Abstract
Historically, nipple-sparing mastectomy (NSM) has been limited by both oncologic and anatomic considerations. From an oncologic standpoint, NSM was offered to women with smaller peripheral tumors with clinically negative nodes. Anatomically, NSM was contraindicated in women with breasts that were excessively large or ptotic (Baker Grade II or III ptosis). To overcome these anatomic limitations in larger, ptotic breasts, a staged nipple-sparing mastectomy following mastopexy or reduction mammoplasty was first described in 2011 to expand the indications for NSM. Early results were encumbered by wound healing complications due to a short interval between stages. Since that time, treatment algorithms and techniques have been improved to enhance oncologic safety and improve wound healing complications. Women are offered a nipple-repositioning procedure (i.e., mastopexy or reduction mammoplasty) combined with a lumpectomy during the initial stage. They are then allowed to achieve full tissue healing for 10–12 weeks before undergoing definitive NSM. This allows women only with large, ptotic breasts to pursue NSM without sacrificing the tissue viability of the nipple-areola complex.
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References
Freeman BS. Technique of subcutaneous mastectomy with replacement; immediate and delayed. Br J Plast Surg. 1969;22:161–6.
Hinton CP, Doyle PJ, Blamey RW, Davies CJ, Holliday HW, Elston CW. Subcutaneous mastectomy for primary operable breast cancer. Br J Surg. 1984;71:469–72.
Kissin MW, Kark AE. Nipple preservation during mastectomy. Br J Surg. 1987;74:58–61.
Hartmann LC, Schaid DJ, Woods JE, et al. Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer. N Engl J Med. 1999;340:77–84.
Agarwal JP, Mendenhall SD, Anderson LA, Ying J, Boucher KM, Liu T, Neumayer LA. The breast reconstruction evaluation of acellular dermal matrix as a sling trial (BREASTrial): design and methods of a prospective randomized trial. Plast Reconstr Surg. 2015;135:20–8e.
Petit JY, Veronesi U, Orecchia R, et al. Risk factors associated with recurrence after nipple-sparing mastectomy for invasive and intraepithelial neoplasia. Ann Oncol. 2012;23:2053–8.
Gabos Z, Thoms J, Ghosh S, Hanson J, Deschenes J, Sabri S, Abdulkarim B. The association between biological subtype and locoregional recurrence in newly diagnosed breast cancer. Breast Cancer Res Treat. 2010;124:187–94.
Lin NU, Vanderplas A, Hughes ME, et al. Clinicopathologic features, patterns of recurrence, and survival among women with triple negative breast cancer in the national comprehensive Cancer network. Cancer. 2012;118:5463–72.
de Alcantara Filho P, Capko D, Barry JM, Morrow M, Pusic A, Sacchini VS. Nipple-sparing mastectomy for breast cancer and risk reducing surgery: the Memorial Sloan-Kettering Cancer Center experience. Ann Surg Oncol. 2011;18:3117–22.
Coopey SB, Tang R, Lei L, et al. Increasing eligibility for nipple sparing mastectomy. Ann Surg Oncol. 2013;20:3218–22.
Wang F, Peled AW, Garwood E, et al. Total skin-sparing mastectomy and immediate breast reconstruction: an evolution of technique and assessment of outcomes. Ann Surg Oncol. 2014;21:3223–30.
Krajewski AC, Boughey JC, Degnim AC, Jakub JW, Jacobson SR, Hoskin TL, Hieken TJ. Expanded indications and improved outcomes for nipple-sparing mastectomy over time. Ann Surg Oncol. 2015;22:3317–23.
Woods JE. Detailed technique of subcutaneous mastectomy with and without mastopexy. Ann Plast Surg. 1987;18(1):51–61.
Broer N, Narayan D, Lannin D, Grube B. A novel technique for nipple-sparing mastectomy and immediate reconstruction in patients with macromastia. Plast Reconstr Surg. 2010;126(2):89e–92e.
Jensen JA, Lin JH, Kapoor N, Giuliano AE. Surgical delay of the nipple-areolar complex: a powerful technique to maximize nipple viability following nipple-sparing mastectomy. Ann Surg Oncol. 2012;19(10):3171–6.
Bertoni DM, Nguyen D, Rochlin D, et al. Protecting nipple perfusion by devascularization and surgical delay in patients at risk for ischemic complications during nipple-sparing mastectomies. Ann Surg Oncol. 2016;23:2665–e72.
Palmieri B, Baitchev G, Grappolini S, et al. Delayed nipple sparing modified subcutaneous mastectomy: rationale and technique. Breast J. 2005;11:173–e8.
Martinez CA, Reis SM, Sato EA, Boutros SG. The nipple-areola preserving mastectomy: a multistage procedure aiming to improve reconstructive outcomes following mastectomy. Plast Reconstr Surg Glob Open. 2015;3:e538.
Spear SL, Hannan CM, Willey SC, Cocilovo C. Nipple-sparing mastectomy. Plast Reconstr Surg. 2009;123:1665–73.
Hieken TJ, Boolbol SK, Dietz JR. Nipple-sparing mastectomy: indications, contraindications, risks, benefits, and techniques. Ann Surg Oncol. 2016;23(10):3138–44.
Spear SL, Rottman SJ, Seiboth LA, Hannan CM. Breast reconstruction using a staged nipple-sparing mastectomy following mastopexy or reduction. Plast Reconstr Surg. 2012;129(3):572–81.
Alperovich M, Tanna N, Samra F, Blechman K, Shapiro RL, Guth AA, Axelrod DM, Choi M, Karp NS. Nipple-sparing mastectomy in patients with a history of reduction mammaplasty or mastopexy: how safe is it? Plast Reconstr Surg. 2013;131(5):962–7.
Chavez-MacGregor M, Clarke CA, Lichtensztajn DY, Giordano SH. Delayed initiation of adjuvant chemotherapy among patients with breast cancer. JAMA Oncol. 2016;2(3):322–9.
Spear SL, Hannan C, Seiboth L, Al-Attar A. Nipple-sparing mastectomy: a review of indications, techniques and safety. Plast Reconstr Surg. 2010;126:25.
Rawlani V, Fiuk J, Johnson SA, Buck DW 2nd, Hirsch E, Hansen N, Khan S, Fine NA, Kim JY. The effect of incision choice on outcomes of nipple-sparing mastectomy reconstruction. Can J Plast Surg. 2011 Winter;19(4):129–33.
Choi M, Frey JD, Alperovich M, Levine JP. Karp NS. “breast in a day”: examining single-stage immediate, permanent implant reconstruction in nipple-sparing mastectomy. Plast Reconstr Surg. 2016;138(2):184e–91e.
Spear SL, Willey SC, Feldman ED, et al. Nipple-sparing mastectomy for prophylactic and therapeutic indications. Plas Reconstr Surg. 2011;128:1005–14.
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Willey, S.C., Pittman, T.A., Economides, J.M. (2020). Staged Nipple-Sparing Mastectomy for Patients with Large or Ptotic Breasts. In: Klimberg, V., Kovacs, T., Rubio, I. (eds) Oncoplastic Breast Surgery Techniques for the General Surgeon. Springer, Cham. https://doi.org/10.1007/978-3-030-40196-2_21
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