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Pelvic Pain

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Pain Management for Clinicians

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Abstract

Chronic pelvic pain is an increasingly important, multifactorial condition requiring a multidisciplinary approach to diagnosis and treatment. Terminology often varies across specialty, and practice guidance for the majority of etiologies of pelvic pain remains nebulous. Randomized controlled trials are emerging. A summary of treatments that are evidence-based, emerging, accepted, and disproven by etiology is provided in tabular form at the end of the chapter.

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References

  1. Abbott J. The use of botulinum toxin in the pelvic floor for women with chronic pelvic pain-a new answer to old problems? J Minim Invasive Gynecol. 2009;16(2):130–5.

    Article  PubMed  Google Scholar 

  2. Abbott JA, Jarvis SK, Lyons SD, Thomson A, Vancaille TG. Botulinum toxin type A for chronic pain and pelvic floor spasm in women: a randomized controlled trial. Obstet Gynecol. 2006;108(4):915–23.

    Article  PubMed  Google Scholar 

  3. Abdi S, Datta S, Trescot AM, Schultz DM, Adlaka R, Atluri SL, Smith HS, Manchikanti L. Epidural steroids in the management of chronic spinal pain: a systematic review. Pain Physician. 2007;10(1):185–212. Review.

    PubMed  Google Scholar 

  4. Acar F, Ozdemir M, Bayrakli F, Cirak B, Coskun E, Burchiel K. Management of medically intractable genitofemoral and ilioingunal neuralgia. Turk Neurosurg. 2013;23(6):753–7.

    PubMed  Google Scholar 

  5. Agarwal MM, ElsiSy M. Gabapentinoids in pain management in urological chronic pelvic pain syndrome: gabapentin or pregabalin? Neurourol Urodyn. 2017;36(8):2028–33.

    Article  CAS  PubMed  Google Scholar 

  6. Anderson RU, Wise D, Sawyer T, Chan CA. Sexual dysfunction in men with chronic prostatitis/chronic pelvic pain syndrome: improvement after trigger point release and paradoxical relaxation training. J Urol. 2006;176(4 Pt 1):1534–8; discussion 1538-9.

    Article  PubMed  Google Scholar 

  7. Angioni S, Pontis A, Dessole M, Surico D, De CiccoNardone C, Melis I. Pain control and quality of life after laparoscopic en-block resection of deep infiltrating endometriosis (DIE) vs. incomplete surgical treatment with or without GnRHa administration after surgery. Arch Gynecol Obstet. 2015;291(2):363–70.

    Article  CAS  PubMed  Google Scholar 

  8. Bachmann GA, Brown CS, Phillips NA, Rawlinson LA, Yu X, Wood R, Foster DC, Gabapentin Study Group. Effect of gabapentin on sexual function in vulvodynia: a randomized, placebo-controlled trial. Am J Obstet Gynecol. 2019;220(1):89.e1–8.

    Article  CAS  Google Scholar 

  9. Bates SM, Hill VA, Anderson JB, Chapple CR, Spence R, Ryan C, Talbot MD. A prospective, randomized, double-blind trial to evaluate the role of a short reducing course of oral corticosteroid therapy in the treatment of chronic prostatitis/chronic pelvic pain syndrome. BJU Int. 2007;99(2):355–9.

    Article  CAS  PubMed  Google Scholar 

  10. Batstone GR, Doble A. Chronic prostatitis. Curr Opin Urol. 2003;13(1):23–9. Review. Erratum in: Curr Opin Urol. 2003;13(2):177. Batstone D [corrected to Batstone G Richard D].

    Article  PubMed  Google Scholar 

  11. Bennis S, Hwang S. Office evaluation of pelvic pain. Phys Med Rehabil Clin N Am. 2017;28(3):461–76.

    Article  PubMed  Google Scholar 

  12. Bergeron S, Khalifé S, Glazer HI, Binik YM. Surgical and behavioral treatments for vestibulodynia: two-and-one-half year follow-up and predictors of outcome. Obstet Gynecol. 2008;111(1):159–66.

    Article  PubMed  Google Scholar 

  13. Bergeron S, Binik YM, Khalifé S, Pagidas K, Glazer HI, Meana M, Amsel R. A randomized comparison of group cognitive--behavioral therapy, surface electromyographic biofeedback, and vestibulectomy in the treatment of dyspareunia resulting from vulvar vestibulitis. Pain. 2001;91(3):297–306.

