Skip to main content
SpringerLink
Log in

Haploidentical Transplantation: Challenges and Solutions

  • Reference work entry
  • First Online:
Contemporary Bone Marrow Transplantation

Part of the book series: Organ and Tissue Transplantation ((OTT))

  • 492 Accesses

Abstract

In the last few years, haploidentical family donor (HFD) has emerged as a front-runner for alternate donor hematopoietic cell transplantation (HCT) in hematological malignancies. The primary reason for this has been the emergence of posttransplantation cyclophosphamide as graft-versus-host disease (GVHD) prophylaxis, which by dint of both, its ease of application and impressive outcomes, has made HFD-HCT feasible across the globe. Studies have confirmed the equivalence of HFD as compared to matched related and unrelated donor HCT in acute leukemia as well lymphomas, with low incidence of both acute and chronic GVHD. However, the risk of relapse has remained unchanged across the donor sources depending on the nature of the underlying malignancy. The different approaches to HFD-HCT have yielded similar overall survival with increase or decrease in relapse and non-relapse mortality balancing each other out, depending on the conditioning, graft manipulation, and GVHD prophylaxis. Adoptive immunotherapy following haploidentical HCT is an exciting and expanding area in HCT, with the emergence of several approaches involving natural killer cells. The application of HFD-HCT in hemoglobinopathies and other nonmalignant diseases, on the other hand, remains challenging. A better understanding of the dynamics of immune subsets in the graft among the antigen-presenting milieu in the host might enable successful tolerance induction in nonmalignant diseases, and even a dissection of a graft-versus-host and a graft-versus-leukemia effect with better precision.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Similar content being viewed by others

References

  • Abboud R, Keller J, Slade M, DiPersio JF, Westervelt P, Rettig MP, Meier S, Fehniger TA, Abboud CN, Uy GL, Vij R, Trinkaus KM, Schroeder MA, Romee R (2016) Severe cytokine-release syndrome after T cell-replete peripheral blood haploidentical donor transplantation is associated with poor survival and anti-IL-6 therapy is safe and well tolerated. Biol Blood Marrow Transplant 22(10):1851–1860. https://doi.org/10.1016/j.bbmt.2016.06.010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arcese W, Picardi A, Santarone S, De Angelis G, Cerretti R, Cudillo L, Pennese E, Bavaro P, Olioso P, Dentamaro T, Cupelli L, Chierichini A, Ferrari A, Mengarelli A, Tirindelli MC, Testi M, Di Piazza F, Di Bartolomeo P, Rome Transplant N (2015) Haploidentical, G-CSF-primed, unmanipulated bone marrow transplantation for patients with high-risk hematological malignancies: an update. Bone Marrow Transplant 50(Suppl 2):S24–S30. https://doi.org/10.1038/bmt.2015.91

    Article  CAS  PubMed  Google Scholar 

  • Arcuri LJ, Aguiar MTM, Ribeiro AAF, Pacheco AGF (2019) Haploidentical transplantation with post-transplant cyclophosphamide versus unrelated donor hematopoietic stem cell transplantation: a systematic review and meta-analysis. Biol Blood Marrow Transplant. https://doi.org/10.1016/j.bbmt.2019.07.028

  • Aversa F (2015) T-cell depletion: from positive selection to negative depletion in adult patients. Bone Marrow Transplant 50(Suppl 2):S11–S13. https://doi.org/10.1038/bmt.2015.88

    Article  PubMed  Google Scholar 

  • Aversa F, Tabilio A, Velardi A, Cunningham I, Terenzi A, Falzetti F, Ruggeri L, Barbabietola G, Aristei C, Latini P, Reisner Y, Martelli MF (1998) Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 339(17):1186–1193. https://doi.org/10.1056/NEJM199810223391702

    Article  CAS  PubMed  Google Scholar 

  • Bachar-Lustig E, Rachamim N, Li HW, Lan F, Reisner Y (1995) Megadose of T cell-depleted bone marrow overcomes MHC barriers in sublethally irradiated mice. Nat Med 1(12):1268–1273. https://doi.org/10.1038/nm1295-1268

    Article  CAS  PubMed  Google Scholar 

  • Bashey A, Zhang MJ, McCurdy SR, St Martin A, Argall T, Anasetti C, Ciurea SO, Fasan O, Gaballa S, Hamadani M, Munshi P, Al Malki MM, Nakamura R, O’Donnell PV, Perales MA, Raj K, Romee R, Rowley S, Rocha V, Salit RB, Solh M, Soiffer RJ, Fuchs EJ, Eapen M (2017) Mobilized peripheral blood stem cells versus unstimulated bone marrow as a graft source for T-cell-replete haploidentical donor transplantation using post-transplant cyclophosphamide. J Clin Oncol 35(26):3002–3009. https://doi.org/10.1200/JCO.2017.72.8428

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Berenbaum MC, Brown IN (1963) Prolongation of homograft survival in mice with single doses of cyclophosphamide. Nature 200:84. https://doi.org/10.1038/200084a0

    Article  CAS  PubMed  Google Scholar 

  • Bernaudin F, Socie G, Kuentz M, Chevret S, Duval M, Bertrand Y, Vannier JP, Yakouben K, Thuret I, Bordigoni P, Fischer A, Lutz P, Stephan JL, Dhedin N, Plouvier E, Margueritte G, Bories D, Verlhac S, Esperou H, Coic L, Vernant JP, Gluckman E, Sfgm TC (2007) Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease. Blood 110(7):2749–2756. https://doi.org/10.1182/blood-2007-03-079665

    Article  CAS  PubMed  Google Scholar 

  • Bertaina A, Merli P, Rutella S, Pagliara D, Bernardo ME, Masetti R, Pende D, Falco M, Handgretinger R, Moretta F, Lucarelli B, Brescia LP, Li PG, Testi M, Cancrini C, Kabbara N, Carsetti R, Finocchi A, Moretta A, Moretta L, Locatelli F (2014) HLA-haploidentical stem cell transplantation after removal of alphabeta+ T and B cells in children with nonmalignant disorders. Blood 124(5):822–826. https://doi.org/10.1182/blood-2014-03-563817

    Article  CAS  PubMed  Google Scholar 

  • Bertaina A, Zecca M, Buldini B, Sacchi N, Algeri M, Saglio F, Perotti C, Gallina AM, Bertaina V, Lanino E, Prete A, Barberi W, Tumino M, Favre C, Cesaro S, Del Bufalo F, Ripaldi M, Boghen S, Casazza G, Rabusin M, Balduzzi A, Fagioli F, Pagliara D, Locatelli F (2018) Unrelated donor vs HLA-haploidentical alpha/beta T-cell- and B-cell-depleted HSCT in children with acute leukemia. Blood 132(24):2594–2607. https://doi.org/10.1182/blood-2018-07-861575

    Article  CAS  PubMed  Google Scholar 

  • Biassoni R, Cantoni C, Pende D, Sivori S, Parolini S, Vitale M, Bottino C, Moretta A (2001) Human natural killer cell receptors and co-receptors. Immunol Rev 181:203–214

    Article  CAS  PubMed  Google Scholar 

  • Billingham RE, Brent L, Medawar PB (1953) Actively acquired tolerance of foreign cells. Nature 172(4379):603–606. https://doi.org/10.1038/172603a0

    Article  CAS  PubMed  Google Scholar 

  • Bolanos-Meade J, Fuchs EJ, Luznik L, Lanzkron SM, Gamper CJ, Jones RJ, Brodsky RA (2012) HLA-haploidentical bone marrow transplantation with posttransplant cyclophosphamide expands the donor pool for patients with sickle cell disease. Blood 120(22):4285–4291. https://doi.org/10.1182/blood-2012-07-438408

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bolanos-Meade J, Cooke KR, Gamper CJ, Ali SA, Ambinder RF, Borrello IM, Fuchs EJ, Gladstone DE, Gocke CB, Huff CA, Luznik L, Swinnen LJ, Symons HJ, Terezakis SA, Wagner-Johnston N, Jones RJ, Brodsky RA (2019) Effect of increased dose of total body irradiation on graft failure associated with HLA-haploidentical transplantation in patients with severe haemoglobinopathies: a prospective clinical trial. Lancet Haematol 6(4):e183–e193. https://doi.org/10.1016/S2352-3026(19)30031-6

    Article  PubMed  PubMed Central  Google Scholar 

  • Brunstein CG, Fuchs EJ, Carter SL, Karanes C, Costa LJ, Wu J, Devine SM, Wingard JR, Aljitawi OS, Cutler CS, Jagasia MH, Ballen KK, Eapen M, O’Donnell PV, Blood and Marrow Transplant Clinical Trials Network (2011) Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts. Blood 118(2):282–288. https://doi.org/10.1182/blood-2011-03-344853

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Canaani J, Savani BN, Labopin M, Huang XJ, Ciceri F, Arcese W, Tischer J, Koc Y, Bruno B, Gulbas Z, Blaise D, Maertens J, Ehninger G, Mohty M, Nagler A (2017) Impact of ABO incompatibility on patients’ outcome after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia – a report from the Acute Leukemia Working Party of the EBMT. Haematologica 102(6):1066–1074. https://doi.org/10.3324/haematol.2016.160804

