Abstract
Venous thromboembolism (VTE) as a first event occurs in 100 per 100,000 persons each year in the United States with an incidence that rises exponentially with age (White RH, Circulation 107:14–8, 2003). More than 60% of symptomatic VTE cases manifest as deep vein thrombosis (DVT) alone, whereas one-third of patients present with pulmonary embolism (PE) (White RH, Circulation 107:14–8, 2003). Recurrence occurs in approximately 7% of patients and happens more frequently with PE than DVT (White RH, Circulation 107:14–8, 2003; Cushman et al., Am J Med 117:19–25, 2004). The incidence of death within 30 days of diagnosis occurs in 6% of patients with DVT and 12% with PE (White RH, Circulation 107:14–8, 2003). Less common manifestations of venous thrombosis include phlegmasia alba dolens, phlegmasia cerulea dolens (PCD), and venous gangrene, which form a clinical spectrum that carries significant morbidity (Sarwar S, Narra S, Munir A, Tex Heart Inst J 36:76, 2009; Haimovici H, J Cardiovasc Surg 5:164–73, 1965). It is important for the emergency practitioner (EP) to appropriately recognize and treat VTE, as delays in diagnosis and treatment may result in a significant increase in morbidity and mortality.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
White RH. The epidemiology of venous thromboembolism. Circulation. 2003;107:I4–8.
Cushman M, Tsai AW, White RH, et al. Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology. Am J Med. 2004;117:19–25.
Sarwar S, Narra S, Munir A. Phlegmasia cerulea dolens. Tex Heart Inst J. 2009;36:76–7.
Haimovici H. The ischemic forms of venous thrombosis. 1. Phlegmasia cerulea dolens. 2. Venous gangrene. J Cardiovasc Surg. 1965;5(Suppl):164–73.
Lee R. A contribution to the pathology of Phlegmasia Dolens. Med chir Trans. 1829;15:132–45.
Lee R. Further researches on the pathology of Phlegmasia Dolens. Med Chir Trans. 1853;36:281–314.
Mackenzie FW. Researches on the pathology of obstructive phlebitis, and the nature and proximate cause of Phlegmasia Dolens. Med Chir Trans. 1853;36:169–244.
De BM, Ochsner A. Phlegmasia cerulea dolens and gangrene associated with thrombophlebitis; case reports and review of the literature. Surgery. 1949;26:16–29.
Perkins JM, Magee TR, Galland RB. Phlegmasia caerulea dolens and venous gangrene. Br J Surg. 1996;83:19–23.
Mumoli N, Invernizzi C, Luschi R, Carmignani G, Camaiti A, Cei M. Phlegmasia cerulea dolens. Circulation. 2012;125:1056–7.
Brockman SK, Vasko JS. Phlegmasia cerulea dolens. Surg Gynecol Obstet. 1965;121:1347–56.
Suwanabol PA, Tefera G, Schwarze ML. Syndromes associated with the deep veins: phlegmasia cerulea dolens, May-Thurner syndrome, and nutcracker syndrome. Perspect Vasc Surg Endovasc Ther. 2010;22:223–30.
Mahomed A, Williams D. Phlegmasia caerulea dolens and venous gangrene. Br J Surg. 1996;83:1160–1.
Warkentin TE, Elavathil LJ, Hayward CP, Johnston MA, Russett JI, Kelton JG. The pathogenesis of venous limb gangrene associated with heparin-induced thrombocytopenia. Ann Intern Med. 1997;127:804–12.
Chinsakchai K, Ten Duis K, Moll FL, de Borst GJ. Trends in management of phlegmasia cerulea dolens. Vasc Endovasc Surg. 2011;45:5–14.
Brockman SK, Vasko JS. The pathologic physiology of phlegmasia cerulea dolens. Surgery. 1966;59:997–1007.
Qvarfordt P, Eklof B, Ohlin P. Intramuscular pressure in the lower leg in deep vein thrombosis and phlegmasia cerulae dolens. Ann Surg. 1983;197:450–3.
Haller JA Jr, Mays T. Experimental studies on Iliofemoral venous thrombosis. Am Surg. 1963;29:567–71.
Laohapensang K, Hanpipat S, Aworn S, Orrapin S. Surgical venous thrombectomy for phlegmasia cerulea dolens and venous gangrene of the lower extremities. J Med Assoc Thai Chotmaihet thangphaet. 2013;96:1463–9.
Klok FA, Huisman MV. Seeking optimal treatment for phlegmasia cerulea dolens. Thromb Res. 2013;131:372–3.
Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e419S–94S.
