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Chaetomium in Indoor Environment and Medically Important Species of Chaetomium

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Recent Developments on Genus Chaetomium

Part of the book series: Fungal Biology ((FUNGBIO))

Abstract

Infections caused by fungi are a significant contributor to morbidity and mortality in humans. These infections range from comparatively innocuous superficial skin diseases caused by dermatophytes to invasive life-threatening infections. Chaetomium species belong to a large genus of saprobic ascomycetes found on dung, straw, paper, bird feathers, seeds, plant debris, and soil. Although Chaetomium species are rarely implicated in human disease, their spectrum of mycoses includes keratitis, onychomycosis, and sinusitis in immunocompetent individuals and empyema, pneumonia, and fatal disseminated cerebral disease in immunocompromised hosts and intravenous drug users. Since many of the diseases caused by Chaetomium are opportunistic in nature, the pathogenesis of fungal infections is complex and our understanding of how these taxa cause disease has lagged behind bacterial and viral pathogens. However, the application of new genomic and other molecular techniques in recent years has revolutionized the field of fungal pathogenesis. This has resulted in a dramatic improvement in our understanding of how fungi cause disease in humans, and this chapter presents a concise overview of Chaetomium taxa including their role in human diseases.

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References

  • Abbott SP, Sigler L, McAleer R et al (1995) Fatal cerebral mycoses caused by the ascomycete Chaetomium strumarium. J Clin Microbiol 33(10):2692–2698

    CAS  PubMed  PubMed Central  Google Scholar 

  • Aghamirian MR, Ghiasian SA (2009) Isolation and characterization of medically important aerobic actinomycetes in soil of Iran (2006–2007). Open Microbiol J 3:53–57

    Article  PubMed  PubMed Central  Google Scholar 

  • Ahmed A, Adelmann D, Fahal A, Verbrugh H, van Belkum A, de Hoog GS (2002) Environmental occurrence of Madurella mycetomatis, the major agent of human eumycetoma in Sudan. J Clin Microbiol 40:1031–1036

    Article  PubMed  PubMed Central  Google Scholar 

  • Ahmed SA, Khan Z, Wang XW et al (2016) Chaetomium-like fungi causing opportunistic infections in humans: a possible role for extremotolerance. Fungal Divers 76:11–26

    Article  Google Scholar 

  • Al-Aidaroos A, Bin-Hussain I, El Solh H, Kofide A, Thawadi S, Belgaumi A, Al Ahmari A (2007) Invasive Chaetomium infection in two immunocompromised pediatric patients. Pediatr Infect Dis J 26:456–458

    Article  PubMed  Google Scholar 

  • Ames LM (1963) A monograph of the Chaetomiaceae. U.S. Army Research and Development, Series 2

    Google Scholar 

  • Anandi V et al (1989) Cerebral phaeohyphomycosis caused by Chaetomium globosum in a renal transplant recipient. J Clin Microbiol 27:2226–2229

    CAS  PubMed  PubMed Central  Google Scholar 

  • Andersen B, Frisvad JC, Søndergaard I et al (2011) Associations between fungal species and water-damaged building materials. Appl Environ Microbiol 77:4180–4188

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Andersen B, Dosen I, Lewinska AM, Nielsen KF (2017) Pre-contamination of new gypsum wallboard with potentially harmful fungal species. Indoor Air 27(1):6–12. https://doi.org/10.1111/ina.12298

    Article  PubMed  CAS  Google Scholar 

  • Apetrei IC, Draganesc GE, Popescu IT et al (2009) Possible cause of allergy for the librarians: books manipulation and ventilation as sources of fungus spores spreading. Aerobiologia 25:159–166

    Article  Google Scholar 

  • Aribandi M, Bazan Iii C, Rinaldi MG (2005) Magnetic resonance imaging findings in fatal primary cerebral infection due to Chaetomium strumarium. Australas Radiol 49(2):166–169

    Article  CAS  PubMed  Google Scholar 

  • Aru A, Munk-Nielsen L, Federspiel BH (1997) The soil fungus Chaetomium in the human paranasal sinuses. Eur Arch Otorhinolaryngol 254:350–352

    Article  CAS  PubMed  Google Scholar 

  • Asgari B, Zare R (2011) The genus Chaetomium in Iran, a phylogenetic study including six new species. Mycologia 103:863–882

    Article  PubMed  Google Scholar 

  • Aspiroz C, Gene J, Rezusta A et al (2007) First Spanish case of onychomycosis caused by Chaetomium globosum. Med Mycol 45:279–282