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Castagnoli R, Delmonte OM, Calzoni E, Notarangelo LD (2019) Hematopoietic stem cell transplantation in primary immunodeficiency diseases: current status and future perspectives. Front Pediatr 7:295. https://doi.org/10.3389/fped.2019.00295

    Article  PubMed  PubMed Central  Google Scholar 

  • Chakrabarti S, Bareford D (2004) Will developments in allogeneic transplantation influence treatment of adult patients with sickle cell disease? Biol Blood Marrow Transplant 10(1):23–31. https://doi.org/10.1016/j.bbmt.2003.09.004

    Article  PubMed  Google Scholar 

  • Chakrabarti S, Buyck HC (2007) Reduced-intensity transplantation in the treatment of haematological malignancies: current status and future-prospects. Curr Stem Cell Res Ther 2(2):163–188

    Article  CAS  PubMed  Google Scholar 

  • Chan WK, Suwannasaen D, Throm RE, Li Y, Eldridge PW, Houston J, Gray JT, Pui CH, Leung W (2015) Chimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity. Leukemia 29(2):387–395. https://doi.org/10.1038/leu.2014.174

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Fukuda T, Thakar MS, Kornblit BT, Storer BE, Santos EB, Storb R, Sandmaier BM (2011) Immunomodulatory effects induced by cytotoxic T lymphocyte antigen 4 immunoglobulin with donor peripheral blood mononuclear cell infusion in canine major histocompatibility complex-haplo-identical non-myeloablative hematopoietic cell transplantation. Cytotherapy 13(10):1269–1280. https://doi.org/10.3109/14653249.2011.586997

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ciurea SO, Thall PF, Milton DR, Barnes TH, Kongtim P, Carmazzi Y, Lopez AA, Yap DY, Popat U, Rondon G, Lichtiger B, Aung F, Afshar-Kharghan V, Ma Q, Fernandez-Vina M, Champlin RE, Cao K (2015a) Complement-binding donor-specific anti-HLA antibodies and risk of primary graft failure in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 21(8):1392–1398. https://doi.org/10.1016/j.bbmt.2015.05.001

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ciurea SO, Zhang MJ, Bacigalupo AA, Bashey A, Appelbaum FR, Aljitawi OS, Armand P, Antin JH, Chen J, Devine SM, Fowler DH, Luznik L, Nakamura R, O’Donnell PV, Perales MA, Pingali SR, Porter DL, Riches MR, Ringden OT, Rocha V, Vij R, Weisdorf DJ, Champlin RE, Horowitz MM, Fuchs EJ, Eapen M (2015b) Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia. Blood 126(8):1033–1040. https://doi.org/10.1182/blood-2015-04-639831

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ciurea SO, Cao K, Fernandez-Vina M, Kongtim P, Malki MA, Fuchs E, Luznik L, Huang XJ, Ciceri F, Locatelli F, Aversa F, Castagna L, Bacigalupo A, Martelli M, Blaise D, Handgretinger R, Roy DC, O’Donnell P, Bashey A, Lazarus HM, Ballen K, Savani BN, Mohty M, Nagler A (2018) The European Society for Blood and Marrow Transplantation (EBMT) consensus guidelines for the detection and treatment of donor-specific anti-HLA antibodies (DSA) in haploidentical hematopoietic cell transplantation. Bone Marrow Transplant 53(5):521–534. https://doi.org/10.1038/s41409-017-0062-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cooley S, Weisdorf DJ, Guethlein LA, Klein JP, Wang T, Le CT, Marsh SG, Geraghty D, Spellman S, Haagenson MD, Ladner M, Trachtenberg E, Parham P, Miller JS (2010) Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia. Blood 116(14):2411–2419. https://doi.org/10.1182/blood-2010-05-283051

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Coudert JD, Held W (2006) The role of the NKG2D receptor for tumor immunity. Semin Cancer Biol 16(5):333–343. https://doi.org/10.1016/j.semcancer.2006.07.008

    Article  CAS  PubMed  Google Scholar 

  • Davies JOJ, Hart AC, De La Fuente J, Bain BJ (2018) Macrophage activation syndrome and post-transplant microangiopathy following haploidentical bone marrow transplantation for sickle cell anemia. Am J Hematol 93(4):588–589. https://doi.org/10.1002/ajh.24995

    Article  PubMed  Google Scholar 

  • de la Fuente J, Dhedin N, Koyama T, Bernaudin F, Kuentz M, Karnik L, Socie G, Culos KA, Brodsky RA, DeBaun MR, Kassim AA (2019) Haploidentical bone marrow transplantation with post-transplantation cyclophosphamide plus thiotepa improves donor engraftment in patients with sickle cell anemia: results of an International Learning Collaborative. Biol Blood Marrow Transplant 25(6):1197–1209. https://doi.org/10.1016/j.bbmt.2018.11.027

    Article  PubMed  Google Scholar 

  • de Lalla C, Rinaldi A, Montagna D, Azzimonti L, Bernardo ME, Sangalli LM, Paganoni AM, Maccario R, Di Cesare-Merlone A, Zecca M, Locatelli F, Dellabona P, Casorati G (2011) Invariant NKT cell reconstitution in pediatric leukemia patients given HLA-haploidentical stem cell transplantation defines distinct CD4+ and CD4- subset dynamics and correlates with remission state. J Immunol 186(7):4490–4499. https://doi.org/10.4049/jimmunol.1003748

    Article  CAS  PubMed  Google Scholar 

  • Della Chiesa M, Sivori S, Carlomagno S, Moretta L, Moretta A (2015) Activating KIRs and NKG2C in viral infections: toward NK cell memory? Front Immunol 6:573. https://doi.org/10.3389/fimmu.2015.00573

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • DeZern AE, Petri M, Drachman DB, Kerr D, Hammond ER, Kowalski J, Tsai HL, Loeb DM, Anhalt G, Wigley F, Jones RJ, Brodsky RA (2011) High-dose cyclophosphamide without stem cell rescue in 207 patients with aplastic anemia and other autoimmune diseases. Medicine (Baltimore) 90(2):89–98. https://doi.org/10.1097/MD.0b013e318210e685

    Article  CAS  Google Scholar 

  • Di Ianni M, Falzetti F, Carotti A, Terenzi A, Castellino F, Bonifacio E, Del Papa B, Zei T, Ostini RI, Cecchini D, Aloisi T, Perruccio K, Ruggeri L, Balucani C, Pierini A, Sportoletti P, Aristei C, Falini B, Reisner Y, Velardi A, Aversa F, Martelli MF (2011) Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 117(14):3921–3928. https://doi.org/10.1182/blood-2010-10-311894

    Article  CAS  PubMed  Google Scholar 

  • Dietrich S, Finel H, Martinez C, Tischer J, Blaise D, Chevallier P, Castagna L, Milpied N, Bacigalupo A, Corradini P, Mohty M, Sanz M, Hausmann A, Montoto S, Robinson S, Boumendil A, Sureda A, Dreger P (2016) Post-transplant cyclophosphamide-based haplo-identical transplantation as alternative to matched sibling or unrelated donor transplantation for non-Hodgkin lymphoma: a registry study by the European society for blood and marrow transplantation. Leukemia 30(10):2086–2089. https://doi.org/10.1038/leu.2016.125

    Article  CAS  PubMed  Google Scholar 

  • Dreger P, Sureda A, Ahn KW, Eapen M, Litovich C, Finel H, Boumendil A, Gopal A, Herrera AF, Schmid C, Diez-Martin JL, Fuchs E, Bolanos-Meade J, Gooptu M, Al Malki MM, Castagna L, Ciurea SO, Dominietto A, Blaise D, Ciceri F, Tischer J, Corradini P, Montoto S, Robinson S, Gulbas Z, Hamadani M (2019) PTCy-based haploidentical vs matched related or unrelated donor reduced-intensity conditioning transplant for DLBCL. Blood Adv 3(3):360–369. https://doi.org/10.1182/bloodadvances.2018027748

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eapen M, Klein JP, Ruggeri A, Spellman S, Lee SJ, Anasetti C, Arcese W, Barker JN, Baxter-Lowe LA, Brown M, Fernandez-Vina MA, Freeman J, He W, Iori AP, Horowitz MM, Locatelli F, Marino S, Maiers M, Michel G, Sanz GF, Gluckman E, Rocha V (2014) Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy. Blood 123(1):133–140. https://doi.org/10.1182/blood-2013-05-506253

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, Negrin RS (2003) CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 9(9):1144–1150. https://doi.org/10.1038/nm915

    Article  CAS  PubMed  Google Scholar 

  • Eissens DN, Van Der Meer A, Van CB, Preijers FW, Joosten I (2010) Rapamycin and MPA, but not CsA, impair human NK cell cytotoxicity due to differential effects on NK cell phenotype. Am J Transplant 10(9):1981–1990. https://doi.org/10.1111/j.1600-6143.2010.03242.x

