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The Microbiome, Surgical Stress, and Infection

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Surgical Metabolism

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Abstract

The microbiome represents an important emerging biology and potential set of manipuable tools in the understanding and care of the surgical patients. New techniques are allowing an understanding of a formerly underappreciated biology which has both direct infectious and mechanistic effects on the health of our patients and their surgical needs and outcomes. This chapter provides a review of the current state of the science on the microbiome as it applies to surgery. Beginning with a history of the biology we provide definitions and an introduction to techniques for surveying, and finally specific applications to surgical science.

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Bibliography

  1. Alverdy JC. Microbiome medicine: this changes everything. J Am Coll Surg. 2018;226:719–29. https://doi.org/10.1016/j.jamcollsurg.2018.02.004.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Integrative HMPRNC. The integrative human microbiome project. Nature. 2019;569:641–8. https://doi.org/10.1038/s41586-019-1238-8.

    Article  CAS  Google Scholar 

  3. Rup L. The human microbiome project. Indian J Microbiol. 2012;52:315. https://doi.org/10.1007/s12088-012-0304-9.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Guyton K, Alverdy JC. The gut microbiota and gastrointestinal surgery. Nat Rev Gastroenterol Hepatol. 2017;14:43–54. https://doi.org/10.1038/nrgastro.2016.139.

    Article  CAS  PubMed  Google Scholar 

  5. Alverdy JC, Luo JN. The influence of host stress on the mechanism of infection: lost microbiomes, emergent pathobiomes, and the role of interkingdom signaling. Front Microbiol. 2017;8:322. https://doi.org/10.3389/fmicb.2017.00322.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Gevers D, Pop M, Schloss PD, Huttenhower C. Bioinformatics for the human microbiome project. PLoS Comput Biol. 2012;8:e1002779. https://doi.org/10.1371/journal.pcbi.1002779.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Brinker P, Fontaine MC, Beukeboom LW, Falcao Salles J. Host, symbionts, and the microbiome: the missing tripartite interaction. Trends Microbiol. 2019;27:480–8. https://doi.org/10.1016/j.tim.2019.02.002.

    Article  CAS  PubMed  Google Scholar 

  8. Johanesen PA, et al. Disruption of the gut microbiome: Clostridium difficile infection and the threat of antibiotic resistance. Genes (Basel). 2015;6:1347–60. https://doi.org/10.3390/genes6041347.

    Article  CAS  Google Scholar 

  9. Asquith M, Rosenbaum JT. The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies. Curr Opin Rheumatol. 2016;28:405–12. https://doi.org/10.1097/BOR.0000000000000299.

    Article  CAS  PubMed  Google Scholar 

  10. Howard BM, et al. Characterizing the gut microbiome in trauma: significant changes in microbial diversity occur early after severe injury. Trauma Surg Acute Care Open. 2017;2:e000108. https://doi.org/10.1136/tsaco-2017-000108.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Rocha BS, Nunes C, Laranjinha J. Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome. Int J Biochem Cell Biol. 2016;81:393–402. https://doi.org/10.1016/j.biocel.2016.10.021.

    Article  CAS  PubMed  Google Scholar 

  12. Nicholson SE, et al. A prospective study in severely injured patients reveals an altered gut microbiome is associated with transfusion volume. J Trauma Acute Care Surg. 2019;86:573–82. https://doi.org/10.1097/TA.0000000000002201.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Nicholson SE, et al. Polytrauma independent of therapeutic intervention alters the gastrointestinal microbiome. Am J Surg. 2018;216:699–705. https://doi.org/10.1016/j.amjsurg.2018.07.026.

    Article  PubMed  Google Scholar 

  14. Nicholson SE, et al. Moderate traumatic brain injury alters the gastrointestinal microbiome in a time-dependent manner. Shock. 2019;52:240–8. https://doi.org/10.1097/SHK.0000000000001211.

    Article  CAS  PubMed  Google Scholar 

  15. Singh V, et al. Microbiota dysbiosis controls the neuroinflammatory response after stroke. J Neurosci. 2016;36:7428–40. https://doi.org/10.1523/JNEUROSCI.1114-16.2016.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Braniste V, et al. The gut microbiota influences blood-brain barrier permeability in mice. Sci Transl Med. 2014;6:263ra158. https://doi.org/10.1126/scitranslmed.3009759.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Panzer AR, et al. Lung microbiota is related to smoking status and to development of acute respiratory distress syndrome in critically ill trauma patients. Am J Respir Crit Care Med. 2018;197:621–31. https://doi.org/10.1164/rccm.201702-0441OC.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Hemmings SMJ, et al. The microbiome in posttraumatic stress disorder and trauma-exposed controls: an exploratory study. Psychosom Med. 2017;79:936–46. https://doi.org/10.1097/PSY.0000000000000512.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Pennington EC, et al. Use of mechanical bowel preparation and oral antibiotics for elective colorectal procedures in children: is current practice evidence-based? J Pediatr Surg. 2014;49:1030–5; discussion 1035. https://doi.org/10.1016/j.jpedsurg.2014.01.048.