    Article  PubMed  Google Scholar 

  • Ayanbimpe GM, Wapwera SD, Kuchin D (2010) Indoor air mycoflora of residential dwellings in Jos metropolis. Afr Health Sci 10:172–176

    CAS  PubMed  PubMed Central  Google Scholar 

  • Badali H, Carvalho VO, Vicente V, Attili-Angelis D, Kwiatkowski IB, Gerrits van den Ende AHG, de Hoog GS (2009) Cladophialophora saturnica sp. nov., a new opportunistic species of Chaetothyriales revealed using molecular data. Med Mycol 47:51–62. https://doi.org/10.1080/13693780802291452

    Article  CAS  PubMed  Google Scholar 

  • Badali H, Chander J, Gupta A, Rani H, Punia RS, de Hoog GS, Meis JF (2011) Fatal cerebral phaeohyphomycosis in an immunocompetent individual due to Thielaviasubthermophila. J Clin Microbiol 49:2336–2341. https://doi.org/10.1128/JCM.02648-10

    Article  PubMed  PubMed Central  Google Scholar 

  • Bakhiet S M, Rubino S, Faha A H (2019). Chaetomium atrobrunneum causing human eumycetoma: The first report. PLOS Neglected Tropical Diseases 13(5): e0007276. https://doi.org/10.1371/journal.pntd.0007276

    Article  PubMed  PubMed Central  Google Scholar 

  • Balne PK, Nalamada S, Kodiganti M, Taneja M (2012) Fungal keratitis caused by Chaetomium atrobrunneum. Cornea 31:94–95

    Article  PubMed  Google Scholar 

  • Barron MA, Sutton DA, Veve R et al (2003) Invasive mycotic infections caused by Chaetomium perlucidum, a new agent of cerebral phaeohyphomycosis. J Clin Microbiol 41(11):5302–5307

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bell A (2005) An illustrated guide to the coprophilous Ascomycetes of Australia. CBS Fungal Biodivers Ser 3:1–172

    Google Scholar 

  • Carter A, Khan RS (1982) New and interesting Chaetomium species from East Africa. Can J Bot 60:1253–1262

    Article  Google Scholar 

  • Chan T-M, Chu M (2007) Sch 213766, a novel chemokine receptor CCR-5 inhibitor from Chaetomium globosum. J Antibiot 60:524–528

    Article  Google Scholar 

  • Chivers AH (1915) A monograph of the genera Chaetomium and Ascotricha. Mem Torrey Bot Club 14:155–240

    Google Scholar 

  • Corda ACJ (1840) Icones fungorum hucusque cognitorum, vol 4, Praha

    Google Scholar 

  • de Hoog GS, Ahmed SA, Najafzadeh MJ et al (2013a) Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. PLoS Negl Trop Dis 7(5):e2229

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • de Hoog G, Guarro J, Gené J, Figueras MJ (2013b) Atlas of clinical fungi, 3rd edn. (e-version). Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands/Universitat Rovirai Virgili, Reus, Spain

    Google Scholar 

  • Došen I, Nielsen KF, Clausen G et al (2017) Potentially harmful secondary metabolites produced by indoor Chaetomium species on artificially and naturally contaminated building materials. Indoor Air 27(1):34–46. https://doi.org/10.1111/ina.12290

    Article  CAS  PubMed  Google Scholar 

  • Doveri F (2008) An update on the genus Chaetomium with descriptions of some coprophilous species, new to Italy. Pagine Micol 29:1–60

    Google Scholar 

  • Dreyfuss M (1976) Taxonomische Untersuchungen innerhalb der Gattung Chaetomium. Sydowia 28:50–133

    Google Scholar 

  • Flannigan B, Miller JD (2011) Microbial growth in indoor environments. In: Flannigan B, Samson RA, Miller JD (eds) Microorganisms in home and indoor work environments. Diversity, health impacts, investigation and control, 2nd edn. CRC Press, Boca Raton, FL, pp 57–107

    Google Scholar 

  • Friedman AH (1998) Cerebral fungal infections in the immunocompromised host: a literature review and a new pathogen—Chaetomium atrobrunneum: case report— comment. Neurosurgery 43:1469

    Google Scholar 

  • Ghosh AK, Gupta A, Rudramurthy SM, Paul S, Hallur VK, Chakrabarti A (2016) Fungal keratitis in North India: spectrum of agents, risk factors and treatment. Mycopathologia 181:843–850

    Article  CAS  PubMed  Google Scholar 

  • Gonianakis M, Neonakis I, Darivianaki E et al (2005) Airborne Ascomycotina on the island of Crete: seasonal patterns based on an 8-year volumetricsurvey. Aerobiologia 21:69–74

