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The Developmental Origins of Osteoporosis

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Early Life Origins of Ageing and Longevity

Part of the book series: Healthy Ageing and Longevity ((HAL,volume 9))

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Abstract

Osteoporosis is a disease characterised by poor bone strength and microarchitecture, causing bone fragility, which leads to an increased risk of fractures. Although primarily seen as a disease of old age, evidence is accumulating that in utero and early life environment can set an individual on a trajectory for osteoporosis and fragility fracture in later life. The development of osteoporosis is dependent on peak bone mass, and the subsequent rate of loss. The peak bone mass achieved by the third decade of life has been shown to be a powerful predictor of osteoporosis; although peak bone mass is partly genetically determined, the remaining majority contribution is attributable to environmental exposures in early life and modifiable lifestyle factors through life. Current osteoporosis management focuses on bone loss later in life, but it is important to consider strategies earlier in the lifecourse. This review will focus on events operating in utero, or early in post-natal life that influence bone health of the individual.

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Authors and Affiliations

  1. MRC Epidemiology Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK

    Clare Shere, Cyrus Cooper & Elaine M. Dennison

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  1. Clare Shere
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  2. Cyrus Cooper
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  3. Elaine M. Dennison
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Correspondence to Elaine M. Dennison .

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  1. Laboratory of Epigenetics, Institute of Gerontology, Kiev, Ukraine

    Alexander Vaiserman

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Shere, C., Cooper, C., Dennison, E.M. (2019). The Developmental Origins of Osteoporosis. In: Vaiserman, A. (eds) Early Life Origins of Ageing and Longevity. Healthy Ageing and Longevity, vol 9. Springer, Cham. https://doi.org/10.1007/978-3-030-24958-8_8

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