Abstract
What are the cellular and molecular processes underlying neural developmental events during embryogenesis? How can we manipulate a human pluripotent stem cell to a neural lineage of interest? Can the in vitro generated neural cells hold the potentiality for replacement therapy in neurological disorders?
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., & Studer, L. (2009). Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nature Biotechnology, 27, 275–280.
Chen, Y., Xiong, M., Dong, Y., Haberman, A., Cao, J., Liu, H., Zhou, W., & Zhang, S.-C. (2016). Chemical control of grafted human PSC-derived neurons in a mouse model of Parkinson’s disease. Cell Stem Cell, 18, 817–826.
Chi, L., Fan, B., Zhang, K., Du, Y., Liu, Z., Fang, Y., Chen, Z., Ren, X., Xu, X., Jiang, C., et al. (2016). Targeted differentiation of regional ventral neuroprogenitors and related neuronal subtypes from human pluripotent stem cells. Stem Cell Reports, 7, 941–954.
Chi, L., Fan, B., Feng, D., Chen, Z., Liu, Z., Hui, Y., Xu, X., Ma, L., Fang, Y., Zhang, Q., et al. (2017). The dorsoventral patterning of human forebrain follows an activation/transformation model. Cerebral Cortex, 27, 2941–2954.
Ericson, J., Muhr, J., Placzek, M., Lints, T., Jessel, T. M., & Edlund, T. (1995). Sonic hedgehog induces the differentiation of ventral forebrain neurons: A common signal for ventral patterning within the neural tube. Cell, 81, 747–756.
Fasano, C. A., Chambers, S. M., Lee, G., Tomishima, M. J., & Studer, L. (2010). Efficient derivation of functional floor plate tissue from human embryonic stem cells. Cell Stem Cell, 6, 336–347.
Gaspard, N., Bouschet, T., Hourez, R., Dimidschstein, J., Naeije, G., van den Ameele, J., Espuny-Camacho, I., Herpoel, A., Passante, L., Schiffmann, S. N., et al. (2008). An intrinsic mechanism of corticogenesis from embryonic stem cells. Nature, 455, 351.
Kikuchi, T., Morizane, A., Doi, D., Magotani, H., Onoe, H., Hayashi, T., Mizuma, H., Takara, S., Takahashi, R., Inoue, H., et al. (2017). Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model. Nature, 548, 592.
Kriks, S., Shim, J.-W., Piao, J., Ganat, Y. M., Wakeman, D. R., Xie, Z., Carrillo-Reid, L., Auyeung, G., Antonacci, C., Buch, A., et al. (2011). Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease. Nature, 480, 547.
Li, X.-J., Du, Z.-W., Zarnowska, E. D., Pankratz, M., Hansen, L. O., Pearce, R. A., & Zhang, S.-C. (2005). Specification of motoneurons from human embryonic stem cells. Nature Biotechnology, 23, 215.
Li, X.-J., Zhang, X., Johnson, M. A., Wang, Z.-B., LaVaute, T., & Zhang, S.-C. (2009). Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telencephalic neuron types from human embryonic stem cells. Development, 136, 4055–4063.
Liu, Y., Weick, J. P., Liu, H., Krencik, R., Zhang, X., Ma, L., Zhou, G.-m., Ayala, M., & Zhang, S.-C. (2013). Medial ganglionic eminence–like cells derived from human embryonic stem cells correct learning and memory deficits. Nature Biotechnology, 31, 440.
Ma, L., Hu, B., Liu, Y., Vermilyea, S. C., Liu, H., Gao, L., Sun, Y., Zhang, X., & Zhang, S.-C. (2012). Human embryonic stem cell-derived GABA neurons correct locomotion deficits in Quinolinic acid-lesioned mice. Cell Stem Cell, 10, 455–464.
Maroof, A. M., Keros, S., Tyson, J. A., Ying, S.-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., et al. (2013). Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells. Cell Stem Cell, 12, 559–572.
Metzis, V., Steinhauser, S., Pakanavicius, E., Gouti, M., Stamataki, D., Ivanovitch, K., Watson, T., Rayon, T., Mousavy Gharavy, S. N., Lovell-Badge, R., et al. (2018). Nervous system regionalization entails axial allocation before neural differentiation. Cell, 175, 1105–1118.e1117.
Sasai, Y., & De Robertis, E. M. (1997). Ectodermal patterning in vertebrate embryos. Developmental Biology, 182, 5–20.
Steinbeck, J. A., Choi, S. J., Mrejeru, A., Ganat, Y., Deisseroth, K., Sulzer, D., Mosharov, E. V., & Studer, L. (2015). Optogenetics enables functional analysis of human embryonic stem cell–derived grafts in a Parkinson’s disease model. Nature Biotechnology, 33, 204–209.
Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998). Embryonic stem cell lines derived from human blastocysts. Science, 282, 1145–1147.
Wang, Y.-K., Zhu, W.-W., Wu, M.-H., Wu, Y.-H., Liu, Z.-X., Liang, L.-M., Sheng, C., Hao, J., Wang, L., Li, W., et al. (2018). Human clinical-grade parthenogenetic ESC-derived dopaminergic neurons recover locomotive defects of nonhuman primate models of Parkinson’s disease. Stem Cell Reports, 11, 171–182.
Wilson, S. W., & Rubenstein, J. L. R. (2000). Induction and dorsoventral patterning of the telencephalon. Neuron, 28, 641–651.
Wu, J., Sheng, C., Liu, Z., Jia, W., Wang, B., Li, M., Fu, L., Ren, Z., An, J., Sang, L., et al. (2015). Lmx1a enhances the effect of iNSCs in a PD model. Stem Cell Research, 14, 1–9.
Xi, J., Liu, Y., Liu, H., Chen, H., Emborg, M. E., & Zhang, S.-C. (2012). Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells, 30, 1655–1663.
Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003). Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nature Biotechnology, 21, 183–186.
Yue, W., Li, Y., Zhang, T., Jiang, M., Qian, Y., Zhang, M., Sheng, N., Feng, S., Tang, K., Yu, X., et al. (2015). ESC-derived basal forebrain cholinergic neurons ameliorate the cognitive symptoms associated with Alzheimer’s disease in mouse models. Stem Cell Reports, 5, 776–790.
Zhang, S.-C., Wernig, M., Duncan, I. D., Brüstle, O., & Thomson, J. A. (2001). In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nature Biotechnology, 19, 1129–1133.
Zhang, X., Huang, C. T., Chen, J., Pankratz, M. T., Xi, J., Li, J., Yang, Y., LaVaute, T. M., Li, X.-J., Ayala, M., et al. (2010). Pax6 is a human neuroectoderm cell fate determinant. Cell Stem Cell, 7, 90–100.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Zhang, X. (2020). Human Pluripotent Stem Cells and Neural Regeneration. In: Brand-Saberi, B. (eds) Essential Current Concepts in Stem Cell Biology. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-33923-4_9
Download citation
DOI: https://doi.org/10.1007/978-3-030-33923-4_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-33922-7
Online ISBN: 978-3-030-33923-4
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)