Abstract
Chronic recurrent multifocal osteomyelitis (CRMO) is an inflammatory, noninfectious disease of children and adolescents. It is characterized by recurrent episodes of fever, pain, and swelling over affected bones. Radiographic findings may be similar to acute osteomyelitis, and histologic examination and culture of bone specimens may be helpful to establish the diagnosis. Treatment with antibiotics is ineffective.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Iyer RS, Thapa MM, Chew FS. Chronic recurrent multifocal osteomyelitis: review. Am J Roentgenol. 2011;196:87–91.
Roderick MR, Sen ES, Ramanan AV. Chronic recurrent multifocal osteomyelitis in children and adults: current understanding and areas for development. Rheumatology. 2018;57(1):41–8.
Falip C, Alison M, Boutry N, Job-Deslandre C, Cotten A, Azoulay R, et al. Chronic recurrent multifocal osteomyelitis (CRMO): a longitudinal case series review. Pediatr Radiol. 2013;43(3):355–75.
Roderick MR, Shah R, Rogers V, Finn A, Ramanan AV. Chronic recurrent multifocal osteomyelitis (CRMO) - advancing the diagnosis. Pediatr Rheumatol. 2016;14(1):47.
Schultz C, Holterhus PM, Seidel A, Jonas S, Barthel M, Kruse K, et al. Chronic recurrent multifocal osteomyelitis in children. Pediatr Infect Dis J. 1999;18(11):1008–13.
Huber AM, Lam PY, Duffy CM, Yeung RSM, Ditchfield M, Laxer D, et al. Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. J Pediatr. 2002;141(2):198–203.
Hedrich CM, Hofmann SR, Pablik J, Morbach H, Girschick HJ. Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol. 2013;11(1):47.
Nurre LD, Rabalais GP, Callen JP. Neutrophilic dermatosis-associated sterile chronic multifocal osteomyelitis in pediatric patients: case report and review. Pediatr Dermatol. 1999;16(3):214–6.
Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep. 2012;14(2):130–41.
Oliver M, Lee TC, Halpern-Felsher B, Murray E, Schwartz R, Zhao Y. Disease burden and social impact of chronic nonbacterial osteomyelitis from the patient and family perspective. Pediatr Rheumatol. 2018;16(1):78
Manson D, Wilmot DM, King S, Laxer RM. Physeal involvement in chronic recurrent multifocal osteomyelitis. Pediatr Radiol. 1989;20(1–2):76–9.
Fritz J, Tzaribatchev N, Claussen CD, Carrino JA, Horger MS. Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. Radiology. 2009;252(3):842–51.
Guérin-Pfyffer S, Guillaume-Czitrom S, Tammam S, Koné-Paut I. Evaluation of chronic recurrent multifocal osteitis in children by whole-body magnetic resonance imaging. Joint Bone Spine. 2012;79(6):616–20.
Girschick HJ, Raab P, Surbaum S, Trusen A, Kirschner S, Schneider P, et al. Chronic non-bacterial osteomyelitis in children. Ann Rheum Dis. 2005;64(2):279–85.
Miettunen PMH, Wei X, Kaura D, Reslan WA, Aguirre AN, Kellner JD. Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis. Pediatr Rheumatol. 2009;7:2.
Eleftheriou D, Gerschman T, Sebire N, Woo P, Pilkington CA, Brogan PA. Biologic therapy in refractory chronic non-bacterial osteomyelitis of childhood. Rheumatology. 2010;49(8):1505–12.
Gleeson H, Wiltshire E, Briody J, Hall J, Chaitow J, Sillence D, et al. Childhood chronic recurrent multifocal osteomyelitis: Pamidronate therapy decreases pain and improves vertebral shape. J Rheumatol. 2008;35(4):707–12.
Voit AM, Arnoldi AP, Douis H, Bleisteiner F, Jansson MK, Reiser MF, et al. Whole-body magnetic resonance imaging in chronic recurrent multifocal osteomyelitis: clinical long-term assessment may underestimate activity. J Rheumatol. 2015;42(8):1455–62.
Catalano-Pons C, Comte A, Wipff J, Quartier P, Faye A, Gendrel D, et al. Clinical outcome in children with chronic recurrent multifocal osteomyelitis. Rheumatology. 2008;47(9):1397–9.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Godbout, E., Koch, W. (2020). Chronic Recurrent Multifocal Osteomyelitis. In: Reznicek, J., Perdue, Jr., P., Bearman, G. (eds) Musculoskeletal Infections. Springer, Cham. https://doi.org/10.1007/978-3-030-41150-3_15
Download citation
DOI: https://doi.org/10.1007/978-3-030-41150-3_15
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-41149-7
Online ISBN: 978-3-030-41150-3
eBook Packages: MedicineMedicine (R0)