Abstract
The present chapter describes the field of biotechnology from earliest known mention till modern-day developments. The introduction throws light on understanding the practice of using microorganisms for making food since prehistoric times and covers aspects on key discoveries in recent past like vaccines and drugs. The section journeys through important seminal contributions that laid the foundation of many branches of biotechnology which would eventually be applied for the benefit of the population. The gradual advancement in the field of knowledge about life, its complexities and processes governing these led to the generation of medicines, diagnostic tests, industrially important materials and environmentally sustainable products in future years. Biotechnology can be classified based on the broad spectrum of deliverables it caters to the society. Starting with the healthcare, which constitutes red biotechnology, the text details significant discoveries and inventions that have greatly enhanced biomedical research. Green biotechnology, mentions important methods which have been applied in the field of crop and livestock improvement to ensure food security. Blue biotechnology, an emerging area enlists and highlights important marine genetic resources which are being adapted for various demands of global economy. Finally, the last section details the application of biotechnology in the field of industry and environment for the generation of better raw materials and its clean-up, respectively.
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References
Aizpurua-Olaizola O, Navarro P et al (2016) Microencapsulation and storage stability of polyphenols from Vitis vinifera grape wastes. Food Chem 190:614–621
Aldridge S (1999) The Discovery and Development of Penicillin 1928–1945: The Alexander Fleming Laboratory Museum, London, UK, November 19, 1999: an International Historic Chemical Landmark, American Chemical Society and Royal Society of Chemistry
Anderson NL, Anderson NG (1998) Proteome and proteomics: new technologies, new concepts, and new words. Electrophoresis 19(11):1853–1861
Andre G, Pellegrini M, Pellegrini L (2002) Cosmetic or dermatological compositions especially useful as antiaging and antiwrinkle products comprise extracts of Ascophyllum and Helopteris seaweeds. I. N. D. L. P. Industrielle, France
Aoi T, Yae K et al (2008) Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 321(5889):699–702
Aranovich D, Lewinsohn E, Zaccai M (2007) Post-harvest enhancement of aroma in transgenic lisianthus (Eustoma grandiflorum) using the Clarkia breweri benzyl alcohol acetyl transferase (BEAT) gene. Postharvest Biol Biotechnol 43(2):255–260
Arber W, Linn S (1969) DNA modification and restriction. Annu Rev Biochem 38:467–500
Arrieta JM, Arnaud-Haond S et al (2010) What lies underneath: conserving the oceans’ genetic resources. Proc Natl Acad Sci U S A 107(43):18318–18324
Banerjee A, Sharma R et al (2002) Botryococcus braunii: a renewable source of hydrocarbons and other chemicals. Crit Rev Biotechnol 22(3):245–279
Banjara M, Zhu L, Shen G et al (2012) Expression of an Arabidopsis sodium/proton antiporter gene (AtNHX1) in peanut to improve salt tolerance. Plant Biotechnol Rep 6(1)
Barghouthi SA (2011) A universal method for the identification of bacteria based on general PCR primers. Indian J Microbiol 51(4):430–444
Barnett JA (2003) Beginnings of microbiology and biochemistry: the contribution of yeast research. Microbiology 149(Pt 3):557–567
Bartlett JM, Stirling D (2003) A short history of the polymerase chain reaction. Methods Mol Biol 226:3–6
Belakova J, Horynova M et al (2007) DNA vaccines: are they still just a powerful tool for the future? Arch Immunol Ther Exp (Warsz) 55(6):387–398
Benn CS, Netea MG et al (2013) A small jab—a big effect: nonspecific immunomodulation by vaccines. Trends Immunol 34(9):431–439
Blunt JW, Copp BR et al (2013) Marine natural products. Nat Prod Rep 30(2):237–323
Boyhan D, Daniell H (2011) Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide. Plant Biotechnol J 9(5):585–598
Brown M, Wittwer C (2000) Flow cytometry: principles and clinical applications in hematology. Clin Chem 46(8 Pt 2):1221–1229
Bud R (1993) The uses of life: a history of biotechnology. Cambridge University Press, Cambridge; New York
Bull, A. T., Holt, G., and Lilly, M. D. (1982). Biotechnology: International Trends and Perspectives. Organisation for Economic Co-Operation and Development, Paris.
