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Bacterial Resistance to Phage and Its Impact on Clinical Therapy

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Phage Therapy: A Practical Approach

Abstract

Antibiotic resistance has incited a renewed interest in phage therapy as an alternative treatment option for bacterial infections. The potential risk of incurring a parallel situation of resistance to phage as to that observed with antibiotics is a veritable concern for evaluating the merits of this therapy. Bacterial resistance to phage is indeed a natural phenomenon but which requires a greater understanding of bacteria–phage interactions and treatment paradigms in order to determine its impact on therapeutic utility. This chapter aims to contextualize this knowledge within the available applied studies in animals and clinical medicine published to date. Options to use phage combinations or implement protocols that allow for phage substitution or combination with antibiotics may mitigate the risk of developing resistance to phage or even antibiotics themselves. While resistance can be anticipated with phage therapy, it is possible to circumvent its negative effects on clinical outcomes, or, in some situations, it may even be a silver lining that could contribute to effective treatment of bacterial infections.

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Authors and Affiliations

  1. Unit of Regenerative Medicine, Department of Musculoskeletal Medicine, Service of Plastic, Reconstructive, & Hand Surgery, University Hospital of Lausanne (CHUV), Lausanne, Switzerland

    Shawna McCallin

  2. Département de biochimie, de microbiologie, et de bio-informatique, Faculté des sciences et de génie, Université Laval, Québec City, QC, Canada

    Frank Oechslin

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  1. Shawna McCallin
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Editors and Affiliations

  1. Ludwik Hirszfeld Institute of Immunology, Polish Academy of Sciences, Wroclaw, Poland

    Andrzej Górski

  2. Ludwik Hirszfeld Institute of Immunology, Polish Academy of Sciences, Wroclaw, Poland

    Ryszard Międzybrodzki

  3. Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland

    Jan Borysowski

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McCallin, S., Oechslin, F. (2019). Bacterial Resistance to Phage and Its Impact on Clinical Therapy. In: Górski, A., Międzybrodzki, R., Borysowski, J. (eds) Phage Therapy: A Practical Approach. Springer, Cham. https://doi.org/10.1007/978-3-030-26736-0_3

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