    Article  CAS  PubMed  Google Scholar 

  • Esteves I, Bonfim C, Pasquini R, Funke V, Pereira NF, Rocha V, Novis Y, Arrais C, Colturato V, de Souza MP, Torres M, Fernandes JF, Kerbauy FR, Ribeiro AA, Santos FP, Hamerschlak N (2015) Haploidentical BMT and post-transplant Cy for severe aplastic anemia: a multicenter retrospective study. Bone Marrow Transplant 50(5):685–689. https://doi.org/10.1038/bmt.2015.20

    Article  CAS  PubMed  Google Scholar 

  • Fisher SA, Lamikanra A, Doree C, Gration B, Tsang P, Danby RD, Roberts DJ (2017) Increased regulatory T cell graft content is associated with improved outcome in haematopoietic stem cell transplantation: a systematic review. Br J Haematol 176(3):448–463. https://doi.org/10.1111/bjh.14433

    Article  CAS  PubMed  Google Scholar 

  • Foell J, Schulte JH, Pfirstinger B, Troeger A, Wolff D, Edinger M, Hofmann P, Aslanidis C, Lang P, Holler E, Eggert A, Corbacioglu S (2019) Haploidentical CD3 or alpha/beta T-cell depleted HSCT in advanced stage sickle cell disease. Bone Marrow Transplant. https://doi.org/10.1038/s41409-019-0550-0

  • Foley B, Cooley S, Verneris MR, Curtsinger J, Luo X, Waller EK, Anasetti C, Weisdorf D, Miller JS (2012) Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen. J Immunol 189(10):5082–5088. https://doi.org/10.4049/jimmunol.1201964

    Article  CAS  PubMed  Google Scholar 

  • Gaballa S, Ge I, El Fakih R, Brammer JE, Kongtim P, Tomuleasa C, Wang SA, Lee D, Petropoulos D, Cao K, Rondon G, Chen J, Hammerstrom A, Lombardi L, Alatrash G, Korbling M, Oran B, Kebriaei P, Ahmed S, Shah N, Rezvani K, Marin D, Bashir Q, Alousi A, Nieto Y, Qazilbash M, Hosing C, Popat U, Shpall EJ, Khouri I, Champlin RE, Ciurea SO (2016) Results of a 2-arm, phase 2 clinical trial using post-transplantation cyclophosphamide for the prevention of graft-versus-host disease in haploidentical donor and mismatched unrelated donor hematopoietic stem cell transplantation. Cancer 122(21):3316–3326. https://doi.org/10.1002/cncr.30180

    Article  CAS  PubMed  Google Scholar 

  • Gagelmann N, Bacigalupo A, Rambaldi A, Hoelzer D, Halter J, Sanz J, Bonifazi F, Meijer E, Itala-Remes M, Markova M, Solano C, Kroger N (2019) Haploidentical stem cell transplantation with posttransplant cyclophosphamide therapy vs other donor transplantations in adults with hematologic cancers: a systematic review and meta-analysis. JAMA Oncol. https://doi.org/10.1001/jamaoncol.2019.3541

  • Galgani M, De Rosa V, La Cava A, Matarese G (2016) Role of metabolism in the immunobiology of regulatory T cells. J Immunol 197(7):2567–2575. https://doi.org/10.4049/jimmunol.1600242

    Article  CAS  PubMed  Google Scholar 

  • Gauthier J, Poire X, Gac AC, Leclerc M, Guillaume T, Chalandon Y, Nguyen S, Forcade E, Regny C, Bay JO, Bazarbachi A, Rohrlich PS, Huynh A, Farhi J, Marchand T, Malfuson JV, Pilorge S, Labussiere-Wallet H, Renard C, Fornecker LM, Detrait M, Dulery R, Delage J, Menard AL, Charbonnier A, Nelken B, Jubert C, Suarez F, de la Tour RP, Beguin Y, Schoemans H, Blaise D, Yakoub-Agha I (2018) Better outcome with haploidentical over HLA-matched related donors in patients with Hodgkin’s lymphoma undergoing allogeneic haematopoietic cell transplantation-a study by the Francophone Society of Bone Marrow Transplantation and Cellular Therapy. Bone Marrow Transplant 53(4):400–409. https://doi.org/10.1038/s41409-017-0018-z

    Article  CAS  PubMed  Google Scholar 

  • Gaziev J, Isgro A, Sodani P, Paciaroni K, De Angelis G, Marziali M, Ribersani M, Alfieri C, Lanti A, Galluccio T, Adorno G, Andreani M (2018) Haploidentical HSCT for hemoglobinopathies: improved outcomes with TCRalphabeta(+)/CD19(+)-depleted grafts. Blood Adv 2(3):263–270. https://doi.org/10.1182/bloodadvances.2017012005

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Giannotti F, Labopin M, Shouval R, Sanz J, Arcese W, Angelucci E, Sierra J, Santasusana JR, Santarone S, Benedetto B, Rambaldi A, Saccardi R, Blaise D, Carella MA, Rocha V, Baron F, Mohty M, Ruggeri A, Nagler A (2018) Haploidentical transplantation is associated with better overall survival when compared to single cord blood transplantation: an EBMT-Eurocord study of acute leukemia patients conditioned with thiotepa, busulfan, and fludarabine. J Hematol Oncol 11(1):110. https://doi.org/10.1186/s13045-018-0655-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guinan EC, Boussiotis VA, Neuberg D, Brennan LL, Hirano N, Nadler LM, Gribben JG (1999) Transplantation of anergic histoincompatible bone marrow allografts. N Engl J Med 340(22):1704–1714. https://doi.org/10.1056/NEJM199906033402202

    Article  CAS  PubMed  Google Scholar 

  • Hamadani M, Saber W, Ahn KW, Carreras J, Cairo MS, Fenske TS, Gale RP, Gibson J, Hale GA, Hari PN, Hsu JW, Inwards DJ, Kamble RT, Klein A, Maharaj D, Marks DI, Rizzieri DA, Savani BN, Schouten HC, Waller EK, Wirk B, Laport GG, Montoto S, Maloney DG, Lazarus HM (2013) Impact of pretransplantation conditioning regimens on outcomes of allogeneic transplantation for chemotherapy-unresponsive diffuse large B cell lymphoma and grade III follicular lymphoma. Biol Blood Marrow Transplant 19(5):746–753. https://doi.org/10.1016/j.bbmt.2013.01.024

    Article  PubMed  PubMed Central  Google Scholar 

  • Henter JI, Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G (2007) HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer 48(2):124–131. https://doi.org/10.1002/pbc.21039

    Article  PubMed  Google Scholar 

  • Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S (2002) Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 196(3):389–399

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoffmann P, Eder R, Boeld TJ, Doser K, Piseshka B, Andreesen R, Edinger M (2006) Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108(13):4260–4267. https://doi.org/10.1182/blood-2006-06-027409

    Article  CAS  PubMed  Google Scholar 

  • Hoffmann P, Boeld TJ, Eder R, Huehn J, Floess S, Wieczorek G, Olek S, Dietmaier W, Andreesen R, Edinger M (2009) Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol 39(4):1088–1097. https://doi.org/10.1002/eji.200838904

    Article  CAS  PubMed  Google Scholar 

  • Hsieh MM, Fitzhugh CD, Weitzel RP, Link ME, Coles WA, Zhao X, Rodgers GP, Powell JD, Tisdale JF (2014) Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype. JAMA 312(1):48–56. https://doi.org/10.1001/jama.2014.7192

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Huang XJ (2011) Hematopoietic stem cell transplantation in China: current status and prospects. Am J Blood Res 1(1):90–97

    PubMed  PubMed Central  Google Scholar 

  • Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W (2007a) Donor lymphocyte infusion for the treatment of leukemia relapse after HLA-mismatched/haploidentical T-cell-replete hematopoietic stem cell transplantation. Haematologica 92(3):414–417

    Article  PubMed  Google Scholar 

  • Huang XJ, Zhao XY, Liu DH, Liu KY, Xu LP (2007b) Deleterious effects of KIR ligand incompatibility on clinical outcomes in haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion. Leukemia 21(4):848–851. https://doi.org/10.1038/sj.leu.2404566

    Article  CAS  PubMed  Google Scholar 

  • Ichinohe T (2010) Long-term feto-maternal microchimerism revisited: Microchimerism and tolerance in hematopoietic stem cell transplantation. Chimerism 1(1):39–43. https://doi.org/10.4161/chim.1.1.12743

    Article  PubMed  PubMed Central  Google Scholar 

  • Im HJ, Koh KN, Seo JJ (2015) Haploidentical hematopoietic stem cell transplantation in children and adolescents with acquired severe aplastic anemia. Korean J Pediatr 58(6):199–205. https://doi.org/10.3345/kjp.2015.58.6.199

    Article  PubMed  PubMed Central  Google Scholar 

  • Jaiswal SR, Chakrabarti S (2016) Haploidentical transplantation in children with acute leukemia: the unresolved issues. Adv Hematol 2016:3467672. https://doi.org/10.1155/2016/3467672

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jaiswal SR, Chakrabarti S (2019) Natural killer cell-based immunotherapy with CTLA4Ig-primed donor lymphocytes following haploidentical transplantation. Immunotherapy 11(14):1221–1230. https://doi.org/10.2217/imt-2019-0037