Bullis K (2010) Biofuels from saltwater crops. from https://www.technologyreview.com/s/417390/biofuels-from-saltwater-crops/. 5 Feb 2010
CDC (2017) National diabetes statistics report. C. f. D. C. a. Prevention, National Institute of Diabetes and Digestive and Kidney Diseases (NIH): 20
Chagastelles PC, Nardi NB (2011) Biology of stem cells: an overview. Kidney Int Suppl (2011) 1(3): 63–67
Chiang JL, Kirkman MS et al (2014) Type 1 diabetes through the life span: a position statement of the American Diabetes Association. Diabetes Care 37(7):2034–2054
Choi T, Huang M et al (1991) A generic intron increases gene expression in transgenic mice. Mol Cell Biol 11(6):3070–3074
Clive J (2015) Executive summary: ISAAA Brief 46-2013. I. S. f. t. A. o. A.-B. Applications, ISAAA
Cole RD (1996) Choh Hao Li: April 21, 1913—November 28, 1987. Biogr Mem Natl Acad Sci 70:221–239
Collins MW, Bryant JA et al (2007) Design and information in biology: from molecules to systems. WIT Press, Southampton, UK; Boston
Consortium TWTCC (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447(7145):661–678
Convention on Biological Diversity (1992).
Crick FHC, Watson JD (1954) The complementary structure of deoxyribonucleic acid. Proc R Soc Lond A 223(1152)
Culver KW, Morgan RA et al (1990) In vivo expression and survival of gene-modified T lymphocytes in rhesus monkeys. Hum Gene Ther 1(4):399–410
Cyranoski D, Reardon S (2015) Embryo editing sparks epic debate. Nat News 520(7549):593–595
D’Amour KA, Bang AG et al (2006) Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 24(11):1392–1401
Danna K, Nathans D (1971) Specific cleavage of simian virus 40 DNA by restriction endonuclease of Hemophilus influenzae. Proc Natl Acad Sci U S A 68(12):2913–2917
Das S, Pingle MR et al (2008) Detection and serotyping of dengue virus in serum samples by multiplex reverse transcriptase PCR-ligase detection reaction assay. J Clin Microbiol 46(10):3276–3284
DaSilva E (2004) The colours of biotechnology: science, development and humankind. Electron J Biotechnol 7(3)
Daston L, Lunbeck E (2011) Histories of scientific observation. University of Chicago Press, Chicago
Doughman SD, Krupanidhi S et al (2007) Omega-3 fatty acids for nutrition and medicine: considering microalgae oil as a vegetarian source of EPA and DHA. Curr Diabetes Rev 3(3):198–203
Eaves CJ (2015) Hematopoietic stem cells: concepts, definitions, and the new reality. Blood 125(17):2605–2613
ECORYS (2014) Study in support of impact assessment work on blue biotechnology. ECORYS, London/Berlin/Brussels/Rotterdam
Edward Jenner (1749–1823) History
Edwards J (1999) Why dolly matters: kinship, culture and cloning. Ethnos 64(3–4):301–324
EIA U (2018) Biofuels: ethanol and biodiesel explained. From https://www.eia.gov/energyexplained/index.cfm?page=biofuel_home. 8 Aug 2018
ERA-NET, EMB, MB (2017) Marine biotechnology: advancing innovation in Europe’s bioeconomy. European Marine Board (EMB), Oostende, Belgium
Erickson B (2009) FDA approves drug from transgenic goat milk. Chemical and Engineering News. American Chemical Society, Washington, DC
Ernst HC (2014) On the extension of the germ theory to the etiology of certain common diseases. University of Adelaide, South Australia
Fiechter ABT (2000) History of modern biotechnology. Springer Science & Business Media, Berlin
Frazzetto G (2003) White biotechnology. EMBO Rep 4(9):835–837
Friedmann T, Roblin R (1972) Gene therapy for human genetic disease? Science 175(4025):949–955
Gasiunas G, Barrangou R et al (2012) Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci U S A 109(39):E2579–E2586
Gaynes R (2017) The discovery of penicillin—new insights after more than 75 years of clinical use. Emerg Infect Dis 23(5):5
Genentech (1993) Genentech receives FDA approval to market Nutropin for growth failure due to chronic renal insufficiency. Press Release, from https://www.gene.com/media/press-releases/4393/1993-11-17/genentech-receives-fda-approval-to-marke
