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Cancer-Related Fatigue in Hodgkin Lymphoma

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Hodgkin Lymphoma

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

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Abstract

Cancer-related fatigue is one of the most common impairments in HL patients and survivors. Symptoms of cancer-related fatigue deserve attention because they are associated with adverse effects on psychological well-being and everyday life including family, work and social reintegration. Early identification of affected individuals and further development of therapeutic interventions are therefore of major importance.

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References

  1. Behringer K, Goergen H, Hitz F, Zijlstra JM, Greil R, Markova J et al (2015) Omission of dacarbazine or bleomycin, or both, from the ABVD regimen in treatment of early-stage favourable Hodgkin’s lymphoma (GHSG HD13): an open-label, randomised, non-inferiority trial. Lancet 385(9976):1418–1427

    Article  CAS  PubMed  Google Scholar 

  2. von Tresckow B, Plutschow A, Fuchs M, Klimm B, Markova J, Lohri A et al (2012) Dose-intensification in early unfavorable Hodgkin’s lymphoma: final analysis of the German Hodgkin study group HD14 trial. J Clin Oncol 30(9):907–913

    Article  CAS  Google Scholar 

  3. Borchmann P, Goergen H, Kobe C, Lohri A, Greil R, Eichenauer DA et al (2018) PET-guided treatment in patients with advanced-stage Hodgkin’s lymphoma (HD18): final results of an open-label, international, randomised phase 3 trial by the German Hodgkin study group. Lancet 390(10114):2790–2802

    Article  Google Scholar 

  4. Swerdlow AJ, Higgins CD, Smith P, Cunningham D, Hancock BW, Horwich A et al (2011) Second cancer risk after chemotherapy for Hodgkin’s lymphoma: a collaborative British cohort study. J Clin Oncol 29(31):4096–4104

    Article  CAS  PubMed  Google Scholar 

  5. Aleman BM, van den Belt-Dusebout AW, De Bruin ML, Van’t Veer MB, Baaijens MH, de Boer JP et al (2007) Late cardiotoxicity after treatment for Hodgkin lymphoma. Blood 109(5):1878–1886

    Article  CAS  PubMed  Google Scholar 

  6. Eichenauer DA, Thielen I, Haverkamp H, Franklin J, Behringer K, Halbsguth T et al (2014) Therapy-related acute myeloid leukemia and myelodysplastic syndromes in patients with Hodgkin lymphoma: a report from the German Hodgkin study group. Blood 123(11):1658–1664

    Article  CAS  PubMed  Google Scholar 

  7. Loge JH, Abrahamsen AF, Ekeberg O, Kaasa S (1999) Reduced health-related quality of life among Hodgkin’s disease survivors: a comparative study with general population norms. Ann Oncol 10(1):71–77

    Article  CAS  PubMed  Google Scholar 

  8. Heutte N, Flechtner HH, Mounier N, Mellink WA, Meerwaldt JH, Eghbali H et al (2009) Quality of life after successful treatment of early-stage Hodgkin’s lymphoma: 10-year follow-up of the EORTC-GELA H8 randomised controlled trial. Lancet Oncol 10(12):1160–1170

    Article  PubMed  Google Scholar 

  9. Ruffer JU, Flechtner H, Tralls P, Josting A, Sieber M, Lathan B et al (2003) Fatigue in long-term survivors of Hodgkin’s lymphoma; a report from the German Hodgkin lymphoma study group (GHSG). Eur J Cancer 39(15):2179–2186

    Article  CAS  PubMed  Google Scholar 

  10. Fobair P, Hoppe RT, Bloom J, Cox R, Varghese A, Spiegel D (1986) Psychosocial problems among survivors of Hodgkin’s disease. J Clin Oncol 4(5):805–814

    Article  CAS  PubMed  Google Scholar 

  11. Kreissl S, Mueller H, Goergen H, Mayer A, Brillant C, Behringer K et al (2016) Cancer-related fatigue in patients with and survivors of Hodgkin’s lymphoma: a longitudinal study of the German Hodgkin study group. Lancet Oncol 17(10):1453–1462

