Skip to main content

Dietary Fiber and Hyperlipidemia and Cardiovascular Disease

  • Chapter
  • First Online:
Science and Technology of Fibers in Food Systems

Part of the book series: Food Engineering Series ((FSES))

Abstract

Cardiovascular disease (CVD) is the main cause of mortality in the world, different strategies have been sought to prevent or limit its consequences. Diet is an important factor in the treatment, particularly dietary fiber. Several clinical and epidemiological studies have shown that fiber consumption decreases the risk of developing CVD and coronary heart disease (CHD). There are some proposed mechanisms by which dietary fiber decreases the risk of CVD: modifying cholesterol metabolism through direct interaction with pancreatic lipase, its binding to bile acids, increased intraluminal viscosity and modulation of cholesterol by intestinal microbiota. In addition, dietary fiber can have beneficial effects on blood pressure, which generates an additional benefit to reduce CVD. In this chapter, emphasis is placed on the use of dietary patterns to reduce the risk of CVD, as well as the modulation of intestinal microbiota by the dietary fiber. Finally, recommendations are generated for the use of the dietary fiber and the management of CVD in accordance with international guidelines.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Agriculture USDA (2007) The food supply and dietary fiber: its availability and effect on health. Promotion CfNPa ed, Washington

    Google Scholar 

  • Agriculture USDA (2010) US Department of Health and Human Services. Dietary Guidelines for Americans. 7th edition. Washington.

    Google Scholar 

  • Anderson JW (2000) Dietary fiber prevents carbohydrate-induced hypertriglyceridemia. Curr Atheroscler Rep 2(6):536–541

    Article  CAS  PubMed  Google Scholar 

  • Anderson JW, Tietyen-Clark J (1986) Dietary fiber: hyperlipidemia, hypertension, and coronary heart disease. Am J Gastroenterol 81(10):907–919

    CAS  PubMed  Google Scholar 

  • Anderson TJ, Meredith IT, Yeung AC, Frei B, Selwyn AP, Ganz P (1995) The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion. N Engl J Med 332(8):488–493

    Article  CAS  PubMed  Google Scholar 

  • Anderson JW, Allgood LD, Lawrence A, Altringer LA, Jerdack GR, Hengehold DA, Morel JG (2000) Cholesterol-lowering effects of psyllium intake adjunctive to diet therapy in men and women with hypercholesterolemia: meta-analysis of 8 controlled trials. Am J Clin Nutr 71(2):472–479

    Article  CAS  PubMed  Google Scholar 

  • Appel LJ, Brands MW, Daniels SR, Karanja N, Elmer PJ, Sacks FM (2006) Dietary approaches to prevent and treat hypertension: a scientific statement from the American Heart Association. Hypertension 47:296–308

    Article  CAS  PubMed  Google Scholar 

  • Ardiansyah OY, Shirakawa H, Koseki T, Komai M (2008) Novel effects of a single administration of ferulic acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously hypertensive rats. J Agric Food Chem 56(8):2825–2830

    Article  CAS  PubMed  Google Scholar 

  • Aron-Wisnewsky J, Clement K (2016) The gut microbiome, diet, and links to cardiometabolic and chronic disorders. Nat Rev Nephrol 12:169–181

    Article  CAS  PubMed  Google Scholar 

  • Baer HJ, Glynn RJ, Hu FB, Hankinson SE, Willett WC, Colditz GA, Stampfer M, Rosner B (2011) Risk factors for mortality in the nurses’ health study: a competing risks analysis. Am J Epidemiol 173(3):319–329

    Article  PubMed  Google Scholar 

  • Batis C, Aburto TC, Sanchez-Pimienta TG, Pedraza LS, Rivera JA (2016) Adherence to dietary recommendations for food group intakes is low in the Mexican population. J Nutr 146(9):1897S–1906S

    Article  CAS  PubMed  Google Scholar 

  • Betters JL, Yu L (2010) NPC1L1 and cholesterol transport. FEBS lett 584(13):2740–2747

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bliss DZ, Savik K, Jung HJ, Whitebird R, Lowry A (2011) Symptoms associated with dietary fiber supplementation over time in individuals with fecal incontinence. Nurs Res 60(3):S58–S67

    Article  PubMed  PubMed Central  Google Scholar 

  • Blundell JE, Burley VJ (1987) Satiation, satiety and the action of fibre on food intake. Int J Obes 11(Suppl 1):9–25