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal SR, Chatterjee S, Mukherjee S, Ray K, Chakrabarti S (2015) Pre-transplant sirolimus might improve the outcome of haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide for patients with severe aplastic anemia. Bone Marrow Transplant 50(6):873–875. https://doi.org/10.1038/bmt.2015.50

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal SR, Chakrabarti A, Chatterjee S, Bhargava S, Ray K, Chakrabarti S (2016a) Hemophagocytic syndrome following haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide. Int J Hematol 103(2):234–242. https://doi.org/10.1007/s12185-015-1905-y

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal SR, Chakrabarti A, Chatterjee S, Bhargava S, Ray K, O’Donnell P, Chakrabarti S (2016b) Haploidentical peripheral blood stem cell transplantation with post-transplantation cyclophosphamide in children with advanced acute leukemia with Fludarabine-, Busulfan-, and Melphalan-based conditioning. Biol Blood Marrow Transplant 22(3):499–504. https://doi.org/10.1016/j.bbmt.2015.11.010

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal SR, Zaman S, Chakrabarti A, Sen S, Mukherjee S, Bhargava S, Ray K, O’Donnell PV, Chakrabarti S (2016c) Improved outcome of refractory/relapsed acute myeloid leukemia after post-transplantation cyclophosphamide-based haploidentical transplantation with myeloablative conditioning and early prophylactic granulocyte colony-stimulating factor-mobilized donor lymphocyte infusions. Biol Blood Marrow Transplant 22(10):1867–1873. https://doi.org/10.1016/j.bbmt.2016.07.016

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal SR, Bhakuni P, Zaman S, Bansal S, Bharadwaj P, Bhargava S, Chakrabarti S (2017a) T cell costimulation blockade promotes transplantation tolerance in combination with sirolimus and post-transplantation cyclophosphamide for haploidentical transplantation in children with severe aplastic anemia. Transpl Immunol 43-44:54–59. https://doi.org/10.1016/j.trim.2017.07.004

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal SR, Zaman S, Nedunchezhian M, Chakrabarti A, Bhakuni P, Ahmed M, Sharma K, Rawat S, O’Donnell P, Chakrabarti S (2017b) CD56-enriched donor cell infusion after post-transplantation cyclophosphamide for haploidentical transplantation of advanced myeloid malignancies is associated with prompt reconstitution of mature natural killer cells and regulatory T cells with reduced incidence of acute graft versus host disease: a pilot study. Cytotherapy 19(4):531–542. https://doi.org/10.1016/j.jcyt.2016.12.006

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal SR, Bhakuni P, Joy A, Murli N, Rajoreya A, Chakrabarti A, Chakrabarti S (2018) Higher CD45RA(+) regulatory T cells in the graft improves outcome in younger patients undergoing T cell-replete haploidentical transplantation: where donor age matters. Biol Blood Marrow Transplant 24(10):2025–2033. https://doi.org/10.1016/j.bbmt.2018.06.003

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal SR, Aiyer HM, Rawat G, Gera A, Chakrabarti S (2019a) CTLA4Ig-based reduced intensity conditioning and donor lymphocyte infusions for haploidentical transplantation in refractory aggressive B-cell lymphoma relapsing after an autograft: early results from a pilot study. Exp Hematol 77:26–35 e21. https://doi.org/10.1016/j.exphem.2019.08.002

    Article  CAS  Google Scholar 

  • Jaiswal SR, Bhakuni P, Bansal S, Aiyer HM, Bhargava S, Chakrabarti S (2019b) Targeting CD28-CD86 pathway for refractory myeloma through CTLA4Ig-based reduced-intensity conditioning and donor lymphocyte infusions after haploidentical transplantation. Clin Lymphoma Myeloma Leuk 19(8):e430–e435. https://doi.org/10.1016/j.clml.2019.04.008

    Article  PubMed  Google Scholar 

  • Jaiswal SR, Bhakuni P, Bhagawati G, Chakrabarti A, Chakrabarti S (2019c) CTLA4Ig-based T-cell costimulation blockade is associated with reduction of adenovirus viremia following post-transplantation cyclophosphamide-based haploidentical transplantation. Bone Marrow Transplant. https://doi.org/10.1038/s41409-019-0549-6

  • Jaiswal SR, Bhakuni P, Bhagwati G, Aiyar HM, Chakrabarti A, Chakrabarti S (2019d) Alterations in NKG2A and NKG2C subsets of natural killer cells following Epstein Barr virus reactivation in CTLA4Ig based haploidentical transplantation is associated with increased chronic graft-versus-host disease. Transplantation. https://doi.org/10.1097/tp.0000000000002941

  • Jaiswal SR, Bhakuni P, Joy A, Kaushal S, Chakrabarti A, Chakrabarti S (2019e) CTLA4Ig primed donor lymphocyte infusion: a novel approach to immunotherapy after haploidentical transplantation for advanced leukemia. Biol Blood Marrow Transplant 25(4):673–682. https://doi.org/10.1016/j.bbmt.2018.12.836

    Article  CAS  PubMed  Google Scholar 

  • Jaiswal SR, Bhakuni P, Joy A, Kaushal S, Sudhish D, Aiyer HM, Chakrabarti S (2019f) Early expansion of CD56dimNKG2Alow with late surge and persistence of CD56dimNKG2AnegNKG2Cbright NK cells attenuate cytomegalovirus (CMV) replication and recurrence as well as leukemia relapse following haploidentical HSCT with T cell co-stimulation blockade and PTCy. Biol Blood Marrow Transplant 25(3):S328. https://doi.org/10.1016/j.bbmt.2018.12.529

    Article  Google Scholar 

  • Jones RJ, Barber JP, Vala MS, Collector MI, Kaufmann SH, Ludeman SM, Colvin OM, Hilton J (1995) Assessment of aldehyde dehydrogenase in viable cells. Blood 85(10):2742–2746

    Article  CAS  PubMed  Google Scholar 

  • Kanakry CG, Ganguly S, Zahurak M, Bolanos-Meade J, Thoburn C, Perkins B, Fuchs EJ, Jones RJ, Hess AD, Luznik L (2013) Aldehyde dehydrogenase expression drives human regulatory T cell resistance to posttransplantation cyclophosphamide. Sci Transl Med 5(211):211ra157. https://doi.org/10.1126/scitranslmed.3006960

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kanate AS, Mussetti A, Kharfan-Dabaja MA, Ahn KW, DiGilio A, Beitinjaneh A, Chhabra S, Fenske TS, Freytes C, Gale RP, Ganguly S, Hertzberg M, Klyuchnikov E, Lazarus HM, Olsson R, Perales MA, Rezvani A, Riches M, Saad A, Slavin S, Smith SM, Sureda A, Yared J, Ciurea S, Armand P, Salit R, Bolanos-Meade J, Hamadani M (2016) Reduced-intensity transplantation for lymphomas using haploidentical related donors vs HLA-matched unrelated donors. Blood 127(7):938–947. https://doi.org/10.1182/blood-2015-09-671834

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kasamon YL, Luznik L, Leffell MS, Kowalski J, Tsai HL, Bolanos-Meade J, Morris LE, Crilley PA, O’Donnell PV, Rossiter N, Huff CA, Brodsky RA, Matsui WH, Swinnen LJ, Borrello I, Powell JD, Ambinder RF, Jones RJ, Fuchs EJ (2010) Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. Biol Blood Marrow Transplant 16(4):482–489. https://doi.org/10.1016/j.bbmt.2009.11.011

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Katewa S, Kharya G, Karnik L, Kassim AA, de la Fuente J (2017) Pre-transplantation suppression of haemopoiesis is associated with a high rate of macrophage activation syndrome in ptcy haploidentical transplantation for haemoglobinopathies. Blood 130(Suppl 1):1931. https://doi.org/10.1182/blood.V130.Suppl_1.1931.1931

    Article  Google Scholar 

  • Kean LS, Manci EA, Perry J, Balkan C, Coley S, Holtzclaw D, Adams AB, Larsen CP, Hsu LL, Archer DR (2003) Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood 102(13):4582–4593. https://doi.org/10.1182/blood-2003-03-0712

    Article  CAS  PubMed  Google Scholar 

  • Kean LS, Hamby K, Koehn B, Lee E, Coley S, Stempora L, Adams AB, Heiss E, Pearson TC, Larsen CP (2006) NK cells mediate costimulation blockade-resistant rejection of allogeneic stem cells during nonmyeloablative transplantation. Am J Transplant 6(2):292–304. https://doi.org/10.1111/j.1600-6143.2005.01172.x

    Article  CAS  PubMed  Google Scholar 

  • Klingebiel T, Cornish J, Labopin M, Locatelli F, Darbyshire P, Handgretinger R, Balduzzi A, Owoc-Lempach J, Fagioli F, Or R, Peters C, Aversa F, Polge E, Dini G, Rocha V, Pediatric D, Acute Leukemia Working Parties of the European Group for B, Marrow T (2010) Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant Group. Blood 115 (17):3437–3446. https://doi.org/10.1182/blood-2009-03-207001