    Article  PubMed  Google Scholar 

  12. Hjermstad MJ, Oldervoll L, Fossa SD, Holte H, Jacobsen AB, Loge JH (2006) Quality of life in long-term Hodgkin’s disease survivors with chronic fatigue. Eur J Cancer 42(3):327–333

    Article  PubMed  Google Scholar 

  13. Loge JH, Abrahamsen AF, Ekeberg O, Kaasa S (1999) Hodgkin’s disease survivors more fatigued than the general population. J Clin Oncol 17(1):253–261

    Article  CAS  PubMed  Google Scholar 

  14. Minton O, Berger A, Barsevick A, Cramp F, Goedendorp M, Mitchell SA et al (2013) Cancer-related fatigue and its impact on functioning. Cancer 119(Suppl 11):2124–2130

    Article  PubMed  Google Scholar 

  15. Aaronson NK, Mattioli V, Minton O, Weis J, Johansen C, Dalton SO et al (2014) Beyond treatment—psychosocial and behavioural issues in cancer survivorship research and practice. EJC Suppl 12(1):54–64

    Article  PubMed  PubMed Central  Google Scholar 

  16. Behringer K, Goergen H, Muller H, Thielen I, Brillant C, Kreissl S et al (2016) Cancer-related fatigue in patients with and survivors of Hodgkin lymphoma: the impact on treatment outcome and social reintegration. J Clin Oncol 34(36):4329–4337

    Article  PubMed  Google Scholar 

  17. Daniels LA, Oerlemans S, Krol AD, Van de Poll-Franse LV, Creutzberg CL (2013) Persisting fatigue in Hodgkin lymphoma survivors: a systematic review. Ann Hematol 92(8):1023–1032

    Article  PubMed  Google Scholar 

  18. Chalder T, Berelowitz G, Pawlikowska T, Watts L, Wessely S, Wright D et al (1993) Development of a fatigue scale. J Psychosom Res 37(2):147–153

    Article  CAS  PubMed  Google Scholar 

  19. Smets EM, Garssen B, Bonke B, De Haes JC (1995) The multidimensional fatigue inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res 39(3):315–325

    Article  CAS  PubMed  Google Scholar 

  20. Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30(6):473–483

    Article  PubMed  Google Scholar 

  21. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ et al (1993) The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 85(5):365–376

    Article  CAS  PubMed  Google Scholar 

  22. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A et al (2012) Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin’s lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial. Lancet 379(9828):1791–1799

    Article  CAS  PubMed  Google Scholar 

  23. Schwarz R, Hinz A (2001) Reference data for the quality of life questionnaire EORTC QLQ-C30 in the general German population. Eur J Cancer 37(11):1345–1351

    Article  CAS  PubMed  Google Scholar 

  24. Minton O, Stone P (2009) A systematic review of the scales used for the measurement of cancer-related fatigue (CRF). Ann Oncol 20(1):17–25

    Article  CAS  PubMed  Google Scholar 

  25. Cocks K, King MT, Velikova G, Fayers PM, Brown JM (2008) Quality, interpretation and presentation of European Organisation for Research and Treatment of Cancer quality of life questionnaire core 30 data in randomised controlled trials. Eur J Cancer 44(13):1793–1798

    Article  PubMed  Google Scholar 

  26. Klinkhammer-Schalke M, Koller M, Ehret C, Steinger B, Ernst B, Wyatt JC et al (2008) Implementing a system of quality-of-life diagnosis and therapy for breast cancer patients: results of an exploratory trial as a prerequisite for a subsequent RCT. Br J Cancer 99(3):415–422

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Ganz PA, Moinpour CM, Pauler DK, Kornblith AB, Gaynor ER, Balcerzak SP et al (2003) Health status and quality of life in patients with early-stage Hodgkin’s disease treated on southwest oncology group study 9133. J Clin Oncol 21(18):3512–3519

    Article  PubMed  Google Scholar 

  28. Hjermstad MJ, Fossa SD, Oldervoll L, Holte H, Jacobsen AB, Loge JH (2005) Fatigue in long-term Hodgkin’s disease survivors: a follow-up study. J Clin Oncol 23(27):6587–6595