    Article  CAS  PubMed  Google Scholar 

  14. Berghmans B. Physiotherapy for pelvic pain and female sexual dysfunction: an untapped resource. Int Urogynecol J. 2018;29(5):631–8. PMC [article].

    Article  PubMed  PubMed Central  Google Scholar 

  15. Bonder JH, Chi M, Rispoli L. Myofascial pelvic pain and related disorders. Phys Med Rehabil Clin N Am. 2017;28(3):501–15.

    Article  PubMed  Google Scholar 

  16. Bosch PC. A randomized, double-blind, placebo controlled trial of adalimumab for interstitial cystitis/bladder pain syndrome. J Urol. 2014;191(1):77–82.

    Article  CAS  PubMed  Google Scholar 

  17. Brown CS, Bachmann GA, Wan J, Foster DC, Abapentin (GABA) Study Group. Gabapentin for the treatment of vulvodynia: a randomized controlled trial. Obstet Gynecol. 2018;131(6):1000–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Brown J, Crawford TJ, Allen C, Hopewell S, Prentice A. Nonsteroidal anti-inflammatory drugs for pain in women with endometriosis. Cochrane Database Syst Rev. 2017;1:CD004753.

    PubMed  Google Scholar 

  19. Carter JE. Surgical treatment for chronic pelvic pain. JSLS. 1998;2(2):129–39. Review.

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Carvalho N, Margatho D, Cursino K, Benetti-Pinto CL, Bahamondes L. Control of endometriosis-associated pain with etonogestrel-releasing contraceptive implant and 52-mg levonorgestrel-releasing intrauterine system: randomized clinical trial. Fertil Steril. 2018;110(6):1129–36.

    Article  CAS  PubMed  Google Scholar 

  21. Cervigni M, Natale F, Nasta L, Padoa A, Voi RL, Porru D. A combined intravesical therapy with hyaluronic acid and chondroitin for refractory painful bladder syndrome/interstitial cystitis. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(7):943–7.

    Article  CAS  PubMed  Google Scholar 

  22. Cervigni M, Sommariva M, Tenaglia R, Porru D, Ostardo E, Giammò A, Trevisan S, Frangione V, Ciani O, Tarricone R, Pappagallo GL. A randomized, open-label, multicenter study of the efficacy and safety of intravesical hyaluronic acid and chondroitin sulfate versus dimethyl sulfoxide in women with bladder pain syndrome/interstitial cystitis. Neurourol Urodyn. 2017;36(4):1178–86.

    Article  CAS  PubMed  Google Scholar 

  23. Cheah PY, Liong ML, Yuen KH, Teh CL, Khor T, Yang JR, Yap HW, Krieger JN. Initial, long-term, and durable responses to terazosin, placebo, or other therapies for chronic prostatitis/chronic pelvic pain syndrome. Urology. 2004;64(5):881–6.

    Article  PubMed  Google Scholar 

  24. Cheah PY, Liong ML, Yuen KH, Teh CL, Khor T, Yang JR, Yap HW, Krieger JN. Terazosin therapy for chronic prostatitis/chronic pelvic pain syndrome: a randomized, placebo controlled trial. J Urol. 2003;169(2):592–6.

    Article  CAS  PubMed  Google Scholar 

  25. Chen R, Nickel JC. Acupuncture ameliorates symptoms in men with chronic prostatitis/chronic pelvic pain syndrome. Urology. 2003;61(6):1156–9; discussion 1159.

    Article  PubMed  Google Scholar 

  26. Chennamsetty A, Khourdaji I, Goike J, Killinger KA, Girdler B, Peters KM. Electrosurgical management of Hunner ulcers in a referral center’s interstitial cystitis population. Urology. 2015;85(1):74–8.

    Article  PubMed  Google Scholar 

  27. Danielsson I, Torstensson T, Brodda-Jansen G, Bohm-Starke N. EMG biofeedback versus topical lidocaine gel: a randomized study for the treatment of women with vulvarvestibulitis. Acta Obstet Gynecol Scand. 2006;85(11):1360–7.

    Article  PubMed  Google Scholar 

  28. Dell JR, Butrick CW. Multimodal therapy for painful bladder syndrome/interstitial cystitis. J Reprod Med. 2006;51(3 Suppl):253–60. Review.

    PubMed  Google Scholar 

  29. Dionisi B, Anglana F, Inghirami P, Lippa P, Senatori R. Use of transcutaneous electrical stimulation and biofeedback for the treatment of vulvodynia (vulvar vestibular syndrome): result of 3 years of experience. Minerva Ginecol. 2008;60(6):485–91. Italian.

