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Abstract

Nutraceutical have emerged as beneficial health products obtained from food, herbal, and pharmaceutical manufacturing industries. Nutraceuticals have gained worldwide popularity and defined as purified or concentrated food and food products with health-promoting and/or disease-preventing properties beyond their basic nutritional function (Gunther et al. 2004). The significance of nutraceuticals has been associated with the treatment of many disorders such as obesity, cancer, metabolic problems, cold and cough, depression, coronary heart disease, osteoporosis, diabetes, cardiovascular problems, delayed gastrointestinal emptying, and other degenerative diseases (Kaur et al. 2015). Nutraceutical has led to the new era of medicine and health, in which the food industry has become a research-oriented sector. Although the use of nutraceuticals by people has a long history, recently it has been scientifically supported by nutritional and medical evidence that has allowed nutraceuticals to emerge as being potentially effective (Dillard and German 2000).

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References

  • Alabdulkarim, B., Bakeet, Z. A. N., & Arzoo, S. (2012). Role of some functional lipids in preventing diseases and promoting health. Journal of King Saud University-Science, 24, 319–329.

    Article  Google Scholar 

  • Amir, H., Karas, M., Giat, J., Danilenko, M., Levy, R., & Yermiahu, T. (1998). Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Nutrition and Cancer, 33, 105–112.

    Article  Google Scholar 

  • Awad, A. B., Fink, C. S., Williams, H., & Kim, U. (2002). In vitro and in vivo (SCID mice) effects of phytosterols on the growth and dissemination of human prostate cancer PC-3 cells. European Journal of Cancer Prevention, 10(6), 507–513.

    Article  Google Scholar 

  • Benavente-García, O., & Castillo, J. (2008). Dietary flavonoids as cancer prevention agents. Update on uses and properties of citrus flavonoids: New findings in anticancer, cardiovascular, and anti-inflammatory activity. Journal of Agricultural and Food Chemistry, 56(15), 6185–6205.

    Article  Google Scholar 

  • Boukhris, M., Bouaziz, M., Feki, I., Jemai, H., Feki, A. E., & Sami, S. (2012). Hypoglycemic and antioxidant effects of leaf essential oil of Pelargonium graveolens L’Hér. In alloxan induced diabetic rats. Lipids in Health and Disease, 11, 81.

    Article  CAS  Google Scholar 

  • De Sousa, E., Zanatta, L., Seifriz, I., Creczynski-Pasa, T. B., Pizzolatti, M. G., Szpoganicz, B., & Silva, F. R. M. B. (2004). Hypoglycemic effect and antioxidant potential of kaempferol-3,7-O-(α)-dirhamnoside from Bauhinia forficata leaves. Journal of Natural Products, 67(5), 829–832.

    Article  Google Scholar 

  • Dillard, C. J., & German, J. B. (2000). Phytochemicals: Nutraceuticals and human health. Journal of the Science of Food and Agriculture, 80, 1744–1756.

    Article  CAS  Google Scholar 

  • Engelking, L. R. (2010). Textbook of veterinary physiological chemistry (updated) (2nd ed.). Amsterdam, Netherlands: Academic Press.

    Google Scholar 

  • Gunther, S., Patterson, R. E., Kristal, A. R., Stratton, K. L., & White, E. (2004). Demographic and health-related correlates of herbal and specialty supplement use. Journal of the American Dietetic Association, 104, 27–34.

    Article  Google Scholar 

  • Innis, M. D. (2008). Vitamin K deficiency disease. Journal of Orthomolecular Medicine, 23(1), 15–20.

    Google Scholar 

  • Institute of Medicine. (2002). Dietary reference intakes for energy, carbohydrate, fibre, fat, fatty acids, cholesterol, protein and amino acids. Journal of the American Dietetic Association, 102(11), 1621–1630.

    Article  Google Scholar 

  • Jeanes, Y. M., Hall, W. L., Ellard, S., Lee, E., & Lodge, J. K. (2004). The absorption of vitamin E is influenced by the amount of fat in a meal and the food matrix. British Journal of Nutrition, 92(4), 575–579.

