Skip to main content

Nanotechnology in Medicine

  • Chapter
  • First Online:
Biotechnology Business - Concept to Delivery

Part of the book series: EcoProduction ((ECOPROD))

Abstract

Nanotechnology is at the frontier of medicine. It plays a critical role in expanding diversity and reach of the drug or drug-like molecules in patients. Nanoparticles act as a protected transport vehicle for hydrophobic drugs or therapeutics such as mRNA, siRNA, and DNA which are normally not bioavailable. In this chapter, we review the different kinds of non-viral nanocarriers that are being employed in modern-day medicine. We also discuss the challenges to effective delivery and function of these particles as well as their application in various aspects of disease treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Akinc A, Battaglia G (2013) Cold Spring Harb Perspect Biol 5

    Google Scholar 

  • Amiji MM, Vyas TK, Shah LK (2009) Discov Med 6:157–162

    Google Scholar 

  • Aquaro S, Caliò R, Balzarini J, Bellocchi MC, Garaci E, Perno CF (2002) Antiviral Res 55:209–225

    Google Scholar 

  • Autio KA, Dreicer R, Anderson J, Garcia JA, Alva A, Hart LL, Milowsky MI, Posadas EM, Ryan CJ, Graf RP, Dittamore R, Schreiber NA, Summa JM, Youssoufian H, Morris MJ, Scher HI (2018) JAMA Oncol 4:1344–1351

    Article  Google Scholar 

  • Babu A, Muralidharan R, Amreddy N, Mehta M, Munshi A, Ramesh R (2016) IEEE Trans Nanobiosci 15:849–863

    Article  Google Scholar 

  • Barenholz YC (2012) J Controlled Release 160:117–134

    Google Scholar 

  • Bender AR, Briesen HV, Kreuter J, Duncan IB, Rübsamen-Waigmann H (1996) Antimicrob Agents Chemother 40:1467–1471

    Google Scholar 

  • Benson ML, Thomson RG, Valli VE (1978) Can J Comp Med 42:368–369

    CAS  Google Scholar 

  • Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G (2016) Sci Rep 6:31750

    Article  CAS  Google Scholar 

  • Chen Y, Zhu X, Zhang X, Liu B, Huang L (2010) Mol Ther 18:1650–1656

    Google Scholar 

  • Conner SD, Schmid SL (2003) Nature 422:37–44

    Article  CAS  Google Scholar 

  • De S, Kuwahara S, Saito A (2014) Membranes (Basel) 4:333–355

    Article  Google Scholar 

  • Diamantis N, Banerji U (2016) Br J Cancer 114:362–367

    Article  CAS  Google Scholar 

  • Doherty GJ, McMahon HT (2009) Annu Rev Biochem 78:857–902

    Article  CAS  Google Scholar 

  • Ducry L, Stump B (2010) Bioconjugate Chem 21:5–13

    Google Scholar 

  • Eltoukhy AA, Sahay G, Cunningham JM, Anderson DG (2014) ACS Nano 8:7905–7913

    Article  CAS  Google Scholar 

  • Feng C, Wang T, Zhang Y, Qu K, Tang S (2017) Am J Med Sci 354:506–512

    Google Scholar 

  • Futerman AH, van Meer G (2004) Nat Rev Mol Cell Biol 5:554–565

    Article  CAS  Google Scholar 

  • Garnacho C, Dhami R, Simone E, Dziubla T, Leferovich J, Schuchman EH, Muzykantov V, Muro S (2008) J Pharmacol Exp Ther 325:400–408

    Article  CAS  Google Scholar 

  • Gillespie DL, Aguirre MT, Ravichandran S, Leishman LL, Berrondo C, Gamboa JT, Wang L, King R, Wang X, Tan M, Malamas A, Lu Z-R, Jensen RL (2015) J Neurosurg 122:331–341

    Google Scholar 

  • Hoff DDV, Mita MM, Ramanathan RK, Weiss GJ, Mita AC, LoRusso PM, Burris HA, Hart LL, Low SC, Parsons DM, Zale SE, Summa JM, Youssoufian H, Sachdev JC (2016) Clin Cancer Res 22:3157–3163

