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Lymphohematopoietic Malignancies

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Occupational Cancers

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Abstract

In this chapter, we present the 2017 revised WHO classification as the current reference standard for lymphohematopoietic malignancies. According to this, we discuss in detail the subgroups of myeloid and lymphoid malignancies, characterizing their biological and clinical features. Then, based on the current list of putative carcinogens maintained by the International Agency for Research on Cancer (updated to November 2018), we describe the possible occupational risk factors for myeloid and lymphoid malignancies. In particular, we focus on ionizing radiations (including fission products, phosphorus-32, strontium-90, thorium-232, and its decay products), benzene, 1,3-butadiene, formaldehyde, two pesticides (lindane and pentachlorophenol), and a generically identified industrial process (rubber production industry). As reviewed in the chapter, the case definitions adopted in epidemiological studies seldom met the classification criteria established by WHO. Hence, knowledge on putative risk factors for lymphohematopoietic malignancies is limited to major groupings, such as non-Hodgkin lymphoma, chronic lymphoid leukemia. Future researches should be oriented to study specific diseases and based on case definitions derived by systematic classifications of lymphohematopoietic malignancies.

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Authors and Affiliations

  1. Occupational Medicine Unit, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

    Francesco Saverio Violante & Andrea Farioli

  2. Occupational Medicine Unit, Department of Biomedical Sciences, Dental and Morphologic and Functional Images, University of Messina, Messina, Italy

    Giovanna Spatari

  3. Institute of Hematology “L. e A. Seràgnoli”, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy

    Alessandro Broccoli & Pier Luigi Zinzani

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  1. Francesco Saverio Violante
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  5. Pier Luigi Zinzani
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Correspondence to Andrea Farioli .

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  1. Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

    Sisko Anttila

  2. Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Paolo Boffetta

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Violante, F.S., Farioli, A., Spatari, G., Broccoli, A., Zinzani, P.L. (2020). Lymphohematopoietic Malignancies. In: Anttila, S., Boffetta, P. (eds) Occupational Cancers. Springer, Cham. https://doi.org/10.1007/978-3-030-30766-0_31

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