Vedantham S. Interventional approaches to acute venous thromboembolism. Semin Respir Crit Care Med. 2008;29:56–65.
Kalagher SD, Kane DD. Phlegmasia cerulea dolens: before and after lysis. Intern Emerg Med. 2015;10:103–4.
Oo TH. Thrombolytic therapy and thrombectomy in phlegmasia cerulea dolens. J R Coll Physicians Edinb. 2010;40:92.
Erdoes LS, Ezell JB, Myers SI, Hogan MB, LeSar CJ, Sprouse LR 2nd. Pharmacomechanical thrombolysis for phlegmasia cerulea dolens. Am Surg. 2011;77:1606–12.
Kuo I, Smith J, Abou-Zamzam AM Jr. A multimodal therapeutic approach to phlegmasia cerulea dolens in a pediatric patient. J Vasc Surg. 2011;53:212–5.
Brockman SK, Vasko JS. Observations on the pathophysiology and treatment of Phlegmasia Cerulea Dolens with special reference to Thrombectomy. Am J Surg. 1965;109:485–92.
Meissner MH. Rationale and indications for aggressive early thrombus removal. Phlebology/Venous Forum of the Royal Society of Medicine. 2012;27(Suppl 1):78–84.
Venkatesh AK, Kline JA, Courtney DM, et al. Evaluation of pulmonary embolism in the emergency department and consistency with a National Quality Measure. Arch Intern Med. 2012;172:1028–32.
Alpert JS, Smith R, Carlson J, et al. Mortality in patients treated for pulmonary embolism. JAMA. 1976;236:1477–80.
Coon WW, Willis PW. Deep venous thrombosis and pulmonary embolism. Am J Cardiol. 1959;4:611–21.
Silverstein MD, Heit JA, Mohr DN, et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism. Arch Intern Med. 1998;158:585–93.
Aujesky D, Obrowsky DS, Stone RA, et al. Derivation and validation of a prognositic model for pulmonary embolism. Am J Respir Crit Care Med. 2005;172:1041–6.
Kline JA, Nordenholz KE, Courtney DM, et al. Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial. J Thromb Haemost. 2014;12:459–68.
Meyer G, Vicaut E, Danays T, et al. Fibrinolysis for patients with intermediate-risk pulmonary embolism. N Engl J Med. 2014;370:1402–11.
Sharifi M, Bay C, Skrocki L, Rahimi F, Mehdipour M, Investigators M. Moderate pulmonary embolism treated with thrombolysis (from the "MOPETT" Trial). Am J Cardiol. 2013;111:273–7.
Monagle P, Adams M, Mahoney M, et al. Outcomes of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia Registry. Pediatr Res. 2000;47:763–6.
Patocka C, Nemeth J. Pulmonary embolism in pediatrics. J Emerg Med. 2012;42:105–16.
Heit JA, Kobbervig CE, James AH, et al. Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study. Ann Intern Med. 2005;143:697–706.
Ghaji N, Boulet SL, Tepper N, Hooper WC. Trends in venous thromboembolism among pregnancy-related hospitalizations, United States, 1994-2009. Am J Obstet Gynecol. 2013;209:433 e1-8.
Kline JA, Kabrhel C. Emergency evaluation for pulmonary embolism, part 1: clinical factors that increase risk. J Emerg Med. 2015;48:771–80.
James AH, Jamison MG, Brancazio LR, Myers ER. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. Am J Obstet Gynecol. 2006;194:1311–5.
Goldhaber SZ, Elliott CG. Acute pulmonary embolism: part I: epidemiology, pathophysiology, and diagnosis. Circulation. 2003;108:2726–9.
Tripodi A, Anstee QM, Sogaard KK, Primignani M, Valla DC. Hypercoagulability in cirrhosis: causes and consequences. J Thromb Haemost. 2011;9:1713–23.
Gorospe L, Blanchard-Rodriguez MJ, Chinea-Rodriguez A. Cement pulmonary embolism after percutaneous vertebroplasty in multiple myeloma. Asian Cardiovasc Thorac Ann. 2016;24(4):400–1.
Nagai H, Maeda H, Kuroda R, et al. Lethal pulmonary air embolism caused by the removal of a double-lumen hemodialysis catheter. Am J Forensic Med Pathol. 2014;35:237–8.
Haider I, Gupta R, Song S. Mobile vegetation leading to septic pulmonary embolism. Lung India. 2014;31:429–30.
Wells PS, Ginsberg JS, Anderson DR, et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med. 1998;129:997–1005.
Tapson VF. Acute pulmonary embolism. N Engl J Med. 2008;358:1037–52.