    PubMed  Google Scholar 

  • Boeckner LS, Schnepf MI, Tungland BC (2001) Inulin: a review of nutritional and health implications. Adv Food Nutr Res 43:1–63

    Article  CAS  PubMed  Google Scholar 

  • Brown JM, Hazen SL (2015) The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases. Annu Rev Med 66:343–359

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brown L, Rosner B, Willett WW, Sacks FM (1999) Cholesterol-lowering effects of dietary fiber: a meta-analysis. Am J Clin Nutr 69(1):30–42

    Article  CAS  PubMed  Google Scholar 

  • Buil-Cosiales P, Zazpe I, Toledo E, Corella D, Salas-Salvado J, Diez-Espino J, Ros E, Fernandez-Creuet Navajas J, Santos-Lozano JM, Aros F, Fio M, Castañer O, Serra-Majem L, Pintó X, Lamuela-Raventós RM, Marti A, Bastera-Gortari FJ, Sorlí JV, Verdu-Rotella JM, Basora J, Ruiz-Gutierrez V, Estruch R, Martinez-González MA (2014) Fiber intake and all-cause mortality in the Prevencion con Dieta Mediterranea (PREDIMED) study. Am J Clin Nutr 100(6):1498–1507

    Article  CAS  PubMed  Google Scholar 

  • Chandalia M, Garg A, Lutjohann D, von Bergmann K, Grundy SM, Brinkley LJ (2000) Beneficial effects of high dietary fiber intake in patients with type 2 diabetes mellitus. N Engl J Med 342(19):1392–1398

    Article  CAS  PubMed  Google Scholar 

  • Chang TY, Li BL, Chang CC, Urano Y (2009) Acyl-coenzyme A: cholesterol acyltransferases. Am J Physiol Endocrinol Metab 297(1):E1–E9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen HP, Liao ZP, Huang QR, He M (2009) Sodium ferulate attenuates anoxia/reoxygenation-induced calcium overload in neonatal rat cardiomyocytes by NO/cGMP/PKG pathway. Eur J Pharmacol 603(1–3):86–92

    Article  CAS  PubMed  Google Scholar 

  • Cho SS, Qi L, Fahey GC Jr, Klurfeld DM (2013) Consumption of cereal fiber, mixtures of whole grains and bran, and whole grains and risk reduction in type 2 diabetes, obesity, and cardiovascular disease. Am J Clin Nutr 98(2):594–619

    Article  CAS  PubMed  Google Scholar 

  • Cicero AF, Fiorito A, Panourgia MP, Sangiorgi Z, Gaddi A (2002) Effects of a new soy/beta-sitosterol supplement on plasma lipids in moderately hypercholesterolemic subjects. J Am Diet Assoc 102(12):1807–1811

    Article  PubMed  Google Scholar 

  • Cicero AF, Minardi M, Mirembe S, Pedro E, Gaddi A (2004) Effects of a new low dose soy protein/beta-sitosterol association on plasma lipid levels and oxidation. Eur J Nutr 43(5):319–322

    Article  CAS  PubMed  Google Scholar 

  • Cooper AD (1997) Hepatic uptake of chylomicron remnants. J Lipid Res 38(11):2173–2192

    CAS  PubMed  Google Scholar 

  • Dahl WJ, Stewart ML (2015) Position of the academy of nutrition and dietetics: health implications of dietary fiber. J Acad Nutr Diet 115(11):1861–1870

    Article  PubMed  Google Scholar 

  • El Khoury D, Cuda C, Luhovyy BL, Anderson GH (2012) Beta glucan: health benefits in obesity and metabolic syndrome. J Nutr Metab 2012.: 851362:1–28

    Google Scholar 

  • Ferri C, Bellini C, Desideri G, Valenti M, De Mattia G, Santucci A, Hollenberg NK, Williams GH (1999) Relationship between insulin resistance and nonmodulating hypertension: linkage of metabolic abnormalities and cardiovascular risk. Diabetes 48(8):1623–1630

    Article  CAS  PubMed  Google Scholar 

  • Fiber evidence analysis project: Evidence analysis library website. http://www.andeal.org/topic.cfm?menu1/41586