    Article  Google Scholar 

  • Guarro J, Soler L, Rinaldi MG (1995) Pathogenicity and antifungal susceptibility of Chaetomium species. Eur J Clin Microbiol Infect Dis 14:613–618

    Article  CAS  PubMed  Google Scholar 

  • Guppy KH et al (1998) Cerebral fungal infections in the immunocompromised host: a literature review and a new pathogen—Chaetomium atrobrunneum: case report. Neurosurgery 43:1463–1469

    CAS  PubMed  Google Scholar 

  • Hall TA (1999) BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symp Ser 41:95–98

    CAS  Google Scholar 

  • Hattori N, Adachi M, Kaneko T, Shimozuma M, Ichinohe M, Iozumi K (2000) Case report. Onychomycosis due to Chaetomium globosum successfully treated with itraconazole. Mycoses 43(1–2):89–92

    Article  CAS  PubMed  Google Scholar 

  • Hoppin EC, McCoy EL, Rinaldi MG (1983) Opportunistic mycotic infection caused by Chaetomium in a patient with acute leukemia. Cancer 52:555–556

    Article  CAS  PubMed  Google Scholar 

  • Hubka V, Mencl K, Skorepova M et al (2011) Phaeohyphomycosis and onychomycosis due to Chaetomium spp., including the first report of Chaetomium brasiliense infection. Med Mycol 49:724–733

    PubMed  Google Scholar 

  • Kaliamurthy J, Kalavathy CM, Nelson Jesudasan CA, Thomas PA (2011) Keratitis due to Chaetomium sp. Case Rep Ophthalmol Med 2011:696145

    PubMed  Google Scholar 

  • Kaul S, Sumbali G (1999) Production of extracellular keratinases by keratinophilic fungal species inhabiting feathers of living poultry birds (Gallus domesticus). Mycopathologia 146:6–19

    Article  Google Scholar 

  • Koch HA, Haneke H (1965) Chaetomium funicolum Cooke alsmoglicher Erreger einer tiefen Mykose. Mkosen 9:23–28

    Article  Google Scholar 

  • Kunze G, Schmidt JK (1817) Mykologische Hefte: 1. Germany, Leipzig

    Google Scholar 

  • Lesire V et al (1999) Possible role of Chaetomium globosum in infection after autologous bone marrow transplantation. Intensive Care Med 25:124–125

    Article  CAS  PubMed  Google Scholar 

  • Lin Y, Li X et al (1995) First case of phaeohyphomycosis caused by Chaetomium murorum in China. Chin J Dermatol 28:367–369

    Google Scholar 

  • Mason S, Cortes D, Horner WE (2010) Detection of gaseous effluents and by products of fungal growth that affect environments (RP-1243). HVAC&R Res 16:109–121

    Article  Google Scholar 

  • Mazzucchetti G (1965) Microfungi della cellulosa eddla carta attivita’s e inquadramento sistematico – Il genere “Chaetomium”. Pubblicazioni Dell’entenazionale Per La Cellulosa e Per La Carta, Roma

    Google Scholar 

  • McMullin DR, Sumarah MW, Miller JD (2013) Chaetoglobosins and azaphilones produced by Canadian strains of Chaetomium globosum isolated from the indoor environment. Mycotoxin Res 29:47–54

    Article  CAS  PubMed  Google Scholar 

  • Mhmoud NA, Santona A, Fiamma M, Siddig EE, Deligios M, Bakhiet SM, Rubino S, Faha AH (2019). Chaetomium atrobrunneum causing human eumycetoma: The first report. PLoS Negl Trop Dis 13(5):e0007276. https://doi.org/10.1371/journal.pntd.0007276

    Article  PubMed  PubMed Central  Google Scholar 

  • Miller JD, McMullin DR (2014) Fungal secondary metabolites as harmful indoor air contaminants: 10 years on. Appl Microbiol Biotechnol 98:9953–9966

    Article  CAS  PubMed  Google Scholar 

  • Millner PD (1977) Radial growth responses to temperature by 58 Chaetomium species, and some taxonomic relationships. Mycologia 69:492–502

    Article  Google Scholar 

  • Millner PD, Motta JJ, Lentz PL (1977) Ascospores, germ pores, ultrastructure, and thermophilism of Chaetomium. Mycologia 69:720–733

    Article  Google Scholar 

  • Möller EM, Bahnweg G, Sandermann H, Geiger HH (1992) A simple and efficient protocol for isolation of high molecular weight DNA from filamentous fungi, fruit bodies, and infected plant tissues. Nucleic Acids Res 20:6115–6116

