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‘Oxygen Level in a Tissue’ – What Do Available Measurements Really Report?

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Oxygen Transport to Tissue XLI

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1232))

Abstract

The aim of the paper is to discuss what currently is feasible clinically to measure the level of oxygen and how that measurement can be clinically useful. Because oxygen in tissues is quite heterogeneous and all methods of measurement can only provide an average across heterogeneities at some spatial and temporal resolution, the values that are obtained may have limitations on their clinical utility. However, even if such limitations are significant, if one utilizes repeated measurements and focuses on changes in the measured levels, rather than ‘absolute levels’, it may be possible to obtain very useful clinical information. While these considerations are especially pertinent in cancer, they also pertain to most other types of pathology.

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Acknowledgments

Major funding is from the National Cancer Institute, PPG Grant P01CA190193. We gratefully acknowledge all the other scientists, clinicians, engineers and coordinators on the PPG. Disclaimer: ABF and HMS are owners of Clin-EPR, LLC which manufacturers clinical EPR instruments for investigational use only.

Author information

Authors and Affiliations

  1. Department Radiology, Dartmouth Medical School, Hanover, NH, USA

    H. M. Swartz, B. B. Williams, W. Schreiber & A. B. Flood

  2. Section Radiation Oncology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA

    H. M. Swartz, B. B. Williams & P. E. Schaner

  3. Department Radiation Oncology, University Medical Center, Mainz, Germany

    P. Vaupel

  4. Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium

    B. Gallez

  5. Department Radiation Oncology, Emory School of Medicine, Atlanta, GA, USA

    A. Ali

Authors
  1. H. M. Swartz
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  2. P. Vaupel
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  3. B. B. Williams
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  4. P. E. Schaner
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  5. B. Gallez
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  6. W. Schreiber
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  7. A. Ali
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  8. A. B. Flood
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Corresponding author

Correspondence to H. M. Swartz .

Editor information

Editors and Affiliations

  1. Department of Veterinary Pharmacology, College of Veterinary Medicine, Seoul National University, Seoul, Korea (Republic of)

    Pan-Dong Ryu

  2. Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA

    Joseph C. LaManna

  3. Heilig-Kreuz-Strasse 19, St. Lorenzen, Italy

    David K. Harrison

  4. Department of Oriental Biomedical Engineering, Sangji University, Wonju, Korea (Republic of)

    Sang-Suk Lee

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Swartz, H.M. et al. (2020). ‘Oxygen Level in a Tissue’ – What Do Available Measurements Really Report?. In: Ryu, PD., LaManna, J., Harrison, D., Lee, SS. (eds) Oxygen Transport to Tissue XLI. Advances in Experimental Medicine and Biology, vol 1232. Springer, Cham. https://doi.org/10.1007/978-3-030-34461-0_19

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