  • Kolb HJ, Schattenberg A, Goldman JM, Hertenstein B, Jacobsen N, Arcese W, Ljungman P, Ferrant A, Verdonck L, Niederwieser D, van RF, Mittermueller J, de WT, Holler E, Ansari H (1995) Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 86 (5):2041–2050

    Google Scholar 

  • Koura DT, Horan JT, Langston AA, Qayed M, Mehta A, Khoury HJ, Harvey RD, Suessmuth Y, Couture C, Carr J, Grizzle A, Johnson HR, Cheeseman JA, Conger JA, Robertson J, Stempora L, Johnson BE, Garrett A, Kirk AD, Larsen CP, Waller EK, Kean LS (2013) In vivo T cell costimulation blockade with abatacept for acute graft-versus-host disease prevention: a first-in-disease trial. Biol Blood Marrow Transplant 19(11):1638–1649. https://doi.org/10.1016/j.bbmt.2013.09.003

    Article  CAS  PubMed  Google Scholar 

  • Kroger N, Solano C, Wolschke C, Bandini G, Patriarca F, Pini M, Nagler A, Selleri C, Risitano A, Messina G, Bethge W, Perez de Oteiza J, Duarte R, Carella AM, Cimminiello M, Guidi S, Finke J, Mordini N, Ferra C, Sierra J, Russo D, Petrini M, Milone G, Benedetti F, Heinzelmann M, Pastore D, Jurado M, Terruzzi E, Narni F, Volp A, Ayuk F, Ruutu T, Bonifazi F (2016) Antilymphocyte globulin for prevention of chronic graft-versus-host disease. N Engl J Med 374(1):43–53. https://doi.org/10.1056/NEJMoa1506002

    Article  CAS  PubMed  Google Scholar 

  • Kumar AJ, Kim S, Hemmer MT, Arora M, Spellman SR, Pidala JA, Couriel DR, Alousi AM, Aljurf MD, Cahn JY, Cairo MS, Cutler CS, Farhan S, Gergis U, Hale GA, Hashmi SK, Inamoto Y, Kamble RT, Kharfan-Dabaja MA, MacMillan ML, Marks DI, Nakasone H, Norkin M, Qayed M, Ringden O, Schouten HC, Schultz KR, Solh MM, Teshima T, Urbano-Ispizua A, Verdonck LF, Gale RP, Hamilton BK, Majhail NS, Loren AW (2018) Graft-versus-host disease in recipients of male unrelated donor compared with parous female sibling donor transplants. Blood Adv 2(9):1022–1031. https://doi.org/10.1182/bloodadvances.2017013052

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lang P, Teltschik HM, Feuchtinger T, Muller I, Pfeiffer M, Schumm M, Ebinger M, Schwarze CP, Gruhn B, Schrauder A, Albert MH, Greil J, Urban C, Handgretinger R (2014) Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia. Br J Haematol 165(5):688–698. https://doi.org/10.1111/bjh.12810

    Article  CAS  PubMed  Google Scholar 

  • Lee J, Zhang T, Hwang I, Kim A, Nitschke L, Kim M, Scott JM, Kamimura Y, Lanier LL, Kim S (2015) Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals. Immunity 42(3):431–442. https://doi.org/10.1016/j.immuni.2015.02.013

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Li Y, Duan F, Xiao H, Wu X, Wang S, Xu D, Liu Q, Fan Z, Nie D, Lai Y, Wu B, Lin D, Du X, Weng J, Jiang Z, Pang Y, Ouyang L, Liu Z, Zhang L, Han N, Chen L, Xiao Y (2018) Therapeutic outcomes of haploidentical allogeneic hematopoietic stem cell transplantation in patients with severe aplastic anemia: a multicenter study. Transplantation 102(10):1724–1731. https://doi.org/10.1097/TP.0000000000002200

    Article  PubMed  Google Scholar 

  • Lucarelli G, Galimberti M, Polchi P, Giardini C, Politi P, Baronciani D, Angelucci E, Manenti F, Delfini C, Aureli G et al (1987) Marrow transplantation in patients with advanced thalassemia. N Engl J Med 316(17):1050–1055. https://doi.org/10.1056/NEJM198704233161703

    Article  CAS  PubMed  Google Scholar 

  • Lucarelli G, Galimberti M, Polchi P, Angelucci E, Baronciani D, Durazzi SM, Giardini C, Nicolini G, Politi P, Albertini F (1991) Bone marrow transplantation in thalassemia. Hematol Oncol Clin North Am 5(3):549–556

    Article  CAS  PubMed  Google Scholar 

  • Luznik L, Jalla S, Engstrom LW, Iannone R, Fuchs EJ (2001) Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide. Blood 98(12):3456–3464

    Article  CAS  PubMed  Google Scholar 

  • Maiers M, Halagan M, Joshi S, Ballal HS, Jagannatthan L, Damodar S, Srinivasan P, Narayan S, Khattry N, Malhotra P, Minz RW, Shah SA, Rajagopal R, Cereb N, Yang SY, Parekh S, Mammen J, Daniels D, Weisdorf D (2014) HLA match likelihoods for Indian patients seeking unrelated donor transplantation grafts: a population-based study. Lancet Haematol 1(2):e57–e63. https://doi.org/10.1016/S2352-3026(14)70021-3

    Article  PubMed  Google Scholar 

  • Martelli MF, Ianni MD, Ruggeri L, Falzetti F, Carotti A, Reisner Y, Velardi A (2015) Next generation HLA-haploidentical HSCT. Bone Marrow Transplant 50(Suppl 2):S63–S66. https://doi.org/10.1038/bmt.2015.98

    Article  CAS  PubMed  Google Scholar 

  • Martinez C, Gayoso J, Canals C, Finel H, Peggs K, Dominietto A, Castagna L, Afanasyev B, Robinson S, Blaise D, Corradini P, Itala-Remes M, Bermudez A, Forcade E, Russo D, Potter M, McQuaker G, Yakoub-Agha I, Scheid C, Bloor A, Montoto S, Dreger P, Sureda A, Lymphoma Working Party of the European Group for Blood and Marrow Transplantation (2017) Post-transplantation cyclophosphamide-based haploidentical transplantation as alternative to matched sibling or unrelated donor transplantation for Hodgkin lymphoma: a registry study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation. J Clin Oncol 35(30):3425–3432. https://doi.org/10.1200/JCO.2017.72.6869

    Article  CAS  PubMed  Google Scholar 

  • McCurdy SR, Iglehart BS, Batista DA, Gocke CD, Ning Y, Knaus HA, Jackson AM, Leffell MS, Luznik L, Gojo I (2016) Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide. Leukemia 30(10):2102–2106. https://doi.org/10.1038/leu.2016.144

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McCurdy SR, Kasamon YL, Kanakry CG, Bolanos-Meade J, Tsai HL, Showel MM, Kanakry JA, Symons HJ, Gojo I, Smith BD, Bettinotti MP, Matsui WH, Dezern AE, Huff CA, Borrello I, Pratz KW, Gladstone DE, Swinnen LJ, Brodsky RA, Levis MJ, Ambinder RF, Fuchs EJ, Rosner GL, Jones RJ, Luznik L (2017) Comparable composite endpoints after HLA-matched and HLA-haploidentical transplantation with post-transplantation cyclophosphamide. Haematologica 102(2):391–400. https://doi.org/10.3324/haematol.2016.144139

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McCurdy SR, Muth ST, Tsai HL, Symons HJ, Huff CA, Matsui WH, Borrello I, Gladstone DE, Swinnen LJ, Cooke KR, Brodsky RA, Bolanos-Meade J, Ambinder RF, Varadhan R, Luznik L, Jones RJ, Bettinot MP, Fuchs EJ (2018a) Early fever after haploidentical bone marrow transplantation correlates with class II HLA-mismatching and myeloablation but not outcomes. Biol Blood Marrow Transplant 24(10):2056–2064. https://doi.org/10.1016/j.bbmt.2018.06.004

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McCurdy SR, Zhang MJ, St Martin A, Al Malki MM, Bashey A, Gaballa S, Keesler DA, Hamadani M, Norkin M, Perales MA, Reshef R, Rocha V, Romee R, Solh M, Urbano-Ispizua A, Waller EK, Fuchs EJ, Eapen M (2018b) Effect of donor characteristics on haploidentical transplantation with posttransplantation cyclophosphamide. Blood Adv 2(3):299–307. https://doi.org/10.1182/bloodadvances.2017014829

    Article  PubMed  PubMed Central  Google Scholar 

  • Merker M, Salzmann-Manrique E, Katzki V, Huenecke S, Bremm M, Bakhtiar S, Willasch A, Jarisch A, Soerensen J, Schulz A, Meisel R, Bug G, Bonig H, Klingebiel T, Bader P, Rettinger E (2019) Clearance of hematologic malignancies by allogeneic cytokine-induced killer cell or donor lymphocyte infusions. Biol Blood Marrow Transplant 25(7):1281–1292. https://doi.org/10.1016/j.bbmt.2019.03.004

