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Takayasu’s Arteritis

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Carotid Artery Disease

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Abstract

Takayasu’s arteritis is a chronic idiopathic inflammatory large vessel vasculitis affecting mostly young adults. The disease process predominantly involves the aorta and its main branches such as the carotid and subclavian arteries. Vessel wall inflammation leads to stenosis, occlusion, or aneurysmal dilation of involved arteries and subsequent end-organ damage. Clinical presentations vary and range from nonspecific constitutional symptoms to symptoms associated with vascular injury, such as pulselessness, limb claudication, renovascular hypertension, angina, carotidynia, and strokes. In addition to comprehensive clinical assessment, imaging techniques, such as ultrasound, Magnetic Resonance Angiography (MRA), Computed Tomography Angiography (CTA) and Positron Emission Tomography (PET) play a critical role in establishing diagnosis and monitoring disease progression and response to treatment. Therapeutic strategies consist of medical therapy focused on immunosuppressive therapy and more recently, biological-targeted therapy. Endovascular and surgical interventions will also be discussed.

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Authors and Affiliations

  1. Cedars-Sinai Medical Center, Department of Neurology, Los Angeles, CA, USA

    Yilin Shek & Shlee S. Song

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  1. Yilin Shek
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Editors and Affiliations

  1. Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA

    Min S. Park

  2. Department of Neurosurgery, University of Virginia, Charlottesville, VA, USA

    M. Yashar S. Kalani

  3. Department of Neurology, University of Utah, Salt Lake City, UT, USA

    Adam de Havenon

  4. Department of Radiology, University of Utah, Salt Lake City, UT, USA

    J. Scott McNally

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Shek, Y., Song, S.S. (2020). Takayasu’s Arteritis. In: Park, M., Kalani, M., de Havenon, A., McNally, J. (eds) Carotid Artery Disease. Springer, Cham. https://doi.org/10.1007/978-3-030-41138-1_16

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