Abstract
Infantile hypertrophic pyloric stenosis (IHPS) is a developmental condition that typically manifests from 2–12 weeks of age, with the average infant presenting at 5 weeks [1, 2]. In these patients, gastric outlet obstruction is caused by abnormal muscular and mucosal thickening at the antro-pyloric junction of the stomach. Secondary to this obstruction, affected infants develop persistent, non-bilious, projectile vomiting that results in dehydration, weight loss, and electrolyte imbalances.
References
Vinycomb TI, Laslett K, Gwini SM, Teague W, Nataraja RM. Presentation and outcomes in hypertrophic pyloric stenosis: an 11-year review. J Paediatr Child Health. 2019;55(10):1183–7.
Chalya PL, Manyama M, Kayange NM, Mabula JB, Massenga A. Infantile hypertrophic pyloric stenosis at a tertiary care hospital in Tanzania: a surgical experience with 102 patients over a 5-year period. BMC Res Notes. 2015;8:690.
Acker SN, Garcia AJ, Ross JT, Somme S. Current trends in the diagnosis and treatment of pyloric stenosis. Pediatr Surg Int. 2015;31(4):363–6.
Hulka F, Campbell TJ, Campbell JR, Harrison MW. Evolution in the recognition of infantile hypertrophic pyloric stenosis. Pediatrics. 1997;100(2):E9.
Feliz A, Holub JL, Azarakhsh N, Bachier-Rodriguez M, Savoie KB. Health disparities in infants with hypertrophic pyloric stenosis. Am J Surg. 2017;214(2):329–35.
Panteli C. New insights into the pathogenesis of infantile pyloric stenosis. Pediatr Surg Int. 2009;25(12):1043–52.
Kobayashi H, Wester T, Puri P. Age-related changes in innervation in hypertrophic pyloric stenosis. J Pediatr Surg. 1997;32(12):1704–7.
Langer JC, Berezin I, Daniel EE. Hypertrophic pyloric stenosis: ultrastructural abnormalities of enteric nerves and the interstitial cells of Cajal. J Pediatr Surg. 1995;30(11):1535–43.
Okazaki T, Yamataka A, Fujiwara T, Nishiye H, Fujimoto T, Miyano T. Abnormal distribution of nerve terminals in infantile hypertrophic pyloric stenosis. J Pediatr Surg. 1994;29(5):655–8.
Ohshiro K, Puri P. Pathogenesis of infantile hypertrophic pyloric stenosis: recent progress. Pediatr Surg Int. 1998;13(4):243–52.
Kusafuka T, Puri P. Altered messenger RNA expression of the neuronal nitric oxide synthase gene in infantile hypertrophic pyloric stenosis. Pediatr Surg Int. 1997;12(8):576–9.
Safford SD, Pietrobon R, Safford KM, Martins H, Skinner MA, Rice HE. A study of 11,003 patients with hypertrophic pyloric stenosis and the association between surgeon and hospital volume and outcomes. J Pediatr Surg. 2005;40(6):967–72; discussion 72–3.
Donda K, Asare-Afriyie B, Ayensu M, Sharma M, Amponsah JK, Bhatt P, et al. Pyloric stenosis: National trends in the incidence rate and resource use in the United States from 2012 to 2016. Hosp Pediatr. 2019;9(12):923–32.
de Laffolie J, Turial S, Heckmann M, Zimmer KP, Schier F. Decline in infantile hypertrophic pyloric stenosis in Germany in 2000–2008. Pediatrics. 2012;129(4):e901–6.
Svenningsson A, Svensson T, Akre O, Nordenskjold A. Maternal and pregnancy characteristics and risk of infantile hypertrophic pyloric stenosis. J Pediatr Surg. 2014;49(8):1226–31.
Aboagye J, Goldstein SD, Salazar JH, Papandria D, Okoye MT, Al-Omar K, et al. Age at presentation of common pediatric surgical conditions: Reexamining dogma. J Pediatr Surg. 2014;49(6):995–9.
Peeters B, Benninga MA, Hennekam RC. Infantile hypertrophic pyloric stenosis--genetics and syndromes. Nat Rev Gastroenterol Hepatol. 2012;9(11):646–60.
Feenstra B, Gortz S, Lund M, Ranthe MF, Geller F, Melbye M. Co-occurrence of infantile hypertrophic pyloric stenosis and congenital heart defects: a nationwide cohort study. Pediatr Res. 2019;85(7):955–60.