    Article  PubMed  Google Scholar 

  • Mo XD, Tang BL, Zhang XH, Zheng CC, Xu LP, Zhu XY, Wang Y, Liu HL, Yan CH, Chu XD, Chen H, Geng LQ, Liu KY, Sun ZM, Huang XJ (2016) Comparison of outcomes after umbilical cord blood and unmanipulated haploidentical hematopoietic stem cell transplantation in children with high-risk acute lymphoblastic leukemia. Int J Cancer 139(9):2106–2115. https://doi.org/10.1002/ijc.30249

    Article  CAS  PubMed  Google Scholar 

  • Moretta A, Vitale M, Sivori S, Morelli L, Pende D, Bottino C (1996) Inhibitory and activatory receptors for HLA class I molecules in human natural killer cells. Chem Immunol 64:77–87

    Article  CAS  PubMed  Google Scholar 

  • Munchel A, Kesserwan C, Symons HJ, Luznik L, Kasamon YL, Jones RJ, Fuchs EJ (2011) Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide. Pediatr Rep 3(Suppl 2):e15. https://doi.org/10.4081/pr.2011.s2.e15

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Murray ME, Gavile CM, Nair JR, Koorella C, Carlson LM, Buac D, Utley A, Chesi M, Bergsagel PL, Boise LH, Lee KP (2014) CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma. Blood 123(24):3770–3779. https://doi.org/10.1182/blood-2013-10-530964

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nirmul G, Severin C, Taub RN (1971) Cyclophosphamide-induced immunologic tolerance to skin homografts. Surg Forum 22:287–288

    CAS  PubMed  Google Scholar 

  • O’Donnell PV, Luznik L, Jones RJ, Vogelsang GB, Leffell MS, Phelps M, Rhubart P, Cowan K, Piantados S, Fuchs EJ (2002) Nonmyeloablative bone marrow transplantation from partially HLA-mismatched related donors using posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 8(7):377–386

    Article  PubMed  Google Scholar 

  • Ong SM, Hadadi E, Dang TM, Yeap WH, Tan CT, Ng TP, Larbi A, Wong SC (2018) The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence. Cell Death Dis 9(3):266. https://doi.org/10.1038/s41419-018-0327-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Owens AH Jr, Santos GW (1971) The effect of cytotoxic drugs on graft-versus-host disease in mice. Transplantation 11(4):378–382. https://doi.org/10.1097/00007890-197104000-00004

    Article  CAS  PubMed  Google Scholar 

  • Pallmer K, Oxenius A (2016) Recognition and regulation of T cells by NK cells. Front Immunol 7:251. https://doi.org/10.3389/fimmu.2016.00251

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Peng Y, Luo G, Zhou J, Wang X, Hu J, Cui Y, Li XC, Tan J, Yang S, Zhan R, Yang J, He W, Wu J (2013) CD86 is an activation receptor for NK cell cytotoxicity against tumor cells. PLoS One 8(12):e83913. https://doi.org/10.1371/journal.pone.0083913

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Perko R, Kang G, Sunkara A, Leung W, Thomas PG, Dallas MH (2015) Gamma delta T cell reconstitution is associated with fewer infections and improved event-free survival after hematopoietic stem cell transplantation for pediatric leukemia. Biol Blood Marrow Transplant 21(1):130–136. https://doi.org/10.1016/j.bbmt.2014.09.027

    Article  PubMed  Google Scholar 

  • Pilat N, Sayegh MH, Wekerle T (2011) Costimulatory pathways in transplantation. Semin Immunol 23(4):293–303. https://doi.org/10.1016/j.smim.2011.04.002

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pilat N, Klaus C, Schwarz C, Hock K, Oberhuber R, Schwaiger E, Gattringer M, Ramsey H, Baranyi U, Zelger B, Brandacher G, Wrba F, Wekerle T (2015) Rapamycin and CTLA4Ig synergize to induce stable mixed chimerism without the need for CD40 blockade. Am J Transplant 15(6):1568–1579. https://doi.org/10.1111/ajt.13154

    Article  CAS  PubMed  Google Scholar 

  • Povoleri GA, Scotta C, Nova-Lamperti EA, John S, Lombardi G, Afzali B (2013) Thymic versus induced regulatory T cells – who regulates the regulators? Front Immunol 4:169. https://doi.org/10.3389/fimmu.2013.00169

    Article  PubMed  PubMed Central  Google Scholar 

  • Povoleri GAM, Nova-Lamperti E, Scotta C, Fanelli G, Chen YC, Becker PD, Boardman D, Costantini B, Romano M, Pavlidis P, McGregor R, Pantazi E, Chauss D, Sun HW, Shih HY, Cousins DJ, Cooper N, Powell N, Kemper C, Pirooznia M, Laurence A, Kordasti S, Kazemian M, Lombardi G, Afzali B (2018) Human retinoic acid-regulated CD161(+) regulatory T cells support wound repair in intestinal mucosa. Nat Immunol 19(12):1403–1414. https://doi.org/10.1038/s41590-018-0230-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Powles RL, Morgenstern GR, Kay HE, McElwain TJ, Clink HM, Dady PJ, Barrett A, Jameson B, Depledge MH, Watson JG, Sloane J, Leigh M, Lumley H, Hedley D, Lawler SD, Filshie J, Robinson B (1983) Mismatched family donors for bone-marrow transplantation as treatment for acute leukaemia. Lancet 1(8325):612–615

    Article  CAS  PubMed  Google Scholar 

  • Raiola AM, Dominietto A, Ghiso A, Di GC, Lamparelli T, Gualandi F, Bregante S, Van Lint MT, Geroldi S, Luchetti S, Ballerini F, Miglino M, Varaldo R, Bacigalupo A (2013) Unmanipulated haploidentical bone marrow transplantation and posttransplantation cyclophosphamide for hematologic malignancies after myeloablative conditioning. Biol Blood Marrow Transplant 19(1):117–122. https://doi.org/10.1016/j.bbmt.2012.08.014

    Article  CAS  PubMed  Google Scholar 

  • Raj K, Pagliuca A, Bradstock K, Noriega V, Potter V, Streetly M, McLornan D, Kazmi M, Marsh J, Kwan J, Huang G, Getzendaner L, Lee S, Guthrie KA, Mufti GJ, O’Donnell P (2014) Peripheral blood hematopoietic stem cells for transplantation of hematological diseases from related, haploidentical donors after reduced-intensity conditioning. Biol Blood Marrow Transplant 20(6):890–895. https://doi.org/10.1016/j.bbmt.2014.03.003

    Article  PubMed  PubMed Central  Google Scholar 

  • Ramsey H, Pilat N, Hock K, Klaus C, Unger L, Schwarz C, Baranyi U, Gattringer M, Schwaiger E, Wrba F, Wekerle T (2013) Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients. Transpl Int 26(2):206–218. https://doi.org/10.1111/tri.12021

    Article  CAS  PubMed  Google Scholar 

  • Rashidi A, DiPersio JF, Westervelt P, Vij R, Schroeder MA, Cashen AF, Fehniger TA, Romee R (2016) Comparison of outcomes after peripheral blood haploidentical versus matched unrelated donor allogeneic hematopoietic cell transplantation in patients with acute myeloid leukemia: a retrospective single-center review. Biol Blood Marrow Transplant 22(9):1696–1701. https://doi.org/10.1016/j.bbmt.2016.05.010

    Article  PubMed  Google Scholar 

  • Reisner Y, Martelli MF (2000) Transplantation tolerance induced by “mega dose” CD34+ cell transplants. Exp Hematol 28(2):119–127

    Article  CAS  PubMed  Google Scholar 

  • Ringden O, Labopin M, Ehninger G, Niederwieser D, Olsson R, Basara N, Finke J, Schwerdtfeger R, Eder M, Bunjes D, Gorin NC, Mohty M, Rocha V (2009) Reduced intensity conditioning compared with myeloablative conditioning using unrelated donor transplants in patients with acute myeloid leukemia. J Clin Oncol 27(27):4570–4577. https://doi.org/10.1200/JCO.2008.20.9692

    Article  PubMed  Google Scholar 

  • Rizzieri DA, Storms R, Chen DF, Long G, Yang Y, Nikcevich DA, Gasparetto C, Horwitz M, Chute J, Sullivan K, Hennig T, Misra D, Apple C, Baker M, Morris A, Green PG, Hasselblad V, Chao NJ (2010) Natural killer cell-enriched donor lymphocyte infusions from a 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation. Biol Blood Marrow Transplant 16(8):1107–1114. https://doi.org/10.1016/j.bbmt.2010.02.018

    Article  PubMed  PubMed Central  Google Scholar 

  • Romee R, Rosario M, Berrien-Elliott MM, Wagner JA, Jewell BA, Schappe T, Leong JW, Abdel-Latif S, Schneider SE, Willey S, Neal CC, Yu L, Oh ST, Lee YS, Mulder A, Claas F, Cooper MA, Fehniger TA (2016) Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia. Sci Transl Med 8(357):357ra123. https://doi.org/10.1126/scitranslmed.aaf2341

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rubin DB, Danish HH, Ali AB, Li K, LaRose S, Monk AD, Cote DJ, Spendley L, Kim AH, Robertson MS, Torre M, Smith TR, Izzy S, Jacobson CA, Lee JW, Vaitkevicius H (2019) Neurological toxicities associated with chimeric antigen receptor T-cell therapy. Brain 142(5):1334–1348. https://doi.org/10.1093/brain/awz053

