Abstract
Wound healing is a dynamic and complex process that results from the interaction between cytokines, growth factors, blood components and the extracellular matrix. Conventional dressings made of natural or synthetic materials have only the ability to manage the wound and protect it from repeated trauma. With the advancement of technology, wound dressings have evolved and are now capable of intervening in the healing process by targeting specific features of the wound, aside from protecting the wounded site. In this work, bioactive dressings capable of promoting healing and fighting infection in chronic wounds were explored. Various antimicrobial biomolecules were examined in light of their pathogen fighting skills and immunoregulatory potentialities. Dressing production processes were also investigated. Biodegradable composite dressings made of poly(vinyl alcohol), polycaprolactone, chitosan and cellulose blends were our main focus. The goal was to evaluate the synergistic effect of biomolecules and biodegradable polymeric dressings, considering the local and systemic treatment demands of chronic wounds.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Martin, P., Nunan, R.: Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br. J. Dermatol. 173, 370–378 (2015)
Felgueiras, H.P., Amorim, M.T.P.: Functionalization of electrospun polymeric wound dressings with antimicrobial peptides. Colloids Surf. B 156, 133–148 (2017)
Felgueiras, H.P., Amorim, M.T.P.: Electrospun polymeric dressings functionalized with antimicrobial peptides and collagen type I for enhanced wound healing. In: 17th World Textile Conference, AUTEX 2017. IOP Conference Series: Materials Science and Engineering, vol. 254, p. 062004 (2017)
Georgescu, M., Chifiriu, M.C., Marutescu, L., Gheorghe, I., Lazar, V., Bolocan, A., Bertesteanu, S.: Bioactive wound dressings for the management of chronic wounds. Curr. Org. Chem. 21(1), 53–63 (2017)
Boateng, J.S., Matthews, K.H., Stevens, H.N.E., Eccleston, G.M.: Wound healing dressings and drug delivery systems: a review. J. Pharm. Sci. 97(8), 2892–2923 (2008)
Querido, M.M., Felgueiras, H.P., Rai, A., Costa, F., Monteiro, C., Borges, I., Oliveira, D., Ferreira, L., Martins, M.C.L.: Cecropin-melittin functionalized polyurethane surfaces prevent Staphylococcus epidermidis adhesion without inducing platelet adhesion and activation. Adv. Mater. Interfaces 5, 1801390 (2018)
Mogoşanu, G.D., Grumezescu, A.M.: Natural and synthetic polymers for wounds and burns dressing. Int. J. Pharm. 463(2), 127–136 (2014)
Mir, M., Ali, M.N., Barakullah, A., Gulzar, A., Arshad, M., Fatima, S., Asad, M.: Synthetic polymeric biomaterials for wound healing: a review. Prog. Biomater. 7, 1–21 (2018)
Park, J.W., Hwang, S.R., Yoon, I.-S.: Advanced growth factor delivery systems in wound management and skin regeneration. Molecules 22(8), 1259–1279 (2017)
Silva, I.O., Ladchumananandasivam, R., Nascimento, J.H.O., Silva, K.O.S., Oliveira, F.R., Souto, A.P., Felgueiras, H.P., Zille, A.: Multifunctional chitosan/gold nanoparticles synergistic coatings for biomedical textiles. Nanomaterials 9(8), 1064–1085 (2019). https://doi.org/10.3390/nano9081064
Acknowledgements
Authors acknowledge the Portuguese Foundation for Science and Technology (FCT), FEDER funds by means of Competitive Factors Operational Program (POCI) for funding the projects POCI-01-0145-FEDER-028074 and UID/CTM/00264/2019.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this paper
Cite this paper
Felgueiras, H.P., Teixeira, M.A., Amorim, M.T.P. (2020). Potentialities of LL37 for Wound Healing Applications: Study of Its Activity in Synergy with Biodegradable Composites Made of PVA and CA. In: Henriques, J., Neves, N., de Carvalho, P. (eds) XV Mediterranean Conference on Medical and Biological Engineering and Computing – MEDICON 2019. MEDICON 2019. IFMBE Proceedings, vol 76. Springer, Cham. https://doi.org/10.1007/978-3-030-31635-8_148
Download citation
DOI: https://doi.org/10.1007/978-3-030-31635-8_148
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-31634-1
Online ISBN: 978-3-030-31635-8
eBook Packages: EngineeringEngineering (R0)