    Article  PubMed  PubMed Central  Google Scholar 

  • Naidu J, Singh SM, Pouranik M (1991) Onychomycosis caused by Chaetomium globosum Kunze. Mycopathologia 113:31–34

    Article  CAS  PubMed  Google Scholar 

  • Najafzadeh MJ, Fata A, Naseri A, Keisari MS, Farahyar S, Ganjbakhsh M, Ziaee M, Dolatabadi S, de Hoog GS (2014) Implantation phaeohyphomycosis caused by a non-sporulating Chaetomium species. J Mycol Med 24:161–165. https://doi.org/10.1016/j.mycmed.2013.09.007

    Article  CAS  PubMed  Google Scholar 

  • Nylander JA, Wilgenbusch JC, Warren DL, Swofford DL (2008) AWTY: a system for graphical exploration of MCMC convergence in Bayesian phylogenetic inference. Bioinformatics 24:581–583

    Article  CAS  PubMed  Google Scholar 

  • Piepenbring M, Caceres MOA, Espino EAA, Kirschner R, Schofer H (2007) Chromoblastomycosis caused by Chaetomium funicola: a case report from Western Panama. Br J Dermatol 157:1025–1029

    Article  CAS  PubMed  Google Scholar 

  • Plumlee Q, Meason-Smith C, Dieterly A, Gomez G, Porter BF, Rodrigues HA (2017) Chaetomiaceae fungi, novel pathogens of equine neurotropic phaeohyphomycosis. Vet Pathol 54(5):813–819

    Article  PubMed  Google Scholar 

  • Polizzi V, Delmulle B, Adams A et al (2009) JEM spotlight: fungi, mycotoxins and microbial volatile organic compounds in mouldy interiors from water-damaged buildings. J Environ Monit 11:1849–1858

    Article  CAS  PubMed  Google Scholar 

  • Pounder J, Simmon KE, Barton CA, Hohmann SL, Brandt ME, Petti CA (2007) Discovering potential pathogens among fungi identified as non-sporulating molds. J Clin Microbiol 45:568–571

    Article  CAS  PubMed  Google Scholar 

  • Rambaut A, Drummond AJ (2007) Tracer v. 1.4. Available from http://beast.bio.ed.ac.uk/tracer. Accessed 29 Sept 2014

  • Reddy M, Venugopal R, Prakash PY, Kamath YS (2017) Corneal ulcer due to a rare coelomycetes fungus Chaetomium strumarium: case report and global review of Chaetomium keratomycosis. Indian J Ophthalmol 65:871–874

    Article  PubMed  PubMed Central  Google Scholar 

  • Rether J, Erkel G, Anke T, Sterner O (2004) Inhibition of inducible TNF-alpha expression by oxaspirodion, a novel spiro-compound from the ascomycete Chaetomium subspirale. Biol Chem 385:829–834

    Article  CAS  PubMed  Google Scholar 

  • Revankar SG, Sutton DA (2010) Melanized fungi in human disease. Clin Microbiol Rev 23:884–928. https://doi.org/10.1128/CMR.00019-10

    Article  PubMed  PubMed Central  Google Scholar 

  • Revankar SG, Patterson JE, Sutton DA, Pullen R, Rinaldi MG (2002) Disseminated phaeohyphomycosis: review of an emerging mycosis. Clin Infect Dis 34:467–476

    Article  PubMed  Google Scholar 

  • Rodríguez K, Stchigel AM, Cano JF, Guarro J (2004) A new species of Achaetomium from Indian soil. Stud Mycol 50:77–82

    Google Scholar 

  • Rock JP (1998) Cerebral fungal infections in the immuno compromised host: a literature review and a new patho- gen—Chaetomium atrobrunneum: case report—comment. Neurosurgery 43:1469

    Google Scholar 

  • Samson RA, Flannigan B, Flannigan ME et al (1994) Health implications offungi in indoor environments. Elsevier, Amsterdam

    Google Scholar 

  • Samson RA, Houbraken J, Thrane U et al (2010) Food and indoor fungi. In: CBS Laboratory Manual Series 2. CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherland

    Google Scholar 

  • Santos DW, Padovan AC, Melo AS, Gonçalves SS, Azevedo VR, Ogawa MM, Freitas TV, Colombo AL (2013) Molecular identification of melanised non-sporulating moulds: a useful tool for studying the epidemiology of phaeohyphomycosis. Mycopathologia 175:445–454. https://doi.org/10.1007/s11046-012-9608-x