    Article  PubMed  Google Scholar 

  • Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K, Urbani E, Negrin RS, Martelli MF, Velardi A (1999) Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 94(1):333–339

    Article  CAS  PubMed  Google Scholar 

  • Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, Posati S, Rogaia D, Frassoni F, Aversa F, Martelli MF, Velardi A (2002) Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295(5562):2097–2100. https://doi.org/10.1126/science.1068440

    Article  CAS  PubMed  Google Scholar 

  • Ruggeri L, Urbani E, Andre P, Mancusi A, Tosti A, Topini F, Blery M, Animobono L, Romagne F, Wagtmann N, Velardi A (2016) Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells. Haematologica 101(5):626–633. https://doi.org/10.3324/haematol.2015.135301

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ruggeri A, Labopin M, Savani B, Paviglianiti A, Blaise D, Volt F, Ciceri F, Bacigalupo A, Tischer J, Chevallier P, Koc Y, Cornelissen JJ, Ehninger G, Sanz G, Deconinck E, Rocha V, Baron F, Mohty M, Gluckman E, Nagler A (2019) Hematopoietic stem cell transplantation with unrelated cord blood or haploidentical donor grafts in adult patients with secondary acute myeloid leukemia, a comparative study from Eurocord and the ALWP EBMT. Bone Marrow Transplant. https://doi.org/10.1038/s41409-019-0582-5

  • Sandmaier BM, McSweeney P, Yu C, Storb R (2000) Nonmyeloablative transplants: preclinical and clinical results. Semin Oncol 27(2 Suppl 5):78–81

    CAS  PubMed  Google Scholar 

  • Santos GW, Tutschka PJ, Brookmeyer R, Saral R, Beschorner WE, Bias WB, Braine HG, Burns WH, Elfenbein GJ, Kaizer H et al (1983) Marrow transplantation for acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. N Engl J Med 309(22):1347–1353. https://doi.org/10.1056/NEJM198312013092202

    Article  CAS  PubMed  Google Scholar 

  • Sarkar S, van Gelder M, Noort W, Xu Y, Rouschop KM, Groen R, Schouten HC, Tilanus MG, Germeraad WT, Martens AC, Bos GM, Wieten L (2015) Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A. Cancer Immunol Immunother 64(8):951–963. https://doi.org/10.1007/s00262-015-1694-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schmidt-Wolf IG, Negrin RS, Kiem HP, Blume KG, Weissman IL (1991) Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. J Exp Med 174(1):139–149. https://doi.org/10.1084/jem.174.1.139

    Article  CAS  PubMed  Google Scholar 

  • Schumm M, Lang P, Bethge W, Faul C, Feuchtinger T, Pfeiffer M, Vogel W, Huppert V, Handgretinger R (2013) Depletion of T-cell receptor alpha/beta and CD19 positive cells from apheresis products with the CliniMACS device. Cytotherapy 15(10):1253–1258. https://doi.org/10.1016/j.jcyt.2013.05.014

    Article  CAS  PubMed  Google Scholar 

  • Shaw BE, Logan BR, Spellman SR, Marsh SGE, Robinson J, Pidala J, Hurley C, Barker J, Maiers M, Dehn J, Wang H, Haagenson M, Porter D, Petersdorf EW, Woolfrey A, Horowitz MM, Verneris M, Hsu KC, Fleischhauer K, Lee SJ (2018) Development of an unrelated donor selection score predictive of survival after HCT: donor age matters most. Biol Blood Marrow Transplant 24(5):1049–1056. https://doi.org/10.1016/j.bbmt.2018.02.006

    Article  PubMed  PubMed Central  Google Scholar 

  • Shouval R, Fein JA, Labopin M, Kroger N, Duarte RF, Bader P, Chabannon C, Kuball J, Basak GW, Dufour C, Galimard JE, Polge E, Lankester A, Montoto S, Snowden JA, Styczynski J, Yakoub-Agha I, Mohty M, Nagler A (2019) Outcomes of allogeneic haematopoietic stem cell transplantation from HLA-matched and alternative donors: a European Society for Blood and Marrow Transplantation registry retrospective analysis. Lancet Haematol 6(11):e573–e584. https://doi.org/10.1016/S2352-3026(19)30158-9

    Article  PubMed  Google Scholar 

  • Slavin S, Morecki S, Weiss L, Shapira MY, Resnick I, Or R (2004) Nonmyeloablative stem cell transplantation: reduced-intensity conditioning for cancer immunotherapy – from bench to patient bedside. Semin Oncol 31(1):4–21

    Article  PubMed  Google Scholar 

  • Sodani P, Isgro A, Gaziev J, Polchi P, Paciaroni K, Marziali M, Simone MD, Roveda A, Montuoro A, Alfieri C, De Angelis G, Gallucci C, Erer B, Isacchi G, Zinno F, Adorno G, Lanti A, Faulkner L, Testi M, Andreani M, Lucarelli G (2010) Purified T-depleted, CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia. Blood 115(6):1296–1302. https://doi.org/10.1182/blood-2009-05-218982

    Article  CAS  PubMed  Google Scholar 

  • Solomon SR, Aubrey MT, Zhang X, Piluso A, Freed BM, Brown S, Jackson KC, Morris LE, Holland HK, Solh MM, Bashey A (2018) Selecting the best donor for haploidentical transplant: impact of HLA, killer cell immunoglobulin-like receptor genotyping, and other clinical variables. Biol Blood Marrow Transplant 24(4):789–798. https://doi.org/10.1016/j.bbmt.2018.01.013

    Article  CAS  PubMed  Google Scholar 

  • Stern M, Ruggeri L, Mancusi A, Bernardo ME, de Angelis C, Bucher C, Locatelli F, Aversa F, Velardi A (2008) Survival after T cell-depleted haploidentical stem cell transplantation is improved using the mother as donor. Blood 112(7):2990–2995. https://doi.org/10.1182/blood-2008-01-135285

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Storb R, Yu C, Zaucha JM, Deeg HJ, Georges G, Kiem HP, Nash RA, McSweeney PA, Wagner JL (1999) Stable mixed hematopoietic chimerism in dogs given donor antigen, CTLA4Ig, and 100 cGy total body irradiation before and pharmacologic immunosuppression after marrow transplant. Blood 94(7):2523–2529

    Article  CAS  PubMed  Google Scholar 

  • Symons HJ, Leffell MS, Rossiter ND, Zahurak M, Jones RJ, Fuchs EJ (2010) Improved survival with inhibitory killer immunoglobulin receptor (KIR) gene mismatches and KIR haplotype B donors after nonmyeloablative, HLA-haploidentical bone marrow transplantation. Biol Blood Marrow Transplant 16(4):533–542. https://doi.org/10.1016/j.bbmt.2009.11.022

    Article  PubMed  Google Scholar 

  • Takagi S, Masuoka K, Uchida N, Ishiwata K, Araoka H, Tsuji M, Yamamoto H, Kato D, Matsuhashi Y, Kusumi E, Ota Y, Seo S, Matsumura T, Matsuno N, Wake A, Miyakoshi S, Makino S, Ohashi K, Yoneyama A, Taniguchi S (2009) High incidence of haemophagocytic syndrome following umbilical cord blood transplantation for adults. Br J Haematol 147(4):543–553. https://doi.org/10.1111/j.1365-2141.2009.07863.x

    Article  PubMed  Google Scholar 

  • Thakar MS, Bonfim C, Sandmaier BM, O’Donnell P, Ribeiro L, Gooley T, Deeg HJ, Flowers ME, Pasquini R, Storb R, Woolfrey AE, Kiem HP (2012) Cyclophosphamide-based in vivo T-cell depletion for HLA-haploidentical transplantation in Fanconi anemia. Pediatr Hematol Oncol 29(6):568–578. https://doi.org/10.3109/08880018.2012.708708

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Thomas ED (1999) A history of haemopoietic cell transplantation. Br J Haematol 105(2):330–339. https://doi.org/10.1111/j.1365-2141.1999.01337.x

    Article  CAS  PubMed  Google Scholar 

  • Thomas ED, Plain GL, Cavins JA, Blumenstock DA (1964) Leukokinetics in dogs given supralethal irradiation with or without a graft of marrow. Ann N Y Acad Sci 113:1020–1032

    Article  CAS  PubMed  Google Scholar 

  • Thomas ED, Storb R, Clift RA, Fefer A, Johnson L, Neiman PE, Lerner KG, Glucksberg H, Buckner CD (1975) Bone-marrow transplantation (second of two parts). N Engl J Med 292(17):895–902. https://doi.org/10.1056/NEJM197504242921706

    Article  CAS  PubMed  Google Scholar 

  • Triplett BM, Shook DR, Eldridge P, Li Y, Kang G, Dallas M, Hartford C, Srinivasan A, Chan WK, Suwannasaen D, Inaba H, Merchant TE, Pui CH, Leung W (2015) Rapid memory T-cell reconstitution recapitulating CD45RA-depleted haploidentical transplant graft content in patients with hematologic malignancies. Bone Marrow Transplant 50(7):968–977. https://doi.org/10.1038/bmt.2014.324

