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Ocular Motor Apraxia

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Advances in Translational Neuroscience of Eye Movement Disorders

Part of the book series: Contemporary Clinical Neuroscience ((CCNE))

Abstract

Ocular motor apraxia is a syndrome of gaze shifting failure, mainly saccades, in which patients show absent or highly delayed voluntary eye movements, although other eye movements can be preserved. One phenotype is characterized by absent or great disability to perform horizontal and vertical voluntary gaze shifting, with preservation of slow and quick phases of vestibular nystagmus. It is observed in acute brain lesions and adult-onset neurodegenerative diseases and results from dysfunction of cortical (and basal ganglia) control of voluntary eye movements. The congenital form, renamed “infantile-onset saccade initiation delay,” is characterized by head thrust, highly hypometric staircase saccades, increased saccade latency, and impaired quick phases of nystagmus. It may result from involvement of superior collicular, cerebellar, and/or cerebrocerebellar circuits of conjugate gaze shifting. This last phenotype is close to the one associated with Joubert syndrome, some Gaucher disease patients, ataxia-telangiectasia, and ataxia with oculomotor apraxia.

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Authors and Affiliations

  1. Hospices Civils de Lyon, Neuro-Ophthalmology, Hôpital Neurologique Pierre Wertheimer, Bron, France

    Caroline Tilikete

  2. Lyon I University, Lyon, France

    Caroline Tilikete

  3. CRNL INSERM U1028 CNRS UMR5292, ImpAct Team, Bron, France

    Caroline Tilikete

  4. Ophthalmology Department, Necker-Enfants Malades University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France

    Matthieu P. Robert

  5. COGNAC-G, UMR 8257 CNRS-IRBA-Université Paris Descartes, Paris, France

    Matthieu P. Robert

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Correspondence to Caroline Tilikete .

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  1. Neurological Institute, University Hospitals Neurology Service, Louis Stokes Cleveland, VA Medical Center, Department of Neurology, Case Western Reserve University, Cleveland, OH, USA

    Aasef Shaikh

  2. Pediatric Ophthalmology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

    Fatema Ghasia

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Tilikete, C., Robert, M.P. (2019). Ocular Motor Apraxia. In: Shaikh, A., Ghasia, F. (eds) Advances in Translational Neuroscience of Eye Movement Disorders. Contemporary Clinical Neuroscience. Springer, Cham. https://doi.org/10.1007/978-3-030-31407-1_22

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