    CAS  PubMed  Google Scholar 

  30. Eickmeyer SM. Anatomy and physiology of the pelvic floor. Phys Med Rehabil Clin N Am. 2017;28(3):455–60.

    Article  PubMed  Google Scholar 

  31. El-Hefnawy AS, Makharita MY, Abed A, Amr YM, Salah El-Badry M, Shaaban AA. Anesthetic bladder hydrodistention is superior to superior hypogastric plexus yeurolysis in treatment of interstitial cystitis-bladder pain syndrome: a prospective randomized trial. Urology. 2015;85(5):1039–44.

    Article  PubMed  Google Scholar 

  32. Elkins N, Hunt J, Scott KM. Neurogenic pelvic pain. Phys Med Rehabil Clin N Am. 2017;28(3):551–69.

    Article  PubMed  Google Scholar 

  33. Eltabbakh GH, Bower NA. Laparoscopic surgery in endometriosis. Minerva Ginecol. 2008;60(4):323–30. Review.

    CAS  PubMed  Google Scholar 

  34. Eppsteiner E, Boardman L, Stockdale CK. Vulvodynia. Best Pract Res Clin Obstet Gynaecol. 2014;28(7):1000–12.

    Article  PubMed  Google Scholar 

  35. Fang H, Zhang J, Yang Y, Ye L, Wang X. Clinical effect and safety of pulsed radiofrequency treatment for pudendal neuralgia: a prospective, randomized controlled clinical trial. J Pain Res. 2018;11:2367–74. eCollection 2018.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Faubion SS, Shuster LT, Bharucha AE. Recognition and management of nonrelaxing pelvic floor dysfunction. Mayo Clin Proc. 2012;87(2):187–93.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Fitzgerald MP, Anderson RU, Potts J, Payne CK, Peters KM, Clemens JQ, Kotarinos R, Fraser L, Cosby A, Fortman C, Neville C, Badillo S, Odabachian L, Sanfield A, O’Dougherty B, Halle-Podell R, Cen L, Chuai S, Landis JR, Mickelberg K, Barrell T, Kusek JW, et al. Randomized multicenter feasibility trial of myofascial physical therapy for the treatment of urological chronic pelvic pain syndromes. J Urol. 2013;189(1 Suppl):S75–85.

    PubMed  Google Scholar 

  38. Fitz Gerald MP, Payne CK, Lukacz ES, Yang CC, Peters KM, Chai TC, Nickel JC, Hanno PM, Kreder KJ, Burks DA, Mayer R, Kotarinos R, Fortman C, Allen TM, Fraser L, Mason-Cover M, Furey C, Odabachian L, Sanfield A, Chu J, Huestis K, Tata GE, et al. Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness. J Urol. 2012;187(6):2113–8.

    Article  CAS  Google Scholar 

  39. Foster DC, Kotok MB, Huang LS, Watts A, Oakes D, Howard FM, Poleshuck EL, Stodgell CJ, Dworkin RH. Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial. Obstet Gynecol. 2010;116(3):583–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Franco JV, Turk T, Jung JH, Xiao YT, Iakhno S, Garrote V, Vietto V. Non-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome. Cochrane Database Syst Rev. 2018;5:CD012551.

    PubMed  Google Scholar 

  41. Gajewski JB, Al-Zahrani AA. The long-term efficacy of sacral neuromodulation in the management of intractable cases of bladder pain syndrome: 14 years of experience in one centre. BJU Int. 2011;107(8):1258–64.

    Article  PubMed  Google Scholar 

  42. Generali JA, Cada DJ. Intravesical heparin: interstitial cystitis (painful bladder syndrome). Hosp Pharm. 2013;48(10):822–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. Giubilei G, Mondaini N, Minervini A, Saieva C, Lapini A, Serni S, Bartoletti R, Carini M. Physical activity of men with chronic prostatitis/chronic pelvic pain syndrome not satisfied with conventional treatments--could it represent a valid option? The physical activity and male pelvic pain trial: a double-blind, randomized study. J Urol. 2007;177(1):159–65.

    Article  PubMed  Google Scholar 

  44. Goldfinger C, Pukall CF, Thibault-Gagnon S, McLean L, Chamberlain S. Effectiveness of cognitive-behavioral therapy and physical therapy for provoked vestibulodynia: a randomized pilot study. J Sex Med. 2016;13(1):88–94.

