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Application of Lymphatic Mapping and Sentinel Node Biopsy in Surgical Oncology

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Clinical Nuclear Medicine

Abstract

The concept of sentinel node (SN) is an important aspect of surgical oncology that has revolutionized the treatment of solid tumors. The concept of sentinel node mapping suggests that lymphatic basin involvement starts from the sentinel nodes, and if sentinel nodes are pathologically clear from tumor cells, the other lymph nodes of the basin are clear either.

In the current chapter, general aspects of sentinel node mapping have been discussed, including various mapping materials and radiopharmaceuticals; injection site, time, dose, and volume; imaging (lymphoscintigraphy); and gamma-probe-related issues.

Special considerations for sentinel node mapping in breast cancer, melanoma, and uterine cervix, endometrial, vulvar, penile, colorectal, and head and neck cancers were also discussed.

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Authors and Affiliations

  1. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Ramin Sadeghi & Leili Zarifmahmoudi

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  1. Ramin Sadeghi
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  2. Leili Zarifmahmoudi
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Correspondence to Ramin Sadeghi .

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Editors and Affiliations

  1. Department of Nuclear Medicine, Klinikum Westfalen - Knappschaftskrankenhaus Academic teaching hospital of the Ruhr University, Dortmund, Nordrhein-Westfalen, Germany

    Hojjat Ahmadzadehfar

  2. Department of Nuclear Medicine, Beta Klinik Bonn, Bonn, Germany

    Hans-Jürgen Biersack

  3. Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, Bronx, NY, USA

    Leonard M. Freeman

  4. Albert Einstein College of Medicine, Bronx, NY, USA

    Lionel S. Zuckier

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Sadeghi, R., Zarifmahmoudi, L. (2020). Application of Lymphatic Mapping and Sentinel Node Biopsy in Surgical Oncology. In: Ahmadzadehfar, H., Biersack, HJ., Freeman, L., Zuckier, L. (eds) Clinical Nuclear Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-39457-8_11

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  • DOI: https://doi.org/10.1007/978-3-030-39457-8_11

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  • Online ISBN: 978-3-030-39457-8

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