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Molecular Aspects of Thermal Tolerance and Exertional Heat Illness Susceptibility

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Exertional Heat Illness

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Abstract

Thermoregulation includes many physiological, molecular/cellular, and genetic mechanisms that are highlighted in Chap. 2. Molecular and cellular mechanisms of thermal tolerance (on a whole-body level) and relationships to EHS (exertional heat stroke) susceptibility include pathways associated with immune, endocrine, antioxidant, metabolic, skeletal muscle, and nervous system function. Research clearly implicates pathophysiology arising from LPS (lipopolysaccharide)-induced TLR4 (toll-like receptor 4) activation and subsequent endotoxemia/sepsis-induced inflammation and tissue damage. However, the role is not clearly defined because many have not considered the vast complexity in LPS and TLR-associated positive feedback to inflammation. We present aspects of immune function that complicate the relationship between endotoxemia and EHS pathophysiology that should be studied in future research and make it difficult to associate immune-related genotypes with EHS risk. Additionally, we present molecular targets of pharmacological treatments and individual genotypes associated with susceptibility to heat stress and MH (malignant hyperthermia) to depict novel molecular mechanisms likely associated with pathophysiology and EHS susceptibility.

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Authors and Affiliations

  1. Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT, USA

    Elaine C. Lee, Jacob S. Bowie, Aidan P. Fiol & Robert A. Huggins

  2. Department of Kinesiology, University of Connecticut, Storrs, CT, USA

    Elaine C. Lee, Jacob S. Bowie, Aidan P. Fiol & Robert A. Huggins

  3. Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs, CT, USA

    Robert A. Huggins

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  1. Elaine C. Lee
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  2. Jacob S. Bowie
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  3. Aidan P. Fiol
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  4. Robert A. Huggins
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Correspondence to Elaine C. Lee .

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Editors and Affiliations

  1. Department of Kinesiology University of North Carolina at Greensboro, Greensboro, NC, USA

    William M. Adams

  2. Korey Stringer Institute, University of Connecticut, Storrs, CT, USA

    John F. Jardine

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Lee, E.C., Bowie, J.S., Fiol, A.P., Huggins, R.A. (2020). Molecular Aspects of Thermal Tolerance and Exertional Heat Illness Susceptibility. In: Adams, W., Jardine, J. (eds) Exertional Heat Illness. Springer, Cham. https://doi.org/10.1007/978-3-030-27805-2_8

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