Gerstein MB, Bruce C et al (2007) What is a gene, post-ENCODE? History and updated definition. Genome Res 17(6):669–681
Gilbert DA, Reid YA et al (1990) Application of DNA fingerprints for cell-line individualization. Am J Hum Genet 47(3):499–514
Goncalves GAR, Paiva RMA (2017) Gene therapy: advances, challenges and perspectives. Einstein (Sao Paulo) 15(3):369–375
Good RA, Meuwissen HJ et al (1969) Bone marrow transplantation: correction of immune deficit in lymphopenic immunologic deficiency and correction of an immunologically induced pancytopenia. Trans Assoc Am Physicians 82:278–285
Gros F (1992) The gene civilization. McGraw Hill, New York
Guionet A, Hosseini B et al (2017) A new mechanism for efficient hydrocarbon electro-extraction from Botryococcus braunii. Biotechnol Biofuels 10(1):39
Haines JL, Hauser MA et al (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308(5720):419–421
Halley PJ, Avérous L (2014) Starch polymers: from genetic engineering to green applications
Helden AV (2010) The origins of the telescope. Amsterdam University Press
Heux S, Meynial-Salles I et al (2015) White biotechnology: state of the art strategies for the development of biocatalysts for biorefining. Biotechnol Adv 33(8):1653–1670
Hicks DG, Tubbs RR (2005) Assessment of the HER2 status in breast cancer by fluorescence in situ hybridization: a technical review with interpretive guidelines. Hum Pathol 36(3):250–261
Hicks DJ, Fooks AR et al (2012) Developments in rabies vaccines. Clin Exp Immunol 169(3):199–204
Hill D, Sugrue I et al (2017) Recent advances in microbial fermentation for dairy and health. F1000Res 6:751
Hirschhorn R, Vawter GF et al (1979) Adenosine deaminase deficiency: frequency and comparative pathology in autosomally recessive severe combined immunodeficiency. Clin Immunol Immunopathol 14(1):107–120
Hsu PD, Lander ES et al (2014) Development and applications of CRISPR-Cas9 for genome engineering. Cell 157(6):1262–1278
Hu W, Kaminski R et al (2014) RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection. Proc Natl Acad Sci U S A 111(31):11461–11466
Hughes SS (2011) Genentech: the beginnings of biotech. University of Chicago Press, Chicago; London
Ishino Y, Shinagawa H et al (1987) Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol 169(12):5429–5433
Ivancevic TD, Kurtovic NK et al (2014) The role of immunophenotyping in differential diagnosis of chronic lymphocytic leukemia. Srp Arh Celok Lek 142(3–4):197–203
Jakab K, Gopcsa L et al (2005) Application of flow cytometry immunophenotyping and multidrug resistance assay in B-cell acute lymphoid leukemia and multiple myeloma. Neoplasma 52(1):36–42
Jansen R, Embden JD et al (2002) Identification of genes that are associated with DNA repeats in prokaryotes. Mol Microbiol 43(6):1565–1575
Jinek M, Chylinski K et al (2012) A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337(6096):816–821
Kafarski P (2012) Rainbow code of biotechnology. CHEMIK 66(8):811–816
Keating GM, Noble S (2003) Recombinant hepatitis B vaccine (Engerix-B): a review of its immunogenicity and protective efficacy against hepatitis B. Drugs 63(10):1021–1051
Kogler G, Sensken S et al (2004) A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med 200(2):123–135
Koreth J, O’Leary JJ et al (1996) Microsatellites and PCR genomic analysis. J Pathol 178(3):239–248
Kubista M, Andrade JM et al (2006) The real-time polymerase chain reaction. Mol Aspects Med 27(2–3):95–125
Kues WA, Niemann H (2011) Advances in farm animal transgenesis. Prev Vet Med 102(2):146–156
Kuiper K (2010) The Britannica guide to theories and ideas that changed the modern world. Britannica Educational Pub. in association with Rosen Educational Services, New York, NY
Kuleshova L, Gianaroli L et al (1999) Birth following vitrification of a small number of human oocytes: case report. Hum Reprod 14(12):3077–3079