    Article  CAS  Google Scholar 

  • Kangralkar, V. A., Gavimath, C. C., Jadhav, N. A., & Burli, S. C. (2010). Potential hypoglycemic effect of essential oil of citrus reticulata in wistar rats. International Journal of Applied Pharmaceutics, 1, 6–9.

    Google Scholar 

  • Kaur, G., Mukundan, S., Wani, V., & Kumar, M. S. (2015). Nutraceuticals in the management and prevention of metabolic syndrome. Austin Journal of Pharmacology and Therapeutics, 3, 1–6.

    Google Scholar 

  • Li, P., Zhang, L., Tian, X., & Xing, J. (2014). Docosahexaenoic acid has an anti-diabetic effect in streptozotocin-induced diabetic mice. International Journal of Clinical and Experimental Medicine, 7(9), 3021–3029.

    PubMed  PubMed Central  Google Scholar 

  • Madden, A., Trivedi, D., Smeeton, N., & Culkin, A. (2017). Modified dietary fat intake for treatment of gallstone disease. Cochrane Database of Systematic Reviews, 2017(3).

    Google Scholar 

  • Malfait, F., & De Paepe, A. (2009). Bleeding in the heritable connective tissue disorders: Mechanisms, diagnosis and treatment. Blood Reviews, 23(5), 191–197.

    Article  CAS  Google Scholar 

  • Morishita, M., Kajita, M., Suzuki, A., Takayama, K., Chiba, Y., Tokiwa, S., & Nagai, T. (2000). The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA. International Journal of Pharmaceutics, 201, 175–185.

    Article  CAS  Google Scholar 

  • Nishikawa, Y., Wang, Z., Kerns, J., Wilcox, C. S., & Carr, B. I. (1999). Inhibition of hepatoma cell growth in vitro by arylating and non-arylating K vitamin analogs. Significance of protein tyrosine phosphatase inhibition. Journal of Biological Chemistry, 274, 34803–34810.

    Article  CAS  Google Scholar 

  • Noto, V., Taper, H. S., Jiang, Y. H., Janssens. J., Bonte. J., & De Loecker, W. (1989). Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. I. Synergism of combined vitamin C and K3 action. Cancer, 63, 901–906.

    Google Scholar 

  • Palakurthi, S. S., Flückiger, R., Aktas, H., Changolkar, A. K., Shahsafaei, A., Harneit, S., … Halperin, J. A. (2000). Inhibition of translation initiation mediates the anticancer effect of the n-3 polyunsaturated fatty acid eicosapentaenoic acid. Cancer Research, 60, 2919–2925.

    CAS  PubMed  Google Scholar 

  • Pandalai, P. K., Pilat, M. J., Yamazaki, K., Naik, H., & Pienta, K. J. (1996). The effects of omega-3 and omega-6 fatty acids on in vitro prostate cancer growth. Anticancer Research, 16(2), 815–820.

    CAS  PubMed  Google Scholar 

  • Pirronen, V., Lindsay, D. G., Miettinen, T. A., Tovio, J., & Lampi, A. M. (2000). Review plant sterols: Biosynthesis, biological function and their importance to human nutrition. Journal of the Science of Food and Agriculture, 80, 939–966.

    Article  Google Scholar 

  • Sharma, B., Balomajumder, C., & Roy, P. (2008). Hypoglycemic and hypolipidemic effects of flavonoid rich extract from Eugenia jambolana seeds on streptozotocin induced diabetic rats. Food Chemistry, 46, 2376–2383.

    Article  CAS  Google Scholar 

  • Shimura, T., Miura, T., Usami, M., Ishihara, E., Tanigawa, K., Ishida, H., & Seino, Y. (1997). Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM). Biological & Pharmaceutical Bulletin, 20(5), 507–510.

    Article  CAS  Google Scholar 

  • Simopoulos, P. A. (2008). The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Experimental Biology and Medicine, 233(6), 674–688.

    Article  CAS  Google Scholar 

  • Singh, C. V., Verma, R. C. (2016). Effect of oral administration of vitamin a on blood glucose level in rabbits and its possible interactions with commonly used oral antidiabetic agents. International Journal of Pharmaceutical science and Research, 7, 2684–2691.

