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Detection Methods for Human Papillomavirus (HPV) in Head and Neck Cancers

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Textbook of Oral Cancer

Part of the book series: Textbooks in Contemporary Dentistry ((TECD))

Abstract

The escalating incidence of squamous cell carcinoma of the oropharynx and base of the tongue (OPC) is associated with remote exposure to hrHPV and thereby indicates that the increasing numbers of these cancers will be seen in the clinical setting. HPV status in OPC impacts a range of clinical factors including primary site determination, extent of surgery, adjuvant treatment, and prognosis. Thus, accurate and reproducible methods to determine HPV status will be needed for an increasing volume of patients. For OPC, p16 is now considered to be a reliable surrogate for detection of hrHPV, but its use will likely wane as molecular testing such as in situ hybridization becomes more widespread and laboratories become more comfortable with application and interpretation of these methodologies.

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Author information

Authors and Affiliations

  1. Department of Pathology, University of California San Francisco, San Francisco, CA, USA

    Annemieke van Zante

  2. Departments of Orofacial Sciences, Pathology, and Radiation Oncology, University of California San Francisco, San Francisco, CA, USA

    Richard C. Jordan

Authors
  1. Annemieke van Zante
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  2. Richard C. Jordan
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Correspondence to Richard C. Jordan .

Editor information

Editors and Affiliations

  1. Faculty of Dentistry, Oral & Craniofacial Sciences,, King’s College London, London, UK

    Saman Warnakulasuriya

  2. Department of Orofacial Sciences, Schools of Dentistry and Medicine, University of California San Francisco, San Francisco, CA, USA

    John S. Greenspan

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van Zante, A., Jordan, R.C. (2020). Detection Methods for Human Papillomavirus (HPV) in Head and Neck Cancers. In: Warnakulasuriya, S., Greenspan, J. (eds) Textbook of Oral Cancer. Textbooks in Contemporary Dentistry. Springer, Cham. https://doi.org/10.1007/978-3-030-32316-5_10

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  • DOI: https://doi.org/10.1007/978-3-030-32316-5_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-32315-8

  • Online ISBN: 978-3-030-32316-5

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