Laflamme MA, Gold J et al (2005) Formation of human myocardium in the rat heart from human embryonic stem cells. Am J Pathol 167(3):663–671
Lakshmi V, Sudha T et al (2011) Application of polymerase chain reaction to detect HIV-1 DNA in pools of dried blood spots. Indian J Microbiol 51(2):147–152
Landgraf W, Sandow J (2016) Recombinant human insulins—clinical efficacy and safety in diabetes therapy. Eur Endocrinol 12(1):12–17
Landmarks, ACS, NHC (2009) Deciphering the genetic code. Commemorative Booklet
Lane N (2015) The unseen world: reflections on Leeuwenhoek (1677) ‘Concerning little animals’. Philos Trans R Soc Lond B Biol Sci 370(1666)
Lansdown AB (2002) Calcium: a potential central regulator in wound healing in the skin. Wound Repair Regen 10(5):271–285
Lee SY, Jang SH (2006a) Commentaries & analyses—WHITE BIOTECHNOLOGY. Asia-Pacific Biotech News 10(10):559–563
Lee SY, Jang SH (2006b) WHITE BIOTECHNOLOGY—commentaries & analyses. Asia-Pacific Biotech News 10(10)
Liang P, Jin LH et al (2006) Human neural stem cells promote corticospinal axons regeneration and synapse reformation in injured spinal cord of rats. Chin Med J (Engl) 119(16):1331–1338
Liang P, Xu Y et al (2015) CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell 6(5):363–372
Liu Z, Cai Y et al (2018) Cloning of macaque monkeys by somatic cell nuclear transfer. Cell 172(4):881–887, e887
Lonnerdal B, Iyer S (1995) Lactoferrin: molecular structure and biological function. Annu Rev Nutr 15:93–110
Lorence A, Verpoorte R (2004) Gene transfer and expression in plants. Methods Mol Biol 267:329–350
Lorenz MG, Wackernagel W (1994) Bacterial gene transfer by natural genetic transformation in the environment. Microbiol Rev 58(3):563–602
Ma LQ, Komar KM et al (2001) A fern that hyperaccumulates arsenic. Nature 411(6836):438
Maksimenko OG, Deykin AV et al (2013) Use of transgenic animals in biotechnology: prospects and problems. Acta Naturae 5(1):33–46
Mancinelli L, Cronin M et al (2000) Pharmacogenomics: the promise of personalized medicine. AAPS PharmSci 2(1):E4
Mavilio F, Ferrari G (2008) Genetic modification of somatic stem cells. The progress, problems and prospects of a new therapeutic technology. EMBO Rep 9(Suppl 1):S64–S69
McIntosh M, Cruz LJ et al (1982) Isolation and structure of a peptide toxin from the marine snail Conus magus. Arch Biochem Biophys 218(1):329–334
McLaren A (2000) Cloning: pathways to a pluripotent future. Science 288(5472):1775–1780
McMillan JD (2010) Biotechnology for fuels and chemicals. In: The thirty-first symposium: proceedings of the thirty-first symposium on biotechnology for fuels and chemicals, 3–6 May 2009, San Francisco, CA. New York, Springer
Milstein C (1999) The hybridoma revolution: an offshoot of basic research. BioEssays 21(11):966–973
Nester EW, Gordon MP et al (1984) Crown Gall: a molecular and physiological analysis. Ann Rev Plant Physiol 35(1):387–413
Nykiforuk CL, Boothe JG et al (2006) Transgenic expression and recovery of biologically active recombinant human insulin from Arabidopsis thaliana seeds. Plant Biotechnol J 4(1):77–85
Oliveira SC, Rosinha GM et al (1999) Immunological properties of gene vaccines delivered by different routes. Braz J Med Biol Res 32(2):207–214
Omidvarborna H, Kumar A et al (2014) Characterization of particulate matter emitted from transit buses fueled with B20 in idle modes. J Environ Chem Eng 2(4):2335–2342
Parvez S, Malik KA et al (2006) Probiotics and their fermented food products are beneficial for health. J Appl Microbiol 100(6):1171–1185
Pasteur L (1879) Studies on fermentation; the diseases of beer, their causes, and the means of preventing them. Macmillan and Co., London
Pearson S, Jia H et al (2004) China approves first gene therapy. Nat Biotechnol 22(1):3–4
Perucho M (1996) Cancer of the microsatellite mutator phenotype. Biol Chem 377(11):675–684
