Abstract
Events in fetal and early postnatal life modulate respiratory health throughout the life-span. Respiratory system development is a highly coordinated and complex process. Several growth factors are involved at each lung development stage. Endogenous and exogenous issues produce disorders related to the growth, maturation, or function of the tissues in formation. Airways and blood pulmonary tissues develop during the fetal stage, but alveolar development occurs mainly postnatally; thus, injuries that affect the fetus or newborn undoubtedly have an impact depending on when they present. Better understanding of normal respiratory system development is essential to improve clinical management of premature newborns with respiratory diseases.
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Baguma-Nibasheka M, Gugic D, Saraga-Babic M, Kablar B. Role of skeletal muscle in lung development. Histhol Histopathol. 2012;27:817–26.
Copland I, Post M. Lung development and fetal lung growth. Pediatr Respir Rev. 2004;5(Suppl A):S259–64.
De Paepe M, Shapiro S, Hansen K, Gündogan F. Postmortem lung volume/body weight standards for term and preterm infants. Pediatr Pulmonol. 2014;49(1):60–6.
Gibson A. Perinatal corticosteroids and the developing lung. Pediatr Respir Rev. 2002;3:70–6.
Greenough A. Factors adversely affecting lung growth. Pediatr Respir Rev. 2000;1:314–20.
Hislop A. Developmental biology of the pulmonary circulation. Pediatr Respir Rev. 2005;6:35–43.
Hulskamp G, Pillow J, Dinger J, Stocks J. Lung function tests in neonates and infants with chronic lung disease of infancy: functional residual capacity. Pediatr Pulmonol. 2006;41:1–22.
Iñiguez F, Sánchez I. Desarrollo pulmonar. Neumología Pediátrica. 2008;3:148–55.
Katz C, Bentur L, Elias N. Clinical implications of lung fluid balance in the perinatal period. J Perinatol. 2011;31:230–5.
Lopuhaa C, Roseboom T, Osmond C, et al. Atopy, lung function, and obstructive airways disease after prenatal exposure to famine. Thorax. 2000;55:555–61.
McEvoy C, Schilling D, Spitale P, Peters D, O’Malley J, Durand M. Decreased respiratory compliance in infants less than or equal to 32 weeks’ gestation, delivered more than 7 days after antenatal steroid therapy. Pediatrics. 2008;121:e1032–8.
Roth-Kleiner M, Post M. Similarities and dissimilarities of branching and septation during lung development. Pediatr Pulmonol. 2005;40:113–34.
Schittny J, Miserocchi G, Sparrow M. Spontaneous peristaltic airway contractions propel lung liquid through the bronchial tree of intact and fetal lung explants. Am J Respir Cell Mol Biol. 2000;23:11–8.
Waburton D, El-Hashash A, Carraro G, et al. Lung organogenesis. Curr Top Dev Biol. 2010;90:73–158.
Wilson S, Olven R, Walters D. Developmental regulation of lumenal lung fluid and electrolyte transport. Respir Physiol Neurobiol. 2007;159:247–55.
Zeman K, Bennet W. Growth of the small airways and alveoli from childhood to the adult lung measured by aerosol-derived airway morphology. J Appl Physiol. 2006;100:956–71.
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Iñiguez Osmer, F., Sánchez, I. (2020). Development of the Respiratory System. In: Bertrand, P., Sánchez, I. (eds) Pediatric Respiratory Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-26961-6_2
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DOI: https://doi.org/10.1007/978-3-030-26961-6_2
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