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Biology of Giant Cell Tumour

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Diagnosis of Musculoskeletal Tumors and Tumor-like Conditions

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Abstract

Giant cell tumour of bone (GCTb) is a locally aggressive osteolytic tumour. Approximately 5% of GCTb develop pulmonary metastases. Although many studies proposed agents targeting osteoclast differentiation and bone resorption, identification of tissue and circulating biomarkers may improve the prediction of malignant progression, early differentiating high-risk patients prone to recive more appropiate therapies.

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Author information

Authors and Affiliations

  1. Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Maria Serena Benassi

Authors
  1. Maria Serena Benassi
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Editor information

Editors and Affiliations

  1. I.S.G. Italian Sarcoma Group, Bologna, Italy

    Piero Picci

  2. IIIrd Clinic of Orthopaedic Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy

    Marco Manfrini

  3. Istituto Ortopedico Rizzoli, Bologna, Italy

    Davide Maria Donati

  4. Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Marco Gambarotti

  5. Department of Pathology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy

    Alberto Righi

  6. Istituto Rizzoli, Bologna, Italy

    Daniel Vanel

  7. Department of Medicine, University of Padua School of Medicine, Padua, Italy

    Angelo Paolo Dei Tos

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Benassi, M.S. (2020). Biology of Giant Cell Tumour. In: Picci, P., et al. Diagnosis of Musculoskeletal Tumors and Tumor-like Conditions. Springer, Cham. https://doi.org/10.1007/978-3-030-29676-6_23

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  • DOI: https://doi.org/10.1007/978-3-030-29676-6_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-29675-9

  • Online ISBN: 978-3-030-29676-6

  • eBook Packages: MedicineMedicine (R0)

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