    Article  PubMed  Google Scholar 

  45. Granese R, Perino A, Calagna G, Saitta S, De Franciscis P, Colacurci N, Triolo O, Cucinella G. Gonadotrophin-releasing hormone analogue or dienogest plus estradiol valerate to prevent pain recurrence after laparoscopic surgery for endometriosis: a multi-center randomized trial. Acta Obstet Gynecol Scand. 2015;94(6):637–45.

    Article  CAS  PubMed  Google Scholar 

  46. Guu SJ, Geng JH, Chao IT, Lin HT, Lee YC, Juan YS, Liu CC, Wang CJ, Tsai CC. Efficacy of low-intensity extracorporeal shock wave therapy on men with chronic pelvic pain syndrome refractory to 3-as therapy. Am J Mens Health. 2018;12(2):441–52.

    Article  PubMed  Google Scholar 

  47. Henzell H, Berzins K. Localised provoked vestibulodynia (vulvodynia): assessment and management. Aust Fam Physician. 2015;44(7):460–6.

    PubMed  Google Scholar 

  48. Hillelsohn JH, Rais-Bahrami S, Friedlander JI, Okhunov Z, Kashan M, Rosen L, Moldwin RM. Fulguration for Hunner ulcers: long-term clinical outcomes. J Urol. 2012;188(6):2238–41.

    Article  PubMed  Google Scholar 

  49. Hoke TP, Goldstein H, Saks EK, Vakili B. Hydrodistention of the bladder for the treatment of bladder pain syndrome/interstitial cystitis (BPS/IC). Neurourol Urodyn. 2017;36(3):784–6.

    Article  PubMed  Google Scholar 

  50. Holland MA, Joyce JS, Brennaman LM, Drobnis EZ, Starr JA, Foster RT Sr. Intravaginal diazepam for the treatment of pelvic floor hypertonic disorder: a double-blind, randomized, placebo-controlled trial. Female Pelvic Med Reconstr Surg. 2019;25(1):76–81.

    Article  PubMed  Google Scholar 

  51. Howard FM. The role of laparoscopy in chronic pelvic pain: promise and pitfalls. Obstet Gynecol Surv. 1993;48(6):357–87. Review.

    Article  CAS  PubMed  Google Scholar 

  52. Iyer S, Lotsof E, Zhou Y, Tran A, Botros C, Sand P, Goldberg R, Tomezsko J, Gafni-Kane A, Botros S. Which bladder instillations are more effective? DMSO vs. bupivacaine/heparin/triamcinolone: a retrospective study. Int Urogynecol J. 2017;28(9):1335–40.

    Article  PubMed  Google Scholar 

  53. Jarrell JF, Vilos GA, Allaire C, Burgess S, Fortin C, Gerwin R, Lapensée L, Lea RH, Leyland NA, Martyn P, Shenassa H, Taenzer P, Abu-Rafea B, Chronic Pelvic Pain Working Group, SOGC. Consensus guidelines for the management of chronic pelvic pain. J Obstet Gynaecol Can. 2005;27(8):781–826. English, French.

    Article  PubMed  Google Scholar 

  54. Jhang JF, Jiang YH, Kuo HC. Potential therapeutic effect of intravesical botulinum toxin type A on bladder pain syndrome/interstitial cystitis. Int J Urol. 2014;21(Suppl 1):49–55.

    Article  CAS  PubMed  Google Scholar 

  55. Jundt K, Peschers U, Kentenich H. The investigation and treatment of female pelvic floor dysfunction. Deutsches Ärzteblatt International. 2015;112(33–34):564–74.

    PubMed  PubMed Central  Google Scholar 

  56. Kanter G, Komesu YM, Qaedan F, Jeppson PC, Dunivan GC, Cichowski SB, Rogers RG. Mindfulness-based stress reduction as a novel treatment for interstitial cystitis/bladder pain syndrome: a randomized controlled trial. Int Urogynecol J. 2016;27(11):1705–11. Epub 2016.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Kehoe S, Luesley D. Vulvar vestibulitis treated by modified vestibulectomy. Int J Gynaecol Obstet. 1999;64(2):147–52.

    Article  CAS  PubMed  Google Scholar 

  58. Keller C, Mück B. Endoscopic triple neurectomy for tumor-induced inguinal pain syndrome. Schmerz. 2018;32(2):128–30.

    Article  CAS  PubMed  Google Scholar 

  59. Khatri G, Khan A, Raval G, Chhabra A. Diagnostic evaluation of chronic pelvic pain. Phys Med Rehabil Clin N Am. 2017;28(3):477–500.

