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Transient Elastography in Chronic Liver Diseases

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Liver Diseases

Abstract

Liver fibrosis is a sign of progressive liver disease and is commonly an indication for treatment. The present standard for diagnosing liver fibrosis is biopsy. But, due to liver biopsy limitations (inter-observer variation amongst pathologists, fibrosis staging systems and sampling errors), there is an urgent need to estimate the liver fibrosis stages and inflammation grades away from liver biopsy by noninvasive maneuvers. Therefore, in medical filed, there are many efforts to find noninvasive markers for estimation of liver fibrosis stage and to monitor disease progression and also response to treatment. One amongst the foremost common is transient elastography (FibroScan). Transient elastography (TE) is a non-invasive tool with acceptable correctness and reproducibility that allows rapid and easy assessment of liver fibrosis in many liver diseases. The aim of this review is to analysis the present proof regarding the clinical applications of TE in major liver diseases.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Mansoura University, Mansoura, Egypt

    Gamal El-Sayed Shiha

  2. Egyptian Liver Research Institute and Hospital (ELRIH), Sherbin, El-Mansoura, Egypt

    Gamal El-Sayed Shiha

  3. Department of Tropical Medicine, Mansoura University, Mansoura, Egypt

    Nasser Mousa

Authors
  1. Gamal El-Sayed Shiha
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  2. Nasser Mousa
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Editor information

Editors and Affiliations

  1. Faculty of Medicine, “Titu Maiorescu” University, Central Military Emergency University Hospital “Dr. Carol Davila”, Bucharest, Romania

    Florentina Radu-Ionita

  2. New Jersey Medical School, Rutgers University New Jersey Medical School, Newark, NJ, USA

    Nikolaos T. Pyrsopoulos

  3. Carol Davila University of Medicine and Pharmacy, Central Military Emergency University Hospital “Dr. Carol Davila”, Bucharest, Romania

    Mariana Jinga

  4. Faculty of Medicine, “Titu Maiorescu” University, Central Military Emergency University Hospital “Dr. Carol Davila”, Bucharest, Romania

    Ion C. Tintoiu

  5. Medical Radiation Sciences, Curtin University, Perth, WA, Australia

    Zhonghua Sun

  6. “Prof. C.C. Iliescu” Emergency Institute for Cardiovascular Diseases, Bucharest, Romania

    Ecaterina Bontas

Self Study

Self Study

1.1 Questions

  1. 1.

    Which statement is true?

    1. (a)

      Liver fibrosis is a sign of progressive liver disease.

    2. (b)

      Transient elastography provides fast estimation of liver stiffness.

    3. (c)

      The stiffer the tissue, the slower the shear wave propagates.

    4. (d)

      TE is done while the patient is requested to lie on right side.

  2. 2.

    Which statement/statements is/are true?

    1. (a)

      Transient elastography is time consuming technique.

    2. (b)

      Transient elastography invasive maneuver.

    3. (c)

      Transient elastography is painless technique.

    4. (d)

      Transient elastography should be made with full information of patient Clinical-demographic data.

  3. 3.

    Which statement/statements is/are true as regard Transient elastography?

    1. (a)

      Standard M test can’t generally be made in obese patients.

    2. (b)

      XL probes were ideal for obese patients.

    3. (c)

      Marked increase in Alanine aminotransferase, might lead to decrease in liver stiffness.

    4. (d)

      Liver stiffness estimations not exaggerated in patients with heart failure.

  4. 4.

    Which statement/statements is/are true?

    1. (a)

      TE has been suggested by the American Association for the Study of Liver Diseases and European Association for the Study of the Liver in patients with CHB.

    2. (b)

      TE is very well validated in NAFLD.

    3. (c)

      TE lacks a high-quality as noninvasive method for the measurement of liver stiffness.

    4. (d)

      Studies have shown non promising results in the use of TE in assessing fibrosis and disease progression in the setting of HIV-HCV co-infection.

1.2 Answers

  1. 1.

    Which statement is true?

    • a

  2. 2.

    Which statement/statements is/are true?

    • c and d

  3. 3.

    Which statement/statements is/are true as regard Transient elastography?

    • a and b

  4. 4.

    Which statement/statements is/are true?

    • a

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Shiha, G.ES., Mousa, N. (2020). Transient Elastography in Chronic Liver Diseases. In: Radu-Ionita, F., Pyrsopoulos, N., Jinga, M., Tintoiu, I., Sun, Z., Bontas, E. (eds) Liver Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-24432-3_48

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