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Abstract

Cancer is the most fatal cause of death and determination of the reasons, making early diagnosis and correct treatment reduces the loss of lives but humans are still far away to produce a complete and permanent solutions to this problem. Nowadays, RNA and gene researches try make this solutions step by step more effective to defect cancer and to improve these researches. However, the number of the genes and complexity of the data makes analysis and experiments more challenging for humans thus, computerized solutions such as machine learning models are needed. This paper presents preliminary results of five types of tumor classification on RNA-Seq. Three machine learning models, Support Vector Machine, Backpropagation neural network and Decision Tree is implemented and various experiments are performed for this task. Obtained results show that machine learning models can effectively be used for tumor classification using gene information and Support Vector Machine achieved superior results than other considered models.

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References

  1. Erdemir, F., Gülzade, U.: Genetik, genomik bilimi ve hemşirelik. Dokuz Eylül Üniversitesi Hemşirelik Yüksekokulu Elektronik Dergisi 3(2), 96–101 (2010). (in Turkish)

    Google Scholar 

  2. Xiao, Y., Wu, J., Lin, Z.: A semi-supervised deep learning method based on stacked sparse auto-encoder for cancer prediction using RNA-seq data. Comput. Meth. Programs Biomed. 166, 99–105 (2018)

    Article  Google Scholar 

  3. Weinstein, J.N., et al.: The cancer genome atlas pan-cancer analysis project. Nat. Genet. 45(10), 1113–1120 (2013)

    Article  Google Scholar 

  4. Danaee, P., Ghaeini, R., Hendrix, D.: A deep learning approach for cancer detection and relevant gene identification. Pacific Symp. Biocomput. 2017, 219–229 (2017)

    Google Scholar 

  5. Tarek, S., Abd Elwahab, R., Shoman, M.: Gene expression based cancer classification. Egypt. Inf. J. 18, 151–159 (2017)

    Article  Google Scholar 

  6. Huang, S., et al.: Applications of support vector machine (SVM) learning in cancer genomics. Cancer Genomics Proteomics 15, 41–51 (2018)

    Google Scholar 

  7. Khashman, A., Sekeroglu, B.: Global binarization of document images using a neural network. In: Third International IEEE Conference on Signal-Image Technologies and Internet-Based System, pp. 665–672, Shanghai (2007)

    Google Scholar 

  8. Dougherty, G.: Pattern recognition and classification. Springer, New York (2013). https://doi.org/10.1007/978-1-4614-5323-9

    Book  MATH  Google Scholar 

  9. Tong, S., Koller, D.: Support vector machine active learning with applications to text classification. J. Mach. Learn. Res. 2, 45–66 (2001)

    MATH  Google Scholar 

  10. Senturk, Z.K., Senturk, A.: Yapay sinir agları ile gögüs kanseri tahmini. El-Cezeri J. Sci. Eng. 3(2), 345–350 (2016). (in Turkish)

    Google Scholar 

  11. Yuan, Z., Wang, C.: An improved network traffic classification algorithm based on Hadoop decision tree. In: 2016 IEEE International Conference of Online Analysis and Computing Science (ICOACS), Chongqing, pp. 53–56 (2016)

    Google Scholar 

  12. Ge L, Shi, J., Zhu, P.: Melt index prediction by support vector regression. In: 2016 International Conference on Control, Automation and Information Sciences (ICCAIS), Ansan, pp. 60–63 (2016)

    Google Scholar 

  13. Polaka, I., Igar, T., Borisov, A.: Decision tree classifiers in bioinformatics. J. Riga Tech. Univ. (42), 118–123 (2010)

    Article  Google Scholar 

Download references

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Correspondence to Kubra Tuncal or Cagri Ozkan .

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Tuncal, K., Ozkan, C. (2020). Tumor Classification Using Gene Expression and Machine Learning Models. In: Aliev, R., Kacprzyk, J., Pedrycz, W., Jamshidi, M., Babanli, M., Sadikoglu, F. (eds) 10th International Conference on Theory and Application of Soft Computing, Computing with Words and Perceptions - ICSCCW-2019. ICSCCW 2019. Advances in Intelligent Systems and Computing, vol 1095. Springer, Cham. https://doi.org/10.1007/978-3-030-35249-3_85

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