  • Gutiérrez JP, Rivera-Dommarco J, Shamah-Levy T, Villalpando-Hernández S, Franco A, Cuevas-Nasu L, Romero-Martínez M, Hernández-Ávila M. Encuesta Nacional de Salud y Nutrición 2012 (National Health and Nutrition Survey (ENSANUT 2012). Resultados Nacionales. Cuernavaca, México: Instituto Nacional de Salud Pública (MX), 2012.er 2010

    Google Scholar 

  • Gylling H (2004) Cholesterol metabolism and its implications for therapeutic interventions in patients with hypercholesterolaemia. Int J Clin Pract 58(9):859–866

    Article  CAS  PubMed  Google Scholar 

  • Harland JI (2012) Food combinations for cholesterol lowering. Nutr Res Rev 25:249–266

    Article  CAS  PubMed  Google Scholar 

  • Hartley L, May MD, Loveman E, Colquitt JL, Rees K (2016) Dietary fibre for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 7(1):CD011472

    Google Scholar 

  • Havel RJ (1984) The formation of LDL: mechanisms and regulation. J Lipid Res 25(13):1570–1576

    CAS  PubMed  Google Scholar 

  • Ikeda I, Matsuoka R, Hamada T, Mitsui K, Imabayashi S, Uchino A, Sato M, Kuwano E, Itamura T, Yamada K, Tanaka K, Imaizumi K (2002) Cholesterol esterase accelerates intestinal cholesterol absorption. Biochim Biophys Acta 1571(1):34–44

    Article  CAS  PubMed  Google Scholar 

  • Institute of Medicine (2005) Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids. Food Nutrition Board. The National Academies Press, Washington DC

    Google Scholar 

  • Iqbal J, Hussain MM (2009) Intestinal lipid absorption. Am J Phys Endocrinol Metab 296(6):E1183–E1194

    Article  CAS  Google Scholar 

  • Jamil H, Dickson JK Jr, Chu CH, Lago MW, Rinehart JK, Biller SA, Gregg RE, Wetterau JR (1995) Microsomal triglyceride transfer protein. Specificity of lipid binding and transport. J Biol Chem 270(12):6549–6554

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Kendall CW, Axelsen M, Augustin LS, Vuksan V (2000) Viscous and nonviscous fibres, nonabsorbable and low glycaemic index carbohydrates, blood lipids and coronary heart disease. Curr Opin Lipidol 11(1):49–56

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Kendall CW, Faulkner D, Vidgen E, Trautwein EA, Parker TL, Marchie A, Koumbridis G, Lapsley KG, Josse RG, Leiter LA, Connelly PW (2002) A dietary portfolio approach to cholesterol reduction: combined effects of plant sterols, vegetable proteins, and viscous fibers in hypercholesterolemia. Metabolism 51(12):1596–1604

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Kendall CW, Marchie A, Faulkner D, Vidgen E, Lapsley KG, Trautwein EA, Parker TL, Josse RG, Leiter LA, Connelly PW (2003a) The effect of combining plant sterols, soy protein, viscous fibers, and almonds in treating hypercholesterolemia. Metabolism 52(11):1478–1483

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Kendall CW, Marchie A, Faulkner DA, Wong JM, de Souza R, Emam A, Parker TL, Vidgen E, Lapsley KG, Trautwein EA, Josse RG, Leiter LA, Connelly PW (2003b) Effects of a dietary portfolio of cholesterol-lowering foods vs lovastatin on serum lipids and C-reactive protein. J Am Med Assoc 290(4):502–510

    Article  CAS  Google Scholar 

  • Jenkins DJ, Kendall CW, Marchie A, Faulkner DA, Wong JM, de Souza R, Emam A, Parker TL, Vidgen E, Trautwein EA, Josse RG, Leiter LA, Singer W, Connelly PW (2005) Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants. Am J Clin Nutr 81(2):380–387

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Kendall CW, Faulkner DA, Nguyen T, Kemp T, Marchie A, Wong JM, de Souza R, Emam A, Vidgen E, Trautwein EA, Lapsley KG, Holmes C, Josse RG, Leiter LA, Connelly PW, Singer W (2006) Assessment of the longer-term effects of a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. Am J Clin Nutr 83(3):582–591

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Josse AR, Wong JM, Nguyen TH, Kendall CW (2007a) The portfolio diet for cardiovascular risk reduction. Curr Atheroscler Rep 9(6):501–507

