Abstract
In the early years of the epidemic, the lack of access to anti-retroviral treatment (ART) resulted in severe opportunistic infections, poor nutrition and high mortality. Patents with AIDS were not fully investigated and about 50% of children with HIV infection died before 2 years. Children developing cancers in this setting were often treated with palliative intent and had poor outcomes. Similar to the experience in adults, cancer was often the first indication of underlying HIV infection and severe immune-suppression, and was often an AIDS defining cancer (ADC). There was a marked year on year increase in ADC. The expanded roll out of antiretroviral therapy has resulted in improved survival of infected children with better nutrition and treatment of opportunistic infections (OIs). Treatment of cancers with curative intent became feasible.
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Thejpal, R. (2020). Malignancies. In: Bobat, R. (eds) HIV Infection in Children and Adolescents. Springer, Cham. https://doi.org/10.1007/978-3-030-35433-6_11
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