    Article  PubMed  Google Scholar 

  20. Ioannidis A, Zoikas A, Wexner SD. Current evidence of combination of oral antibiotics and mechanical bowel preparation in elective colorectal surgery and their impact on anastomotic leak. Surg Innov. 2019:1553350619851672. https://doi.org/10.1177/1553350619851672.

  21. Luijten J, Vugts G, Nieuwenhuijzen GAP, Luyer MDP. The importance of the microbiome in bariatric surgery: a systematic review. Obes Surg. 2019;29:2338–49. https://doi.org/10.1007/s11695-019-03863-y.

    Article  PubMed  Google Scholar 

  22. Lee CJ, et al. Changes in gut microbiome after bariatric surgery versus medical weight loss in a pilot randomized trial. Obes Surg. 2019. https://doi.org/10.1007/s11695-019-03976-4.

  23. Alexander JL, Kohoutova D, Powell N. Science in focus: the microbiome and cancer therapy. Clin Oncol (R Coll Radiol). 2019;31:1–4. https://doi.org/10.1016/j.clon.2018.09.004.

    Article  CAS  Google Scholar 

  24. Bhatt AP, Redinbo MR, Bultman SJ. The role of the microbiome in cancer development and therapy. CA Cancer J Clin. 2017;67:326–44. https://doi.org/10.3322/caac.21398.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Helmink BA, Khan MAW, Hermann A, Gopalakrishnan V, Wargo JA. The microbiome, cancer, and cancer therapy. Nat Med. 2019;25:377–88. https://doi.org/10.1038/s41591-019-0377-7.

    Article  CAS  PubMed  Google Scholar 

  26. Khanna S, et al. A novel microbiome therapeutic increases gut microbial diversity and prevents recurrent Clostridium difficile infection. J Infect Dis. 2016;214:173–81. https://doi.org/10.1093/infdis/jiv766.

    Article  PubMed  Google Scholar 

  27. Lee YJ, et al. Protective factors in the intestinal microbiome against Clostridium difficile infection in recipients of allogeneic hematopoietic stem cell transplantation. J Infect Dis. 2017;215:1117–23. https://doi.org/10.1093/infdis/jix011.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Rubin TA, Gessert CE, Aas J, Bakken JS. Fecal microbiome transplantation for recurrent Clostridium difficile infection: report on a case series. Anaerobe. 2013;19:22–6. https://doi.org/10.1016/j.anaerobe.2012.11.004.

    Article  PubMed  Google Scholar 

  29. Gaines S, Shao C, Hyman N, Alverdy JC. Gut microbiome influences on anastomotic leak and recurrence rates following colorectal cancer surgery. Br J Surg. 2018;105:e131–41. https://doi.org/10.1002/bjs.10760.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Gershuni VM, Friedman ES. The microbiome-host interaction as a potential driver of anastomotic leak. Curr Gastroenterol Rep. 2019;21:4. https://doi.org/10.1007/s11894-019-0668-7.

    Article  PubMed  Google Scholar 

  31. Alverdy JC, Hyoju SK, Weigerinck M, Gilbert JA. The gut microbiome and the mechanism of surgical infection. Br J Surg. 2017;104:e14–23. https://doi.org/10.1002/bjs.10405.

    Article  CAS  PubMed  Google Scholar 

  32. Ge X, et al. Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility. Sci Rep. 2017;7:441. https://doi.org/10.1038/s41598-017-00612-y.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Tajima Y, et al. Comparison of the risk of surgical site infection and feasibility of surgery between sennoside versus polyethylene glycol as a mechanical bowel preparation of elective colon cancer surgery: a randomized controlled trial. Surg Today. 2016;46:735–40. https://doi.org/10.1007/s00595-015-1239-7.

    Article  PubMed  Google Scholar 

  34. Zinocker MK, Lindseth IA. The western diet-microbiome-host interaction and its role in metabolic disease. Nutrients. 2018;10. https://doi.org/10.3390/nu10030365.

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Author information

Authors and Affiliations

  1. Denver Health Medical Center, Denver, CO, USA

    Mitchell Jay Cohen

  2. Division of Bioinformatics and Personalized Medicine, University of Colorado School of Medicine, Aurora, CO, USA

    Mitchell Jay Cohen

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  1. Mitchell Jay Cohen
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Correspondence to Mitchell Jay Cohen .

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Editors and Affiliations

  1. Department of Surgery, Yale University School of Medicine, New Haven, CT, USA

    Kimberly A. Davis

  2. Department of Anesthesiology, Yale University School of Medicine, New Haven, CT, USA

    Stanley H. Rosenbaum

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Cohen, M.J. (2020). The Microbiome, Surgical Stress, and Infection. In: Davis, K., Rosenbaum, S. (eds) Surgical Metabolism. Springer, Cham. https://doi.org/10.1007/978-3-030-39781-4_17

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  • DOI: https://doi.org/10.1007/978-3-030-39781-4_17

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-39780-7

  • Online ISBN: 978-3-030-39781-4

  • eBook Packages: MedicineMedicine (R0)

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