    Article  PubMed  Google Scholar 

  60. Khoder W, Hale D. Pudendal neuralgia. Obstet Gynecol Clin N Am. 2014;41(3):443–52.

    Article  Google Scholar 

  61. Kliethermes CJ, Shah M, Hoffstetter S, Gavard JA, Steele A. Effect of vestibulectomy for intractable vulvodynia. J Minim Invasive Gynecol. 2016;23(7):1152–7.

    Article  PubMed  Google Scholar 

  62. Krieger JN, Nyberg L Jr, Nickel JC. NIH consensus definition and classification of prostatitis. JAMA. 1999;282(3):236–7.

    Article  CAS  PubMed  Google Scholar 

  63. Kruszka PS, Kruszka SJ. Evaluation of acute pelvic pain in women. Am Fam Physician. 2010;82(2):141–7. Review.

    PubMed  Google Scholar 

  64. Labat JJ, Delavierre D, Sibert L, Rigaud J. Electrophysiological studies of chronic pelvic and perineal pain. Prog Urol. 2010;20(12):905–10.

    Article  PubMed  Google Scholar 

  65. Lee D, Chang J, Zimmern PE. Iatrogenic pelvic pain: surgical and mesh complications. Phys Med Rehabil Clin N Am. 2017;28(3):603–19.

    Article  PubMed  Google Scholar 

  66. Lee SW, Liong ML, Yuen KH, Leong WS, Chee C, Cheah PY, Choong WP, Wu Y, Khan N, Choong WL, Yap HW, Krieger JN. Acupuncture versus sham acupuncture for chronic prostatitis/chronic pelvic pain. Am J Med. 2008;121(1):79.e1–7.

    Article  Google Scholar 

  67. Lefaucheur JP, Labat JJ, Amarenco G, Herbaut AG, Prat-Pradal D, Benaim J, Aranda B, Arne-Bes MC, Bonniaud V, Boohs PM, Charvier K, Daemgen F, Dumas P, Galaup JP, Sheikh Ismael S, Kerdraon J, Lacroix P, Lagauche D, Lapeyre E, Lefort M, Leroi AM, Opsomer RJ, et al. What is the place of electroneuromyographic studies in the diagnosis and management of pudendal neuralgia related to entrapment syndrome? Neurophysiol Clin. 2007;37(4):223–8. Epub 2007. Review.

    Article  PubMed  Google Scholar 

  68. Leskinen MJ, Kilponen A, Lukkarinen O, Tammela TL. Transurethral needle ablation for the treatment of chronic pelvic pain syndrome (category III prostatitis): a randomized, sham-controlled study. Urology. 2002;60(2):300–4.

    Article  PubMed  Google Scholar 

  69. Levesque A, Riant T, Labat JJ, Ploteau S. Use of high-concentration capsaicin patch for the treatment of pelvic pain: observational study of 60 inpatients. Pain Physician. 2017;20(1):E161–7.

    Article  PubMed  Google Scholar 

  70. Lewis SC, Bhattacharya S, Wu O, Vincent K, Jack SA, Critchley HO, Porter MA, Cranley D, Wilson JA, Horne AW. Gabapentin for the management of chronic pelvic pain in women (GaPP1): a pilot randomised controlled trial. PLoS One. 2016;11(4):e0153037.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  71. Lim YN, Dwyer P, Murray C, Karmakar D, Rosamilia A, Thomas E. Long-term outcomes of intravesical dimethyl sulfoxide/heparin/hydrocortisone therapy for interstitial cystitis/bladder pain syndrome. Int Urogynecol J. 2017;28(7):1085–9.

    Article  PubMed  Google Scholar 

  72. Maher C, Feiner B, Baessler K, Christmann-Schmid C, Haya N, Marjoribanks J. Transvaginal mesh or grafts compared with native tissue repair for vaginal prolapse. Cochrane Database Syst Rev. 2016;2:CD012079.

    PubMed  Google Scholar 

  73. Martellucci J, Naldini G, Carriero A. Sacral nerve modulation in the treatment of chronic pelvic pain. Int J Color Dis. 2012;27(7):921–6.

    Article  CAS  Google Scholar 

  74. Mayer RD, Howard FM. Sacral nerve stimulation: neuromodulation for voiding dysfunction and pain. Neurotherapeutics. 2008;5(1):107–13.