Almaramhy HH, Al-Zalabani AH. The association of prenatal and postnatal macrolide exposure with subsequent development of infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis. Ital J Pediatr. 2019;45(1):20.
Mowrer AR, Esparaz JR, Hwang EH, Chakraborty SR, Nierstedt RT, Wolfe DJ, et al. Low socioeconomic status and formula feeding directly correlate with increased incidence of hypertrophic pyloric stenosis. J Pediatr Surg. 2019;54(12):2498–502.
Wayne C, Hung JH, Chan E, Sedgwick I, Bass J, Nasr A. Formula-feeding and hypertrophic pyloric stenosis: is there an association? A case-control study. J Pediatr Surg. 2016;51(5):779–82.
Tom CM, Niino C, Lee AD, Friedlander S, Sakai-Bizmark R, Lee SL. Effects of hospital volume on patient outcomes and costs in infants with pyloric stenosis. J Surg Res. 2019;233:65–73.
Massoumi RL, Sakai-Bizmark R, Tom CM, Howell E, Childers CP, Jen HC, et al. Differences in outcomes based on sex for pediatric patients undergoing pyloromyotomy. J Surg Res. 2020;245:207–11.
White MC, Langer JC, Don S, DeBaun MR. Sensitivity and cost minimization analysis of radiology versus olive palpation for the diagnosis of hypertrophic pyloric stenosis. J Pediatr Surg. 1998;33(6):913–7.
Glatstein M, Carbell G, Boddu SK, Bernardini A, Scolnik D. The changing clinical presentation of hypertrophic pyloric stenosis: the experience of a large, tertiary care pediatric hospital. Clin Pediatr (Phila). 2011;50(3):192–5.
Taylor ND, Cass DT, Holland AJ. Infantile hypertrophic pyloric stenosis: has anything changed? J Paediatr Child Health. 2013;49(1):33–7.
Alvarez SM, Poelstra BA, Burd RS. Evaluation of a Bayesian decision network for diagnosing pyloric stenosis. J Pediatr Surg. 2006;41(1):155–61; discussion −61.
Bensard DD, Hendrickson RJ, Clark KS, Giesting KJ, Kokoska ER. Use of ultrasound measurements to direct laparoscopic pyloromyotomy in infants. JSLS. 2010;14(4):553–7.
Hukeri A, Gupta A, Kothari P, Dikshit V, Kekre G, Patil P, et al. Our experience of laparoscopic pyloromyotomy with ultrasound-guided parameters. J Minim Access Surg. 2019;15(1):51–5.
Jobson M, Hall NJ. Contemporary management of pyloric stenosis. Semin Pediatr Surg. 2016;25(4):219–24.
Hall NJ, Eaton S, Seims A, Leys CM, Densmore JC, Calkins CM, et al. Risk of incomplete pyloromyotomy and mucosal perforation in open and laparoscopic pyloromyotomy. J Pediatr Surg. 2014;49(7):1083–6.
Kethman WC, Harris AHS, Hawn MT, Wall JK. Trends and surgical outcomes of laparoscopic versus open pyloromyotomy. Surg Endosc. 2018;32(7):3380–5.
Mercer AE, Phillips R. Question 2: can a conservative approach to the treatment of hypertrophic pyloric stenosis with atropine be considered a real alternative to surgical pyloromyotomy? Arch Dis Child. 2013;98(6):474–7.
Wu SF, Lin HY, Huang FK, Chen AC, Su BH, Li CI, et al. Efficacy of medical treatment for infantile hypertrophic pyloric stenosis: a meta-analysis. Pediatr Neonatol. 2016;57(6):515–21.
Teele RL, Smith EH. Ultrasound in the diagnosis of idiopathic hypertrophic pyloric stenosis. N Engl J Med. 1977;296(20):1149–50.
Stunden RJ, LeQuesne GW, Little KE. The improved ultrasound diagnosis of hypertrophic pyloric stenosis. Pediatr Radiol. 1986;16(3):200–5.
Blumhagen JD, Maclin L, Krauter D, Rosenbaum DM, Weinberger E. Sonographic diagnosis of hypertrophic pyloric stenosis. AJR Am J Roentgenol. 1988;150(6):1367–70.
O’Keeffe FN, Stansberry SD, Swischuk LE, Hayden CK Jr. Antropyloric muscle thickness at US in infants: what is normal? Radiology. 1991;178(3):827–30.
Hernanz-Schulman M, Sells LL, Ambrosino MM, Heller RM, Stein SM, Neblett WW 3rd. Hypertrophic pyloric stenosis in the infant without a palpable olive: accuracy of sonographic diagnosis. Radiology. 1994;193(3):771–6.
