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Burn Reconstruction: Skin Substitutes and Tissue Engineering

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Handbook of Burns Volume 2

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Abstract

Skin, also known as the integument, is not only the largest laminar organ but also the appropriate interface between the human organism and its environment. Besides other functions, the skin represents the primary barrier of the immune system. Thus, an extensive skin loss due to thermal trauma represents in the majority of cases a life-threatening situation and demands particular requirements from the plastic and burn surgery to provide a sufficient skin substitution. Development and improvement of innovative strategies concerning skin expansion and tissue engineering have contributed to the fact that burns affecting more than 80% of the body surface (TBS) are survivable today [1]. Although the application of cultured epidermis and compound cultured skin analogues is approved as a life-saving method today, the indications for this novel approach have become more differentiated. Besides historical aspects, the present chapter gives insights into both the conventional techniques and the application forms of current cultured skin substitutes.

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Notes

  1. 1.

    Sample references. In case of doubt, kindly consult Springer to obtain detailed guidelines for accurate reference entries for particular subject fields.

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Authors and Affiliations

  1. Department of Plastic and Hand Surgery, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuernberg FAU, Erlangen, Germany

    Raymund E. Horch & Andreas Arkudas

  2. Department for Plastic and Breast Surgery, Zealand University Hospital Roskilde, Roskilde, Denmark

    Volker J. Schmidt

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  1. Raymund E. Horch
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  2. Volker J. Schmidt
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  3. Andreas Arkudas
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Correspondence to Raymund E. Horch .

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Editors and Affiliations

  1. Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Graz, Austria

    Lars-Peter Kamolz

  2. Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

    Marc G. Jeschke

  3. Department of Plastic and Hand Surgery, University Hospital of Erlangen, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany

    Raymund E. Horch

  4. Department of Plastic and Hand Surgery, Evangelische Elisabeth Klinik Krankenhau, Berlin, Germany

    Markus Küntscher

  5. Department of Burns & Reconstructive Surgery, Masaryk University, Brno, Czech Republic

    Pavel Brychta

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Horch, R.E., Schmidt, V.J., Arkudas, A. (2020). Burn Reconstruction: Skin Substitutes and Tissue Engineering. In: Kamolz, LP., Jeschke, M.G., Horch, R.E., Küntscher, M., Brychta, P. (eds) Handbook of Burns Volume 2. Springer, Cham. https://doi.org/10.1007/978-3-030-34511-2_16

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  • DOI: https://doi.org/10.1007/978-3-030-34511-2_16

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  • Print ISBN: 978-3-030-34510-5

  • Online ISBN: 978-3-030-34511-2

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