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Triplett BM, Muller B, Kang G, Li Y, Cross SJ, Moen J, Cunningham L, Janssen W, Mamcarz E, Shook DR, Srinivasan A, Choi J, Hayden RT, Leung W (2018) Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared with CD3-targeted T-cell depletion. Transpl Infect Dis 20(1). https://doi.org/10.1111/tid.12823

  • Uppuluri R, Jayaraman D, Sivasankaran M, Patel S, Swaminathan VV, Vaidhyanathan L, Kandath S, Raj R (2018) Hematopoietic stem cell transplantation for primary immunodeficiency disorders: experience from a referral center in India. Indian Pediatr 55(8):661–664

    Article  PubMed  Google Scholar 

  • van Rood JJ, Claas F (2000) Noninherited maternal HLA antigens: a proposal to elucidate their role in the immune response. Hum Immunol 61(12):1390–1394. https://doi.org/10.1016/s0198-8859(00)00211-1

    Article  PubMed  Google Scholar 

  • Vermylen C, Cornu G, Ferster A, Brichard B, Ninane J, Ferrant A, Zenebergh A, Maes P, Dhooge C, Benoit Y, Beguin Y, Dresse MF, Sariban E (1998) Haematopoietic stem cell transplantation for sickle cell anaemia: the first 50 patients transplanted in Belgium. Bone Marrow Transplant 22(1):1–6. https://doi.org/10.1038/sj.bmt.1701291

    Article  CAS  PubMed  Google Scholar 

  • Vinchi F, Costa da Silva M, Ingoglia G, Petrillo S, Brinkman N, Zuercher A, Cerwenka A, Tolosano E, Muckenthaler MU (2016) Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease. Blood 127(4):473–486. https://doi.org/10.1182/blood-2015-08-663245

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wagner JA, Rosario M, Romee R, Berrien-Elliott MM, Schneider SE, Leong JW, Sullivan RP, Jewell BA, Becker-Hapak M, Schappe T, Abdel-Latif S, Ireland AR, Jaishankar D, King JA, Vij R, Clement D, Goodridge J, Malmberg KJ, Wong HC, Fehniger TA (2017) CD56bright NK cells exhibit potent antitumor responses following IL-15 priming. J Clin Invest 127(11):4042–4058. https://doi.org/10.1172/JCI90387

    Article  PubMed  PubMed Central  Google Scholar 

  • Walters MC, Patience M, Leisenring W, Eckman JR, Scott JP, Mentzer WC, Davies SC, Ohene-Frempong K, Bernaudin F, Matthews DC, Storb R, Sullivan KM (1996) Bone marrow transplantation for sickle cell disease. N Engl J Med 335(6):369–376. https://doi.org/10.1056/NEJM199608083350601

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Liu DH, Xu LP, Liu KY, Chen H, Zhang XH, Chen YH, Han W, Wang FR, Wang JZ, Yan CH, Huang XJ (2012) Prevention of relapse using granulocyte CSF-primed PBPCs following HLA-mismatched/haploidentical, T-cell-replete hematopoietic SCT in patients with advanced-stage acute leukemia: a retrospective risk-factor analysis. Bone Marrow Transplant 47(8):1099–1104. https://doi.org/10.1038/bmt.2011.213

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Chang YJ, Xu LP, Liu KY, Liu DH, Zhang XH, Chen H, Han W, Chen YH, Wang FR, Wang JZ, Chen Y, Yan CH, Huo MR, Li D, Huang XJ (2014) Who is the best donor for a related HLA haplotype-mismatched transplant? Blood 124(6):843–850. https://doi.org/10.1182/blood-2014-03-563130

    Article  CAS  PubMed  Google Scholar 

  • Wang Y, Wu DP, Liu QF, Xu LP, Liu KY, Zhang XH, Xu Y, Huang F, Huang XJ (2018) Donor and recipient age, gender and ABO incompatibility regardless of donor source: validated criteria for donor selection for haematopoietic transplants. Leukemia 32(2):492–498. https://doi.org/10.1038/leu.2017.199

    Article  CAS  PubMed  Google Scholar 

  • Wekerle T, Kurtz J, Bigenzahn S, Takeuchi Y, Sykes M (2002) Mechanisms of transplant tolerance induction using costimulatory blockade. Curr Opin Immunol 14(5):592–600

    Article  CAS  PubMed  Google Scholar 

  • Xu LP, Jin S, Wang SQ, Xia LH, Bai H, Gao SJ, Liu QF, Wang JM, Wang X, Jiang M, Zhang X, Wu DP, Huang XJ (2017) Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant. J Hematol Oncol 10(1):25. https://doi.org/10.1186/s13045-017-0398-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang S, Yuan X, Ma R, Jiang L, Guo J, Zang Y, Shi J, Yang J, Lei P, Liu Z, Zhang Y, Zhu Z (2019) Comparison of outcomes of frontline immunosuppressive therapy and frontline haploidentical hematopoietic stem cell transplantation for children with severe aplastic anemia who lack an HLA-matched sibling donor. Biol Blood Marrow Transplant 25(5):975–980. https://doi.org/10.1016/j.bbmt.2019.01.017

    Article  PubMed  Google Scholar 

  • Yoshihara S, Li Y, Xia J, Danzl N, Sykes M, Yang YG (2019) Posttransplant hemophagocytic lymphohistiocytosis driven by myeloid cytokines and vicious cycles of T-cell and macrophage activation in humanized mice. Front Immunol 10:186. https://doi.org/10.3389/fimmu.2019.00186

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zecca M, Strocchio L, Pagliara D, Comoli P, Bertaina A, Giorgiani G, Perotti C, Corbella F, Brescia L, Locatelli F (2014) HLA-haploidentical T cell-depleted allogeneic hematopoietic stem cell transplantation in children with Fanconi anemia. Biol Blood Marrow Transplant 20(4):571–576. https://doi.org/10.1016/j.bbmt.2014.01.015

    Article  CAS  PubMed  Google Scholar 

  • Zenclussen AC (2013) Adaptive immune responses during pregnancy. Am J Reprod Immunol 69(4):291–303. https://doi.org/10.1111/aji.12097

    Article  CAS  PubMed  Google Scholar 

  • Zenclussen AC, Gerlof K, Zenclussen ML, Sollwedel A, Bertoja AZ, Ritter T, Kotsch K, Leber J, Volk HD (2005) Abnormal T-cell reactivity against paternal antigens in spontaneous abortion: adoptive transfer of pregnancy-induced CD4+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model. Am J Pathol 166(3):811–822. https://doi.org/10.1016/S0002-9440(10)62302-4

    Article  PubMed  PubMed Central  Google Scholar 

  • Zenclussen AC, Gerlof K, Zenclussen ML, Ritschel S, Zambon Bertoja A, Fest S, Hontsu S, Ueha S, Matsushima K, Leber J, Volk HD (2006) Regulatory T cells induce a privileged tolerant microenvironment at the fetal-maternal interface. Eur J Immunol 36(1):82–94. https://doi.org/10.1002/eji.200535428

    Article  CAS  PubMed  Google Scholar 

  • Zenclussen AC, Schumacher A, Zenclussen ML, Wafula P, Volk HD (2007) Immunology of pregnancy: cellular mechanisms allowing fetal survival within the maternal uterus. Expert Rev Mol Med 9(10):1–14. https://doi.org/10.1017/S1462399407000294

    Article  PubMed  Google Scholar 

  • Zhao JX, Zeng YY, Liu Y (2007) Fetal alloantigen is responsible for the expansion of the CD4(+)CD25(+) regulatory T cell pool during pregnancy. J Reprod Immunol 75(2):71–81. https://doi.org/10.1016/j.jri.2007.06.052

    Article  CAS  PubMed  Google Scholar 

  • Zheng Y, Josefowicz S, Chaudhry A, Peng XP, Forbush K, Rudensky AY (2010) Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463(7282):808–812. https://doi.org/10.1038/nature08750

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cellular Therapy and Immunology, Manashi Chakrabarti Foundation, Kolkata, India

    Suparno Chakrabarti & Sarita Rani Jaiswal

  2. Department of Blood and Marrow Transplantation, Dharamshila Narayana Superspeciality Hospital and Research Centre, New Delhi, India

    Suparno Chakrabarti & Sarita Rani Jaiswal

Authors
  1. Suparno Chakrabarti
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sarita Rani Jaiswal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Suparno Chakrabarti .

Editor information

Editors and Affiliations

  1. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Mammen Chandy

  2. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Vivek S. Radhakrishnan

  3. Department of Pediatric Hematology-Oncology, Tata Medical Center, Kolkata, India

    Reghu K. Sukumaran

Section Editor information

  1. Tata Medical Center, Kolkata, India

    Vivek Radhakrishnan

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Chakrabarti, S., Jaiswal, S.R. (2021). Haploidentical Transplantation: Challenges and Solutions. In: Chandy, M., Radhakrishnan, V.S., Sukumaran, R.K. (eds) Contemporary Bone Marrow Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-36358-1_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-36358-1_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-36357-4

  • Online ISBN: 978-3-030-36358-1

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation