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Immunotherapy in Lung Cancer: From a Minor God to the Olympus

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Immunotherapy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1244))

Abstract

Over the last decade, we have witnessed a paradigm shift in cancer treatment, with the advent of novel therapeutic approaches that target or manipulate the immune system, also known as immunotherapy. Blocking immune checkpoints has emerged as an effective strategy with unprecedented results in several solid tumors, including lung cancer. Since 2012 when PD(L)-1 inhibitors showed first clinical signals of activity in lung cancer, immune checkpoint blockade (ICB) has emerged as a novel effective therapeutic strategy in different settings, determining a dramatic change in the therapeutic landscape of both non-small cell lung cancer (NSCLC) and, more recently, small cell lung cancer (SCLC). Although the benefit from this novel therapeutic approach is undeniable, several open questions still remain unanswered. Herein, we summarize the major breakthroughs in the immunotherapy journey in lung cancer and how it is changing our clinical practice.

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Conflict of Interest Disclosures

Dr. Rolfo reports personal fees from Novartis, personal fees from MSD, non-financial support from OncoDNA, personal fees and non-financial support from GuardantHealth, outside the submitted work. Dr. Mehra reports research funding from AstraZeneca and consultation for Genentech. All other authors have no conflicts of interest to report.

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  1. University of Maryland Medical Center, Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA

    Alessandro Russo, Michael G. McCusker, Katherine A. Scilla, Katherine E. Arensmeyer, Ranee Mehra & Christian Rolfo

  2. Medical Oncology Unit A.O. Papardo & Department of Human Pathology, University of Messina, Messina, Italy

    Alessandro Russo & Vincenzo Adamo

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    Aung Naing

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    Joud Hajjar

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Russo, A. et al. (2020). Immunotherapy in Lung Cancer: From a Minor God to the Olympus. In: Naing, A., Hajjar, J. (eds) Immunotherapy. Advances in Experimental Medicine and Biology, vol 1244. Springer, Cham. https://doi.org/10.1007/978-3-030-41008-7_4

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