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Salivary Bioscience Research in Health Psychology and Behavioral Medicine

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Salivary Bioscience

Abstract

Since their inception, the fields of health psychology and behavioral medicine have largely adopted a biopsychosocial approach to understanding health and the manner in which psychological and social factors “get under the skin.” Facilitated by advances in salivary bioscience, great strides over the past several decades have been made in understanding the biological processes by which such factors influence health and disease. Health psychology and behavioral medicine research have integrated advanced clinical and laboratory assessments of relevant immune system and neuroendocrine markers in saliva to identify mechanisms, stress processes, and evaluate the impact of clinical intervention on physiological systems. This chapter highlights contributions of salivary bioscience to health psychology and behavioral medicine with an emphasis on research related to understanding adjustment to chronic illness and the influence of psychological and social factors on disease processes. Research utilizing salivary markers of hypothalamic–pituitary–adrenal axis activity, sympathetic nervous system activation, as well as other neuroendocrine and immune processes has greatly contributed to our understanding of psychological adaptation to illness and the composition of clusters of adjustment-related symptoms such as fatigue, pain, and depression. In addition, documented changes in salivary levels of health-relevant biomarkers in response to behavioral interventions have contributed to a new definition of intervention efficacy. This broad synthesis of the literature emphasizes a more integrated biopsychosocial framework for understanding health and well-being.

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References

  • Abercrombie, H. C., Giese-Davis, J., Sephton, S., Epel, E. S., Turner-Cobb, J. M., & Spiegel, D. (2004). Flattened cortisol rhythms in metastatic breast cancer patients. Psychoneuroendocrinology, 29, 1082–1092.

    Article  CAS  PubMed  Google Scholar 

  • Adam, E. K., & Kumari, M. (2009). Assessing salivary cortisol in large-scale, epidemiological research. Psychoneuroendocrinology, 34, 1423–1436.

    Article  CAS  PubMed  Google Scholar 

  • Baldwin, A. S., Kellerman, Q. D., & Christensen, A. J. (2010). Coping with chronic illness. In J. M. Suls, K. W. Davidson, & R. M. Kaplan (Eds.), Handbook of health psychology and behavioral medicine (pp. 494–507). New York: Guilford Press.

    Google Scholar 

  • Barroso, J., Burrage, J., Carlson, J., & Carlson, B. W. (2006). Salivary cortisol values in HIV-positive people. Journal of the Association of Nurses in AIDS Care, 17, 29–36.

    Article  Google Scholar 

  • Bhagwagar, Z., & Cowen, P. J. (2008). ‘It’s not over when it’s over’: Persistent neurobiological abnormalities in recovered depressed patients. Psychological Medicine, 38, 307–313.

    Article  CAS  PubMed  Google Scholar 

  • Bosch, J. A., de Geus, E. J., Veerman, E. C., Hoogstraten, J., & Nieuw Amerongen, A. V. (2003). Innate secretory immunity in response to laboratory stressors that evoke distinct patterns of cardiac autonomic activity. Psychosomatic Medicine, 65, 245–258.

    Article  PubMed  Google Scholar 

  • Bower, J. E. (2008). Behavioral symptoms in patients with breast cancer and survivors. Journal of Clinical Oncology, 26, 768–777.

    Article  PubMed  Google Scholar 

  • Bower, J. E., Ganz, P. A., & Aziz, N. (2005). Altered cortisol response to psychologic stress in breast cancer survivors with persistent fatigue. Psychosomatic Medicine, 67, 277–280.

    Article  PubMed  Google Scholar 

  • Carlson, L. E., Doll, R., Stephen, J., Faris, P., Tamagawa, R., Drysdale, E., & Speca, M. (2013). Randomized controlled trial of mindfulness-based cancer recovery versus supportive expressive group therapy for distressed survivors of breast cancer. Journal of Clinical Oncology, 31, 3119–3126.

    Article  PubMed  Google Scholar 

  • Carlson, L. E., Speca, M., Patel, K. D., & Goodey, E. (2004). Mindfulness-based stress reduction in relation to quality of life, mood, symptoms of stress and levels of cortisol, dehydroepiandrosterone sulfate (DHEAS) and melatonin in breast and prostate cancer outpatients. Psychoneuroendocrinology, 29, 448–474.