    Article  CAS  PubMed  Google Scholar 

  • Seth HK (1970) A monograph of the genus Chaetomium. Beiheftezur Nova Hedwigia 37:1–133

    Google Scholar 

  • Skolko AJ, Groves JW (1948) Notes on seed-borne fungi V. Chaetomium species with dichotomously branched hairs. Can J Res 26:269–280

    Article  Google Scholar 

  • Skolko AJ, Groves JW (1953) Notes on seed-borne fungi VII. Chaetomium. Can J Bot 31:779–809

    Article  Google Scholar 

  • Sörgel G (1960) Zum problem der trennung von arten bei pilzen, dargestellt am beispiel der ascomycetengattung Chaetomium. Arch Microbiol 36:51–66

    Google Scholar 

  • Stamatakis A (2014) RAxML Version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics 30:1312–1313. https://doi.org/10.1093/bioinformatics/btu033

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stiller MJ, Rosenthal S, Summerbell RC et al (1992) Onychomycosis of the toenails caused by Chaetomium globosum. J Am Acad Dermatol 26:775–776

    Article  CAS  PubMed  Google Scholar 

  • Straus DC (2011) The possible role of fungal contamination in sick building syndrome. Front Biosci 3:562–580

    Article  Google Scholar 

  • Sugiyama K, Sano A, Murakami M et al (2008) Three isolations of Chaetomium globosum from erythematous epilation of canine skin. Med Mycol 46(5):505–510

    Article  CAS  PubMed  Google Scholar 

  • Teixeira AB et al (2003) Phaeohyphomycosis caused by Chaetomium globosum in an allogeneic bone marrow trans- plant recipient. Mycopathologia 156(4):309–312

    Article  CAS  PubMed  Google Scholar 

  • Thomas C et al (1999) Fatal Chaetomium cerebritis in a bone marrow transplant patient. Hum Pathol 30:874–879

    Article  CAS  PubMed  Google Scholar 

  • Vesper S, McKinstry C, Ashley P et al (2007) Quantitative PCR analysis ofmolds in the dust from homes of asthmatic children in North Carolina. J Environ Monit 9:826–830

    Article  CAS  PubMed  Google Scholar 

  • Vinod Mootha V, Shahinpoor P, Sutton DA, Xin L, Najafzadeh MJ, de Hoog GS (2012) Identification problems with sterile fungi, illustrated by a keratitis due to a non-sporulating chaetomium-like species. Med Mycol 50:361–367. https://doi.org/10.3109/13693786.2011.611179

    Article  CAS  PubMed  Google Scholar 

  • von Arx JA, Dreyfuss M, Müller E (1984) A reevaluation of Chaetomium and Chaetomiaceae. Persoonia 12:169–179

    Google Scholar 

  • von Arx JA, Guarro J, Figueras MJ (1986) The Ascomycete genus Chaetomium. Beiheftezur Nova Hedwigia 84:1–162

    Google Scholar 

  • Wang XW, Lombard L, Groenewald JZ et al (2016) Phylogenetic reassessment of the Chaetomium globosum species complex. Persoonia 36:83–133

    Article  CAS  PubMed  Google Scholar 

  • WHO (2009) WHO guidelines for indoor air quality: dampness and mould. World Health Organization Regional Office for Europe, Copenhagen

    Google Scholar 

  • Yeghen T et al (1996) Chaetomium pneumonia in a patient with acute myeloid leukaemia. J Clin Pathol 49:184–186

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Youngchim S et al (2004) Production of melanin by Aspergillus fumigatus. J Med Microbiol 53:175–181

    Article  CAS  PubMed  Google Scholar 

  • Zhang N, Castlebury LA, Miller AN, Huhndorf SM, Schoch CL et al (2006) An overview of the systematics of the Sordariomycetes based on a four-gene phylogeny. Mycologia 98:1076–1087

    Article  CAS  PubMed  Google Scholar 

  • Zopf W (1881) Zur Entwicklungsgeschichte der Ascomyceten: Chaetomium. Nova Acta der Kaiserlich Leopoldinisch-Carolinisch Deutschen Akademieder Naturforscher 42:199–292

    Google Scholar 

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Attia, E.A., Abdel-Azeem, A.M. (2020). Chaetomium in Indoor Environment and Medically Important Species of Chaetomium. In: Abdel-Azeem, A. (eds) Recent Developments on Genus Chaetomium . Fungal Biology. Springer, Cham. https://doi.org/10.1007/978-3-030-31612-9_5

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