diseases of the Breast during Pregnancy and Lactation. Advances in Experimental Medicine and Biology, vol 1252. Springer, Cham. https://doi.org/10.1007/978-3-030-41596-9_17

Download citation

Publish with us

Policies and ethics