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Management of Strongyloides Hyperinfection Syndrome

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Evidence-Based Critical Care

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Abstract

Strongyloides stercoralis is an infectious helminth endemic to the tropics and subtropics, and can be seen in immigrants and returning travelers. Symptoms of acute infection involve organs of the typical life cycle of the nematode. In milder forms of chronic infections, strongyloides is capable of persisting in a host for years to decades. Severe strongyloidiasis includes the hyperinfection syndrome and disseminated infection, and occurs most frequently in the immunocompromised and immunosuppressed populations. We illustrate a case of severe strongyloidiasis, discuss clinical manifestations and diagnosis of infection, and present the evidence for treatment options. The key to successful therapy is early recognition of disease, and prompt diagnosis in high risk patients.

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Acknowledgments

Disclosure: The findings and conclusions in this document are those of the authors, who are responsible for its content, and do not necessarily represent the views of the Agency for Healthcare Research and Quality (AHRQ). No statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services.

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Authors and Affiliations

  1. Internal Medicine, Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA

    Shijing Jia

  2. Department of Pathology, University of Michigan and Veterans Affairs Ann Arbor Health System, Ann Arbor, MI, USA

    Hedwig S. Murphy

  3. Division of Healthcare-Associated Infections, Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD, USA

    Melissa A. Miller

Authors
  1. Shijing Jia
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  2. Hedwig S. Murphy
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  3. Melissa A. Miller
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Corresponding author

Correspondence to Shijing Jia .

Editor information

Editors and Affiliations

  1. Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA

    Robert C. Hyzy

  2. Division of Pulmonary and Critical Care, University of Michigan, Ann Arbor, MI, USA

    Jakob McSparron

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Jia, S., Murphy, H.S., Miller, M.A. (2020). Management of Strongyloides Hyperinfection Syndrome. In: Hyzy, R.C., McSparron, J. (eds) Evidence-Based Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-030-26710-0_62

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  • DOI: https://doi.org/10.1007/978-3-030-26710-0_62

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-26709-4

  • Online ISBN: 978-3-030-26710-0

  • eBook Packages: MedicineMedicine (R0)

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