Calle-Toro JS, Kaplan SL, Andronikou S. Are we performing ultrasound measurements of the wall thickness in hypertrophic pyloric stenosis studies the same way? Pediatr Surg Int. 2020;36(3):399–405.
Iqbal CW, Rivard DC, Mortellaro VE, Sharp SW, St Peter SD. Evaluation of ultrasonographic parameters in the diagnosis of pyloric stenosis relative to patient age and size. J Pediatr Surg. 2012;47(8):1542–7.
Cohen HL, Chism PB, Radtke I. Excessive bright echoes sign for hypertrophic pyloric stenosis suggest the diagnosis: gastric pneumatosis and portal venous gas in infants suggest HPS. J Ultrasound Med. 2017;36(5):1059–63.
Daniel S, Francis D, Tobin M, Chawla A. Case of hepatic portal venous gas in an infant with hypertrophic pyloric stenosis. BMJ Case Rep. 2018;2018:bcr2018224794.
Kelly MM, Cantu C, Richer EJ, Braithwaite KA, Linam LE, Riedesel EL, et al. Incidence and importance of portal venous gas in children with hypertrophic pyloric stenosis. Pediatr Radiol. 2020;50(8):1102–6.
Sivitz AB, Tejani C, Cohen SG. Evaluation of hypertrophic pyloric stenosis by pediatric emergency physician sonography. Acad Emerg Med. 2013;20(7):646–51.
Wyrick DL, Smith SD, Dassinger MS. Surgeon as educator: bedside ultrasound in hypertrophic pyloric stenosis. J Surg Educ. 2014;71(6):896–8.
Copeland DR, Cosper GH, McMahon LE, Boneti C, Little DC, Dassinger MS, et al. Return of the surgeon in the diagnosis of pyloric stenosis. J Pediatr Surg. 2009;44(6):1189–92; discussion 92.
Rollins MD, Shields MD, Quinn RJ, Wooldridge MA. Pyloric stenosis: congenital or acquired? Arch Dis Child. 1989;64(1):138–9.
Keckler SJ, Ostlie DJ, Holcomb Iii GW, St Peter SD. The progressive development of pyloric stenosis: a role for repeat ultrasound. Eur J Pediatr Surg. 2008;18(3):168–70.
Sauerbrei EE, Paloschi GG. The ultrasonic features of hypertrophic pyloric stenosis, with emphasis on the postoperative appearance. Radiology. 1983;147(2):503–6.
Okorie NM, Dickson JA, Carver RA, Steiner GM. What happens to the pylorus after pyloromyotomy? Arch Dis Child. 1988;63(11):1339–41.
Yoshizawa J, Eto T, Higashimoto Y, Saitou T, Maie M. Ultrasonographic features of normalization of the pylorus after pyloromyotomy for hypertrophic pyloric stenosis. J Pediatr Surg. 2001;36(4):582–6.
Binet A, Klipfel C, Meignan P, Bastard F, Cook AR, Braik K, et al. Laparoscopic pyloromyotomy for hypertrophic pyloric stenosis: a survey of 407 children. Pediatr Surg Int. 2018;34(4):421–6.
Waldron LS, St Peter SD, Muensterer OJ. Management and outcome of mucosal injury during pyloromyotomy--an analytical survey study. J Laparoendosc Adv Surg Tech A. 2015;25(12):1044–6.
Hendricks CM, Edgerton CA, Lesher AP. Recurrent pyloric stenosis. Am Surg. 2018;84(9):e354–e6.
Al-Ansari A, Altokhais TI. Recurrent pyloric stenosis. Pediatr Int. 2016;58(7):619–21.
Hiller DJ, Petty JK, Sieren LM. Recurrent pyloric stenosis: a rare entity. Am Surg. 2015;81(9):e330–1.
Granstrom A, Felder S, Frykman P. Laparoscopic repyloromyotomy following open pyloromyotomy for recurrent pyloric stenosis: a case report and review of the literature. Eur J Pediatr Surg. 2013;23(6):499–501.
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Hryhorczuk, A., Hamman, S.M. (2022). Imaging of Infantile Hypertrophic Pyloric Stenosis. In: Otero, H.J., Kaplan, S.L., Medina, L.S., Blackmore, C.C., Applegate, K.E. (eds) Evidence-Based Imaging in Pediatrics. Evidence-Based Imaging. Springer, Cham. https://doi.org/10.1007/978-3-030-38095-3_104-1
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