    Article  PubMed  PubMed Central  Google Scholar 

  75. McKay E, Kaufman RH, Doctor U, Berkova Z, Glazer H, Redko V. Treating vulvar vestibulitis with electromyographic biofeedback of pelvic floor musculature. J Reprod Med. 2001;46(4):337–42.

    CAS  PubMed  Google Scholar 

  76. Mehik A, Alas P, Nickel JC, Sarpola A, Helström PJ. Alfuzosin treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, double-blind, placebo-controlled, pilot study. Urology. 2003;62(3):425–9.

    Article  PubMed  Google Scholar 

  77. Morgia G, Russo GI, Urzì D, Privitera S, Castelli T, Favilla V, Cimino S. A phase II, randomized, single-blinded, placebo-controlled clinical trial on the efficacy of Curcumina and Calendula suppositories for the treatment of patients with chronic prostatitis/chronic pelvic pain syndrome type III. Arch Ital Urol Androl. 2017;89(2):110–3.

    Article  CAS  PubMed  Google Scholar 

  78. Nesbitt-Hawes EM, Won H, Jarvis SK, Lyons SD, Vancaillie TG, Abbott JA. Improvement in pelvic pain with botulinum toxin type A-single vs. repeat injections. Toxicon. 2013;63:83–7.

    Article  CAS  PubMed  Google Scholar 

  79. Nickel JC, Herschorn S, Whitmore KE, Forrest JB, Hu P, Friedman AJ, Baseman AS. Pentosanpolysulfate sodium for treatment of interstitial cystitis/bladder pain syndrome: insights from a randomized, double-blind, placebo controlled study. J Urol. 2015;193(3):857–62.

    Article  CAS  PubMed  Google Scholar 

  80. Nickel JC, Barkin J, Forrest J, Mosbaugh PG, Hernandez-Graulau J, Kaufman D, Lloyd K, Evans RJ, Parsons CL, Atkinson LE, Elmiron Study Group. Randomized, double-blind, dose-ranging study of pentosanpolysulfate sodium for interstitial cystitis. Urology. 2005;65(4):654–8.

    Article  PubMed  Google Scholar 

  81. Nickel JC, Moldwin R, Lee S, Davis EL, Henry RA, Wyllie MG. Intravesical alkalinized lidocaine (PSD597) offers sustained relief from symptoms of interstitial cystitis and painful bladder syndrome. BJU Int. 2009;103(7):910–8.

    Article  CAS  PubMed  Google Scholar 

  82. Nickel JC, Forrest JB, Tomera K, Hernandez-Graulau J, Moon TD, Schaeffer AJ, Krieger JN, Zeitlin SI, Evans RJ, Lama DJ, Neal DE Jr, Sant GR. Pentosan polysulfate sodium therapy for men with chronic pelvic pain syndrome: a multicenter, randomized, placebo controlled study. J Urol. 2005;173(4):1252–5.

    Article  PubMed  Google Scholar 

  83. Nickel JC, Downey J, Pontari MA, Shoskes DA, Zeitlin SI. A randomized placebo-controlled multicentre study to evaluate the safety and efficacy of finasteride for male chronic pelvic pain syndrome (category IIIA chronic nonbacterial prostatitis). BJU Int. 2004;93(7):991–5.

    Article  CAS  PubMed  Google Scholar 

  84. Nickel JC, Narayan P, McKay J, Doyle C. Treatment of chronic prostatitis/chronic pelvic pain syndrome with tamsulosin: a randomized double blind trial. J Urol. 2004;171(4):1594–7.

    Article  CAS  PubMed  Google Scholar 

  85. Nickel JC, Pontari M, Moon T, Gittelman M, Malek G, Farrington J, Pearson J, Krupa D, Bach M, Drisko J, Rofecoxib Prostatitis Investigator Team. A randomized, placebo controlled, multicenter study to evaluate the safety and efficacy of rofecoxib in the treatment of chronic nonbacterial prostatitis. J Urol. 2003;169(4):1401–5.

    Article  CAS  PubMed  Google Scholar 

  86. Olsen AL, Smith VJ, Bergstrom JO, Colling JC, Clark AL. Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence. Obstet Gynecol. 1997;89(4):501–6.

    Article  CAS  PubMed  Google Scholar 

  87. Parsons CL, Koziol JA, Proctor JG, Zupkas P, Argade S. Heparin and alkalinized lidocaine versus alkalinized lidocaine for treatment of interstitial cystitis symptoms. Can J Urol. 2015;22(2):7739–44.