Piechulla B, Effmert U (2010) Biosynthesis and regulation of flower scent. Plant developmental biology—biotechnological perspectives. In: Davey M, Pua E (eds) Springer Nature Switzerland AG, Berlin, Heidelberg
Plotkin S (2014) History of vaccination. Proc Natl Acad Sci U S A 111(34):12283–12287
Pope JE, Deer TR (2013) Ziconotide: a clinical update and pharmacologic review. Expert Opin Pharmacother 14(7):957–966
Poste G (2001) Molecular diagnostics: a powerful new component of the healthcare value chain. Expert Rev Mol Diagn 1(1):1–5
Quispe-Huamanquispe DG, Gheysen G et al (2017) Horizontal gene transfer contributes to plant evolution: the case of agrobacterium T-DNAs. Front Plant Sci 8:2015
Rd D (2004) Recombinant human antithrombin III: rhATIII. Drugs R D 5(2):110–112
Reeves RD (2003) Tropical hyperaccumulators of metals and their potential for phytoextraction. Plant Soil 249(1):57–65
Ribeiro BD, Coelho MAZ et al (2016) Principles of green chemistry and white biotechnology. In: White biotechnology for sustainable chemistry, pp 1–8
Riedel S (2005) Edward Jenner and the history of smallpox and vaccination. Proc (Bayl Univ Med Cent) 18(1):21–25
Rinehart KL (2000) Antitumor compounds from tunicates. Med Res Rev 20(1):1–27
Rocha-Munive MG, Soberon M et al (2018) Evaluation of the impact of genetically modified cotton after 20 years of cultivation in Mexico. Front Bioeng Biotechnol 6:82
Roewer L (2013) DNA fingerprinting in forensics: past, present, future. Investig Genet 4(1):22
Rollier CS, Reyes-Sandoval A et al (2011) Viral vectors as vaccine platforms: deployment in sight. Curr Opin Immunol 23(3):377–382
Rosenberg SA, Aebersold P et al (1990) Gene transfer into humans–immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. N Engl J Med 323(9):570–578
Ruane J, Sonnino A et al (2006) The role of biotechnology in exploring and protecting agricultural genetic resources. Food and Agriculture Organization of the United Nations, Rome
Russell N, Bessell E et al (2000) Allogeneic haemopoietic stem cell transplantation for multiple myeloma or plasma cell leukaemia using fractionated total body radiation and high-dose melphalan conditioning. Acta Oncol 39(7):837–841
Saad R (2005) Discovery, development, and current applications of DNA identity testing. Proc (Bayl Univ Med Cent) 18(2):130–133
Sabirova JS, Ferrer M et al (2006) Mutation in a “tesB-like” hydroxyacyl-coenzyme A-specific thioesterase gene causes hyperproduction of extracellular polyhydroxyalkanoates by Alcanivorax borkumensis SK2. J Bacteriol 188(24):8452–8459
Sadelain M (2006) Recent advances in globin gene transfer for the treatment of beta-thalassemia and sickle cell anemia. Curr Opin Hematol 13(3):142–148
Sambu S (2015) A Bayesian approach to optimizing cryopreservation protocols. PeerJ 3:e1039
Schneiker S, Martins dos Santos VA et al (2006) Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium Alcanivorax borkumensis. Nat Biotechnol 24(8):997–1004
Schumann K, Lin S et al (2015) Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proc Natl Acad Sci U S A 112(33):10437–10442
Setlow JK, Hollaender A (2002) Genetic engineering; principles and methods, vol 4, Plenum Press, New York
Sharma AK, Bury MI et al (2011) A nonhuman primate model for urinary bladder regeneration using autologous sources of bone marrow-derived mesenchymal stem cells. Stem Cells 29(2):241–250
Shata MT, Stevceva L et al (2000) Recent advances with recombinant bacterial vaccine vectors. Mol Med Today 6(2):66–71
Singh RS (2018) Introduction to principles of plant pathology. Oxford and IBH Publishing
Slater A, Scott NW et al (2008) Plant biotechnology: the genetic manipulation of plants. Oxford University Press, Oxford; New York
Smith CA, O’Maille G et al (2005) METLIN: a metabolite mass spectral database. Ther Drug Monit 27(6):747–751
Spemann H (1938) Embryonic development and induction. Yale University Press; H. Milford, Oxford University Press, New Haven, London
