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Parvovirus-Related Arthritis

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Infections and the Rheumatic Diseases

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Abstract

Parvovirus B19 is a small virus with worldwide distribution and high infectivity rates, that affects mainly school-aged children, but previously non-infected adults are also susceptible. After infection, patients develop life-lasting neutralizing antibodies.

Infected patients may present with a myriad of symptoms, ranging between an asymptomatic state and flu-like disease to several manifestations of diverse severity, including fetal complications.

The most frequent manifestation of the disease in children is erythema infectiosum (fifth disease), while adults, especially woman, usually present with arthritis. Nevertheless, there is controversy on a possible role of Parvovirus B19 as a trigger for rheumatic diseases such as rheumatoid arthritis, lupus, vasculitis, and myositis, among others.

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Abbreviations

ACPA:

Anti-citrullinated protein Antibodies

CFS:

Chronic Fatigue Syndrome

CNS:

Central Nervous System

CRP:

C Reactive Protein

CSF:

Cerebrospinal Fluid

EI:

Erythema Infectiosum

ESR:

Erythrocyte Sedimentation Rate

FM:

Fibromyalgia

HBoV:

Human Bocavirus 1 to 4

HLA:

Human Leukocitary Antigen

INF-γ:

Interferon γ

IL:

Interleukin

IUT:

Intrauterine Transfusion

JIA:

Juvenile Idiopathic Arthritis

kD:

Kilo Dalton

NIHF:

Non-Immune Hydrops Fetalis

OA:

Osteoarthritis

ORF:

Open Reading Frame

PCR:

Polymerase Chain Reaction

PPGSS:

Papular Purpuric Gloves and Socks Syndrome

PRCA:

Pure Red Cell Aplasia

PV-B19:

Parvovirus B19

RA:

Rheumatoid Arthritis

SLE:

Systemic Lupus Erythematosus

sPLA2:

Secreted Phospholipase A2

STAT3:

Signal Transducer and Activator of Transcription 3

TAC:

Transient Aplastic Crisis

TGF-β:

Tissular Grow Factor β

TNF-α:

Tumor Necrosis Factor α

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Authors and Affiliations

  1. Fundación Favaloro, Buenos Aires, Argentina

    Martin Brom & Carlos Edgardo Perandones

  2. Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

    Martin Brom

  3. FLENI (Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia), Buenos Aires, Argentina

    Carlos Edgardo Perandones

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  1. Martin Brom
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  2. Carlos Edgardo Perandones
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  1. LSU Health Sciences at New Orleans, Louisiana State University, New Orleans, LA, USA

    Luis R. Espinoza

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Brom, M., Perandones, C.E. (2019). Parvovirus-Related Arthritis. In: Espinoza, L. (eds) Infections and the Rheumatic Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-23311-2_14

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