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The International Society for Mild Approaches in Assisted Reproduction (ISMAAR) Definitions for Mild Stimulation and Their Rationale for Assisted Reproductive Technologies

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Diminished Ovarian Reserve and Assisted Reproductive Technologies

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Abstract

In order to increase the oocyte yield from a single in vitro fertilization (IVF) cycle, controlled ovarian stimulation (COS) protocols were developed. Increased daily doses of follicle-stimulating hormone (FSH) products in conventional COS protocols brought concerns about their association with ovarian hyperstimulation syndrome, multiple pregnancies due to the transfer of increased number of embryos to achieve pregnancy, increased embryonic aneuploidy, and inferior IVF outcomes. This leads to revisiting milder stimulation protocols for IVF. The International Society for Mild Approaches in Assisted Reproduction (ISMAAR) brought the definition for mild stimulation. Gentle approaches to IVF including natural cycle and mild and minimal stimulation protocols found acceptance especially in women with expected poor ovarian response, mostly due to diminished ovarian reserve and advanced reproductive age.

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Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Fertility and Advanced Reproductive Medicine Assisted Reproductive Technologies Program, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Orhan Bukulmez

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  1. Orhan Bukulmez
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Correspondence to Orhan Bukulmez .

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  1. Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, TX, USA

    Orhan Bukulmez

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Bukulmez, O. (2020). The International Society for Mild Approaches in Assisted Reproduction (ISMAAR) Definitions for Mild Stimulation and Their Rationale for Assisted Reproductive Technologies. In: Bukulmez, O. (eds) Diminished Ovarian Reserve and Assisted Reproductive Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-23235-1_10

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  • DOI: https://doi.org/10.1007/978-3-030-23235-1_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-23234-4

  • Online ISBN: 978-3-030-23235-1

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