    Article  CAS  PubMed  Google Scholar 

  • Carvalho, L. A., Urbanova, L., Hamer, M., Hackett, R. A., Lazzarino, A. I., & Steptoe, A. (2015). Blunted glucocorticoid and mineralocorticoid sensitivity to stress in people with diabetes. Psychoneuroendocrinology, 51, 09–218.

    Article  CAS  Google Scholar 

  • Cash, E., Salmon, P., Weissbecker, I., Rebholz, W. N., Bayley-Veloso, R., Zimmaro, L. A., … Sephton, S. E. (2016). Mindfulness meditation alleviates fibromyalgia symptoms in women: Results of a randomized clinical trial. Annals of Behavioral Medicine, 49, 319–330.

    Article  Google Scholar 

  • Cash, E., Sephton, S. E., Chagpar, A. B., Spiegel, D., Rebholz, W. N., Zimmaro, L. A., … Dhabar, F. S. (2015). Circadian disruption and biomarkers of tumor progression in breast cancer patients awaiting surgery. Brain, Behavior, and Immunity, 48, 102–114.

    Article  CAS  PubMed  Google Scholar 

  • Castonguay, A. L., Wrosch, C., & Sabiston, C. M. (2017). The roles of negative affect and goal adjustment capacities in breast cancer survivors: Associations with physical activity and diurnal cortisol secretion. Health Psychology, 36, 320–331.

    Article  PubMed  Google Scholar 

  • Centers for Disease Control and Prevention, U.S. Department of Health and Human Services. (2017). Deaths: Final data for 2015. National Vital Statistics Report, 66, 1–73.

    Google Scholar 

  • Chaborski, K., Bitterlich, N., Alteheld, B., Parsi, E., & Metzner, C. (2015). Placebo-controlled dietary intervention of stress-induced neurovegetative disorders with a specific amino acid composition: A pilot-study. Nutrition Journal, 14, 43.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cochran, D. M., Fallon, D., Hill, M., & Frazier, J. A. (2013). The role of oxytocin in psychiatric disorders: A review of biological and therapeutic research findings. Harvard Review of Psychiatry, 21, 219–247.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cohen, L., Cole, S. W., Sood, A. K., Prinsloo, S., Kirchbaum, C., Arevalo, J. M. G., … Pisters, L. (2012). Depressive symptoms and cortisol rhythmicity predict survival in patients with renal cell carcinoma: Role of inflammatory signaling. PLoS One, 7, s42324.

    Article  CAS  Google Scholar 

  • Costanzo, E. S., Stawski, R. S., Ryff, C. D., Coe, C. L., & Almeida, D. M. (2012). Cancer survivors’ responses to daily stressors: Implications for quality of life. Health Psychology, 31, 360–370.

    Article  PubMed  PubMed Central  Google Scholar 

  • Crofford, L. J., Young, E. A., Engleberg, N. C., Korszun, A., Brucksch, C. B., McClure, L. A., … Demitrack, M. A. (2004). Basal circadian and pulsatile ACTH and cortisol secretion in patients with fibromyalgia and/or chronic fatigue syndrome. Brain, Behavior and Immunity, 18, 314–325.

    Article  CAS  Google Scholar 

  • Cruess, D. G., Antoni, M. H., Kumar, M., & Schneiderman, N. (2000). Reductions in salivary cortisol are associated with mood improvement during relaxation training among HIV-seropositive men. Journal of Behavioral Medicine, 23, 107–122.

    Article  CAS  PubMed  Google Scholar 

  • Deuschle, M., Schweiger, U., Weber, B., Gotthardt, U., Körner, A., Schmider, J., … Heuser, J. (1997). Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls. Journal of Clinical Endocrinology and Metabolism, 82, 234–238.

    Article  CAS  PubMed  Google Scholar 

  • Diaz, M., Aldridge-Gerry, A., & Spiegel, D. (2014). Posttraumatic growth and diurnal cortisol slope among women with metastatic breast cancer. Psychoneuroendocrinology, 44, 83–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dickerson, S. S., & Kemeny, M. E. (2004). Acute stressors and cortisol responses: A theoretical integration of laboratory research. Psychological Bulletin, 130, 355–391.