    Article  PubMed  Google Scholar 

  29. Gil-Fernandez J, Ramos C, Tamayo T, Tomas F, Figuera A, Arranz R et al (2003) Quality of life and psychological Well-being in Spanish long-term survivors of Hodgkin’s disease: results of a controlled pilot study. Ann Hematol 82(1):14–18

    Article  CAS  PubMed  Google Scholar 

  30. Montazeri A (2009) Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008. Health Qual Life Outcomes 7:102

    Article  PubMed  PubMed Central  Google Scholar 

  31. Quinten C, Coens C, Mauer M, Comte S, Sprangers MA, Cleeland C et al (2009) Baseline quality of life as a prognostic indicator of survival: a meta-analysis of individual patient data from EORTC clinical trials. Lancet Oncol 10(9):865–871

    Article  PubMed  Google Scholar 

  32. NCCN (2012) Clinical practice guidelines in oncology. Cancer related fatigue

    Google Scholar 

  33. Bower JE, Bak K, Berger A, Breitbart W, Escalante CP, Ganz PA et al (2014) Screening, assessment, and management of fatigue in adult survivors of cancer: an American Society of Clinical oncology clinical practice guideline adaptation. J Clin Oncol 32(17):1840–1850

    Article  PubMed  PubMed Central  Google Scholar 

  34. Cramp F, Byron-Daniel J (2012) Exercise for the management of cancer-related fatigue in adults. Cochrane Database Syst Rev 11:CD006145

    PubMed  Google Scholar 

  35. Oldervoll LM, Kaasa S, Knobel H, Loge JH (2003) Exercise reduces fatigue in chronic fatigued Hodgkins disease survivors--results from a pilot study. Eur J Cancer 39(1):57–63

    Article  CAS  PubMed  Google Scholar 

  36. McNeely ML, Courneya KS (2010) Exercise programs for cancer-related fatigue: evidence and clinical guidelines. J Natl Compr Cancer Netw 8(8):945–953

    Article  Google Scholar 

  37. Alexander S, Minton O, Andrews P, Stone P (2009) A comparison of the characteristics of disease-free breast cancer survivors with or without cancer-related fatigue syndrome. Eur J Cancer 45(3):384–392

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Gielissen MF, Verhagen S, Witjes F, Bleijenberg G (2006) Effects of cognitive behavior therapy in severely fatigued disease-free cancer patients compared with patients waiting for cognitive behavior therapy: a randomized controlled trial. J Clin Oncol 24(30):4882–4887

    Article  PubMed  Google Scholar 

  39. Knoop H, Stulemeijer M, de Jong LW, Fiselier TJ, Bleijenberg G (2008) Efficacy of cognitive behavioral therapy for adolescents with chronic fatigue syndrome: long-term follow-up of a randomized, controlled trial. Pediatrics 121(3):e619–e625

    Article  PubMed  Google Scholar 

  40. Gielissen MF, Verhagen CA, Bleijenberg G (2007) Cognitive behaviour therapy for fatigued cancer survivors: long-term follow-up. Br J Cancer 97(5):612–618

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Knoop H, Bleijenberg G, Gielissen MF, van der Meer JW, White PD (2007) Is a full recovery possible after cognitive behavioural therapy for chronic fatigue syndrome? Psychother Psychosom 76(3):171–176

    Article  PubMed  Google Scholar 

  42. Bruggeman-Everts FZ, Wolvers MDJ, van de Schoot R, Vollenbroek-Hutten MMR, Van der Lee ML (2017) Effectiveness of two web-based interventions for chronic Cancer-related fatigue compared to an active control condition: results of the “fitter na Kanker” randomized controlled trial. J Med Internet Res 19(10):e336

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Stefanie Kreissl .

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Kreissl, S., Hagenbeek, A., Knoop, H., Borchmann, P. (2020). Cancer-Related Fatigue in Hodgkin Lymphoma. In: Engert, A., Younes, A. (eds) Hodgkin Lymphoma. Hematologic Malignancies. Springer, Cham. https://doi.org/10.1007/978-3-030-32482-7_29

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  • DOI: https://doi.org/10.1007/978-3-030-32482-7_29

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-32481-0

  • Online ISBN: 978-3-030-32482-7

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