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Glutamate Receptor Auxiliary Subunits and Interacting Protein Partners in the Cerebellum

  • Reference work entry
  • First Online:
Handbook of the Cerebellum and Cerebellar Disorders

Abstract

AMPA- and kainate-type glutamate receptors play a central role in excitatory signaling and synaptic plasticity in the cerebellum. Considerable attention has therefore focused on the molecular mechanisms involved in the dynamic control of these receptors and their constituent subunits. A number of transmembrane and intracellular proteins have emerged as key molecular determinants of AMPA and kainate receptor behavior.

Much of the early information on transmembrane AMPAR regulatory proteins (TARPs) arose from experiments on cerebellar neurons in stargazer mice. Although it is clear that the TARPs regulate AMPAR properties throughout the brain, the cerebellum continues to be a particularly suitable brain region for studies on the functional role of TARPs and many of the other receptor-associated proteins. This chapter focuses on the AMPA and kainate receptor subtypes and subunits present in the main cerebellar neurons and glia. In particular, we will consider recent evidence for the dynamic regulation of these receptor subunits by transmembrane and intracellular protein partners – in relation to cerebellar synaptic transmission and plasticity.

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Acknowledgments

We are grateful to the Wellcome Trust, the MRC and the Royal Society for support, and to our colleagues for invaluable discussions.

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Authors and Affiliations

  1. Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK

    Ian D. Coombs & Stuart G. Cull-Candy

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  1. Ian D. Coombs
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Correspondence to Ian D. Coombs .

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Editors and Affiliations

  1. CHU-Charleroi, University of Mons, Charleroi, Belgium

    Mario U. Manto

  2. Department of Neuroscience, The Scripps Research Institute, La Jolla, CA, USA

    Donna L. Gruol

  3. Ataxia Center, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

  4. Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  5. Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA

    Roy V. Sillitoe

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  1. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Jeremy D. Schmahmann

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Coombs, I.D., Cull-Candy, S.G. (2022). Glutamate Receptor Auxiliary Subunits and Interacting Protein Partners in the Cerebellum. In: Manto, M.U., Gruol, D.L., Schmahmann, J.D., Koibuchi, N., Sillitoe, R.V. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-23810-0_35

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