    Article  PubMed  Google Scholar 

  • Domes, G., Normann, C., & Heinrichs, M. (2016). The effect of oxytocin on attention to angry and happy faces in chronic depression. BMC Psychiatry, 16, 92.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Eller, N. H., Netterstrøm, B., & Allerup, P. (2005). Progression in intima media thickness -the significance of hormonal biomarkers of chronic stress. Psychoneuroendocrinology, 30, 715–723.

    Article  CAS  PubMed  Google Scholar 

  • Fagundes, C. P., Murdock, K. W., Chirinos, D. A., & Green, P. A. (2017). Biobehavioral pathways to cancer incidence, progression, and quality of life. Current Directions in Psychological Science, 26, 548–553.

    Article  Google Scholar 

  • Fancourt, D., Williamon, A., Cavalho, L. A., Steptoe, A., Dow, R., & Lewis, I. (2016). Singing modulates mood, stress, cortisol and neuropeptide activity in cancer patients and carers. Ecancermedicalscience, 10, 631.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fischer, S., Doerr, J. M., Strahler, J., Mewes, R., Thieme, K., & Nater, U. M. (2016). Stress exacerbates pain in the everyday lives of women with fibromyalgia syndrome: The role of cortisol and alpha-amylase. Psychoneuroendocrinology, 63, 68–77.

    Article  CAS  PubMed  Google Scholar 

  • Friedman, H. S., & Adler, N. E. (2007). The history and background of health psychology. In H. S. Friedman & R. C. Silver (Eds.), Foundations of health psychology (pp. 3–18). New York, NY: Oxford University Press.

    Google Scholar 

  • Gebert, D., Auer, M. K., Steig, M. R., Freitag, M. T., Lahne, M., Fuss, J., … Kopczak, A. (2018). De-masking oxytocin-deficiency in craniopharyngioma and assessing its link with affective function. Psychoneuroendocrinology, 88, 61–69.

    Article  CAS  PubMed  Google Scholar 

  • Gold, P. W. (2015). The organization of the stress system and its dysregulation in depressive illness. Molecular Psychiatry, 20, 32–47.

    Article  CAS  PubMed  Google Scholar 

  • Granger, D. A., Kivlighan, K. T., El-Sheikh, M., Gordis, E. B., & Stroud, L. R. (2008). Assessment of salivary α-amylase in biobehavioral research. In L. Luecken & L. C. Gallo (Eds.), Handbook of physiological research methods in health psychology (pp. 95–114). Thousand Oaks, CA: Sage.

    Chapter  Google Scholar 

  • Helgeson, V. S., & Zajdel, M. (2017). Adjusting to chronic health conditions. Annual Review of Psychology, 68, 545–571.

    Article  PubMed  Google Scholar 

  • Hoyt, M. A., Gamarel, K. E., Saigal, C. S., & Stanton, A. L. (2016). Goal navigation, approach-oriented coping, and cancer adjustment in young men with testicular cancer. Annals of Behavioral Medicine, 50, 572–581.

    Article  PubMed  Google Scholar 

  • Hoyt, M. A., Gaffey, A. E., Wang, A. W., & Lawsin, C. J. (2018). Sexual well-being and diurnal cortisol after prostate cancer treatment. Journal of Health Psychology. https://doi.org/10.1177/1359105318772655

  • Hoyt, M. A., Marin-Chollom, A. M., Bower, J. E., Thomas, K. S., Irwin, M. R., & Stanton, A. L. (2014). Approach and avoidance coping: Diurnal cortisol rhythm in prostate cancer survivors. Psychoneuroendocrinology, 49, 182–186.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoyt, M. A., & Stanton, A. L. (2018). Adjustment to chronic illness. In T. A. Revenson & R. A. R. Gurung (Eds.), Handbook of health psychology (3rd ed.). New York, NY: Taylor & Francis.

    Google Scholar 

  • Ironson, G., O’Cleirigh, C. O., Kumar, M., Kaplan, L., Balbin, E., Kelsch, C. B., … Shneiderman, N. (2015). Psychosocial and neurohormonal predictors of HIV disease progression (CD4 cells and viral load): A 4 year prospective study. AIDS & Behavior, 19, 1388–1397.

    Article  CAS  Google Scholar 

  • Irwin, M. R., & Slavich, G. M. (2017). In J. T. Cacioppo, L. G. Tassinary, & G. G. Berntson (Eds.), Handbook of psychophysiology (pp. 377–397). New York: Cambridge University Press.