    Google Scholar 

  • Hsu J, Serrano D, Bhowmick T, Kumar K, Shen Y, Kuo YC, Garnacho C, Muro S (2011) J Control Release 149:323–331

    Google Scholar 

  • Hsu J, Northrup L, Bhowmick T, Muro S (2012) Nanomedicine 8:731–739

    Google Scholar 

  • Huang SK, Mayhew E, Gilani S, Lasic DD, Martin FJ, Papahadjopoulos D (1992) Cancer Res 52:6774–6781

    Google Scholar 

  • Ikonen E (2008) Nat Rev Mol Cell Biol 9:125–138

    Article  CAS  Google Scholar 

  • Kosicek M, Gudelj I, Horvatic A, Jovic T, Vuckovic F, Lauc G, Hecimovic S (2018) Mol Cell Proteomics 17:631–642

    Article  CAS  Google Scholar 

  • Lahtinen U, Honsho M, Parton RG, Simons K, Verkade P (2003) FEBS Lett 538:85–88

    Google Scholar 

  • Lorusso PM, Edelman MJ, Bever SL, Forman KM, Pilat M, Quinn MF, Li J, Heath EI, Malburg LM, Klein PJ, Leamon CP, Messmann RA, Sausville EA (2012) J Clin Oncol Official J Am Soc Clin Oncol 30:4011–4016

    Google Scholar 

  • Minelli C, Lowe SB, Stevens MM (2010) Small 6:2336–2357

    Article  CAS  Google Scholar 

  • Minshall RD, Tiruppathi C, Vogel SM, Niles WD, Gilchrist A, Hamm HE, Malik AB (2000) J Cell Biol 150:1057–1070

    Google Scholar 

  • Muggia FM, Hainsworth JD, Jeffers S, Miller P, Groshen S, Tan M, Roman L, Uziely B, Muderspach L, Garcia A, Burnett A, Greco FA, Morrow CP, Paradiso LJ, Liang LJ (1997) J Clin Oncol 15:987–993

    Google Scholar 

  • Muro S, Wiewrodt R, Thomas A, Koniaris L, Albelda SM, Muzykantov VR, Koval M (2003) J Cell Sci 116:1599–1609

    Google Scholar 

  • Muro S, Gajewski C, Koval M, Muzykantov VR (2005) Blood 105:650–658

    Article  CAS  Google Scholar 

  • Nabhan C, Tallman MS (2002) Clin Lymphoma 2(Suppl 1)S19–S23

    Google Scholar 

  • Northfelt DW, Martin FJ, Working P, Volberding PA, Russell J, Newman M, Amantea MA, Kaplan LD (1996) J Clin Pharmacol 36:55–63

    Google Scholar 

  • Oh P, Borgstrom P, Witkiewicz H, Li Y, Borgstrom BJ, Chrastina A, Iwata K, Zinn KR, Baldwin R, Testa JE, Schnitzer JE (2007) Nat Biotechnol 25:327–337

    Article  CAS  Google Scholar 

  • Olsen E, Duvic M, Frankel A, Kim Y, Martin A, Vonderheid E, Jegasothy B, Wood G, Gordon M, Heald P, Oseroff A, Pinter-Brown L, Bowen G, Kuzel T, Fivenson D, Foss F, Glode M, Molina A, Knobler E, Stewart S, Cooper K, Stevens S, Craig F, Reuben J, Bacha P, Nichols J (2001) J Clin Oncol Official J Am Soc Clin Oncol 19:376–388

    Google Scholar 

  • Ramesh R, Saeki T, Smyth Templeton N, Ji L, Stephens LC, Ito I, Wilson DR, Wu Z, Branch CD, Minna JD, Roth JA (2001) Mol Therapy 3:337–350

    Google Scholar 

  • Ramesh R, Ito I, Saito Y, Wu Z, Mhashikar AM, Wilson DR, Branch CD, Roth JA, Chada S (2004) DNA Cell Biol 23:850–857