    PubMed  Google Scholar 

  88. Pedraza R, Nieto J, Ibarra S, Haas EM. Pelvic muscle rehabilitation: a standardized protocol for pelvic floor dysfunction. Adv Urol. 2014;2014:487436.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Pérez-López FR, Hita-Contreras F. Management of pudendal neuralgia. Climacteric. 2014;17(6):654–6.

    Article  PubMed  Google Scholar 

  90. Petersen CD, Giraldi A, Lundvall L, Kristensen E. Botulinum toxin type A-a novel treatment for provoked vestibulodynia? Results from a randomized, placebo controlled, double blinded study. J Sex Med. 2009;6(9):2523–37.

    Article  CAS  PubMed  Google Scholar 

  91. Petrov-Kondratov V, Chhabra A, Jones S. Pulsed radiofrequency ablation of pudendal nerve for treatment of a case of refractory pelvic pain. Pain Physician. 2017;20(3):E451–4.

    PubMed  Google Scholar 

  92. Pettit PD, Thompson JR, Chen AH. Sacral neuromodulation: new applications in the treatment of female pelvic floor dysfunction. Curr Opin Obstet Gynecol. 2002;14(5):521–5. Review.

    Article  PubMed  Google Scholar 

  93. Prendergast SA. Pelvic floor physical therapy for vulvodynia: a clinician’s guide. Obstet Gynecol Clin N Am. 2017;44(3):509–22. https://doi.org/10.1016/j.ogc.2017.05.006.Review.

    Article  Google Scholar 

  94. Rao SS, Paulson J, Mata M, Zimmerman B. Clinical trial: effects of botulinum toxin on Levator ani syndrome--a double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2009;29(9):985–91.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  95. Rao SS, Go JT. Treating pelvic floor disorders of defecation: management or cure? Curr Gastroenterol Rep. 2009;11(4):278–87.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Rizk B, Fischer AS, Lotfy HA, Turki R, Zahed HA, Malik R, Holliday CP, Glass A, Fishel H, Soliman MY, Herrera D. Recurrence of endometriosis after hysterectomy. Facts Views Vis Obgyn. 2014;6(4):219–27.

    CAS  PubMed  PubMed Central  Google Scholar 

  97. Romito S, Bottanelli M, Pellegrini M, Vicentini S, Rizzuto N, Bertolasi L. Botulinum toxin for the treatment of genital pain syndromes. Gynecol Obstet Invest. 2004;58(3):164–7. Epub 2004.

    Article  CAS  PubMed  Google Scholar 

  98. Rosenbaum TY. Physiotherapy treatment of sexual pain disorders. J Sex Marital Ther. 2005;31(4):329–40. Review.

    Article  PubMed  Google Scholar 

  99. Roy H, Offiah I, Dua A. Neuromodulation for pelvic and urogenital pain. Brain Sci. 2018;8(10):E180.

    Article  PubMed  Google Scholar 

  100. Ryu J, Pak S, Song M, Chun JY, Hong S, Choo MS. Elimination of Hunner’s ulcers by fulguration in patients with interstitial cystitis: is it effective and long lasting? Korean J Urol. 2013;54(11):767–71.

    Article  PubMed  PubMed Central  Google Scholar 

  101. Sahin S, Bicer M, Eren GA, Tas S, Tugcu V, Tasci AI, Cek M. Acupuncture relieves symptoms in chronic prostatitis/chronic pelvic pain syndrome: a randomized, sham-controlled trial. Prostate Cancer Prostatic Dis. 2015;18(3):249–54.

    Article  CAS  PubMed  Google Scholar 

  102. Saltiel E, Garabedian-Ruffalo SM. Pharmacologic management of endometriosis. Clin Pharm. 1991;10(7):518–31. Review.

    CAS  PubMed  Google Scholar 

  103. Schey R, Cromwell J, Rao SS. Medical & surgical management of pelvic floor disorders affecting defecation. Am J Gastroenterol. 2012;107(11):1624–34.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Schlaeger JM, Xu N, Mejta CL, Park CG, Wilkie DJ. Acupuncture for the treatment ofvulvodynia: a randomized wait-list controlled pilot study. J Sex Med. 2015;12(4):1019–27.

    Article  PubMed  Google Scholar 

  105. Schoeb DS, Schlager D, Boeker M, Wetterauer U, Schoenthaler M, Herrmann TRW, Miernik A. Surgical therapy of prostatitis: a systematic review. World J Urol. 2017;35(11):1659–68.