    Google Scholar 

  • Jehn, C. F., Kuehnhardt, D., Bartholomae, A., Pfeiffer, S., Krebs, M., Regierer, A. C., … Flath, B. C. (2006). Biomarkers of depression in cancer patients. Cancer, 107, 2723–2729.

    Article  CAS  PubMed  Google Scholar 

  • Jessop, D. S., & Turner-Cobb, J. M. (2008). Measurement and meaning of salivary cortisol: A focus on health and disease in children. Stress, 11, 1–14.

    Article  CAS  PubMed  Google Scholar 

  • Kornienko, O., Schaefer, D. R., Pressman, S. D., & Granger, D. A. (2018). Associations between secretory immunoglobulin a and social network structure. International Journal of Behavioral Medicine, 25, 669–681.

    Article  CAS  PubMed  Google Scholar 

  • Kuhlman, K. R., Irwin, M. R., Ganz, P. A., Crespi, C. M., Petersen, M. S., Asher, A., & Bower, J. E. (2017). Cortisol awakening response as a prospective risk factor for depressive symptoms in women after treatment for breast cancer. Psychosomatic Medicine, 79, 763–769.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lazarus, R. S., & Folkman, S. (1984). Stress, appraisal, and coping. New York, NY: Springer.

    Google Scholar 

  • Leggett, A. N., Liu, Y., Klein, L. C., & Zarit, S. H. (2016). Sleep duration and the cortisol awakening response in dementia caregivers utilizing adult day services. Health Psychology, 35, 465–473.

    Article  PubMed  Google Scholar 

  • Le-Scherban, F., Brenner, A., Hicken, M. T., Needham, B. L., Seeman, T., Sloan, R. P., … Diez Roux, A. V. (2018). Child and adult socioeconomic status and the cortisol response to acute stress: Evidence from the multi-ethnic study of atherosclerosis. Psychosomatic Medicine, 80, 184–192.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Leventhal, H., Halm, E., Horowitz, C., Leventhal, E. A., & Ozakinci, G. (2005). Living with chronic illness: A contextualized, self-regulation approach. In S. Sutton, A. Baum, & M. Johnston (Eds.), The Sage handbook of health psychology (pp. 197–240). Thousand Oaks, CA: Sage.

    Google Scholar 

  • Lipschitz, L., Kuhn, R., Kinney, Y., Donaldson, W., & Nakamura, Y. (2013). Reduction in salivary α-amylase levels following a mind–body intervention in cancer survivors—an exploratory study. Psychoneuroendocrinology, 38, 1521–1531.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lutgendorf, S. K., Weinrib, A. Z., Penedo, F., Russell, D., DeGeest, K., Costanzo, E. S., … Lubaroff, D. M. (2008). Interleukin-6, cortisol, and depressive symptoms in ovarian cancer patients. Journal of Clinical Oncology, 26, 4820–4827.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nater, U. M., & Rohleder, N. (2009). Salivary alpha-amylase as a noninvasive biomarker for the sympathetic nervous system: Current state of research. Psychoneuroendocrinology, 34, 486–496.

    Article  CAS  PubMed  Google Scholar 

  • Nater, U. M., Rohleder, N., Schlotz, W., Ehlert, U., & Kirschbaum, C. (2007). Determinants of the diurnal course of salivary alpha-amylase. Psychoneuroendocrinology, 32, 392–401.

    Article  CAS  PubMed  Google Scholar 

  • Nater, U. M., Skoluda, N., & Starhler, J. (2013). Biomarkers of stress in behavioral medicine. Current Opinion in Psychiatry, 260, 440–445.

    Article  Google Scholar 

  • Nicolson, N. A. (2008). Measurement of cortisol. In L. Luecken & L. C. Gallo (Eds.), Handbook of physiological research methods in health psychology (pp. 37–74). Thousand Oaks, CA: Sage.

    Chapter  Google Scholar 

  • Nikkheslat, N., Zunszain, P. A., Horowitz, M. A., Barbosa, I. G., Parker, J. A., Myint, A. M., … Pariante, C. M. (2015). Insufficient glucocorticoid signaling and elevated inflammation in coronary heart disease patients with comorbid depression. Brain, Behavior, and Immunity, 48, 8–18.