    Google Scholar 

  • Rappaport J, Garnacho C, Muro S (2014) Mol Pharm 11:2887–2895

    Article  CAS  Google Scholar 

  • Sahay G, Alakhova DY, Kabanov AV (2010) J Control Release 145:182–195

    Article  CAS  Google Scholar 

  • Sahay G, Querbes W, Alabi C, Eltoukhy A, Sarkar S, Zurenko C, Karagiannis E, Love K, Chen D, Zoncu R, Buganim Y, Schroeder A, Langer R, Anderson DG (2013) Nat Biotechnol 31:653–658

    Article  CAS  Google Scholar 

  • Sakakibara T, Chen F-A, Kida H, Kunieda K, Cuenca RE, Martin FJ, Bankert RB (1996) Cancer Res 56:3743–3746

    Google Scholar 

  • Schmid B, Chung D-E, Warnecke A, Fichtner I, Kratz F (2007) Bioconjug Chem 18:702–716

    Google Scholar 

  • Shah LK, Amiji MM (2006) Pharm Res 23:2638–2645

    Article  CAS  Google Scholar 

  • Stürzl M, Zietz C, Eisenburg B, Goebel F-D, Gillitzer R, Hofschneider PH, Bogner JR (1994) Res Virol 145:261–269

    Google Scholar 

  • Svenson S, Tomalia DA (2005) Adv Drug Deliv Rev 57:2106–2129

    Article  CAS  Google Scholar 

  • Tai IT, Tang MJ (2008) Drug Resist Updates 11:231–246

    Google Scholar 

  • Tharkeshwar AK, Trekker J, Vermeire W, Pauwels J, Sannerud R, Priestman DA, Te Vruchte D, Vints K, Baatsen P, Decuypere JP, Lu H, Martin S, Vangheluwe P, Swinnen JV, Lagae L, Impens F, Platt FM, Gevaert K, Annaert W (2017) Sci Rep 7:41408

    Google Scholar 

  • Tiruppathi C, Song W, Bergenfeldt M, Sass P, Malik AB (1997) J Biol Chem 272:25968–25975

    Google Scholar 

  • Torchilin VP (2005) Nat Rev Drug Discov 4:145–160

    Article  CAS  Google Scholar 

  • Unezaki S, Maruyama K, Ishida O, Suginaka A, Hosoda J-I, Iwatsuru M (1995) Int J Pharm 126:41–48

    Google Scholar 

  • Vaage J, Donovan D, Uster P, Working P (1997) Br J Cancer 75:482–486

    Article  CAS  Google Scholar 

  • Vaishnaw AK, Gollob J, Gamba-Vitalo C, Hutabarat R, Sah D, Meyers R, de Fougerolles T, Maraganore J (2010) Silence 1:14

    Article  Google Scholar 

  • Vanier MT (2010) Orphanet J Rare Dis 5:16

    Google Scholar 

  • Varkouhi AK, Scholte M, Storm G, Haisma HJ (2011) J Control Release 151:220–228

    Article  CAS  Google Scholar 

  • Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh D-Y, Diéras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K, E. S. Group (2012) New Eng J Med 367:1783–1791

    Google Scholar 

  • Vogel U, Sandvig K, van Deurs B (1998) J Cell Sci 111(Pt 6):825–832

    Google Scholar 

  • Wang AZ, Gu F, Zhang L, Chan JM, Radovic-Moreno A, Shaikh MR, Farokhzad OC (2008) Expert Opin Biol Ther 8:1063–1070

    Article  CAS  Google Scholar 

  • Younes A, Bartlett NL, Leonard JP, Kennedy DA, Lynch CM, Sievers EL, Forero-Torres A (2010) New Eng J Med 363:1812–1821

    Google Scholar 

  • Young SWS, Stenzel M, Jia-Lin Y (2016) Crit Rev Oncol/Hematol 98:159–169

    Google Scholar 

  • Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC (2008) Clin Pharmacol Ther 83:761–769

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anindit Mukherjee .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Mukherjee, A., Bhattacharyya, S. (2020). Nanotechnology in Medicine. In: Saxena, A. (eds) Biotechnology Business - Concept to Delivery. EcoProduction. Springer, Cham. https://doi.org/10.1007/978-3-030-36130-3_3

Download citation

Publish with us

Policies and ethics