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Kendall CW, Nguyen TH, Teitel J, Marchie A, Chiu M, Taha AY, Faulkner DA, Kemp T, Wong JM, de Souza R, Emam A, Trautwein EA, Lapsley EK, Holmes C, Josse RG, Leiter LA, Singer W (2007b) Effect on hematologic risk factors for coronary heart disease of a cholesterol reducing diet. Eur J Clin Nutr 61(4):483–492

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Kendall CW, Faulkner DA, Kemp T, Marchie A, Nguyen TH, Wong JM, de Souza R, Emam A, Vidgen E, Trautwein EA, Lapsley KG, Josse RG, Leiter LA, Singer W (2008a) Long-term effects of a plant-based dietary portfolio of cholesterol-lowering foods on blood pressure. Eur J Clin Nutr 62(6):781–788

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Kendall CW, Nguyen TH, Marchie A, Faulkner DA, Ireland C, Josse AR, Vidgen E, Trautwein EA, Lapsley KG, Holmes C, Josse RG, Leiter LA, Connelly PW, Singer W (2008b) Effect of plant sterols in combination with other cholesterol-lowering foods. Metabolism 57(1):130–139

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Nguyen TH, Kendall CW, Faulkner DA, Bashyam B, Kim IJ, Ireland C, Patel D, Vidgen E, Josse AR, Sesso HD, Burton-Freeman B, Josse RG, Leiter LA, Singer W (2008c) The effect of strawberries in a cholesterol-lowering dietary portfolio. Metabolism 57(12):1636–1644

    Article  CAS  PubMed  Google Scholar 

  • Jenkins DJ, Chiavaroli L, Wong JM, Kendall C, Lewis GF, Vidgen E, Connelly PW, Leiter LA, Josse RG, Lamarche B (2010) Adding monounsaturated fatty acids to a dietary portfolio of cholesterol-lowering foods in hypercholesterolemia. Can Med Assoc J 182(18):1961–1967

    Article  Google Scholar 

  • Jenkins DJ, Jones PJ, Lamarche B, Kendall CW, Faulkner D, Cermakova L, Gigleux I, Ramprasath V, de Souza R, Ireland C, Patel D, Srichalkul K, Abdulnour S, Bashyam B, Coller C, Hoshizaki S, Josse RG, Leiter LA, Cornnelly PW, Frohlich J (2011) Effect of a dietary portfolio of cholesterol-lowering foods given at 2 levels of intensity of dietary advice on serum lipids in hyperlipidemia: a randomized controlled trial. J Am Med Assoc 306(8):831–839

    Article  CAS  Google Scholar 

  • Jenkins DJ, Jones PJ, Frohlich J, Lamarche B, Ireland C, Nishi SK, Srichaikul K, Galange P, Pellini C, Faulkner D, de Souza RJ, Sievenpiper JL, Mirrahimi A, Jayalath VH, Augustin LS, Bashyam B, Leiter LA, Josse R, Couture P, Ramprasath V, Kendall CW (2015) The effect of a dietary portfolio compared to a DASH-type diet on blood pressure. Nutr Metab Cardiovasc Dis 25(2):1132–1139

    Article  CAS  PubMed  Google Scholar 

  • Katakam PV, Ujhelyi MR, Hoenig ME, Miller AW (1998) Endothelial dysfunction precedes hypertension in diet-induced insulin resistance. Am J Phys 275(3):R788–R792

    CAS  Google Scholar 

  • King DE, Mainous AG, Lambourne CA (2012) Trends in dietary fiber intake in the United States, 1999–2008. J Acad Nutr Diet 112(5):642–648

    Article  PubMed  Google Scholar 

  • Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL (2013) Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 19(5):576–585

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koh A, De Vadder F, Kovatcheva-Datchary P, Backhed F (2016) From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165(6):1332–1345

    Article  CAS  PubMed  Google Scholar 

  • Kris-Etherton PM, Hecker KD, Bonanome A, Coval SM, Binkoski AE, Hilpert KF, Griel AE, Etherton TD (2002) Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med 113(9):71S–88S

    Article  CAS  PubMed  Google Scholar 

  • Kumar M, Nagpal R, Kumarm R, Hemalatha R, Verma V, Kumar A, Chakraborty C, Singh B, Marotta F, Jain S, Yadav H (2012) Cholesterol-lowering probiotics as potential biotherapeutics for metabolic diseases. Exp Diabetes Res 2012.: 902917:1–14

