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CCL3 Signaling in the Tumor Microenvironment

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Tumor Microenvironment

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1231))

Abstract

Within the tumor microenvironment, chemokines play a key role in immune cell trafficking regulation and immune landscape formulation. CCL3 or macrophage inflammatory protein-1α (MIP-1α), an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies. CCL3 exerts both antitumor and pro-tumor behavior which is context dependent highlighting the complexity of the underlying interrelated signaling cascades. Current CCL3-directed therapeutic approaches are investigational and further optimization is required to increase efficacy and minimize adverse events.

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Authors and Affiliations

  1. Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece

    Ioannis Ntanasis-Stathopoulos, Despoina Fotiou & Evangelos Terpos

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  1. Ioannis Ntanasis-Stathopoulos
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  2. Despoina Fotiou
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  3. Evangelos Terpos
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Correspondence to Evangelos Terpos .

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  1. Department of Radiology, Columbia University Medical Center, New York, NY, USA

    Alexander Birbrair

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Ntanasis-Stathopoulos, I., Fotiou, D., Terpos, E. (2020). CCL3 Signaling in the Tumor Microenvironment. In: Birbrair, A. (eds) Tumor Microenvironment. Advances in Experimental Medicine and Biology, vol 1231. Springer, Cham. https://doi.org/10.1007/978-3-030-36667-4_2

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