    Article  PubMed  Google Scholar 

  106. Sokolov AV. Transrectal microwave hyperthermia in the treatment of chronic prostatitis. Urologiia. 2003;(5):20–6. Russian.

    Google Scholar 

  107. Stockdale CK, Lawson HW. 2013 vulvodynia guideline update. J Low Genit Tract Dis. 2014;18(2):93–100.

    Article  PubMed  Google Scholar 

  108. Tanmahasamut P, Rattanachaiyanont M, Angsuwathana S, Techatraisak K, Indhavivadhana S, Leerasiri P. Postoperative levonorgestrel-releasing intrauterine system for pelvic endometriosis-related pain: a randomized controlled trial. Obstet Gynecol. 2012;119(3):519–26.

    Article  PubMed  Google Scholar 

  109. Tirlapur SA, Vlismas A, Ball E, Khan KS. Nerve stimulation for chronic pelvic pain and bladder pain syndrome: a systematic review. Acta Obstet Gynecol Scand. 2013;92(8):881–7.

    Article  PubMed  Google Scholar 

  110. Tommola P, Unkila-Kallio L, Paavonen J. Long-term well-being after surgical or conservative treatment of severe vulvar vestibulitis. Acta Obstet Gynecol Scand. 2012;91(9):1086–93.

    Article  PubMed  Google Scholar 

  111. Tommola P, Unkila-Kallio L, Paavonen J. Surgical treatment of vulvar vestibulitis: a review. Acta Obstet Gynecol Scand. 2010;89(11):1385–95.

    Article  PubMed  Google Scholar 

  112. Van Alstyne LS, Harrington KL, Haskvitz EM. Physical therapist management of chronic prostatitis/chronic pelvic pain syndrome. Phys Ther. 2010;90(12):1795–806.

    Article  PubMed  Google Scholar 

  113. Wang J, Wang Q, Wu Q, Chen Y, Wu P. Intravesical botulinum toxin a injections for bladder pain syndrome/interstitial cystitis: a systematic review and meta-analysis of controlled studies. Med Sci Monit. 2016;22:3257–67. Review.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  114. Wang J, Yan D, Liang K, Xu Z. A randomized controlled trial of levofloxacin, terazosin, and combination therapy in patients with category III chronic prostatitis/chronic pelvic pain syndrome. Int Urol Nephrol. 2016;48(1):13–8.

    Article  CAS  PubMed  Google Scholar 

  115. Wattier JM. Conventional analgesics and non-pharmacological multidisciplinary therapeutic treatment in endometriosis: CNGOF-HAS endometriosis guidelines. Gynecol Obstet Fertil Senol. 2018;46(3):248–55.

    PubMed  Google Scholar 

  116. Xie JX, Hu HT, Xiao DN, Xie HZ, Zhu CB, Yang WT, Huang XX, He XJ, Liang GR, Wang ZG. Safety and efficacy of Qianliean Suppository for chronic prostatitis of damp-heat and blood-stasis syndrome: a randomized, single-blind, parallel controlled, multi-centered phase III clinical trial. Zhonghua Nan KeXue. 2009;15(11):1049–52. Chinese.

    Google Scholar 

  117. Xu Y, Zhao W, Li T, Zhao Y, Bu H, Song S. Effects of acupuncture for the treatment of endometriosis-related pain: a systematic review and meta-analysis. PLoS One. 2017;12(10):e0186616.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  118. Zarbo C, Brugnera A, Frigerio L, Malandrino C, Rabboni M, Bondi E, Compare A. Behavioral, cognitive, and emotional coping strategies of women with endometriosis: a critical narrative review. Arch Womens Ment Health. 2018;21(1):1–13.

    Article  PubMed  Google Scholar 

  119. Zheng F, Lin Y, Verbeken E, Claerhout F, Fastrez M, De Ridder D, Deprest J. Host response after reconstruction of abdominal wall defects with porcine dermal collagen in a rat model. Am J Obstet Gynecol. 2004;191(6):1961–70.

    Article  CAS  PubMed  Google Scholar 

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  1. Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Avinash S. Chavda & Kelly M. Scott

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  1. Professor in the Department of Pain Management and Anesthesiology, UT Southwestern Medical Center, Eugene McDermott Center for Pain Management, Dallas, TX, USA

    Carl Edward Noe

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Chavda, A.S., Scott, K.M. (2020). Pelvic Pain. In: Noe, C. (eds) Pain Management for Clinicians. Springer, Cham. https://doi.org/10.1007/978-3-030-39982-5_11

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