    Article  CAS  Google Scholar 

  • Lairon D (1996) Dietary fibres: effects on lipid metabolism and mechanisms of action. Eur J Clin Nutr 50(3):125–133

    CAS  PubMed  Google Scholar 

  • Leinonen KS, Poutanen KS, Mykkanen HM (2000) Rye bread decreases serum total and LDL cholesterol in men with moderately elevated serum cholesterol. J Nutr 130(2):164–170

    Article  CAS  PubMed  Google Scholar 

  • Liu S, Willett WC, Stampfer MJ, Hu FB, Franz M, Sampson L, Hennekens CH, Manson JE (2000) A prospective study of dietary glycemic load, carbohydrate intake, and risk of coronary heart disease in US women. Am J Clin Nutr 71(6):1455–1461

    Article  CAS  PubMed  Google Scholar 

  • Lopez-Olmedo N, Carriquiry AL, Rodriguez-Ramirez S, Ramirez-Silva I, Espinosa-Montero J, Hernandez-Barrera L, Campirano F, Martinez-Tapia B, Rivera JA (2016) Usual intake of added sugars and saturated fats is high while dietary fiber is low in the Mexican population. J Nutr 146(9):1856S–1865S

    Article  CAS  PubMed  Google Scholar 

  • Lunn J, Buttriss JL (2007) Carbohydrates and dietary fibre. Nutr Bull 32(1):21–64

    Article  Google Scholar 

  • Ma ZC, Hong Q, Wang YG, Tan HL, Xiao CR, Liang QD, Cai SH, Gao Y (2010) Ferulic acid attenuates adhesion molecule expression in gamma-radiated human umbilical vascular endothelial cells. Biol Pharm Bull 33(5):752–758

    Article  PubMed  Google Scholar 

  • Mendis S, Puska P, Norrving B (2011) Global atlas on cardiovascular disease prevention and control. World Health Organization, World Heart Federation, World Stroke Organization, Geneva, pp 1–164

    Google Scholar 

  • Morgan AE, Mooney KM, Wilkinson SJ, Pickles NA, Mc Auley MT (2016) Cholesterol metabolism: a review of how ageing disrupts the biological mechanisms responsible for its regulation. Ageing Res Rev 27:108–124

    Article  CAS  PubMed  Google Scholar 

  • Mozaffarian D (2016) Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review. Circulation 133(2):187–225

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jiménez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB, American Heart Association Statistics Committee; Stroke Statistics Subcommittee (2016) Executive summary: heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation 133:447–454

    Article  PubMed  Google Scholar 

  • National Institute of Health (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP): expert panel on detection, evaluation and treatment of high blood cholesterol in adults (adult treatment panel III). J Am Med Assoc 285:2486–2497

    Article  Google Scholar 

  • Neter JE, Stam BE, Kok FJ, Grobbee DE, Geleijnse JM (2003) Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension 42(5):878–884

    Article  CAS  PubMed  Google Scholar 

  • Ning H, Van Horn L, Shay CM, Lloyd-Jones DM (2014) Associations of dietary fiber intake with long-term predicted cardiovascular disease risk and C-reactive protein levels (from the National Health and Nutrition Examination Survey Data [2005–2010]). Am J Cardiol 113(2):287–291

    Article  CAS  PubMed  Google Scholar 

  • Olafiranye O, Zizi F, Brimah P, Jean-louis G, Makaryus AN, McFarlane S, Ogedegbe G (2011) Management of hypertension among patients with coronary heart disease. Int J Hypertens 2011.: 653903:1–6

    Article  Google Scholar 

  • Oner O, Aslim B, Aydas SB (2014) Mechanisms of cholesterol-lowering effects of lactobacilli and bifidobacteria strains as potential probiotics with their bsh gene analysis. J Mol Microbiol Biotechnol 24(1):12–18

    Article  PubMed  CAS  Google Scholar 

  • Otsuka F, Yasuda S, Noguchi T, Ishibashi-Ueda H (2016) Pathology of coronary atherosclerosis and thrombosis. Cardiovasc Diagn Ther 6(4):396–408

    Article  PubMed  PubMed Central  Google Scholar 

  • Park Y, Subar AF, Hollenbeck A, Schatzkin A (2011) Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med 171(12):1061–1068

    Article  PubMed  PubMed Central  Google Scholar 

  • Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ (2002) Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem 277(21):18793–18800