Wells PS, Anderson DR, Rodger M. Derivation of a simple clinical model to categorize patients' probability of pulmonary embolism: increasing the model's utility with the SimliRED D-dimer. Thromb Haemost. 2000;83:416–20.
Wells PS, Anderson DR, Rodger M. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and d-dimer. Ann Intern Med. 2001;135:98–107.
Wells PS, Hirsh J, Anderson DR, et al. Accuracy of clinical assessment of deep-vein thrombosis. Lancet. 1995;345:1326–30.
Kline JA, Courtney DM, Kabrhel C, et al. Prospective multicenter evaluation of the pulmonary embolism rule-out criteria. J Thromb Haemost. 2008;6:772–80.
Klok FA, Mos ICM, Nijkeuter M, et al. Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism. Arch Intern Med. 2008;168:2131–6.
Le Gal G, Righini M, Roy P, et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score. Ann Intern Med. 2006;144:165–71.
Wicki J, Perneger TV, Junod AF, et al. Assessing clinical probability of pulmonary embolism in the emergency ward. Arch Intern Med. 2001;161:92–7.
Khouzam R, Gallahan MJ. Polycythemia rubra vera: an unlikely cause of severe pulmonary embolism. JAAPA. 2011;25:51–3.
Vu K, Luong NV, Hubbard J, et al. A retrospective study of venous thromboembolism in acute leukemia patients treated at the University of Texas MD Anderson Cancer Center. Cancer Med. 2015;4:27–35.
Miniati M, Bottai M, Monti S, Salvadori M, Serasini L, Passera M. Simple and accurate prediction of the clinical probability of pulmonary embolism. Am J Respir Crit Care Med. 2008;178:290–4.
Elliott CG, Goldhaber SZ, Visani L, DeRosa M. Chest radiographs in acute pulmonary embolism. Results from the international cooperative pulmonary embolism registry. Chest. 2000;118:33–8.
Stein PD, Terrin ML, Hales CA, et al. Clinical, laboratory, roentgenographic and electrocardiographic findings in patients with acute pulmonary embolism and no pre-existing cardiac or pulmonary disease. Chest. 1991;100:598–603.
Kukla P, McIntyre WF, Fijorek K, et al. Electrocardiographic abnormalities in patients with acute pulmonary embolism complicated by cardiogenic shock. Am J Emerg Med. 2014;32:507–10.
Kabrhel C, Mark Courtney D, Camargo CA Jr, et al. Potential impact of adjusting the threshold of the quantitative D-dimer based on pretest probability of acute pulmonary embolism. Acad Emerg Med. 2009;16:325–32.
Kline JA, Kabrhel C. Emergency evaluation for pulmonary embolism, part 2: diagnostic approach. J Emerg Med. 2015;49:104–17.
Stein PD, Fowler SE, Goodman LR, et al. Multidetector computed tomography for acute pulmonary embolism. NEJM. 2006;354:2317–27.
Kline JA, Courtney DM, Beam DM, King MC, Steuerwald M. Incidence and predictors of repeated computed tomographic pulmonary angiography in emergency department patients. Ann Emerg Med. 2009;54:41–8.
Einstein AJ, Henzlova MJ, Rajagopalan S. Estimating risk of cancer associated with radiation exposure from 64-slice computed coronary angiography. JAMA. 2007;298:317–23.
Mitchell AM, Kline JA, Jones AE, Tumlin JA. Major adverse events one year after acute kidney injury after contrast-enhanced computed tomography. Clin J Am Soc Nephrol. 2010;5:4–9.
Worsley DF, Alavi A. Comprehensive analysis of the results of the PIOPED study. J Nucl Med. 1995;36:2380–7.
Stein PD, Chenevert TL, Fowler SE, et al. Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism. Ann Intern Med. 2010;152:434.
Nazerian P, Vanni S, Volpicelli G, et al. Accuracy of point-of-care multiorgan ultrasonography for the diagnosis of pulmonary embolism. Chest. 2014;145:950–7.
Jaff MR, McMurtry MS, Archer SL, et al. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation. 2011;123:1788–830.
Jeffrey A, Kline MTS, Marchick MR, Hernandez-Nino J, Rose GA. Prospective evaluation of right heart function and functional status at 6 months after acute submassive pulmonary embolism. Chest. 2009;136:1202–10.
Kline JANK, Courtney DM, et al. Treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial. J Thromb Haemost. 2014;12:459–68.