    Article  CAS  PubMed  Google Scholar 

  • Pariante, C. M., & Miller, A. H. (2001). Glucocorticoid receptors in major depression: Relevance to pathophysiology and treatment. Biological Psychiatry, 49, 391–404.

    Article  CAS  PubMed  Google Scholar 

  • Pinto, A. R., da Silva, N. C., & Pinato, L. (2016). Analyses of melatonin, cytokines, and sleep in chronic renal failure. Sleep & Breathing, 20, 339–334.

    Article  Google Scholar 

  • Polsky, D., Doshi, J. A., Marcus, S., Oslin, D., Rothbard, A., Thomas, N., & Thompson, C. L. (2005). Long-term risk for depressive symptoms after a medical diagnosis. Archives of Internal Medicine, 165, 1260–1266.

    Article  PubMed  Google Scholar 

  • Rash, J. A., Aguirre-Camacho, A., & Campbell, T. S. (2014). Oxytocin and pain: A systematic review and synthesis of findings. The Clinical Journal of Pain, 30, 453–462.

    PubMed  Google Scholar 

  • Riis, J. L., Granger, D. A., DiPietro, J. A., Bandeen-Roche, K., & Johnson, S. B. (2015). Salivary cytokines as a minimally-invasive measure of immune functioning in young children: Correlates of individual differences and sensitivity to laboratory stress. Developmental Psychobiology, 57, 153–167.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Robles, T. F., Slatcher, R. B., Trombello, J. M., & McGinn, M. M. (2014). Marital quality and health: A meta-analytic review. Psychological Bulletin, 140, 140–187.

    Article  PubMed  Google Scholar 

  • Ryan, R., Booth, S., Spathis, A., Mollart, S., & Clow, A. (2016). Use of salivary diurnal cortisol as an outcome measure in randomised controlled trials: A systematic review. Annals of Behavioral Meidicne, 50, 210–236.

    Article  Google Scholar 

  • Sapolsky, R. M., & Donnelly, T. M. (1985). Vulnerability to stress-induced tumor growth increases with age in rats: Role of glucocorticoids. Endocrinology, 117, 662–666.

    Article  CAS  PubMed  Google Scholar 

  • Schneiderman, N., Ironson, G., & Siegel, S. (2005). Stress and health: Psychological, behavioral and biological determinants. Annual Review of Clinical Psychology, 1, 607–628.

    Article  PubMed  PubMed Central  Google Scholar 

  • Schoorlemmer, R. M., Peeters, G. M., van Schoor, N. M., & Lips, P. (2009). Relationships between cortisol level, mortality and chronic diseases in older persons. Clinical Endocrinology, 71, 779–786.

    Article  CAS  PubMed  Google Scholar 

  • Schrepf, A., Thaker, P. H., Goodheart, M. J., Bender, D., Slavich, G. M., Dahmoush, L., … Lutgendorf, S. K. (2015). Diurnal cortisol and survival in epithelial ovarian cancer. Psychoneuroendocrinology, 53, 256–267.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sephton, S. E., Dhabhar, F. S., Keuroghlian, A. S., Giese-Davis, J., McEwen, B. S., Ionan, A. C., & Spiegel, D. (2009). Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer. Brain, Behavior, and Immunity, 23, 1148–1155.

    Article  CAS  PubMed  Google Scholar 

  • Sephton, S. E., Lush, E., Dedert, E. A., Floyd, A. R., Rebholz, W. N., Dhabhar, F. S., … Salmon, P. (2013). Diurnal cortisol rhythm as a predictor of lung cancer survival. Brain, Behavior, and Immunity, 30, S163–S170.

    Article  CAS  PubMed  Google Scholar 

  • Shimada, M., Seki, H., Samejima, M., Hayase, M., & Shirai, F. (2016). Salivary melatonin levels and sleep-wake rhythms in pregnant women with hypertensive and glucose metabolic disorders: A prospective analysis. Bioscience Trends, 10, 34–41.

    Article  CAS  PubMed  Google Scholar 

  • Shin, Y. S., Liu, J. N., Kim, J., Nam, Y., Choi, G. S., & Park, H. (2014). The impact of asthma control on salivary cortisol level in adult asthmatics. Allergy, Asthma and Immunology Research, 6, 463–466.