    Article  CAS  PubMed  Google Scholar 

  • Rissanen TH, Voutilainen S, Virtanen JK, Venho B, Vanharanta M, Mursu J, Salonen JT (2003) Low intake of fruits, berries and vegetables is associated with excess mortality in men: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study. J Nutr 133(1):199–204

    Article  CAS  PubMed  Google Scholar 

  • Rosiek A, Leksowski K (2016) The risk factors and prevention of cardiovascular disease: the importance of electrocardiogram in the diagnosis and treatment of acute coronary syndrome. Ther Clin Risk Manag 12:1223–1229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sanchez-Muniz FJ (2012) Dietary fibre and cardiovascular health. Nutr Hosp 27(1):31–45

    CAS  PubMed  Google Scholar 

  • Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A (2016) Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med 4(13):256

    Article  PubMed  PubMed Central  Google Scholar 

  • Savica V, Bellinghieri G, Kopple JD (2010) The effect of nutrition on blood pressure. Annu Rev Nutr 30:365–401

    Article  CAS  PubMed  Google Scholar 

  • Shih DM, Wang Z, Lee R, Meng Y, Che N, Charugundla S, Qi H, Wu J, Pan C, Brown JM, Vallim T, Bennett BJ, Graham M, Hazen SL, Lusis AJ (2015) Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res 56(1):22–37

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shrestha S, Volek JS, Udani J, Wood RJ, Greene CM, Aggarwal D, Contois JH, Kavoussi B, Fernandez ML (2006) A combination therapy including psyllium and plant sterols lowers LDL cholesterol by modifying lipoprotein metabolism in hypercholesterolemic individuals. J Nutr 136(10):2492–2497

    Article  CAS  PubMed  Google Scholar 

  • Soroka CJ, Boyer JL (2014) Biosynthesis and trafficking of the bile salt export pump, BSEP: therapeutic implications of BSEP mutations. Mol Asp Med 37:3–14

    Article  CAS  Google Scholar 

  • Srimahachota S, Wunsuwan R, Siritantikorn A, Boonla C, Chaiwongkarjohn S, Tosukhowong P (2010) Effects of lifestyle modification on oxidized LDL, reactive oxygen species production and endothelial cell viability in patients with coronary artery disease. Clin Biochem 43(10–11):858–862

    Article  CAS  PubMed  Google Scholar 

  • Streppel MT, Arends LR, van ‘t Veer P, Grobbee DE, Geleijnse JM (2005) Dietary fiber and blood pressure: a meta-analysis of randomized placebo-controlled trials. Arch Intern Med 165(2):150–156

    Article  PubMed  Google Scholar 

  • Streppel MT, Ocke MC, Boshuizen HC, Kok FJ, Kromhout D (2008) Dietary fiber intake in relation to coronary heart disease and all-cause mortality over 40 y: the Zutphen study. Am J Clin Nutr 88(4):1119–1125

    Article  CAS  PubMed  Google Scholar 

  • Suzuki A, Yamamoto M, Jokura H, Fujii A, Tokimitsu I, Hase T, Saito I (2007) Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats. Am J Hypertens 20(5):508–513

    Article  CAS  PubMed  Google Scholar 

  • Tancharoenrat P, Ravindran V, Zaefarian F, Ravindran G (2014) Digestion of fat and fatty acids along the gastrointestinal tract of broiler chickens. Poult Sci 93(2):371–379

    Article  CAS  PubMed  Google Scholar 

  • Tang WH, Hazen SL (2014) The contributory role of gut microbiota in cardiovascular disease. J Clin Invest 124(10):4204–4211

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tang WH, Wang Z, Kennedy DJ, Wu Y, Buffa JA, Agatisa-Boyle B, Li XS, Levison BS, Hazen SL (2015) Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res 116(3):448–455

    Article  CAS  PubMed  Google Scholar 

  • Thebaudin JY, Harrington M, Bourgeois CM (1997) Dietary fibres: nutritional and technological interest. Trends Food Sci Technol 8:41–48

    Article  CAS  Google Scholar 

  • Theuwissen E, Mensink RP (2007) Simultaneous intake of beta-glucan and plant stanol esters affects lipid metabolism in slightly hypercholesterolemic subjects. J Nutr 137(3):583–588

    Article  CAS  PubMed  Google Scholar 

  • Theuwissen E, Mensink RP (2008) Water-soluble dietary fibers and cardiovascular disease. Physiol Behav 94(2):285–292

