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Chemoembolization for Colorectal Liver Metastases

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Colorectal Cancer Liver Metastases

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Abstract

In the last decade most of the relevant literature to support TACE in the treatment of CRLM came from reports using the drug-eluting carrier-based delivery treatment. More specifically, DEBIRI has the majority of the data in this context and is the only TACE treatment with a reported phase III study and two published systematic reviews. The combination of TACE and thermal ablation has potential synergistic benefits although it has been scarcely exploited in the literature. Scheduled TACE administration with concurrent systemic chemotherapy seems promising, and two randomized controlled trials exploiting this association have been published. Although different TACE modalities can show high tumor response rate and adequate progression-free survival rate or overall survival, the optimal intra-arterial approach to CRLM has not been established, and recognized competitive modalities such as radioembolization and intra-arterial chemotherapy treatment must be addressed in a head-to-head comparison to TACE.

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Author information

Authors and Affiliations

  1. Head Interventional Radiology Unit, Radiology Department, INCA – Brazilian National Cancer Institute, Rio de Janeiro, Brazil

    José Hugo Mendes Luz

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  1. José Hugo Mendes Luz
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Editors and Affiliations

  1. National Cancer Institute, Rio de Janeiro, Brazil

    Mauro Monteiro Correia

  2. Banner MD Anderson Cancer Center, Phoenix, AZ, USA

    Michael A. Choti

  3. Virginia Mason Medical Center, Seattle, WA, USA

    Flavio G. Rocha

  4. Center for Advanced Treatment of HBP Diseases, Ageo Central General Hospital, Ageo Shi, Saitama, Japan

    Go Wakabayashi

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Luz, J.H.M. (2020). Chemoembolization for Colorectal Liver Metastases. In: Correia, M., Choti, M., Rocha, F., Wakabayashi, G. (eds) Colorectal Cancer Liver Metastases. Springer, Cham. https://doi.org/10.1007/978-3-030-25486-5_37

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  • DOI: https://doi.org/10.1007/978-3-030-25486-5_37

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  • Online ISBN: 978-3-030-25486-5

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