    Article  PubMed  PubMed Central  Google Scholar 

  • Slavish, D. C., Graham-Engeland, J. E., Smyth, J. M., & Engeland, C. G. (2015). Salivary markers of inflammation in response to acute stress. Brain, Behavior, and Immunity, 44, 253–269.

    Article  CAS  PubMed  Google Scholar 

  • Spiegel, D. (2012). Mind matters in cancer. Psycho-Oncology, 21, 588–593.

    Article  PubMed  PubMed Central  Google Scholar 

  • Stetler, C., & Miller, G. E. (2011). Depression and hypothalamic-pituitary-adrenal activation: A quantitative summary of four decades of research. Psychosomatic Medicine, 73, 114–126.

    Article  PubMed  Google Scholar 

  • Tomiyama, A. J., Epel, E. S., McClatchey, T. M., Poelke, G., Kemeny, M. E., McCoy, S. K., & Daubenmier, J. (2014). Associations of weight stigma with cortisol and oxidative stress independent of adiposity. Health Psychology, 33, 862–867.

    Article  PubMed  PubMed Central  Google Scholar 

  • Tornhage, C. J., Skogar, Ö., Borg, A., Larrson, B., Robertsson, L., Ansersson, L., … Lökk, J. (2013). Short- and long-term effects of tactile massage on salivary cortisol concentrations in Parkinson’s disease: A randomised controlled pilot study. BMC Complementary and Alternative Medicine, 13, 357.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Turner-Cobb, J., Sephton, S., Koopmanm, C., Blake-Mortimer, J., & Spiegel, D. (2000). Social support and salivary cortisol in women with metastatic breast cancer. Psychosomatic Medicine, 62, 337–345.

    Article  CAS  PubMed  Google Scholar 

  • Weinrib, A. Z., Sephton, S. E., DeGeest, K., Penedo, F., Bender, D., Zimmerman, B., … Lutgendorf, S. K. (2010). Dirunal cortisol dysregulation, functional disability, and depression in women with ovarian cancer. Cancer, 116, 4410–4419.

    Article  PubMed  Google Scholar 

  • World Health Organization. (2017). Noncommunicable diseases. Accessed June, 2017 from http://www.who.int/mediacentre/factsheets/fs355/en/

  • Wrosch, C., Miller, G. E., Lupien, S., & Pruessner, J. (2008). Diurnal cortisol secretion and 2-year changes in older adults’ physical symptoms: The moderating roles of negative affect and sleep. Health Psychology, 27, 685–693.

    Article  PubMed  Google Scholar 

  • Wrosch, C., Miller, G. E., Scheier, M. F., & de Pontet, S. B. (2007). Giving up on unattainable goals: Benefits for health? Personality and Social Psychology Bulletin, 33, 251–265.

    Article  PubMed  Google Scholar 

  • Wrosch, C., Scheier, M. F., Miller, G. E., Schulz, R., & Carver, C. S. (2003). Adaptive self-regulation of unattainable goals: Goal disengagement, goal reengagement, and subjective well-being. Personality and Social Psychology Bulletin, 29, 1494–1508. https://doi.org/10.1177/0146167203256921

    Article  PubMed  Google Scholar 

  • Yeung, E. W., Davis, M. C., & Ciaramitaro, M. C. (2016). Cortisol profile mediates the relation between childhood neglect and pain and emotional symptoms among patients with fibromyalgia. Annals of Behavioral Medicine, 50, 87–97.

    Article  PubMed  Google Scholar 

  • Yoon, S. A., & Weierich, M. R. (2016). Salivary biomarkers of neural hypervigilance in trauma-exposed women. Psychoneuroendocrinology, 63, 17–25.

    Article  CAS  PubMed  Google Scholar 

  • Zhdanova, I. V., Lynch, H. J., & Wurtman, R. J. (1997). Melatonin: A sleep-promoting hormone. Sleep, 20, 899–907.

    CAS  PubMed  Google Scholar 

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Hoyt, M.A., Zimmermann, C.F. (2020). Salivary Bioscience Research in Health Psychology and Behavioral Medicine. In: Granger, D., Taylor, M. (eds) Salivary Bioscience. Springer, Cham. https://doi.org/10.1007/978-3-030-35784-9_21

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