Lualdi JC, Goldhaber SZ. Right ventricular dysfunction after acute pulmonary embolism: pathophysiologic factors, detection, and therapeutic implications. Am Heart J. 1995;130:1276–82.
Fengler BT, Brady WJ. Fibrinolytic therapy in pulmonary embolism: an evidence-based treatment algorithm. Am J Emerg Med. 2009;27:84–95.
Layish DT, Tapson VF. Pharmacologic hemodynamic support in massive pulmonary embolism. Chest. 1997;111:218–24.
Mebazaa A, Karpati P, Renaud E, Algotsson L. Acute right ventricular failure--from pathophysiology to new treatments. Intensive Care Med. 2004;30:185–96.
Lee FA. Hemodynamics of the right ventricle in normal and disease states. Cardiol Clin. 1992;10:59–67.
Angle MR, Molloy DW, Penner B, Jones D, Prewitt RM. The cardiopulmonary and renal hemodynamic effects of norepinephrine in canine pulmonary embolism. Chest. 1989;95:1333–7.
Torbicki A, Perrier A, Konstantinides S, et al. Guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J. 2008;29:2276–315.
Hirsch LJ, Rooney MW, Wat SS, Kleinmann B, Mathru M. Norepinephrine and phenylephrine effects on right ventricular function in experimental canine pulmonary embolism. Chest. 1991;100:796–801.
Layish DTMD, Tapson VFMD. Pharmacologic hemodynamic support in massive pulmonary embolism∗. [review]. Chest. 1997;111:218–24.
deBoisblanc BP. Treatment of massive pulmonary embolism. Clin Pulm Med. 1995;2:353–8.
Molloy WD, Lee KY, Girling L, Schick U, Prewitt RM. Treatment of shock in a canine model of pulmonary embolism. Am Rev Respir Dis. 1984;130:870–4.
Boulain T, Lanotte R, Legras A, Perrotin D. Efficacy of epinephrine therapy in shock complicating pulmonary embolism. Chest. 1993;104:300–2.
Gold J, Cullinane S, Chen J, et al. Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure. Am J Cardiol. 2000;85:506–8, A11.
Jardin F, Vieillard-Baron A. Right ventricular function and positive pressure ventilation in clinical practice: from hemodynamic subsets to respirator settings. Intensive Care Med. 2003;29:1426–34.
Haddad F, Couture P, Tousignant C, Denault AY. The right ventricle in cardiac surgery, a perioperative perspective: I. anatomy, physiology, and assessment. Anesth Analg. 2009;108:407–21.
Smulders YM. Pathophysiology and treatment of haemodynamic instability in acute pulmonary embolism: the pivotal role of pulmonary vasoconstriction. Cardiovasc Res. 2000;48:23–33.
Wan S, Quinlan DJ, Agnelli G, Eikelboom JW. Thrombolysis compared with heparin for the initial treatment of pulmonary embolism: a meta-analysis of the randomized controlled trials. Circulation. 2004;110:744–9.
Capstick T, Henry MT. Efficacy of thrombolytic agents in the treatment of pulmonary embolism. Eur Respir J. 2005;26:864–74.
Kearon C, Kahn SR, Agnelli G, Goldhaber S, Raskob GE, Comerota AJ. Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest. 2008;133:454S–545S.
Sharifi MBC, Skrocki L, et al. Moderate pulmonary embolism treated with thrombolysis (from the "MOPETT" trial). J Cardiol. 2013;111:273–7.
Aujesky D, Roy P-M, Verschuren F, et al. Outpatient versus inpatient treatment for patients with acute pulmonary embolism: an international, open-label, randomised, non-inferiority trial. Lancet. 2011;378:41–8.
Zondag W, Mos IC, Creemers-Schild D, et al. Outpatient treatment in patients with acute pulmonary embolism: the Hestia study. J Thromb Haemost. 2011;9:1500–7.
Yoo HHB, Queluz T, El Dib R. Outpatient versus inpatient treatment for acute pulmonary embolism (review). Cochrane Collab. 2014:CD010019.
Spencer FA, Emery C, Lessard D, et al. The Worcester venous Thromboembolism study: a population-based study of the clinical epidemiology of venous thromboembolism. J Gen Intern Med. 2006;21:722–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Ellender, T.J., Hackenson, D., Gundert, E. (2020). Pulmonary Embolism and Massive DVT for Emergency Critical Care. In: Shiber, J., Weingart, S. (eds) Emergency Department Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-030-28794-8_7
Download citation
DOI: https://doi.org/10.1007/978-3-030-28794-8_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-28792-4
Online ISBN: 978-3-030-28794-8
eBook Packages: MedicineMedicine (R0)