Abstract
There are growing concerns about health risks in pet animals due to the exposure to brominated compounds. This chapter describes the available information on tissue-specific accumulation and biotransformation of PBDEs and their hydroxylated and methoxylated derivatives (OH-PBDEs and MeO-PBDEs) in pet dogs and cats. Cats tend to exhibit higher tissue and blood concentrations of PBDEs. Furthermore, brominated compounds are also found at relatively high concentrations in cat brains, suggesting that they can cross through the blood–brain barrier. Thus, cats might be at a high risk from PBDEs and their derivatives. In dogs, BDE47 is the dominant congener in the bile, which suggests a species-specific excretory capacity of the liver. Regarding PBDEs metabolites, the major congeners of OH-/MeO-PBDEs identified in both pet food products and blood were natural products (6OH-/MeO-BDE47 and 2′OH-/MeO-BDE68) from marine organisms. The profiles and tissue distribution of PBDEs and metabolites are described for both species, and possible explanations for the differences observed between these pets are put forward.
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Acknowledgments
This study was partly supported by the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) to a project on Joint Usage/Research Center –Leading Academia in Marine and Environmental Research (LaMer), Ehime University. This study was supported by Grants-in-Aid (KAKENHI) for Young Scientists (B) (No. 15K16132), Scientific Research (S) (No. 26220103), and Scientific Research (B) (No. 16H02989) from the Japan Society for the Promotion of Science (JSPS) and Grants-in-Aid for Scientific Research from Nippon Life Insurance Foundation.
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Mizukawa, H., Nomiyama, K. (2020). Biotransformation of Brominated Compounds by Pet Dogs and Cats. In: Pastorinho, M., Sousa, A. (eds) Pets as Sentinels, Forecasters and Promoters of Human Health. Springer, Cham. https://doi.org/10.1007/978-3-030-30734-9_6
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