    Google Scholar 

  • Singh, T. P., Malik, R. K., Katkamwar, S. G., & Kaur, G. (2015). Hypocholesterolemic effects of Lactobacillus reuteri LR6 in rats fed on high-cholesterol diet. International Journal of Food Sciences and Nutrition, 66(1), 71–75.

    Article  CAS  Google Scholar 

  • Stokes, C. S., Gluud, L. L., Casper, M., & Lammert, F. (2014). Ursodeoxycholic acid and diets higher in fat prevent gallbladder stones during weight loss: A meta-analysis of randomized controlled trials. Clinical Gastroenterology and Hepatology, 12(7), 1090–1100. e1092.

    Article  CAS  Google Scholar 

  • Suksomboon, N., Poolsup, N., & Sinprasert, S. (2011). Effects of vitamin E supplementation on glycaemic control in type 2 diabetes: Systematic review of randomized controlled trials. Journal of Clinical Pharmacy and Therapeutics, 36(1), 53–63.

    Article  CAS  Google Scholar 

  • Taghizadeh, M., Jamilian, M., Mazloomi, M., Sanami, M., Asemi, Z. (2016). A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids and vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. Journal of Clinical Lipidology, 10, 386–393.

    Google Scholar 

  • Tahir, H. U., Sarfraz, R. A., Ashraf, A., & Adil, S. (2016). Chemical composition and antidiabetic activity of essential oils obtained from two spices (Syzygium aromaticum and Cuminum cyminum). International Journal of Food Properties, 19, 2156–2164.

    Article  CAS  Google Scholar 

  • Tanaka, M., Misawa, E., Ito, Y., Habara, N., Nomaguchi, K., Yamada, M., … Higuchi, R. (2006). Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biological & Pharmaceutical Bulletin, 29(7), 1418–1422.

    Article  CAS  Google Scholar 

  • Udupa, A., Nahar, P., Shah, S., Kshirsagar, M., & Ghongane, B. (2013). A comparative study of effects of omega-3 fatty acids, alpha lipoic acid and vitamin E in type 2 diabetes mellitus. Annals of Medical and Health Sciences Research, 3(3), 442–446.

    Article  CAS  Google Scholar 

  • Wang, X., Hang, Y., Liu, J., Hou, Y., Wang, N., & Wang, M. (2017). Anticancer effect of curcumin inhibits cell growth through mir-21/pten/akt pathway in breast cancer cell. Oncology Letters, 13, 4825–4831.

    Article  CAS  Google Scholar 

  • Winstein, S. J., Wright, M. E., Lawson, K. A., Snyder, K., Männisto, S., Taylor, P. R., Virtamo, J., Albanes, D. (2007) Serum and dietary vitamin E in relation to prostate cancer risk. Cancer Epidemiology Biomarkers and Prevention, 16, 1253–1259.

    Google Scholar 

  • Wu, F. Y., Liao, W. C., & Chang, H. M. (1993). Comparison of antitumor activity of vitamins K1, K2 and K3 on human tumor cells by two (MTT and SRB) cell viability assays. Life Sciences, 52, 1797–1804.

    Article  CAS  Google Scholar 

  • Yu, H., & Huang, G. (2010). Enhanced in vitro anti-cancer activity of curcumin encapsulated in Hydrophobically modified starch. Food Chemistry, 119, 669–674.

    Article  CAS  Google Scholar 

  • Yu, N. H., Yin, J. J., & Shen, S. R. (2004). Growth inhibition of prostate cancer cells by epigallocatechin in the presence of Cu2. Journal of Agricultural and Food Chemistry, 52, 462–466.

    Article  CAS  Google Scholar 

  • Zhang, M., Binns, C. V., & Lee, A. H. (2002). Tea consumption and ovarian cancer risk: A case-control study in China. Cancer Epidemiology, Biomarkers & Prevention, 11, 713–718.

    Google Scholar 

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Swamy, G.J., Natarajan, E.P., Rajamanickam, G. (2021). Nutraceutical Properties of Lipids. In: Gani, A., Ashwar, B.A. (eds) Food biopolymers: Structural, functional and nutraceutical properties. Springer, Cham. https://doi.org/10.1007/978-3-030-27061-2_17

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