    Article  CAS  PubMed  Google Scholar 

  • Threapleton DE, Greenwood DC, Evans CE, Cleghorn CL, Nykjaer C, Woodhead C, Cade JE, Gale CP, Burley VJ (2013) Dietary fibre intake and risk of cardiovascular disease: systematic review and meta-analysis. Br Med J 347(6879):1–12

    Google Scholar 

  • Torres N, Guevara-Cruz M, Velazquez-Villegas LA, Tovar AR (2015) Nutrition and atherosclerosis. Arch Med Res 46(5):408–426

    Article  CAS  PubMed  Google Scholar 

  • Trinidad TP, Mallillin AC, Valdez DH, Loyola AS, Askali-Mercado FC, Castillo JC, Encabo RR, Masa DB, Maglaya AS, Chua MT (2006) Dietary Fiber from coconut flour: a functional food. Innov Food Sci Emerg Technol 7:309–317

    Article  CAS  Google Scholar 

  • Trowell H (1972) Ischemic heart disease and dietary fiber. Am J Clin Nutr 25(9):926–932

    Article  CAS  PubMed  Google Scholar 

  • Truswell AS (2002) Cereal grains and coronary heart disease. Eur J Clin Nutr 56(1):1–14

    Article  CAS  PubMed  Google Scholar 

  • Usual Dietary Intakes (2007) Food Intakes, US Population, 2007–10. Applied Research Program. Web site http://appliedresearch.cancer.gov/diet/usualintakes/pop/2007–10

  • Van Horn L, McCoin M, Kris-Etherton PM, Burke F, Carson JA, Champagne CM, Karmally W, Sikand G (2008) The evidence for dietary prevention and treatment of cardiovascular disease. J Am Diet Assoc 108(2):287–331

    Article  PubMed  CAS  Google Scholar 

  • Veniant MM, Zlot CH, Walzem RL, Pierotti V, Driscoll R, Dichek D, Herz J, Young SG (1998) Lipoprotein clearance mechanisms in LDL receptor-deficient “Apo-B48-only” and “Apo-B100-only” mice. J Clin Investig 102(8):1559–1568

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Viuda-Martos M, Fernandez-Lopez MC, Fernandez-Lopez J, Lopez-Vargas JH, Perez-Alvarez JA (2010) Role of fiber in cardiovascular diseases: a review. Compr Rev Food Sci Food Saf 9(2):240–258

    Article  CAS  Google Scholar 

  • Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM (2011) Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472(7341):57–63

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Warrier M, Shih DM, Burrows AC, Ferguson D, Gromovsky AD, Brown AL, Marshall S, McDaniel A, Schugar RC, Wang Z, Sacks J, Rong X, Vallim TA, Chou J, Ivanova PT, Myers DS, Brown HA, Lee RG, Crooke RM, Graham MJ, Liu X, Parini P, Tontonoz P, Lusis AJ, Hazen SL, Temel RE, Brown JM (2015) The TMAO-generating enzyme flavin monooxygenase 3 is a central regulator of cholesterol balance. Cell Rep 14:S2211–S1247

    Google Scholar 

  • Wong JM, de Souza R, Kendall CW, Emam A, Jenkins DJ (2006) Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 40(3):235–243

    Article  CAS  PubMed  Google Scholar 

  • Wu Y, Qian Y, Pan Y, Li P, Yang J, Ye X, Xu G (2015) Association between dietary fiber intake and risk of coronary heart disease: a meta-analysis. Clin Nutr 34(4):603–611

    Article  PubMed  Google Scholar 

  • Zhang JX, Hallmans G, Andersson H, Bosaeus I, Aman P, Tidehag P, Stenling R, Lundin E, Dhlgren S (1992) Effect of oat bran on plasma cholesterol and bile acid excretion in nine subjects with ileostomies. Am J Clin Nutr 56(1):99–105

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Tovar, A.R., Guevara-Cruz, M., Serralde Zúñiga, A.E., Torres, N. (2020). Dietary Fiber and Hyperlipidemia and Cardiovascular Disease. In: Welti-Chanes, J., Serna-Saldívar, S., Campanella, O., Tejada-Ortigoza, V. (eds) Science and Technology of Fibers in Food Systems. Food Engineering Series. Springer, Cham. https://doi.org/10.1007/978-3-030-38654-2_10

Download citation

Publish with us

Policies and ethics