Spencer CC, Su Z et al (2009) Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet 5(5):e1000477
Sussulini A (2017) Metabolomics: from fundamentals to clinical applications
Tabebordbar M, Zhu K et al (2016) In vivo gene editing in dystrophic mouse muscle and muscle stem cells. Science 351(6271):407–411
Takahashi N, Miura I et al (2005) Fluorescence in situ hybridization monitoring of BCR-ABL-positive neutrophils in chronic-phase chronic myeloid leukemia patients during the primary stage of imatinib mesylate therapy. Int J Hematol 81(3):235–241
Tang G, Qin J et al (2009) Golden rice is an effective source of vitamin A. Am J Clin Nutr 89(6):1776–1783
Tautz D (1993) Notes on the definition and nomenclature of tandemly repetitive DNA sequences. EXS 67:21–28
Tempest HG, Ko E et al (2008) Sperm aneuploidy frequencies analysed before and after chemotherapy in testicular cancer and Hodgkin’s lymphoma patients. Hum Reprod 23(2):251–258
Thomson JA, Itskovitz-Eldor J et al (1998) Embryonic stem cell lines derived from human blastocysts. Science 282(5391):1145–1147
TMR (2018, Jan 2018) Human growth hormone market: ToC. Market research report, from https://www.transparencymarketresearch.com/report-toc/16283
US F&DA (1982) Human insulin receives FDA approval. FDA Drug Bull 12(3):18–19
Valones MA, Guimaraes RL et al (2009) Principles and applications of polymerase chain reaction in medical diagnostic fields: a review. Braz J Microbiol 40(1):1–11
van Berkel PH, Welling MM et al (2002) Large scale production of recombinant human lactoferrin in the milk of transgenic cows. Nat Biotechnol 20(5):484–487
Vogenberg FR, Isaacson Barash C et al (2010) Personalized medicine: part 1: evolution and development into theranostics. P T 35(10):560–576
Vutyavanich T, Piromlertamorn W et al (2010) Rapid freezing versus slow programmable freezing of human spermatozoa. Fertil Steril 93(6):1921–1928
Walker L, Levine H et al (2006) Koch’s postulates and infectious proteins. Acta Neuropathol 112(1):1–4
Walsh G (2005) Therapeutic insulins and their large-scale manufacture. Appl Microbiol Biotechnol 67(2):151–159
Waltz E (2017) First genetically engineered salmon sold in Canada. Scientific American, Springer Nature America Inc., United States of America
Whitelaw CB, Archibald AL et al (1991) Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice. Transgenic Res 1(1):3–13
WHO (2018) Factsheet: diabetes. W. H. Organization
Wishart DS, Tzur D et al (2007) HMDB: the human metabolome database. Nucleic Acids Res 35(Database issue):D521–D526
Wu CH, Huang H et al (2002) The protein information resource: an integrated public resource of functional annotation of proteins. Nucleic Acids Res 30(1):35–37
Yamamoto Y (2002) PCR in diagnosis of infection: detection of bacteria in cerebrospinal fluids. Clin Diagn Lab Immunol 9(3):508–514
Yang NS, Burkholder J et al (1990) In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci U S A 87(24):9568–9572
Yang P, Wang J et al (2008) Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for large-scale production of functional human lactoferrin. PLoS ONE 3(10):e3453
Yaskowiak ES, Shears MA et al (2006) Characterization and multi-generational stability of the growth hormone transgene (EO-1alpha) responsible for enhanced growth rates in Atlantic Salmon. Transgenic Res 15(4):465–480
Zhao JR, Bai YJ et al (2005) Detection of hepatitis B virus DNA by real-time PCR using TaqMan-MGB probe technology. World J Gastroenterol 11(4):508–510
Zhou S, Flamier A et al (2015) Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFbeta and Wnt signaling. Development 142(19):3294–3306
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Kumar, H. (2020). Biotechnology: Discoveries and Their Applications in Societal Welfare. In: Saxena, A. (eds) Biotechnology Business - Concept to Delivery. EcoProduction. Springer, Cham. https://doi.org/10.1007/978-3-030-36130-3_1
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